-
1
-
-
0036236895
-
An invitation to T and more: Notch signaling in lymphopoiesis
-
Allman D., Punt J.A., Izon D.J., et al. An invitation to T and more: Notch signaling in lymphopoiesis. Cell 109 (2002) S1-S11
-
(2002)
Cell
, vol.109
-
-
Allman, D.1
Punt, J.A.2
Izon, D.J.3
-
2
-
-
17044430985
-
CSF biomarkers for mild cognitive impairment and early Alzheimer's disease
-
Andreasen N., and Blennow K. CSF biomarkers for mild cognitive impairment and early Alzheimer's disease. Clin Neurol Neurosurg 107 (2005) 165-173
-
(2005)
Clin Neurol Neurosurg
, vol.107
, pp. 165-173
-
-
Andreasen, N.1
Blennow, K.2
-
3
-
-
0028934741
-
Improved learning and memory in aged rats with chronic administration of the nicotinic reporter agonist GTS-21
-
Arendash G.W., Sengstock G.J., Sanberg P.R., et al. Improved learning and memory in aged rats with chronic administration of the nicotinic reporter agonist GTS-21. Brain Res 674 (1995) 252-259
-
(1995)
Brain Res
, vol.674
, pp. 252-259
-
-
Arendash, G.W.1
Sengstock, G.J.2
Sanberg, P.R.3
-
5
-
-
0031278270
-
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition
-
46
-
Bales K., Verina T., Dodel R.C., et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet 17 (1997) 263 46
-
(1997)
Nat Genet
, vol.17
, pp. 263
-
-
Bales, K.1
Verina, T.2
Dodel, R.C.3
-
6
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard F., Cannon C., Barbour R., et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Med. 6 (2000) 916-919
-
(2000)
Nature Med.
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
-
7
-
-
11444267243
-
Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD
-
Bayer A.J., Bullock R., Jones R.W., et al. Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD. Neurology 64 (2005) 94-101
-
(2005)
Neurology
, vol.64
, pp. 94-101
-
-
Bayer, A.J.1
Bullock, R.2
Jones, R.W.3
-
8
-
-
0027476024
-
A synaptic model of memory: Long term potentiation in the hippocampus
-
Bliss T.V., and Collingridge G.L. A synaptic model of memory: Long term potentiation in the hippocampus. Nature 361 (1993) 31-39
-
(1993)
Nature
, vol.361
, pp. 31-39
-
-
Bliss, T.V.1
Collingridge, G.L.2
-
9
-
-
0036315584
-
Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid
-
Bodendorf U., Danner S., Fischer F., et al. Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid. J Neurochem 80 (2002) 799-806
-
(2002)
J Neurochem
, vol.80
, pp. 799-806
-
-
Bodendorf, U.1
Danner, S.2
Fischer, F.3
-
10
-
-
0038244830
-
Nicotinic receptors and Alzheimer's disease
-
Bourin M., Ripoll N., and Dailly E. Nicotinic receptors and Alzheimer's disease. Curr Med Res Opin 19 (2003) 169-177
-
(2003)
Curr Med Res Opin
, vol.19
, pp. 169-177
-
-
Bourin, M.1
Ripoll, N.2
Dailly, E.3
-
11
-
-
0028114610
-
Anxiolytic-like effects on the novel cholinergic channel activator ABT-418
-
Brioni J.D., O'Neill A.B., Kim D.J., et al. Anxiolytic-like effects on the novel cholinergic channel activator ABT-418. J Pharmacol Exp Ther 271 (1994) 353-361
-
(1994)
J Pharmacol Exp Ther
, vol.271
, pp. 353-361
-
-
Brioni, J.D.1
O'Neill, A.B.2
Kim, D.J.3
-
12
-
-
0029080035
-
Improvement in performance of a delayed matching-to-sample task by monkeys following ABT-418: A novel cholinergic channel activator for memory enhancement
-
Buccafusco J.J., Jackso W.J., Terry Jr. A.V., et al. Improvement in performance of a delayed matching-to-sample task by monkeys following ABT-418: A novel cholinergic channel activator for memory enhancement. Psychopharmacology (Berl) 120 (1995) 256-266
-
(1995)
Psychopharmacology (Berl)
, vol.120
, pp. 256-266
-
-
Buccafusco, J.J.1
Jackso, W.J.2
Terry Jr., A.V.3
-
13
-
-
0035112647
-
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons
-
Cai H., Wang Y., McCarthy D., et al. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci 4 (2001) 233-234
-
(2001)
Nat Neurosci
, vol.4
, pp. 233-234
-
-
Cai, H.1
Wang, Y.2
McCarthy, D.3
-
14
-
-
10044225937
-
Peroxisome Proliferator-Activated Receptor induces a clearance mechanism for the amyloid-beta peptide
-
Camacho I.E., Serneels L., Spittaels K., et al. Peroxisome Proliferator-Activated Receptor induces a clearance mechanism for the amyloid-beta peptide. J Neurosci 24 (2004) 10908-10917
-
(2004)
J Neurosci
, vol.24
, pp. 10908-10917
-
-
Camacho, I.E.1
Serneels, L.2
Spittaels, K.3
-
15
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
-
Cherny R.A., Atwood C.S., Xilinas M.E., et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30 (2001) 665-676
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
-
16
-
-
16644379264
-
Natural oligomers of the amyloid- protein specifically disrupt cognitive function
-
Cleary J.P., Walsh D.M., Hofmeister J.J., et al. Natural oligomers of the amyloid- protein specifically disrupt cognitive function. Nat Neurosci 8 (2004) 79-84
-
(2004)
Nat Neurosci
, vol.8
, pp. 79-84
-
-
Cleary, J.P.1
Walsh, D.M.2
Hofmeister, J.J.3
-
17
-
-
0037219221
-
Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with apoliprotein E-epsilon 4 allele
-
Cook D.G., Leverenz J.B., McMillan P.J., et al. Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with apoliprotein E-epsilon 4 allele. Am J Path 162 (2003) 313-319
-
(2003)
Am J Path
, vol.162
, pp. 313-319
-
-
Cook, D.G.1
Leverenz, J.B.2
McMillan, P.J.3
-
18
-
-
0035251750
-
Nicotinic receptor abnormalities in Alzheimer's disease
-
Court J., Martin-Cruz, Piggott M., et al. Nicotinic receptor abnormalities in Alzheimer's disease. Biol Psychiatry 49 (2001) 175-184
-
(2001)
Biol Psychiatry
, vol.49
, pp. 175-184
-
-
Court, J.1
Martin-Cruz2
Piggott, M.3
-
19
-
-
19944428635
