메뉴 건너뛰기




Volumn 21, Issue 5, 2009, Pages 489-498

Th17 cells: From precursors to players in inflammation and infection

Author keywords

Autoimmunity; Cytokines; Infection; Regulatory T cells; Th subsets

Indexed keywords

CYTOKINE; INTERLEUKIN 17; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 65549152333     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxp021     Document Type: Review
Times cited : (201)

References (110)
  • 1
    • 33947720523 scopus 로고    scopus 로고
    • Development in motion: Helper T cells at work
    • Reiner, S. L. 2007. Development in motion: Helper T cells at work. Cell 129:33.
    • (2007) Cell , vol.129 , pp. 33
    • Reiner, S.L.1
  • 2
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. and Coffman, R. L. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
    • (1986) J. Immunol , vol.136 , pp. 2348
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 3
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann, T. R. and Coffman, R. L. 1989. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
    • (1989) Annu. Rev. Immunol , vol.7 , pp. 145
    • Mosmann, T.R.1    Coffman, R.L.2
  • 4
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan, M. H., Sun, Y. L., Hoey, T. and Grusby, M. J. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174.
    • (1996) Nature , vol.382 , pp. 174
    • Kaplan, M.H.1    Sun, Y.L.2    Hoey, T.3    Grusby, M.J.4
  • 5
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    • Meraz, M. A., White, J. M., Sheehan, K. C. et al. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431.
    • (1996) Cell , vol.84 , pp. 431
    • Meraz, M.A.1    White, J.M.2    Sheehan, K.C.3
  • 6
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan, M. H., Schindler, U., Smiley, S. T. and Grusby, M. J. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4:313.
    • (1996) Immunity , vol.4 , pp. 313
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 7
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G. and Glimcher, L. H. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100:655.
    • (2000) Cell , vol.100 , pp. 655
    • Szabo, S.J.1    Kim, S.T.2    Costa, G.L.3    Zhang, X.4    Fathman, C.G.5    Glimcher, L.H.6
  • 8
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng, W. and Flavell, R. A. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89:587.
    • (1997) Cell , vol.89 , pp. 587
    • Zheng, W.1    Flavell, R.A.2
  • 9
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann, B., Lesley, R., Blom, B. et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715.
    • (2000) Immunity , vol.13 , pp. 715
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 10
    • 0029671318 scopus 로고    scopus 로고
    • Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    • Ferber, I. A., Brocke, S., Taylor-Edwards, C. et al. 1996. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156:5.
    • (1996) J. Immunol , vol.156 , pp. 5
    • Ferber, I.A.1    Brocke, S.2    Taylor-Edwards, C.3
  • 11
    • 45749101727 scopus 로고    scopus 로고
    • Induction and effector functions of T(H)17 cells
    • Bettelli, E., Korn, T., Oukka, M. and Kuchroo, V. K. 2008. Induction and effector functions of T(H)17 cells. Nature 453:1051.
    • (2008) Nature , vol.453 , pp. 1051
    • Bettelli, E.1    Korn, T.2    Oukka, M.3    Kuchroo, V.K.4
  • 12
    • 0036219003 scopus 로고    scopus 로고
    • T cell response in experimental autoimmune encephalomyelitis (EAE): Role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire
    • Kuchroo, V. K., Anderson, A. C., Waldner, H., Munder, M., Bettelli, E. and Nicholson, L. B. 2002. T cell response in experimental autoimmune encephalomyelitis (EAE): Role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu. Rev. Immunol. 20:101.
    • (2002) Annu. Rev. Immunol , vol.20 , pp. 101
    • Kuchroo, V.K.1    Anderson, A.C.2    Waldner, H.3    Munder, M.4    Bettelli, E.5    Nicholson, L.B.6
  • 13
    • 0007179779 scopus 로고    scopus 로고
    • Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein
    • Das, M. P., Nicholson, L. B., Greer, J. M. and Kuchroo, V. K. 1997. Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein. J. Exp. Med. 186:867.
    • (1997) J. Exp. Med , vol.186 , pp. 867
    • Das, M.P.1    Nicholson, L.B.2    Greer, J.M.3    Kuchroo, V.K.4
  • 14
    • 41549134361 scopus 로고    scopus 로고
    • Th17 cell differentiation: The long and winding road
    • McGeachy, M. J. and Cua, D. J. 2008. Th17 cell differentiation: The long and winding road. Immunity 28:445.
