The 5-HT6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged Rats

Neuropsychopharmacology

Volumn 29, Issue 1, 2004, Pages 93-100

  Foley, Andrew G ^a   Murphy, Keith J ^a   Hirst, Warren D ^b   Gallagher, Helen C ^a   Hagan, Jim J ^b   Upton, Neil ^b   Walsh, Frank S ^b   Regan, Ciaran M ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Acute and chronic administration; Cholinergic deficits; Neuroplasticity; Probe trial; Search strategy; Swim angle

Indexed keywords

5 CHLORO N (4 METHOXY 3 PIPERAZIN 1 YLPHENYL) 3 METHYL 2 BENZOTHIOPHENE SULFONAMIDE; 5 CHLORO N [4 METHOXY 3 (1 PIPERAZINYL)PHENYL] 3 METHYL 2 BENZOTHIOPHENESULFONAMIDE; CHOLINERGIC RECEPTOR BLOCKING AGENT; SCOPOLAMINE; SEROTONIN 6 RECEPTOR; SULFONAMIDE; UNCLASSIFIED DRUG;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; EXPERIMENTAL TEST; LATENT PERIOD; LEARNING DISORDER; LEARNING TEST; LIGHT DARK CYCLE; MALE; MAZE TEST; MEASUREMENT; MEMORY CONSOLIDATION; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT; RAT STRAIN; RECALL; STATISTICAL SIGNIFICANCE; TASK PERFORMANCE; TRAINING;

ADMINISTRATION, ORAL; AGING; AMNESIA; ANALYSIS OF VARIANCE; ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; LOCOMOTION; MALE; MAZE LEARNING; MEMORY; RATS; RATS, WISTAR; REACTION TIME; RECEPTORS, SEROTONIN; SCOPOLAMINE; SEROTONIN ANTAGONISTS; SPATIAL BEHAVIOR; SULFONAMIDES; SWIMMING; THIOPHENES;

EID: 0346057791     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300332     Document Type: Article

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