-
4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention
-
Cowart M., Faghih R., Curtis M.P., et al. 4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention. J Med Chem 48 (2005) 38-55
-
(2005)
J Med Chem
, vol.48
, pp. 38-55
-
-
Cowart, M.1
Faghih, R.2
Curtis, M.P.3
-
20
-
-
0031907459
-
Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype
-
Craft S., Peskind E., Schwartz M.W., et al. Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype. Neurology 50 (1998) 164-168
-
(1998)
Neurology
, vol.50
, pp. 164-168
-
-
Craft, S.1
Peskind, E.2
Schwartz, M.W.3
-
21
-
-
0033851022
-
Genetic epidemiology of Alzheimer's disease
-
Dartigues J.F., and Letenneur L. Genetic epidemiology of Alzheimer's disease. Curr Opin Neurol 13 (2000) 385-389
-
(2000)
Curr Opin Neurol
, vol.13
, pp. 385-389
-
-
Dartigues, J.F.1
Letenneur, L.2
-
22
-
-
0035902619
-
Peripheral anti-Abeta antibody alters CNS and plasma Abeta clearance and decreases brain Abeta burden in a mouse model of Alzheimer's disease
-
DeMattos R.B., Bales K.R., Cummins D.J., et al. Peripheral anti-Abeta antibody alters CNS and plasma Abeta clearance and decreases brain Abeta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 98 (2001) 8850-8855
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8850-8855
-
-
DeMattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
-
23
-
-
0037431082
-
Aph-1, Pen-2, and nicastrin with presenilin generate an active γ-secretase complex
-
De Strooper B. Aph-1, Pen-2, and nicastrin with presenilin generate an active γ-secretase complex. Neuron 38 (2003) 9-12
-
(2003)
Neuron
, vol.38
, pp. 9-12
-
-
De Strooper, B.1
-
24
-
-
0036240395
-
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
-
Dodart J., Bales K.R., Gannon K.S., et al. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci. 5 (2002) 452-457
-
(2002)
Nat Neurosci.
, vol.5
, pp. 452-457
-
-
Dodart, J.1
Bales, K.R.2
Gannon, K.S.3
-
25
-
-
24744449320
-
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice
-
Dominguez D., Tournoy J., Hartmann D., et al. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem 280 (2005) 30797-30806
-
(2005)
J Biol Chem
, vol.280
, pp. 30797-30806
-
-
Dominguez, D.1
Tournoy, J.2
Hartmann, D.3
-
26
-
-
0035163347
-
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
-
Dovey H.F., John V., Anderson J.P., et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem 76 (2001) 173-181
-
(2001)
J Neurochem
, vol.76
, pp. 173-181
-
-
Dovey, H.F.1
John, V.2
Anderson, J.P.3
-
27
-
-
85047691727
-
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Aβ42 in vivo
-
Eriksen J., Sage S.A., Smith T.E., et al. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Aβ42 in vivo. J Clin Invest 112 (2003) 440-449
-
(2003)
J Clin Invest
, vol.112
, pp. 440-449
-
-
Eriksen, J.1
Sage, S.A.2
Smith, T.E.3
-
28
-
-
1642290835
-
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid β-protein
-
Farris W., Mansourian S., Leissring M.A., et al. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid β-protein. Am J Pathol 164 (2004) 1425-1434
-
(2004)
Am J Pathol
, vol.164
, pp. 1425-1434
-
-
Farris, W.1
Mansourian, S.2
Leissring, M.A.3
-
29
-
-
0001504829
-
Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
-
Fassbender K., Simons M., Bergmann C., et al. Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci USA 98 (2001) 5856-5861
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5856-5861
-
-
Fassbender, K.1
Simons, M.2
Bergmann, C.3
-
30
-
-
0022929881
-
Characterization of L-[3H] nicotine binding in human cerebral cortex: Comparison between Alzheimer's disease and the normal
-
Flynn D., and Mash D. Characterization of L-[3H] nicotine binding in human cerebral cortex: Comparison between Alzheimer's disease and the normal. J Neurochem 47 (1986) 1948-1954
-
(1986)
J Neurochem
, vol.47
, pp. 1948-1954
-
-
Flynn, D.1
Mash, D.2
-
31
-
-
0346057791
-
The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats
-
Foley A.G., Murphy K.J., Hirst W.D., et al. The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Neuropsychopharmacology 29 (2004) 93-100
-
(2004)
Neuropsychopharmacology
, vol.29
, pp. 93-100
-
-
Foley, A.G.1
Murphy, K.J.2
Hirst, W.D.3
-
32
-
-
0037061554
-
Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup
-
Fox G.B., Pan J.B., Esbenshade T., et al. Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup. Behav Brain Res 131 (2002) 151-161
-
(2002)
Behav Brain Res
, vol.131
, pp. 151-161
-
-
Fox, G.B.1
Pan, J.B.2
Esbenshade, T.3
-
33
-
-
0037393568
-
Identification of novel H3 receptor (H3R) antagonists with cognition enhancing properties in rats
-
Fox G.B., Pan J.B., Faghih R., et al. Identification of novel H3 receptor (H3R) antagonists with cognition enhancing properties in rats. Inflamm Res 52 (2003) S31-S32
-
(2003)
Inflamm Res
, vol.52
-
-
Fox, G.B.1
Pan, J.B.2
Faghih, R.3
-
34
-
-
12144286099
-
Cognition enhancing effects of novel H(3) receptor (H(3)R) antagonists in several animal models
-
Fox G.B., Pan J.B., Lewis A.M., et al. Cognition enhancing effects of novel H(3) receptor (H(3)R) antagonists in several animal models. Inflamm Res 53 (2004) S49-S50
-
(2004)
Inflamm Res
, vol.53
-
-
Fox, G.B.1
Pan, J.B.2
Lewis, A.M.3
-
35
-
-
18144415471
-
Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
-
for the AN1792(QS-21)-201 Study Team
-
Fox N.C., Black R.S., Gilman S., et al., for the AN1792(QS-21)-201 Study Team. Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease. Neurology 64 (2005) 1563-1572
-
(2005)
Neurology
, vol.64
, pp. 1563-1572
-
-
Fox, N.C.1
Black, R.S.2
