A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, Hi-6) to counteract acute toxic effects of tabun and cyclosarin in mice

Drug and Chemical Toxicology

Volumn 31, Issue 1, 2008, Pages 127-135

  Kassa, Jiří ^a,b   Humlicek, Vojtech ^b  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Acute toxicity; Atropine; Cyclosarin; Mice; Oximes; Tabun

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1,4 BIS(4 HYDROXYIMINOMETHYLPYRIDINIUM)BUT 2 EN DIBROMIDE; 1,4 BIS(4 HYDROXYIMINOMETHYLPYRIDINIUM)BUTANE DIBROMIDE; ANTIDOTE; ATROPINE; CYCLOSARIN; K 074; K 075; OBIDOXIME; OXIME DERIVATIVE; TABUN; TRIMEDOXIME; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; LD 50; MALE; MOUSE; NONHUMAN;

ANIMALS; ANTIDOTES; ATROPINE; BUTANES; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; LETHAL DOSE 50; MALE; MICE; MUSCARINIC ANTAGONISTS; OBIDOXIME CHLORIDE; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; PHOSPHORIC ACID ESTERS; POISONING; PYRIDINIUM COMPOUNDS; TRIMEDOXIME;

MUS;

EID: 37649010527     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540701688816     Document Type: Article

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