Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker-Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 11, 2007, Pages 3172-3176

  Musilek, Kamil ^a,b   Holas, Ondrej ^a   Kuca, Kamil ^b,c   Jun, Daniel ^b,c   Dohnal, Vlastimil ^d   Opletalova, Veronika ^a   Dolezal, Martin ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

^d MENDEL UNIVERSITY IN BRNO   (Czech Republic)

Author keywords

Acetylcholinesterase; Nerve agent; Oxime; Paraoxon; Pesticide; Reactivation; Reactivator; Tabun

Indexed keywords

ACETYLCHOLINESTERASE; BISPIRIDIUM; PARAOXON; PHENAZOPYRIDINE; PRALIDOXIME; TABUN; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY;

ACETYLCHOLINESTERASE; BUTANES; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; HUMANS; OXIMES; PARAOXON; PHOSPHORIC ACID ESTERS; PYRIDINIUM COMPOUNDS;

EID: 34248197142     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.025     Document Type: Article

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