Gilman, S.3
-
36
-
-
15244340676
-
Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model
-
Fryer J.D., Simmons K., Parsadanian M., et al. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J Neurosci 25 (2005) 2803-2810
-
(2005)
J Neurosci
, vol.25
, pp. 2803-2810
-
-
Fryer, J.D.1
Simmons, K.2
Parsadanian, M.3
-
37
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
-
Games D., Adams D., Alessandrini R., et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373 (1995) 523-527
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
-
38
-
-
6344273111
-
Rosiglitazone improves contextual fear conditioning in aged rats
-
Gemma C., Stellwagen H., Fister M., et al. Rosiglitazone improves contextual fear conditioning in aged rats. Neuroreport 15 (2004) 2255-2259
-
(2004)
Neuroreport
, vol.15
, pp. 2255-2259
-
-
Gemma, C.1
Stellwagen, H.2
Fister, M.3
-
39
-
-
0035829382
-
Behavioural tests of hippocampal function: simple paradigms complex problems
-
Gerlai R. Behavioural tests of hippocampal function: simple paradigms complex problems. Behav Brain Res 125 (2001) 269-277
-
(2001)
Behav Brain Res
, vol.125
, pp. 269-277
-
-
Gerlai, R.1
-
40
-
-
20944448555
-
Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
-
Gilman S., Koller M., Black R.S., et al. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64 (2005) 1553-1562
-
(2005)
Neurology
, vol.64
, pp. 1553-1562
-
-
Gilman, S.1
Koller, M.2
Black, R.S.3
-
41
-
-
21544438539
-
Stereoselective inhibition of amyloid beta peptide secretion by LY450139, a novel functional gamma secretase inhibitor
-
Gitter B.D., Czilli D.L., Li W., et al. Stereoselective inhibition of amyloid beta peptide secretion by LY450139, a novel functional gamma secretase inhibitor. Neurobiol Aging 25 (2004) 571
-
(2004)
Neurobiol Aging
, vol.25
, pp. 571
-
-
Gitter, B.D.1
Czilli, D.L.2
Li, W.3
-
42
-
-
0021256895
-
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner G.G., and Wong C.W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120 (1984) 885-890
-
(1984)
Biochem Biophys Res Commun
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
43
-
-
0038460888
-
Higher-end serotonin receptors: 5-HT5, 5-HT6 and 5-HT7
-
Glennon R.A. Higher-end serotonin receptors: 5-HT5, 5-HT6 and 5-HT7. J Med Chem 46 (2003) 2795-2812
-
(2003)
J Med Chem
, vol.46
, pp. 2795-2812
-
-
Glennon, R.A.1
-
44
-
-
0035888328
-
Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease
-
Golde T.E., and Eckman C.B. Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease. Drug Discov Today 20 (2001) 1049-1055
-
(2001)
Drug Discov Today
, vol.20
, pp. 1049-1055
-
-
Golde, T.E.1
Eckman, C.B.2
-
45
-
-
0042838303
-
Alzheimer's disease-affected brain: Presence of oligomeric Ab ligands (ADDLs) suggests a molecular basis for memory loss
-
Gong Y., Chang L., Viola K.L., et al. Alzheimer's disease-affected brain: Presence of oligomeric Ab ligands (ADDLs) suggests a molecular basis for memory loss. Proc Natl Acad Sci USA 100 (2003) 0417-10422
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 0417-10422
-
-
Gong, Y.1
Chang, L.2
Viola, K.L.3
-
46
-
-
0027143781
-
A drug that facilitates glutamatergic transmission reduces exploratory activity and improves performance in learning dependant task
-
Granger R., Staubli U., Davis M., et al. A drug that facilitates glutamatergic transmission reduces exploratory activity and improves performance in learning dependant task. Synapse 15 (1993) 326-329
-
(1993)
Synapse
, vol.15
, pp. 326-329
-
-
Granger, R.1
Staubli, U.2
Davis, M.3
-
47
-
-
0028535113
-
Anatomy and physiology of glutamate in CNS
-
Greenamyre J.Y., and Porter R.H. Anatomy and physiology of glutamate in CNS. Neurology 44 (1994) S9-S13
-
(1994)
Neurology
, vol.44
-
-
Greenamyre, J.Y.1
Porter, R.H.2
-
48
-
-
0024363934
-
Excitatory amino acids and Alzheimer's disease
-
Greenamyre J.Y., and Young A.B. Excitatory amino acids and Alzheimer's disease. Neurobiol Aging 10 (1989) 593-602
-
(1989)
Neurobiol Aging
, vol.10
, pp. 593-602
-
-
Greenamyre, J.Y.1
Young, A.B.2
-
49
-
-
5444268112
-
Perspectives on cognition domains, H3 receptor ligands and neurological disease
-
Hancock A.A., and Fox G.B. Perspectives on cognition domains, H3 receptor ligands and neurological disease. Expert Opin Investig Drugs 13 (2004) 1237-1248
-
(2004)
Expert Opin Investig Drugs
, vol.13
, pp. 1237-1248
-
-
Hancock, A.A.1
Fox, G.B.2
-
50
-
-
21544468846
-
Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits and hippocampal long-term potentiation in a mouse model of Alzheimer's disease
-
Hartman R.E., Izumi Y., Bales K.R., et al. Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. J Neurosci 25 (2005) 6213-6220
-
(2005)
J Neurosci
, vol.25
, pp. 6213-6220
-
-
Hartman, R.E.1
Izumi, Y.2
Bales, K.R.3
-
51
-
-
20444499367
-
Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice
-
Heneka M.T., Sastre M., Dumitrescu-Ozimek L., et al. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain 128 (2005) 1442-1453
-
(2005)
Brain
, vol.128
, pp. 1442-1453
-
-
Heneka, M.T.1
Sastre, M.2
Dumitrescu-Ozimek, L.3
-
52
-
-
4644286910
-
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
-
Ho L., Qin W., Pompl P.N., Xiang Z., et al. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB J 18 (2004) 902-904
-
(2004)
FASEB J
, vol.18
, pp. 902-904
-
-
Ho, L.1
Qin, W.2
Pompl, P.N.3
Xiang, Z.4
-
53
-
-
0038100154
-
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
-
Hock C., Konietzko U., Streffer J.R., et al. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron 38 (2003) 547-554
