In vitro reactivation potency of acetylcholinesterase reactivators - K074 and K075 - To reactivate tabun-inhibited human brain cholinesterases

Neurotoxicity Research

Volumn 11, Issue 2, 2007, Pages 101-106

  Kuca, Kamil ^a,b   Cabal, Jiri ^b   Jun, Daniel ^a,b   Musilek, Kamil ^b,c  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Acetylcholinesterase; K074; K075; Nerve agents; Oximes; Reactivators; Tabun

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1,4 BIS(4 HYDROXYIMINOMETHYLPYRIDINIUM)BUT 2 EN DIBROMIDE; CHOLINESTERASE; CHOLINESTERASE REACTIVATOR; K 074; K 075; METHOXIME; OBIDOXIME; PRALIDOXIME; TABUN; UNCLASSIFIED DRUG; 1,4 BIS(4 HYDROXYIMINOMETHYLPYRIDINIUM)BUTANE DIBROMIDE; 1,4-BIS(4-HYDROXYIMINOMETHYLPYRIDINIUM)BUTANE DIBROMIDE; ACETYLCHOLINESTERASE; BUTANE; CHOLINESTERASE INHIBITOR; K075 COMPOUND; N,N' MONOMETHYLENEBIS(PYRIDINIUMALDOXIME); N,N'-MONOMETHYLENEBIS(PYRIDINIUMALDOXIME); ORGANOPHOSPHATE; OXIME; PYRIDINIUM DERIVATIVE;

ARTICLE; BRAIN HOMOGENATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; ENZYME REACTIVATION; HUMAN; IN VITRO STUDY; PRIORITY JOURNAL; CAUDATE NUCLEUS; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM;

ACETYLCHOLINESTERASE; BUTANES; CAUDATE NUCLEUS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; ENZYME ACTIVATION; HUMANS; OBIDOXIME CHLORIDE; OXIMES; PHOSPHORIC ACID ESTERS; PRALIDOXIME COMPOUNDS; PYRIDINIUM COMPOUNDS;

EID: 34249731938     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033389     Document Type: Article

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