    • (2008) Immunity , vol.28 , pp. 445
    • McGeachy, M.J.1    Cua, D.J.2
  • 15
    • 0036604306 scopus 로고    scopus 로고
    • A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
    • Parham, C., Chirica, M., Timans, J. et al. 2002. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168:5699.
    • (2002) J. Immunol , vol.168 , pp. 5699
    • Parham, C.1    Chirica, M.2    Timans, J.3
  • 16
    • 0035877257 scopus 로고    scopus 로고
    • Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death
    • Wiekowski, M. T., Leach, M. W., Evans, E. W. et al. 2001. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J. Immunol. 166:7563.
    • (2001) J. Immunol , vol.166 , pp. 7563
    • Wiekowski, M.T.1    Leach, M.W.2    Evans, E.W.3
  • 17
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua, D. J., Sherlock, J., Chen, Y. et al. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421:744.
    • (2003) Nature , vol.421 , pp. 744
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3
  • 18
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • Gran, B., Zhang, G. X., Yu, S. et al. 2002. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol. 169:7104.
    • (2002) J. Immunol , vol.169 , pp. 7104
    • Gran, B.1    Zhang, G.X.2    Yu, S.3
  • 19
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal, S., Ghilardi, N., Xie, M. H., de Sauvage, F. J. and Gurney, A. L. 2003. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278:1910.
    • (2003) J. Biol. Chem , vol.278 , pp. 1910
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    de Sauvage, F.J.4    Gurney, A.L.5
  • 20
    • 0033134608 scopus 로고    scopus 로고
    • IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    • Kotake, S., Udagawa, N., Takahashi, N. et al. 1999. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J. Clin. Invest. 103:1345.
    • (1999) J. Clin. Invest , vol.103 , pp. 1345
    • Kotake, S.1    Udagawa, N.2    Takahashi, N.3
  • 21
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock, C., Hermans, G., Pedotti, R. et al. 2002. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 8:500.
    • (2002) Nat. Med , vol.8 , pp. 500
    • Lock, C.1    Hermans, G.2    Pedotti, R.3
  • 22
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro- and anti-inflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    • Murphy, C. A., Langrish, C. L., Chen, Y. et al. 2003. Divergent pro- and anti-inflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198:1951.
    • (2003) J. Exp. Med , vol.198 , pp. 1951
    • Murphy, C.A.1    Langrish, C.L.2    Chen, Y.3
  • 23
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • Langrish, C. L., Chen, Y., Blumenschein, W. M. et al. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201:233.
    • (2005) J. Exp. Med , vol.201 , pp. 233
    • Langrish, C.L.1    Chen, Y.2    Blumenschein, W.M.3
  • 24
    • 0027215897 scopus 로고
    • CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene
    • Rouvier, E., Luciani, M. F., Mattei, M. G., Denizot, F. and Golstein, P. 1993. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J. Immunol. 150:5445.
    • (1993) J. Immunol , vol.150 , pp. 5445
    • Rouvier, E.1    Luciani, M.F.2    Mattei, M.G.3    Denizot, F.4    Golstein, P.5
  • 25
    • 34250667109 scopus 로고    scopus 로고
    • Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression
    • Maitra, A., Shen, F., Hanel, W. et al. 2007. Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. Proc. Natl Acad. Sci. USA 104:7506.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 7506
    • Maitra, A.1    Shen, F.2    Hanel, W.3
  • 26
    • 5644289875 scopus 로고    scopus 로고
    • IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways
    • Hwang, S. Y., Kim, J. Y., Kim, K. W. et al. 2004. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways. Arthritis Res. Ther. 6:R120.
    • (2004) Arthritis Res. Ther , vol.6
    • Hwang, S.Y.1    Kim, J.Y.2    Kim, K.W.3
  • 28
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls, J. K. and Linden, A. 2004. Interleukin-17 family members and inflammation. Immunity 21:467.
    • (2004) Immunity , vol.21 , pp. 467
    • Kolls, J.K.1    Linden, A.2
  • 29
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E., Carrier, Y., Gao, W. et al. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235.
    • (2006) Nature , vol.441 , pp. 235
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 30
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. and Stockinger, B. 2006. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24:179.