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
-
54
-
-
12444313989
-
Treatment with the selective muscarinic M1 agonist talsaclidine decreases cerebospinal fluid levels of Abeta 42 in patients with Alzheimer's disease
-
Hock C., Maddalena A., Raschig A., et al. Treatment with the selective muscarinic M1 agonist talsaclidine decreases cerebospinal fluid levels of Abeta 42 in patients with Alzheimer's disease. Amyloid 10 (2003) 1-6
-
(2003)
Amyloid
, vol.10
, pp. 1-6
-
-
Hock, C.1
Maddalena, A.2
Raschig, A.3
-
55
-
-
0031450275
-
Neuronal nicotinic receptors as targets for drug discovery
-
Holladay M.W., Dart M.J., and Linch J.K. Neuronal nicotinic receptors as targets for drug discovery. J Med Chem 40 (1997) 4169-4193
-
(1997)
J Med Chem
, vol.40
, pp. 4169-4193
-
-
Holladay, M.W.1
Dart, M.J.2
Linch, J.K.3
-
56
-
-
4243215848
-
Apolipoprotein E isoform-dependant amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
-
Holtzman D.M., Bales K.R., Tenkova T., et al. Apolipoprotein E isoform-dependant amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 97 (2000) 2892-2897
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 2892-2897
-
-
Holtzman, D.M.1
Bales, K.R.2
Tenkova, T.3
-
57
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as beta-secretase
-
Hussain I., Powell D., Howlett D.R., et al. Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci 14 (1999) 419-427
-
(1999)
Mol Cell Neurosci
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
-
58
-
-
0037424348
-
The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage
-
Ikeuchi T., and Sisodia S.S. The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage. J Biol Chem 278 (2003) 7751-7754
-
(2003)
J Biol Chem
, vol.278
, pp. 7751-7754
-
-
Ikeuchi, T.1
Sisodia, S.S.2
-
59
-
-
0034700471
-
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
-
Janus C., Pearson J., McLaurin J., et al. Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408 (2000) 979-982
-
(2000)
Nature
, vol.408
, pp. 979-982
-
-
Janus, C.1
Pearson, J.2
McLaurin, J.3
-
60
-
-
0029072551
-
Interactions of apolipoprotein E genotype, total cholesterol level, age and sex in prediction of Alzheimer's disease: a case-control study
-
Jarvik G.P., Wijsman E.M., Kukull W.A., et al. Interactions of apolipoprotein E genotype, total cholesterol level, age and sex in prediction of Alzheimer's disease: a case-control study. Neurology 45 (1995) 1092-1096
-
(1995)
Neurology
, vol.45
, pp. 1092-1096
-
-
Jarvik, G.P.1
Wijsman, E.M.2
Kukull, W.A.3
-
61
-
-
18544404101
-
Control of endodermal endocrine development by Hes-1
-
Jensen J., Pedersen E.E., Galante P., et al. Control of endodermal endocrine development by Hes-1. Nat Genet 24 (2000) 36-44
-
(2000)
Nat Genet
, vol.24
, pp. 36-44
-
-
Jensen, J.1
Pedersen, E.E.2
Galante, P.3
-
62
-
-
0034638746
-
Statins and the risk of dementia
-
Jick H. Statins and the risk of dementia. Lancet 356 (2000) 1627-1631
-
(2000)
Lancet
, vol.356
, pp. 1627-1631
-
-
Jick, H.1
-
63
-
-
0026733220
-
Effects of acute subcutaneous nicotine on attention, information processing and short term memory in Alzheimer's disease
-
Jones G.M.M., Sahakian B.J., Levy R., et al. Effects of acute subcutaneous nicotine on attention, information processing and short term memory in Alzheimer's disease. Psychopharmacology (Berl) 108 (1992) 485-494
-
(1992)
Psychopharmacology (Berl)
, vol.108
, pp. 485-494
-
-
Jones, G.M.M.1
Sahakian, B.J.2
Levy, R.3
-
64
-
-
0036653703
-
Recent advances in the development of γ-secretase inhibitors
-
Josien H. Recent advances in the development of γ-secretase inhibitors. Curr Opin Drug Discovery Dev 5 (2002) 513-525
-
(2002)
Curr Opin Drug Discovery Dev
, vol.5
, pp. 513-525
-
-
Josien, H.1
-
65
-
-
20744458852
-
Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta 2-subunit regulates cell adhesion and migration
-
Kim D.Y., Ingano L.A., Carey B.W., et al. Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta 2-subunit regulates cell adhesion and migration. J Biol Chem 17 (2005) 23251-23261
-
(2005)
J Biol Chem
, vol.17
, pp. 23251-23261
-
-
Kim, D.Y.1
Ingano, L.A.2
Carey, B.W.3
-
66
-
-
0035923502
-
Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage and secretion of a Golgi-resident sialyltransferase
-
Kitazume S., Tachida Y., Oka R., et al. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage and secretion of a Golgi-resident sialyltransferase. Proc Natl Acad Sci USA 98 (2001) 13554-13559
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13554-13559
-
-
Kitazume, S.1
Tachida, Y.2
Oka, R.3
-
67
-
-
0035826909
-
Low cholesterol stimulates non-amyloidogenic pathway by its effect on the alpha-secretase ADAM 10
-
Kojro E. Low cholesterol stimulates non-amyloidogenic pathway by its effect on the alpha-secretase ADAM 10. Proc Natl Acad Sci USA 98 (2001) 5815-5820
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5815-5820
-
-
Kojro, E.1
-
68
-
-
0038236931
-
H3 receptor blockade by thioperamide enhances cognition in rats without inducing locomotor sensitization
-
Komater V.A., Browman K.E., Curzon P., et al. H3 receptor blockade by thioperamide enhances cognition in rats without inducing locomotor sensitization. Psychopharmacology (Berl) 167 (2003) 363-372
-
(2003)
Psychopharmacology (Berl)
, vol.167
, pp. 363-372
-
-
Komater, V.A.1
Browman, K.E.2
Curzon, P.3
-
69
-
-
9844229370
-
Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apoliprotein E4 phenotype: Cross sectional population based study
-
