Design of a potent reactivator of tabun-inhibited acetylcholinesterase- synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4- hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203)

Journal of Medicinal Chemistry

Volumn 50, Issue 22, 2007, Pages 5514-5518

  Musilek, Kamil ^a,b   Jun, Daniel ^a,c   Cabal, Jiri ^a   Kassa, Jiri ^a   Gunn Moore, Frank ^d   Kuca, Kamil ^a,c  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

^d UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 CARBAMOYLPYRIDINIUM) 4 (4 HYDROXYIMINOMETHYLPYRIDINIUM)BUT 2 ENE DIBROMIDE; ACETYLCHOLINESTERASE; ANTIDOTE; CHOLINESTERASE REACTIVATOR; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; ORGANOPHOSPHATE; PYRIDINIUM DERIVATIVE; SARIN; SOMAN; TABUN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; EVALUATION RESEARCH; IN VITRO STUDY; IN VIVO STUDY; INTOXICATION; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DRUG DESIGN; KINETICS; OXIMES; PHOSPHORIC ACID ESTERS; PYRIDINIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35848930605     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070653r     Document Type: Article

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