Blood-brain barrier penetration of novel pyridinealdoxime methiodide (PAM)-type oximes examined by brain microdialysis with LC-MS/MS

Toxicology and Applied Pharmacology

Volumn 227, Issue 1, 2008, Pages 8-15

  Okuno, Sou ^a   Sakurada, Koichi ^b   Ohta, Hikoto ^b   Ikegaya, Hiroshi ^b   Kazui, Yuko ^b   Akutsu, Tomoko ^b   Takatori, Takehiko ^b   Iwadate, Kimiharu ^a  

^a Division of Public Health   (Japan)

^b NATIONAL RESEARCH INSTITUTE OF POLICE SCIENCE   (Japan)

Author keywords

2 Pyridinealdoxime methiodide (2 PAM); Acetylcholinesterase (AChE); Blood brain barrier (BBB); Microdialysis; Organophosphate poisoning; Oxime

Indexed keywords

4 [(HYDROXYIMINO) METHYL] 1 (2 PHENYLETHYL) PYRIDINIUM BROMIDE; 4 [(HYDROXYIMINO)METHYL] 1 OCTYLPYRIDINIUM BROMIDE; BROMINE DERIVATIVE; CHOLINESTERASE; METHYL IODIDE; ORGANOPHOSPHATE; OXIME DERIVATIVE; PYRIDINEALDOXIME METHIODIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CHEMICAL STRUCTURE; CONTROLLED STUDY; EXTRACELLULAR FLUID; INTOXICATION; LIQUID CHROMATOGRAPHY; MICRODIALYSIS; NONHUMAN; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CALIBRATION; CHROMATOGRAPHY, LIQUID; CORPUS STRIATUM; EXTRACELLULAR FLUID; MALE; MICRODIALYSIS; PRALIDOXIME COMPOUNDS; RATS; RATS, WISTAR; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

RATTUS; RATTUS NORVEGICUS;

EID: 38849120721     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.09.021     Document Type: Article

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