Kuusisto J., Koivisto K., Mykkanen L., et al. Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apoliprotein E4 phenotype: Cross sectional population based study. Br Med J 315 (1997) 1045-1049
-
(1997)
Br Med J
, vol.315
, pp. 1045-1049
-
-
Kuusisto, J.1
Koivisto, K.2
Mykkanen, L.3
-
70
-
-
0347785491
-
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide
-
Lammich S., Okochi M., Takeda M., et al. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide. J Biol Chem 277 (2002) 44754-44759
-
(2002)
J Biol Chem
, vol.277
, pp. 44754-44759
-
-
Lammich, S.1
Okochi, M.2
Takeda, M.3
-
71
-
-
1642564704
-
Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders
-
Lane H., Lin C., Huang C., et al. Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders. Schizophrenia Res 67 (2004) 63-70
-
(2004)
Schizophrenia Res
, vol.67
, pp. 63-70
-
-
Lane, H.1
Lin, C.2
Huang, C.3
-
72
-
-
0033994676
-
Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons
-
Lauterborn J.C., Lynch G., Vanderklish P., et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci 20 (2000) 8-21
-
(2000)
J Neurosci
, vol.20
, pp. 8-21
-
-
Lauterborn, J.C.1
Lynch, G.2
Vanderklish, P.3
-
73
-
-
18244422005
-
Effects of S18986-1, a novel cognition enhancer, on memory performances in an object recognition task
-
Lebrun C., Pilliere E., and Lestage P. Effects of S18986-1, a novel cognition enhancer, on memory performances in an object recognition task. Eur J Pharmacol 401 (2000) 205-212
-
(2000)
Eur J Pharmacol
, vol.401
, pp. 205-212
-
-
Lebrun, C.1
Pilliere, E.2
Lestage, P.3
-
74
-
-
0031858013
-
Therapeutic potential of histamine H3 receptor agonists and antagonists
-
Leurs R., Blandina P., Tedford C., et al. Therapeutic potential of histamine H3 receptor agonists and antagonists. Trends Pharmacol Sci 19 (1998) 177-183
-
(1998)
Trends Pharmacol Sci
, vol.19
, pp. 177-183
-
-
Leurs, R.1
Blandina, P.2
Tedford, C.3
-
75
-
-
1642345964
-
Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1
-
Li Q., and Südhof T.C. Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. J Biol Chem 279 (2003) 10542-10550
-
(2003)
J Biol Chem
, vol.279
, pp. 10542-10550
-
-
Li, Q.1
Südhof, T.C.2
-
76
-
-
0842325530
-
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1
-
Lichtenthaler S.F., Dominguez D.I., Westmeyer G.G., et al. The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. J Biol Chem 278 (2003) 48713-48719
-
(2003)
J Biol Chem
, vol.278
, pp. 48713-48719
-
-
Lichtenthaler, S.F.1
Dominguez, D.I.2
Westmeyer, G.G.3
-
77
-
-
0032463756
-
Neurochemical and behavioural effects of ciproxifan, a potent histamine H3-receptor antagonist
-
Ligneau X., Lin J., Vanni-Mercier G., et al. Neurochemical and behavioural effects of ciproxifan, a potent histamine H3-receptor antagonist. J Pharmacol Exp Ther 287 (1998) 658-666
-
(1998)
J Pharmacol Exp Ther
, vol.287
, pp. 658-666
-
-
Ligneau, X.1
Lin, J.2
Vanni-Mercier, G.3
-
78
-
-
0030439041
-
RJR-2403: A nicotinic agonist with CNS selectivity II: In vivo characterization
-
Lippiello P.M., Bencherif M., Gray J.A., et al. RJR-2403: A nicotinic agonist with CNS selectivity II: In vivo characterization. J Pharmacol Exp Ther 279 (1996) 1422-1429
-
(1996)
J Pharmacol Exp Ther
, vol.279
, pp. 1422-1429
-
-
Lippiello, P.M.1
Bencherif, M.2
Gray, J.A.3
-
79
-
-
0032571222
-
The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents
-
Lloyd G.K., Menzaghi F., Bontempi B., et al. The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents. Life Sci 62 (1998) 1601-1606
-
(1998)
Life Sci
, vol.62
, pp. 1601-1606
-
-
Lloyd, G.K.1
Menzaghi, F.2
Bontempi, B.3
-
80
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue L., Kuo Y., Roher A.E., et al. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 155 (1999) 853-862
-
(1999)
Am J Pathol
, vol.155
, pp. 853-862
-
-
Lue, L.1
Kuo, Y.2
Roher, A.E.3
-
81
-
-
0035116273
-
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
-
Luo Y., Bolon B., Kahn S., et al. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci 4 (2001) 231-232
-
(2001)
Nat Neurosci
, vol.4
, pp. 231-232
-
-
Luo, Y.1
Bolon, B.2
Kahn, S.3
-
82
-
-
0031148706
-
Evidence that a positive modulator of AMPA-type receptors improves delayed recall in aged humans
-
Lynch G., Granger R., Ambros-Ingerson J., et al. Evidence that a positive modulator of AMPA-type receptors improves delayed recall in aged humans. Exp Neurol 145 (1997) 89-92
-
(1997)
Exp Neurol
, vol.145
, pp. 89-92
-
-
Lynch, G.1
Granger, R.2
Ambros-Ingerson, J.3
-
84
-
-
0032716595
-
Review of 5-HT system and cognition
-
Meneses A. Review of 5-HT system and cognition. Neurosci Biobehav Rev 23 (1999) 1111-1125
-
(1999)
Neurosci Biobehav Rev
, vol.23
, pp. 1111-1125
-
-
Meneses, A.1
-
85
-
-
84984755327
-
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan D., Diamond D.M., Gottschall P.E., et al. Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408 (2000) 982-985
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
-
86
-
-
21544432780
-
Reduced β-amyloid burden, increased C-99 concentrations and evaluation of neuropathology in the brains of PDAPP mice given LY450139 dihydrate daily by gavage for 5 months
-
Ness D.K., Boggs L.N., Hepburn D.L., et al. Reduced β-amyloid burden, increased C-99 concentrations and evaluation of neuropathology in the brains of PDAPP mice given LY450139 dihydrate daily by gavage for 5 months. Neurobiol Aging 25 (2004) 238-239
-
(2004)
Neurobiol Aging
, vol.25
, pp. 238-239
-
-
Ness, D.K.1
Boggs, L.N.2
Hepburn, D.L.3
-
88
-
-
0030459333
-
Effects of nicotinic cholinergic agents on cognitive functioning in Alzheimer's and Parkinson's disease
-