    • (2006) Immunity , vol.24 , pp. 179
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 31
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • Mangan, P. R., Harrington, L. E., O'Quinn, D. B. et al. 2006. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441:231.
    • (2006) Nature , vol.441 , pp. 231
    • Mangan, P.R.1    Harrington, L.E.2    O'Quinn, D.B.3
  • 32
    • 48449086316 scopus 로고    scopus 로고
    • TGF-beta: A master of all T cell trades
    • Li, M. O. and Flavell, R. A. 2008. TGF-beta: A master of all T cell trades. Cell 134:392.
    • (2008) Cell , vol.134 , pp. 392
    • Li, M.O.1    Flavell, R.A.2
  • 33
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    • Shull, M. M., Ormsby, I., Kier, A. B. et al. 1992. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359:693.
    • (1992) Nature , vol.359 , pp. 693
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3
  • 34
    • 0027531528 scopus 로고
    • Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni, A. B., Huh, C. G., Becker, D. et al. 1993. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl Acad. Sci. USA 90:770.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 770
    • Kulkarni, A.B.1    Huh, C.G.2    Becker, D.3
  • 35
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., Nomura, T. and Sakaguchi, S. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057.
    • (2003) Science , vol.299 , pp. 1057
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 36
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot, J. D., Gavin, M. A. and Rudensky, A. Y. 2003. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4:330.
    • (2003) Nat. Immunol , vol.4 , pp. 330
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 37
    • 17144400393 scopus 로고    scopus 로고
    • TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    • Marie, J. C., Letterio, J. J., Gavin, M. and Rudensky, A. Y. 2005. TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J. Exp. Med. 201:1061.
    • (2005) J. Exp. Med , vol.201 , pp. 1061
    • Marie, J.C.1    Letterio, J.J.2    Gavin, M.3    Rudensky, A.Y.4
  • 38
    • 33646168597 scopus 로고    scopus 로고
    • FOXP3: Of mice and men
    • Ziegler, S. F. 2006. FOXP3: Of mice and men. Annu. Rev. Immunol. 24:209.
    • (2006) Annu. Rev. Immunol , vol.24 , pp. 209
    • Ziegler, S.F.1
  • 39
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare, C. and Medzhitov, R. 2003. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299:1033.
    • (2003) Science , vol.299 , pp. 1033
    • Pasare, C.1    Medzhitov, R.2
  • 40
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • Korn, T., Bettelli, E., Gao, W. et al. 2007. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448:484.
    • (2007) Nature , vol.448 , pp. 484
    • Korn, T.1    Bettelli, E.2    Gao, W.3
  • 41
    • 33750142276 scopus 로고    scopus 로고
    • Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
    • Veldhoen, M., Hocking, R. J., Flavell, R. A. and Stockinger, B. 2006. Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat. Immunol. 7:1151.
    • (2006) Nat. Immunol , vol.7 , pp. 1151
    • Veldhoen, M.1    Hocking, R.J.2    Flavell, R.A.3    Stockinger, B.4
  • 42
    • 0031920882 scopus 로고    scopus 로고
    • IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein
    • Okuda, Y., Sakoda, S., Bernard, C. C. et al. 1998. IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein. Int. Immunol. 10:703.
    • (1998) Int. Immunol , vol.10 , pp. 703
    • Okuda, Y.1    Sakoda, S.2    Bernard, C.C.3
  • 43
    • 57449112782 scopus 로고    scopus 로고
    • IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells
    • Korn, T., Mitsdoerffer, M., Croxford, A. L. et al. 2008. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc. Natl Acad. Sci. USA 105:18460.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 18460
    • Korn, T.1    Mitsdoerffer, M.2    Croxford, A.L.3
  • 44
    • 34247122412 scopus 로고    scopus 로고
    • Stat3 and Stat4 direct development of IL-17-secreting Th cells
    • Mathur, A. N., Chang, H. C., Zisoulis, D. G. et al. 2007. Stat3 and Stat4 direct development of IL-17-secreting Th cells. J. Immunol. 178:4901.
    • (2007) J. Immunol , vol.178 , pp. 4901
    • Mathur, A.N.1    Chang, H.C.2    Zisoulis, D.G.3
  • 45
    • 34248592104 scopus 로고    scopus 로고
    • T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
    • Li, M. O., Wan, Y. Y. and Flavell, R. A. 2007. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 26:579.
