Synthesis and evaluation of novel bis-pyridinium oximes as reactivators of DFP-inhibited acetylcholinesterase

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1335-1340

  Acharya, Jyotiranjan ^a   Gupta, Arvind Kumar ^a   Dubey, Devendra Kumar ^a   Raza, Syed Kalbey ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

2 PAM; Acetylcholinesterase; Bis pyridinium oximes; DFP; Nerve agents; Organophosphorus pesticides; Reactivators

Indexed keywords

1,3 DIMETHOXYMETHYL BENZENE BIS [4,4' (HYDROXYIMINOMETHYL) PYRIDINIUM]DICHLORIDE; 1,4 DIMETHOXY BUT 2 ENE BIS [4,4' (HYDROXYIMINOMETHYL)PYRIDINIUM]; ACETYLCHOLINESTERASE; DYFLOS; OBIDOXIME; OXIME DERIVATIVE; PRALIDOXIME; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DRUG EVALUATION, PRECLINICAL; ISOFLUROPHATE; MAGNETIC RESONANCE SPECTROSCOPY; OXIMES;

EID: 60549114749     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.02.029     Document Type: Article

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