Newhouse P.A., Potter A., and Corwin J. Effects of nicotinic cholinergic agents on cognitive functioning in Alzheimer's and Parkinson's disease. Drug Dev Res 38 (1996) 278-289
-
(1996)
Drug Dev Res
, vol.38
, pp. 278-289
-
-
Newhouse, P.A.1
Potter, A.2
Corwin, J.3
-
89
-
-
0035824391
-
Gamma-secretase cleavage and nuclear localization of erbB-4 receptor tyrosine kinase
-
Ni C.Y., Murphy M.P., Golde T.E., et al. Gamma-secretase cleavage and nuclear localization of erbB-4 receptor tyrosine kinase. Science 294 (2001) 2179-2181
-
(2001)
Science
, vol.294
, pp. 2179-2181
-
-
Ni, C.Y.1
Murphy, M.P.2
Golde, T.E.3
-
90
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report
-
Nicoll J., Wilkinson D., Holmes C., et al. Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report. Nature Med 9 (2003) 448-452
-
(2003)
Nature Med
, vol.9
, pp. 448-452
-
-
Nicoll, J.1
Wilkinson, D.2
Holmes, C.3
-
91
-
-
0346055155
-
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease
-
Ohno M., Sametsky E.A., Younkin L.H., et al. BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron 41 (2004) 27-33
-
(2004)
Neuron
, vol.41
, pp. 27-33
-
-
Ohno, M.1
Sametsky, E.A.2
Younkin, L.H.3
-
92
-
-
0036007934
-
Histamine H3-receptor blockade in the rat nucleus basalis magnocellularis improves place recognition memory
-
Orsetti M., Ferretti C., Gamalero R., et al. Histamine H3-receptor blockade in the rat nucleus basalis magnocellularis improves place recognition memory. Psychopharmacology (Berl) 159 (2002) 133-137
-
(2002)
Psychopharmacology (Berl)
, vol.159
, pp. 133-137
-
-
Orsetti, M.1
Ferretti, C.2
Gamalero, R.3
-
93
-
-
23844550927
-
Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of β-amyloid peptide
-
Pangalos M.N., Jacobsen S.J., and Reinhart P.H. Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of β-amyloid peptide. Biochem Soc Trans 33 (2005) 553-558
-
(2005)
Biochem Soc Trans
, vol.33
, pp. 553-558
-
-
Pangalos, M.N.1
Jacobsen, S.J.2
Reinhart, P.H.3
-
95
-
-
0028890920
-
Alteration in nicotinic binding sites in Parkinson's disease, Lewy body dementia, and Alzheimer's disease: Possible index of early neuropathology
-
Perry E.K., Morris C.M., Court J.A., et al. Alteration in nicotinic binding sites in Parkinson's disease, Lewy body dementia, and Alzheimer's disease: Possible index of early neuropathology. Neuroscience 64 (1995) 385-395
-
(1995)
Neuroscience
, vol.64
, pp. 385-395
-
-
Perry, E.K.1
Morris, C.M.2
Court, J.A.3
-
96
-
-
0032953838
-
Acute effects of the selective cholinergic channel activator (Nicotinic agonist) ABT-418 in Alzheimer's disease
-
Potter A., Corwin J., Lang K., et al. Acute effects of the selective cholinergic channel activator (Nicotinic agonist) ABT-418 in Alzheimer's disease. Psychopharmacology 142 (1999) 334-342
-
(1999)
Psychopharmacology
, vol.142
, pp. 334-342
-
-
Potter, A.1
Corwin, J.2
Lang, K.3
-
97
-
-
0030599187
-
Histaminergic neurons facilitate social memory in rats
-
Prast H., Argyriou A., and Philippu A. Histaminergic neurons facilitate social memory in rats. Brain Res 734 (1996) 316-318
-
(1996)
Brain Res
, vol.734
, pp. 316-318
-
-
Prast, H.1
Argyriou, A.2
Philippu, A.3
-
98
-
-
0034795651
-
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyolid beta-peptide
-
Puglielli L., Konopka G., Pack-Chung E., et al. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyolid beta-peptide. Nat Cell Biol 3 (2001) 905-912
-
(2001)
Nat Cell Biol
, vol.3
, pp. 905-912
-
-
Puglielli, L.1
Konopka, G.2
Pack-Chung, E.3
-
99
-
-
0027991714
-
Hyperinsulinaemia and Alzheimer's disease
-
Razay G., and Wilcock G.K. Hyperinsulinaemia and Alzheimer's disease. Age Ageing 23 (1994) 396-399
-
(1994)
Age Ageing
, vol.23
, pp. 396-399
-
-
Razay, G.1
Wilcock, G.K.2
-
100
-
-
0035154738
-
The therapeutic potential of 5-HT6 receptor antagonists
-
Reavill C., and Rogers D.C. The therapeutic potential of 5-HT6 receptor antagonists. Curr Opin Invest Drugs 2 (2001) 104-109
-
(2001)
Curr Opin Invest Drugs
, vol.2
, pp. 104-109
-
-
Reavill, C.1
Rogers, D.C.2
-
101
-
-
0033833354
-
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
-
Erratum in: Neurobiol Dis 7: 690
-
Refolo L.M., Malester B., LaFrancois J., et al. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis 7 (2000) 321-331 Erratum in: Neurobiol Dis 7: 690
-
(2000)
Neurobiol Dis
, vol.7
, pp. 321-331
-
-
Refolo, L.M.1
Malester, B.2
LaFrancois, J.3
-
102
-
-
0035160066
-
A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease
-
Refolo L.M., Pappolla M.A., LaFrancois J., et al. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis 8 (2001) 890-899
-
(2001)
Neurobiol Dis
, vol.8
, pp. 890-899
-
-
Refolo, L.M.1
Pappolla, M.A.2
LaFrancois, J.3
-
103
-
-
66049161574
-
-
Society for Neuroscience 33rd Annual Meeting, New Orleans, USA (Abstract no. 835.21)
-
Regan C.M., Foley A.G., Murphy K.J., et al. The 5-HT6 receptor antagonists SB-271046 and SB-399885 increase basal and learning induced NCAM-polysialylation in the rat dentate gyrus. Society for Neuroscience 33rd Annual Meeting, New Orleans, USA (2003) (Abstract no. 835.21)
-
(2003)
The 5-HT6 receptor antagonists SB-271046 and SB-399885 increase basal and learning induced NCAM-polysialylation in the rat dentate gyrus
-
-
Regan, C.M.1
Foley, A.G.2
Murphy, K.J.3
-
105
-
-
0037417238
-
Memantine Study Group. Memantine in moderate-to-severe Alzheimer's disease
-
Reisberg B., Doody R., Stoffler A., et al. Memantine Study Group. Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med 348 (2003) 1333-1341
-
(2003)
N Engl J Med
, vol.348
, pp. 1333-1341
-
-
Reisberg, B.1