    • (2007) Immunity , vol.26 , pp. 579
    • Li, M.O.1    Wan, Y.Y.2    Flavell, R.A.3
  • 46
    • 51049092467 scopus 로고    scopus 로고
    • Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
    • Jaensson, E., Uronen-Hansson, H., Pabst, O. et al. 2008. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J. Exp. Med. 205:2139.
    • (2008) J. Exp. Med , vol.205 , pp. 2139
    • Jaensson, E.1    Uronen-Hansson, H.2    Pabst, O.3
  • 47
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes, J. L., Siddiqui, K. R., Arancibia-Carcamo, C. V. et al. 2007. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J. Exp. Med. 204:1757.
    • (2007) J. Exp. Med , vol.204 , pp. 1757
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3
  • 48
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida, D., Park, Y., Kim, G. et al. 2007. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317:256.
    • (2007) Science , vol.317 , pp. 256
    • Mucida, D.1    Park, Y.2    Kim, G.3
  • 49
    • 53149137849 scopus 로고    scopus 로고
    • Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression
    • Xiao, S., Jin, H., Korn, T. et al. 2008. Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J. Immunol. 181:2277.
    • (2008) J. Immunol , vol.181 , pp. 2277
    • Xiao, S.1    Jin, H.2    Korn, T.3
  • 50
    • 34548128307 scopus 로고    scopus 로고
    • The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
    • Brustle, A., Heink, S., Huber, M. et al. 2007. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat. Immunol. 8:958.
    • (2007) Nat. Immunol , vol.8 , pp. 958
    • Brustle, A.1    Heink, S.2    Huber, M.3
  • 51
    • 58549094107 scopus 로고    scopus 로고
    • IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
    • Huber, M., Brustle, A., Reinhard, K. et al. 2008. IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc. Natl Acad. Sci. USA 105:20846.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 20846
    • Huber, M.1    Brustle, A.2    Reinhard, K.3
  • 52
    • 55549084247 scopus 로고    scopus 로고
    • Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells
    • Hill, J. A., Hall, J. A., Sun, C. M. et al. 2008. Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity 29:758.
    • (2008) Immunity , vol.29 , pp. 758
    • Hill, J.A.1    Hall, J.A.2    Sun, C.M.3
  • 53
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • Laurence, A., Tato, C. M., Davidson, T. S. et al. 2007. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26:371.
    • (2007) Immunity , vol.26 , pp. 371
    • Laurence, A.1    Tato, C.M.2    Davidson, T.S.3
  • 54
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C. and Horak, I. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253.
    • (1993) Cell , vol.75 , pp. 253
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 55
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot, J. D., Rasmussen, J. P., Gavin, M. A. and Rudensky, A. Y. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6:1142.
    • (2005) Nat. Immunol , vol.6 , pp. 1142
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 56
    • 43449135305 scopus 로고    scopus 로고
    • TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    • Zhou, L., Lopes, J. E., Chong, M. M. et al. 2008. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453:236.
    • (2008) Nature , vol.453 , pp. 236
    • Zhou, L.1    Lopes, J.E.2    Chong, M.M.3
  • 57
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    • Ivanov, I. I., Frutos Rde, L., Manel, N., Yoshinaga, K. et al. 2008. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4:337.
    • (2008) Cell Host Microbe , vol.4 , pp. 337
    • Ivanov, I.I.1    Frutos Rde, L.2    Manel, N.3    Yoshinaga, K.4
  • 58
    • 0031777526 scopus 로고    scopus 로고
    • Regulation of T helper cell differentiation by STAT molecules
    • Kaplan, M. H. and Grusby, M. J. 1998. Regulation of T helper cell differentiation by STAT molecules. J. Leukoc. Biol. 64:2.
    • (1998) J. Leukoc. Biol , vol.64 , pp. 2
    • Kaplan, M.H.1    Grusby, M.J.2
  • 59
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • Nurieva, R., Yang, X. O., Martinez, G. et al. 2007. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448:480.
    • (2007) Nature , vol.448 , pp. 480
    • Nurieva, R.1    Yang, X.O.2    Martinez, G.3
  • 60
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou, L., Ivanov, I. I., Spolski, R., Min, R. et al. 2007. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8:967.
