Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: Structural basis for differences in the ability to reactivate tabun conjugates

Biochemical Pharmacology

Volumn 72, Issue 5, 2006, Pages 597-607

  Ekström, Fredrik ^a   Pang, Yuan Ping ^b   Boman, Malin ^a   Artursson, Elisabet ^a   Akfur, Christine ^a   Börjegren, Susanne ^a  

^a SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^b Mayo Clinic   (United States)

Author keywords

Acetylcholinesterase; HI 6; Obidoxime; Ortho 7; Structural change; X ray crystallography

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; ASPARTIC ACID; CARBOXYL GROUP; CHOLINESTERASE REACTIVATOR; NITROGEN; OBIDOXIME; ORTHO 7; PYRIDINIUM DERIVATIVE; TABUN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG CONFORMATION; DRUG INHIBITION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HYDROGEN BOND; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ACETYLCHOLINESTERASE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; MODELS, MOLECULAR; NITROGEN; OBIDOXIME CHLORIDE; PHOSPHORIC ACID ESTERS; PROTEIN CONFORMATION; PYRIDINIUM COMPOUNDS;

EID: 33746765583     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.05.027     Document Type: Article

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