Twelve different HI-6 salts and their potency to reactivate cyclosarin inhibited AChE in vitro

Letters in Drug Design and Discovery

Volumn 4, Issue 7, 2007, Pages 510-512

  Kuca, Kamil ^a,b   Musilek, Kamil ^c   Stodulka, Petr ^a   Marek, Jan ^b,d   Hanusova, Petra ^d   Jun, Daniel ^a,b   Hrabinova, Martina ^a   Kassa, Jiri ^b   Dolezal, Bohuslav ^d  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

^d Vakos XT as   (Czech Republic)

Author keywords

Acetylcholinesterase; Antidote; Cyclosarine; HI 6; Ion exchange; Nerve agent; Oxime; Quaternary nitrogen; Reactivator; Salt

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETIC ACID; ACETYLCHOLINESTERASE; BROMIDE; CHLORIDE; CYCLOSARIN; IODIDE; MALEIC ACID; MALONIC ACID; MESYLIC ACID; PHOSPHATE; SALICYLIC ACID; SULFATE; TARTARIC ACID; TOLUENESULFONIC ACID DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; DRUG EFFECT; DRUG POTENCY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 35349031105     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018007781788462     Document Type: Article

References (24)

1. Antonijevic, B.; Stojiljkovic, M.P. Clin. Med. Res., 2007, 5, 71.
2. Lundy, P.M.; Raveh, L.; Amitai, G. Toxicol. Rev., 2006, 25, 231.
3. Kassa, J.; Kuca, K.; Bartosova, L.; Kunesova, G. Curr. Org. Chem., 2007, 11, 267.
4. Kuca, K.; Jun, D.; Cabal, J.; Hrabinova, M.; Bartosova, L.; Opletalova, V. Basic Clin. Pharmacol. Toxicol., 2006, 98, 389.
5. Kuca, K.; Kassa, J. Hum. Exp. Toxicol., 2004, 23, 167.
6. Kassa, J.; Cabal, J. Toxicology, 1999, 132, 111.
7. Petroianu, G.A.; Arafat, K.; Kuca, K.; Kassa, J. J. Appl. Toxicol., 2006, 26, 64.
8. Petroianu, G.A.; Nurulain, S.M.; Nagelkerke, N.; Al-Sultan, M.A.H.; Kuca, K.; Kassa, J. J. Appl. Toxicol., 2006, 26, 262.
9. Petroianu, G.A.; Arafat, K.; Nurulain, S.M.; Kuca, K.; Kassa, J. J. Appl. Toxicol., 2007, 27, 168.
10. Petroianu, G.A.; Nurulain, S.M.; Nagelkerke, N.; Shafiullah, M.; Kassa, J.; Kuca, K. J. Appl. Toxicol., 2007, 27, 453.
11. Calic, M.; Vrdoljak, A.L.; Radic, B.; Jelic, D.; Jun, D.; Kuca, K.; Kovarik, Z. Toxicology, 2006, 219, 85.
12. Kuca, K.; Jun, D.; Bajgar, J. Drug Chem. Toxicol., 2007, 30, 31.
13. Hagedorn, I. U.S. Pat. No. 3,773,775, 1973.
14. Hagedorn, I., U.S. Pat. No. 4,128,651, 1978.
15. Yang, G.Y.; Yoon, J.H.; Seong, C.M.; Park, N.S.; Jung, Y.S. B. Kor. Chem. Soc., 2003, 24, 1368.
16. Hagedorn, I., U.S. Pat. No. 3,852,294, 1974.
17. Thiermann, H.; Seidl, S.; Eyer, P. Int. J. Pharm., 1996, 137, 167.
18. Lundy, P.M.; Hill, I., Lecavalier, P.; Hamilton. M.G.; Vair, C.; Davidson, C.; Weatherby, K.L.; Berger, B.J. Toxicology, 2005, 208, 399.
19. Eyer, P.; Hagedorn, I.; Ladstetter, B. Arch. Toxicol., 1988, 62, 224.
20. Krummer, S.; Thiermann, H.; Worek, F.; Eyer, P. Arch. Toxicol., 2002, 76, 589.
21. Kuca, K.; Cabal, J. Toxicol. Mech. Method, 2005, 15, 247.
22. Kuca, K.; Patocka, J. J. Enzyme Inhib. Med. Chem., 2004, 19, 39.
23. Musilek, K.; Kuca, K; Jun, D.; Dolezal, M. Curr. Org. Chem., 2007, 11, 229.
24. Kassa, J.; Jun, D.; Kuca, K.; Bajgar, J. Bas. Clin. Pharmacol. Toxicol. 2007, (In Press).