New oxime reactivators connected with CH2O(CH2)nOCH2 linker and their reactivation potency for organophosphorus agents-inhibited acetylcholinesterase

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 24, 2007, Pages 7704-7710

  Yang, Garp Yeol ^a   Oh, Kyung Ae ^a   Park, No Joong ^a   Jung, Young Sik ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Acetylcholinesterase; Bis pyridinium oxime reactivators; Linker; Organophosphorus agents; Pesticide

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1,2 DIMETHOXYETHYLENE BIS N,N' 3 PYRIDIUMALDOXIME; 1,2 DIMETHOXYETHYLENE BIS N,N' 4 PYRIDIUMALDOXIME; 1,2 DIMETHOXYPROPYLENE BIS N,N' 2 PYRIDIUMALDOXIME; 1,2 DIMETHOXYPROPYLENE BIS N,N' 4 PYRIDIUMALDOXIME; ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; CHOLINESTERASE REACTIVATOR; DYFLOS; ORGANOPHOSPHORUS COMPOUND; OXIME DERIVATIVE; PARAOXON; PRALIDOXIME; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; ERYTHROCYTE; IN VITRO STUDY; NONHUMAN;

ACETYLCHOLINESTERASE; ANIMALS; CATTLE; CHOLINESTERASE REACTIVATORS; CROSS-LINKING REAGENTS; DRUG EVALUATION, PRECLINICAL; HOUSEFLIES; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; PARAOXON; PYRIDINIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

BOVINAE;

EID: 35348866954     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.056     Document Type: Article

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