    • (2007) Nat. Immunol , vol.8 , pp. 967
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4
  • 61
    • 34848821989 scopus 로고    scopus 로고
    • Distinct regulation of interleukin-17 in human T helper lymphocytes
    • Chen, Z., Tato, C. M., Muul, L., Laurence, A. and O'Shea, J. J. 2007. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 56:2936.
    • (2007) Arthritis Rheum , vol.56 , pp. 2936
    • Chen, Z.1    Tato, C.M.2    Muul, L.3    Laurence, A.4    O'Shea, J.J.5
  • 62
    • 46749156754 scopus 로고    scopus 로고
    • Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
    • Coquet, J. M., Chakravarti, S., Smyth, M. J. and Godfrey, D. I. 2008. Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J. Immunol. 180:7097.
    • (2008) J. Immunol , vol.180 , pp. 7097
    • Coquet, J.M.1    Chakravarti, S.2    Smyth, M.J.3    Godfrey, D.I.4
  • 63
    • 52949091915 scopus 로고    scopus 로고
    • IL-21 signaling is critical for the development of type I diabetes in the NOD mouse
    • Spolski, R., Kashyap, M., Robinson, C., Yu, Z. and Leonard, W. J. 2008. IL-21 signaling is critical for the development of type I diabetes in the NOD mouse. Proc. Natl Acad. Sci. USA 105:14028.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 14028
    • Spolski, R.1    Kashyap, M.2    Robinson, C.3    Yu, Z.4    Leonard, W.J.5
  • 64
    • 18444385868 scopus 로고    scopus 로고
    • IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
    • Pflanz, S., Timans, J. C., Cheung, J. et al. 2002. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16:779.
    • (2002) Immunity , vol.16 , pp. 779
    • Pflanz, S.1    Timans, J.C.2    Cheung, J.3
  • 65
    • 0038326688 scopus 로고    scopus 로고
    • Cutting edge: Role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    • Takeda, A., Hamano, S., Yamanaka, A. et al. 2003. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 170:4886.
    • (2003) J. Immunol , vol.170 , pp. 4886
    • Takeda, A.1    Hamano, S.2    Yamanaka, A.3
  • 66
    • 0345570521 scopus 로고    scopus 로고
    • The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection
    • Villarino, A., Hibbert, L., Lieberman, L. et al. 2003. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19:645.
    • (2003) Immunity , vol.19 , pp. 645
    • Villarino, A.1    Hibbert, L.2    Lieberman, L.3
  • 67
    • 30344488706 scopus 로고    scopus 로고
    • Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liver immunopathology
    • Rosas, L. E., Satoskar, A. A., Roth, K. M. et al. 2006. Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liver immunopathology. Am. J. Pathol. 168:158.
    • (2006) Am. J. Pathol , vol.168 , pp. 158
    • Rosas, L.E.1    Satoskar, A.A.2    Roth, K.M.3
  • 68
    • 14844355133 scopus 로고    scopus 로고
    • The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis
    • Holscher, C., Holscher, A., Ruckerl, D. et al. 2005. The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J. Immunol. 174:3534.
    • (2005) J. Immunol , vol.174 , pp. 3534
    • Holscher, C.1    Holscher, A.2    Ruckerl, D.3
  • 69
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • Batten, M., Li, J., Yi, S. et al. 2006. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7:929.
    • (2006) Nat. Immunol , vol.7 , pp. 929
    • Batten, M.1    Li, J.2    Yi, S.3
  • 70
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    • Stumhofer, J. S., Laurence, A., Wilson, E. H. et al. 2006. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 7:937.
    • (2006) Nat. Immunol , vol.7 , pp. 937
    • Stumhofer, J.S.1    Laurence, A.2    Wilson, E.H.3
  • 71
    • 36248970701 scopus 로고    scopus 로고
    • A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
    • Awasthi, A., Carrier, Y., Peron, J. P. et al. 2007. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 8:1380.
    • (2007) Nat. Immunol , vol.8 , pp. 1380
    • Awasthi, A.1    Carrier, Y.2    Peron, J.P.3
  • 72
    • 36248951161 scopus 로고    scopus 로고
    • Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
    • Stumhofer, J. S., Silver, J. S., Laurence, A. et al. 2007. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 8:1363.
    • (2007) Nat. Immunol , vol.8 , pp. 1363
    • Stumhofer, J.S.1    Silver, J.S.2    Laurence, A.3
  • 73
    • 36248970702 scopus 로고    scopus 로고
    • Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    • Fitzgerald, D. C., Zhang, G. X., El-Behi, M. et al. 2007. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8:1372.
