A rapid cation-exchange HPLC method for detection and quantification of pyridinium oximes in plasma and tissue

Journal of Analytical Toxicology

Volumn 31, Issue 2, 2007, Pages 69-74

  Singh, Harry ^a   Moorad Doctor, Deborah ^a   Ratcliffe, Ruthie H ^a   Wachtel, Katie ^a   Castillo, Andres ^a   Garcia, Gregory E ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' METHYLENEBIS(4[HYDROXYIMINO)METHYL]PYRIDINIUM); DIMETHYLSULFONATE SALT; OXIME DERIVATIVE; PYRIDINIUM DERIVATIVE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CATION EXCHANGE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STRUCTURE; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; TISSUE HOMOGENATE; ULTRAFILTRATION; ULTRAVIOLET RADIATION;

CAVIA;

EID: 34147103909     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/31.2.69     Document Type: Article

References (14)

1. W.N. Aldridge and E. Reiner. Enzyme Inhibitors as Substrates. North Holland Publishing, Amsterdam, The Netherlands, 1972.
2. I.B. Wilson and S. Ginsburg. A powerful reactivator of alkylphosphate-inhibited acetylcholinesterase. Biochim. Biophys. Acta 18: 168-170 (1955).
3. J.G. Clement. HI-6: reactivation of central and peripheral acetylcholinesterase following inhibition by soman, sarin and tabun in vivo in the rat. Biochem. Pharmacol. 31: 1283-1287 (1982).
4. B. Boskovic, V. Kovacervic, and D. Jovaniovic. PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning. Fundam. Appl. Toxicol. 4: S106-S115 (1984).
5. M. Maksimovic, B. Boskovic, J. Radovic, V. Tadic, V. Deljac, and Z. Binenfeld. Antidotal effects of bisypyridinium-2-monoxime carbonyl derivates in intoxication with highly toxic organophosphorus compounds. Acta Pharm. Jugols. 30: 151-160 (1980).
6. M.G. Hamilton and P.M. Lundy. HI-6 therapy of soman and tabun poisoning in primates and rodents. Arch. Toxicol. 63: 144-149 (1989).
7. E. Heilbronn and A. Sundwall. Studies on reactivation and aging of blood cholinesterases of Tabun intoxicated dogs. Biochem. Pharmacol. 13: 59-67 (1964).
8. D.J. Ecobichon, A.M. Coeau, W.M. O'Neil, and W.D. Marshall. Kinetics, distribution, and biotransformation of the chemical HI-6 in the rat, dog, and rhesus monkey. Can. J. Physiol. Pharmacol. 68: 614-621 (1990).
9. E.J. Poziomek, B.E. Hackley, Jr., and M. Steinberg. Pyridinium aldoximes. J. Org. Chem. 23: 714-717 (1958).
10. A.J. Lin, and D.L. Klayman. Stability studies of bis(pyridiniumiumaldoxime) reactivators of organophosphate-inhibited acetylcholinesterase. J. Pharm. Sci. 75: 797-799 (1986).
11. D. Noonan. The guinea pig. ANZCCART News 7(3): 1-8 (1994).
12. R. Klimmek and P. Eyer. Pharmacokinetics and pharmacodynamics of the oxime HI-6 in dogs. Arch. Toxicol. 59: 272-278 (1986).
13. M.P. McCluskey, C.R. Clark, B.G. Talbot, M.D. Green, and B.J. Lukey. A high-performance liquid chromatography assay for HI-6 oxime in plasma. J. Anal. Toxicol. 14: 239-242 (1990).
14. M.L. Shih, J.R. Smith, and G.W. Salem. High-performance liquid chromatographic analysis of imidazolium and pyridinium oximes in plasma and urine. J. Chromatogr. 527: 371-379 (1990).