Doody, R.2
Stoffler, A.3
-
106
-
-
10744224267
-
Metal- protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
-
Ritchie C.W., Bush A.I., Mackinnon A., et al. Metal- protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol 60 (2003) 1685-1691
-
(2003)
Arch Neurol
, vol.60
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
Mackinnon, A.3
-
107
-
-
0001167474
-
Arousal systems and attention
-
Gazzangia M. (Ed), MIT Press, Cambridge, MA
-
Robbins T., and Everitt B. Arousal systems and attention. In: Gazzangia M. (Ed). The Cognitive Neurosciences (1995), MIT Press, Cambridge, MA 703-720
-
(1995)
The Cognitive Neurosciences
, pp. 703-720
-
-
Robbins, T.1
Everitt, B.2
-
108
-
-
17344388652
-
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: Implications for Alzheimer's disease therapeutics
-
Roberds S.L., Anderson J., Basi G., et al. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: Implications for Alzheimer's disease therapeutics. Hum Mol Genet 10 (2001) 1317-1324
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1317-1324
-
-
Roberds, S.L.1
Anderson, J.2
Basi, G.3
-
109
-
-
0028211386
-
Nicotine and THA: Evidence for improved attention in patients with dementia of the Alzheimer type
-
Sahakian B.J., and Coull J.T. Nicotine and THA: Evidence for improved attention in patients with dementia of the Alzheimer type. Drug Res 31 (1994) 80-88
-
(1994)
Drug Res
, vol.31
, pp. 80-88
-
-
Sahakian, B.J.1
Coull, J.T.2
-
110
-
-
0242609178
-
Nonsteroidal anti-inflammatory drugs and peroxisome proliferators-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase
-
Sastre M., Dewachter I., Landreth G.E., et al. Nonsteroidal anti-inflammatory drugs and peroxisome proliferators-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci 23 (2003) 9796-9804
-
(2003)
J Neurosci
, vol.23
, pp. 9796-9804
-
-
Sastre, M.1
Dewachter, I.2
Landreth, G.E.3
-
111
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D., Barbour R., Dunn W., et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400 (1999) 173-177
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
-
112
-
-
0037164314
-
PROSPER study group. PROspective Study of Pravastatin in the Elderly at Risk. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial
-
Shepherd J., Blauw G.J., Murphy M.B., et al. PROSPER study group. PROspective Study of Pravastatin in the Elderly at Risk. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial. Lancet 360 (2002) 1623-1630
-
(2002)
Lancet
, vol.360
, pp. 1623-1630
-
-
Shepherd, J.1
Blauw, G.J.2
Murphy, M.B.3
-
113
-
-
0034521392
-
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
-
Shibata M., Yamada S., Kumar S.R., et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 106 (2000) 1489-1499
-
(2000)
J Clin Invest
, vol.106
, pp. 1489-1499
-
-
Shibata, M.1
Yamada, S.2
Kumar, S.R.3
-
114
-
-
21544458621
-
Safety, tolerability, and changes in amyloid β concentrations after administration of a γ-secretase inhibitor in volunteers
-
Siemers E., Skinner M., Dean R.A., et al. Safety, tolerability, and changes in amyloid β concentrations after administration of a γ-secretase inhibitor in volunteers. Clin Neuropharmacol 28 (2005) 126-132
-
(2005)
Clin Neuropharmacol
, vol.28
, pp. 126-132
-
-
Siemers, E.1
Skinner, M.2
Dean, R.A.3
-
115
-
-
0032568552
-
Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
-
Simons M., Keller P., De Strooper B., et al. Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 95 (1998) 6460-6464
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6460-6464
-
-
Simons, M.1
Keller, P.2
De Strooper, B.3
-
116
-
-
0021824223
-
Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation
-
Sing C.F., and Davingnon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet 37 (1985) 268-285
-
(1985)
Am J Hum Genet
, vol.37
, pp. 268-285
-
-
Sing, C.F.1
Davingnon, J.2
-
117
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
Sinha S., Anderson J.P., Barbour R., et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402 (1999) 537-540
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
-
118
-
-
0036259109
-
Discovery of an ectopic activation site on the M1 muscarinic receptor
-
Spalding T.A., Trotter C., Skjaerbaek N., et al. Discovery of an ectopic activation site on the M1 muscarinic receptor. Mol Pharmacol 61 (2002) 1297-1302
-
(2002)
Mol Pharmacol
, vol.61
, pp. 1297-1302
-
-
Spalding, T.A.1
Trotter, C.2
Skjaerbaek, N.3
-
119
-
-
0028177562
-
Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol
-
Sparks D.L., Scheff S.W., Hunsaker III J.C., et al. Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp Neurol 126 (1994) 88-94
-
(1994)
Exp Neurol
, vol.126
, pp. 88-94
-
-
Sparks, D.L.1
Scheff, S.W.2
Hunsaker III, J.C.3
-
120
-
-
0028088995
-
Facilitation of glutamate receptors enhances memory
-
Staubli U., Rogers G., and Lynch G. Facilitation of glutamate receptors enhances memory. Proc Natl Acad Sci USA 91 (1994) 777-781
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 777-781
-
-
Staubli, U.1
Rogers, G.2
Lynch, G.3
-
122
-
-
0345872128
-
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial
-
Memantine Study Group
-
Tariot P.N., Farlow M.R., Grossberg G.T., et al., Memantine Study Group. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial. JAMA 291 (2004) 317-324
-
(2004)
JAMA
, vol.291
, pp. 317-324
-
-
Tariot, P.N.1
Farlow, M.R.2
Grossberg, G.T.3
-
123
-
-
15644368250
-
Enhanced delayed matching performance in younger and older macaques administered the 5-HT4 receptor agonist, RS 17071
-