    • (2007) Nat. Immunol , vol.8 , pp. 1372
    • Fitzgerald, D.C.1    Zhang, G.X.2    El-Behi, M.3
  • 74
    • 44449146212 scopus 로고    scopus 로고
    • Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: Role of intracellular osteopontin
    • Shinohara, M. L., Kim, J. H., Garcia, V. A. and Cantor, H. 2008. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: Role of intracellular osteopontin. Immunity 29:68.
    • (2008) Immunity , vol.29 , pp. 68
    • Shinohara, M.L.1    Kim, J.H.2    Garcia, V.A.3    Cantor, H.4
  • 75
    • 71849086031 scopus 로고    scopus 로고
    • Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis
    • Murugaiyan, G., Mittal, A. and Weiner, H. L. 2008. Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis. J. Immunol. 181:7480.
    • (2008) J. Immunol , vol.181 , pp. 7480
    • Murugaiyan, G.1    Mittal, A.2    Weiner, H.L.3
  • 76
    • 27144502396 scopus 로고    scopus 로고
    • TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1
    • Park, I. K., Shultz, L. D., Letterio, J. J. and Gorham, J. D. 2005. TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J. Immunol. 175:5666.
    • (2005) J. Immunol , vol.175 , pp. 5666
    • Park, I.K.1    Shultz, L.D.2    Letterio, J.J.3    Gorham, J.D.4
  • 77
    • 0034327176 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression
    • Gorelik, L., Fields, P. E. and Flavell, R. A. 2000. Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression. J. Immunol. 165:4773.
    • (2000) J. Immunol , vol.165 , pp. 4773
    • Gorelik, L.1    Fields, P.E.2    Flavell, R.A.3
  • 78
    • 37749021324 scopus 로고    scopus 로고
    • Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity
    • Harris, T. J., Grosso, J. F., Yen, H. R. et al. 2007. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J. Immunol. 179:4313.
    • (2007) J. Immunol , vol.179 , pp. 4313
    • Harris, T.J.1    Grosso, J.F.2    Yen, H.R.3
  • 79
    • 44449136105 scopus 로고    scopus 로고
    • Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases
    • Liu, X., Lee, Y. S., Yu, C. R. and Egwuagu, C. E. 2008. Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. J. Immunol. 180:6070.
    • (2008) J. Immunol , vol.180 , pp. 6070
    • Liu, X.1    Lee, Y.S.2    Yu, C.R.3    Egwuagu, C.E.4
  • 80
    • 33744479688 scopus 로고    scopus 로고
    • Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
    • Chen, Z., Laurence, A., Kanno, Y. et al. 2006. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc. Natl Acad. Sci. USA 103:8137.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 8137
    • Chen, Z.1    Laurence, A.2    Kanno, Y.3
  • 81
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E. et al. 2006. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126:1121.
    • (2006) Cell , vol.126 , pp. 1121
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4
  • 82
    • 54549100120 scopus 로고    scopus 로고
    • Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells
    • Zhang, F., Meng, G. and Strober, W. 2008. Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat. Immunol. 9:1297.
    • (2008) Nat. Immunol , vol.9 , pp. 1297
    • Zhang, F.1    Meng, G.2    Strober, W.3
  • 83
    • 37849048599 scopus 로고    scopus 로고
    • T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    • Yang, X. O., Pappu, B. P., Nurieva, R. et al. 2008. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28:29.
    • (2008) Immunity , vol.28 , pp. 29
    • Yang, X.O.1    Pappu, B.P.2    Nurieva, R.3
  • 84
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva, R. I., Chung, Y., Hwang, D. et al. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29:138.
    • (2008) Immunity , vol.29 , pp. 138
    • Nurieva, R.I.1    Chung, Y.2    Hwang, D.3
  • 85
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and T(H)-17 cells
    • Bauquet, A. T., Jin, H., Paterson, A. M. et al. 2008. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and T(H)-17 cells. Nat. Immunol. 10:167.
    • (2008) Nat. Immunol , vol.10 , pp. 167
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3
  • 86
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • Tzartos, J. S., Friese, M. A., Craner, M. J. et al. 2008. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am. J. Pathol. 172:146.
