An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice

Toxicology

Volumn 243, Issue 3, 2008, Pages 311-316

  Kassa, Jiri ^a   Karasova, Jana ^a   Musilek, Kamil ^a   Kuca, Kamil ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Acetylcholinesterase; HI 6; K156; K203; Mice; Obidoxime; Rats; Tabun; Trimedoxime

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ATROPINE; CHOLINE ACETYLTRANSFERASE; K 156; K 203; OBIDOXIME; OXIME DERIVATIVE; TABUN; TRIMEDOXIME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CONTROLLED STUDY; DIAPHRAGM; DRUG EFFICACY; ENZYME REACTIVATION; INTOXICATION; LD 50; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCHOLINESTERASE; ACUTE TOXICITY TESTS; ANIMALS; ANTIDOTES; ATROPINE; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG THERAPY, COMBINATION; INJECTIONS, INTRAMUSCULAR; LETHAL DOSE 50; MALE; MICE; MOLECULAR STRUCTURE; OBIDOXIME CHLORIDE; OXIMES; PHOSPHORIC ACID ESTERS; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR; SEIZURES; SPECIES SPECIFICITY; TRIMEDOXIME;

MUS; RATTUS;

EID: 37149011244     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.10.015     Document Type: Article

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