Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 22, Issue 4, 2007, Pages 425-432

  Musilek, Kamil ^a,b   Holas, Ondrej ^b   Kuca, Kamil ^a,c   Jun, Daniel ^a,c   Dohnal, Vlastimil ^d   Dolezal, Martin ^b  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

^d MENDEL UNIVERSITY IN BRNO   (Czech Republic)

Author keywords

Acetylcholinesterase; Nerve agent; Oxime; Paraoxon; Pesticide; Reactivation; Tabun

Indexed keywords

1 (2 BROMOETHYLBENZYL) 3 HYDROXYIMINOMETHYLPYRIDINIUM BROMIDE; 1 (2 BROMOETHYLBENZYL) 4 HYDROXYIMINOMETHYLPYRIDINIUM BROMIDE; 1 (3 BROMOETHYLBENZYL) 3 HYDROXYIMINOMETHYLPYRIDINIUM BROMIDE; 1 (3 BROMOETHYLBENZYL) 4 HYDROXYIMINOMETHYLPYRIDINIUM BROMIDE; 1 (4 BROMOETHYLBENZYL) 3 HYDROXYIMINOMETHYLPYRIDINIUM BROMIDE; 1 (4 BROMOETHYLBENZYL) 4 HYDROXYIMINOMETHYLPYRIDINIUM BROMIDE; 2,3' BIS(HYDROXYIMINOMETHYL) 1,1' (1,2 PHENYLENEDIMETHYL) BISPYRIDINIUM DIBROMIDE; 2,3' BIS(HYDROXYIMINOMETHYL) 1,1' (1,3 PHENYLENEDIMETHYL) BISPYRIDINIUM DIBROMIDE; 2,4' BIS(HYDROXYIMINOMETHYL) 1,1' (1,2 PHENYLENEDIMETHYL) BISPYRIDINIUM DIBROMIDE; 2,4' BIS(HYDROXYIMINOMETHYL) 1,1' (1,4 PHENYLENEDIMETHYL) BISPYRIDINIUM DIBROMIDE; 3,4' BIS(HYDROXYIMINOMETHYL) 1,1' (1,2 PHENYLENEDIMETHYL) BISPYRIDINIUM DIBROMIDE; 3,4' BIS(HYDROXYIMINOMETHYL) 1,1' (1,3 PHENYLENEDIMETHYL) BISPYRIDINIUM DIBROMIDE; ACETYLCHOLINESTERASE; BIS(PYRIDINIUM OXIME) DERIVATIVE; CHOLINESTERASE REACTIVATOR; OBIDOXIME; PARAOXON; PRALIDOXIME; TABUN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCHOLINESTERASE; CHEMICAL WARFARE AGENTS; CHEMISTRY; CHEMISTRY, PHARMACEUTICAL; CHOLINESTERASE INHIBITORS; DRUG DESIGN; MODELS, CHEMICAL; OBIDOXIME CHLORIDE; PARAOXON; PESTICIDES; PHOSPHORIC ACID ESTERS; PYRIDINIUM COMPOUNDS; SALTS; XYLENES;

EID: 34547820435     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360601164960     Document Type: Article

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