A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 22, Issue 3, 2007, Pages 297-300

  Kassa, Jiri ^a   Jun, Daniel ^a   Kuca, Kamil ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Acetylcholinesterase; Cyclosarin; Inhibition; Oximes; Rat; Reactivation; Tabun

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1,4 BIS(4 HYDROXYIMINOMETHYLPYRIDINIUM)BUT 2 EN DIBROMIDE; 1,4 BIS(4 HYDROXYIMINOMETHYLPYRIDINIUM)BUTANE DIBROMIDE; ACETYLCHOLINESTERASE; ANTIDOTE; ATROPINE; CYCLOSARIN; K 074; K 075; OBIDOXIME; OXIME; TABUN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME REACTIVATION; IN VITRO STUDY; IN VIVO STUDY; INTOXICATION; LD 50; LETHAL DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIDOTES; BRAIN; BUTANES; CHOLINESTERASE REACTIVATORS; DRUG EVALUATION, PRECLINICAL; MALE; OBIDOXIME CHLORIDE; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; PHOSPHORIC ACID ESTERS; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 34547767717     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360601114361     Document Type: Article

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