New safe method for preparation of sarin-exposed human erythrocytes acetylcholinesterase using non-toxic and stable sarin analogue isopropyl p-nitrophenyl methylphosphonate and its application to evaluation of nerve agent antidotes

Pharmaceutical Research

Volumn 23, Issue 12, 2006, Pages 2827-2833

  Ohta, Hikoto ^a   Ohmori, Takeshi ^a   Suzuki, Shinichi ^a   Ikegaya, Hiroshi ^a   Sakurada, Koichi ^a   Takatori, Takehiko ^a  

^a NATIONAL RESEARCH INSTITUTE OF POLICE SCIENCE   (Japan)

Author keywords

Acetylcholinesterase; Antidote; Isopropyl p nitrophenyl methylphosphonate (INMP); PAM; Sarin

Indexed keywords

2 [(HYDROXYIMINO)METHYL] 1 [4 (TERT BUTYL)BENZYL]PYRIDINIUM BROMIDE; ACETYLCHOLINESTERASE; ANTIDOTE; ISOPROPYL 4 NITROPHENYL METHYLPHOSPHONATE; METHYLPHOSPHONIC ACID; PYRIDINEALDOXIME METHIODIDE; PYRIDINIUM DERIVATIVE; SARIN;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG SYNTHESIS; ENZYME ACTIVITY; ERYTHROCYTE; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ANTIDOTES; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DRUG EVALUATION, PRECLINICAL; ERYTHROCYTES; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; SARIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845369068     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9123-1     Document Type: Article

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