In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages

Toxicology in Vitro

Volumn 22, Issue 2, 2008, Pages 525-530

  Acharya, Jyotiranjan ^a   Gupta, Arvind Kumar ^a   Mazumder, Avik ^a   Dubey, Devendra Kumar ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

2 PAM; Acetylcholinesterase; Bis pyridinium oximes; Nerve agents; Obidoxime; Reactivators; Sarin

Indexed keywords

1,2 DIMETHOXY ETHYLENE BIS[3,30 (HYDROXYIMINOMETHYL)PYRIDINIUM]; 1,3 DIMETHOXY PROPYLENE BIS[3,30 (HYDROXYIMINOMETHYL)PYRIDINIUM]; ACETYLCHOLINESTERASE; ANTIDOTE; BIS(PYRIDINIUM OXIME) DERIVATIVE; OBIDOXIME; PRALIDOXIME; SARIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; EEL; ENZYME INHIBITION; ENZYME REACTIVATION; IN VITRO STUDY; NEUROPROTECTION; REGENERATION;

ACETYLCHOLINESTERASE; ANIMALS; CHEMISTRY, PHYSICAL; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; ELECTROPHORUS; OBIDOXIME CHLORIDE; OXIMES; PRALIDOXIME COMPOUNDS; PYRIDINIUM COMPOUNDS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SARIN;

ELECTROPHORUS ELECTRICUS;

EID: 38549145987     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.10.006     Document Type: Article

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