Terry Jr. A.V., Buccafusco J.J., Jackson W.J., et al. Enhanced delayed matching performance in younger and older macaques administered the 5-HT4 receptor agonist, RS 17071. Psychopharmacology 135 (1998) 407-415
-
(1998)
Psychopharmacology
, vol.135
, pp. 407-415
-
-
Terry Jr., A.V.1
Buccafusco, J.J.2
Jackson, W.J.3
-
124
-
-
0033595706
-
Beta- secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R., Bennett B.D., Babu-Khan S., et al. Beta- secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286 (1999) 735-741
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
-
125
-
-
0029586823
-
Epibatidine and ABT-418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains
-
Warpman U., and Nordberg A. Epibatidine and ABT-418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains. Neuroreport 6 (1995) 2419-2423
-
(1995)
Neuroreport
, vol.6
, pp. 2419-2423
-
-
Warpman, U.1
Nordberg, A.2
-
126
-
-
33644592598
-
Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study
-
Watson G.S., Cholerton B.A., Reger M.A., et al. Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. Am J Geriatr Psychiatry 13 (2005) 950-958
-
(2005)
Am J Geriatr Psychiatry
, vol.13
, pp. 950-958
-
-
Watson, G.S.1
Cholerton, B.A.2
Reger, M.A.3
-
127
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
-
Weggen S., Eriksen J.L., Das P., et al. A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity. Nature 414 (2001) 212-216
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
-
128
-
-
0022457840
-
Nicotinic acetylcholine binding sites in Alzheimer's disease
-
Whitehouse P., Martino A., Antuono P.G., et al. Nicotinic acetylcholine binding sites in Alzheimer's disease. Brain Res 371 (1986) 146-151
-
(1986)
Brain Res
, vol.371
, pp. 146-151
-
-
Whitehouse, P.1
Martino, A.2
Antuono, P.G.3
-
129
-
-
0037531198
-
Intracranially administered anti-Aβ antibodies reduce β-amyloid deposition by mechanisms both independent of and associated with microglial activation
-
Wilcock D.M., DiCarlo G., Henderson D., et al. Intracranially administered anti-Aβ antibodies reduce β-amyloid deposition by mechanisms both independent of and associated with microglial activation. J Neurosci 23 (2003) 3745-3751
-
(2003)
J Neurosci
, vol.23
, pp. 3745-3751
-
-
Wilcock, D.M.1
DiCarlo, G.2
Henderson, D.3
-
130
-
-
1642497601
-
Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration
-
Wilcock D.M., Munireddy S.K., Rosenthal A., et al. Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration. Neurobiology of Disease 15 (2004) 1-20
-
(2004)
Neurobiology of Disease
, vol.15
, pp. 1-20
-
-
Wilcock, D.M.1
Munireddy, S.K.2
Rosenthal, A.3
-
131
-
-
14244255355
-
Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhaemorrhage
-
Wilcock D.M., Rojiani A., Rosenthal A., et al. Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhaemorrhage. J Neuroinflammation 1 (2004) 24
-
(2004)
J Neuroinflammation
, vol.1
, pp. 24
-
-
Wilcock, D.M.1
Rojiani, A.2
Rosenthal, A.3
-
132
-
-
0005990931
-
A controlled trial of ABT-418 in attention deficit hyperactivity disorder in adults
-
Wilens T., Biederman J., Spencer T., et al. A controlled trial of ABT-418 in attention deficit hyperactivity disorder in adults. Am J Psychiatry 156 (1998) 1931-1937
-
(1998)
Am J Psychiatry
, vol.156
, pp. 1931-1937
-
-
Wilens, T.1
Biederman, J.2
Spencer, T.3
-
133
-
-
0029054285
-
Nicotine patches in Alzheimer's disease: Pilot study on learning, memory, and safety
-
Wilson A.L., Langley L.K., Monley J., et al. Nicotine patches in Alzheimer's disease: Pilot study on learning, memory, and safety. Pharmacol Biochem Behav 51 (1995) 509-514
-
(1995)
Pharmacol Biochem Behav
, vol.51
, pp. 509-514
-
-
Wilson, A.L.1
Langley, L.K.2
Monley, J.3
-
134
-
-
0033772113
-
Decreased prevalence of Alzheimer's disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
-
Wolozin B. Decreased prevalence of Alzheimer's disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol 57 (2000) 1439-1443
-
(2000)
Arch Neurol
, vol.57
, pp. 1439-1443
-
-
Wolozin, B.1
-
135
-
-
11144355129
-
Chronic treatment with the γ-secretase inhibitor LY-411575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation
-
Wong G.T., Manfra D., Poulet F.M., et al. Chronic treatment with the γ-secretase inhibitor LY-411575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem 279 (2004) 12876-12882
-
(2004)
J Biol Chem
, vol.279
, pp. 12876-12882
-
-
Wong, G.T.1
Manfra, D.2
Poulet, F.M.3
-
136
-
-
20744454142
-
Beta subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase
-
Wong H.K., Sakurai T., Oyama F., et al. Beta subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J Biol Chem 280 (2005) 23009-23017
-
(2005)
J Biol Chem
, vol.280
, pp. 23009-23017
-
-
Wong, H.K.1
Sakurai, T.2
Oyama, F.3
-
137
-
-
0034064056
-
Therapeutic potential of positive AMPA receptor modulators in the treatment of neurological disease
-
Yamada K.A. Therapeutic potential of positive AMPA receptor modulators in the treatment of neurological disease. Exp Opin Invest Drugs 9 (2000) 765-777
-
(2000)
Exp Opin Invest Drugs
, vol.9
, pp. 765-777
-
-
Yamada, K.A.1
-
138
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
337
-
Yan R., Bienkowski M.J., Shuck M.E., et al. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402 (1999) 533 337
-
(1999)
Nature
, vol.402
, pp. 533
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
-
139
-
-
2542475986
-
Clearing amyloid through the blood-brain barrier
-
Zlokovic B.V. Clearing amyloid through the blood-brain barrier. J Neurochem 89 (2004) 807-811
-
(2004)
J Neurochem
, vol.89
, pp. 807-811
-
-
Zlokovic, B.V.1
|