    • (2008) Am. J. Pathol , vol.172 , pp. 146
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3
  • 87
    • 34948909646 scopus 로고    scopus 로고
    • Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
    • Kebir, H., Kreymborg, K., Ifergan, I. et al. 2007. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat. Med. 13:1173.
    • (2007) Nat. Med , vol.13 , pp. 1173
    • Kebir, H.1    Kreymborg, K.2    Ifergan, I.3
  • 88
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr, R. H., Taylor, K. D., Brant, S. R. et al. 2006. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314:1461.
    • (2006) Science , vol.314 , pp. 1461
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3
  • 89
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of interleukin 17 in inflammatory bowel disease
    • Fujino, S., Andoh, A., Bamba, S. et al. 2003. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52:65.
    • (2003) Gut , vol.52 , pp. 65
    • Fujino, S.1    Andoh, A.2    Bamba, S.3
  • 90
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A. and Sallusto, F. 2007. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8:942.
    • (2007) Nat. Immunol , vol.8 , pp. 942
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 91
    • 34548133583 scopus 로고    scopus 로고
    • Development, cytokine profile and function of human interleukin 17-producing helper T cells
    • Wilson, N. J., Boniface, K., Chan, J. R. et al. 2007. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat. Immunol. 8:950.
    • (2007) Nat. Immunol , vol.8 , pp. 950
    • Wilson, N.J.1    Boniface, K.2    Chan, J.R.3
  • 92
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    • Manel, N., Unutmaz, D. and Littman, D. R. 2008. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat. Immunol. 9:641.
    • (2008) Nat. Immunol , vol.9 , pp. 641
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 93
    • 47549112840 scopus 로고    scopus 로고
    • IL-21 and TGF-beta are required for differentiation of human T(H)17 cells
    • Yang, L., Anderson, D. E., Baecher-Allan, C. et al. 2008. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 454:350.
    • (2008) Nature , vol.454 , pp. 350
    • Yang, L.1    Anderson, D.E.2    Baecher-Allan, C.3
  • 94
    • 34547734621 scopus 로고    scopus 로고
    • Phenotypic and functional features of human Th17 cells
    • Annunziato, F., Cosmi, L., Santarlasci, V. et al. 2007. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 204:1849.
    • (2007) J. Exp. Med , vol.204 , pp. 1849
    • Annunziato, F.1    Cosmi, L.2    Santarlasci, V.3
  • 95
    • 54949139265 scopus 로고    scopus 로고
    • The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation
    • Annunziato, F., Cosmi, L., Liotta, F., Maggi, E. and Romagnani, S. 2008. The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. Int. Immunol. 20:1361.
    • (2008) Int. Immunol , vol.20 , pp. 1361
    • Annunziato, F.1    Cosmi, L.2    Liotta, F.3    Maggi, E.4    Romagnani, S.5
  • 96
    • 37549011317 scopus 로고    scopus 로고
    • Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
    • Zaba, L. C., Cardinale, I., Gilleaudeau, P. et al. 2007. Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J. Exp. Med. 204:3183.
    • (2007) J. Exp. Med , vol.204 , pp. 3183
    • Zaba, L.C.1    Cardinale, I.2    Gilleaudeau, P.3
  • 97
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    • Sato, K., Suematsu, A., Okamoto, K. et al. 2006. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J. Exp. Med. 203:2673.
    • (2006) J. Exp. Med , vol.203 , pp. 2673
    • Sato, K.1    Suematsu, A.2    Okamoto, K.3
  • 98
    • 33745321276 scopus 로고    scopus 로고
    • IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    • Komiyama, Y., Nakae, S., Matsuki, T. et al. 2006. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177:566.
    • (2006) J. Immunol , vol.177 , pp. 566
    • Komiyama, Y.1    Nakae, S.2    Matsuki, T.3
  • 99
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae, S., Nambu, A., Sudo, K. and Iwakura, Y. 2003. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 171:6173.
    • (2003) J. Immunol , vol.171 , pp. 6173
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 100
    • 30944452780 scopus 로고    scopus 로고
    • Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
    • Hofstetter, H. H., Ibrahim, S. M., Koczan, D. et al. 2005. Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell. Immunol. 237:123.
    • (2005) Cell. Immunol , vol.237 , pp. 123
    • Hofstetter, H.H.1    Ibrahim, S.M.2    Koczan, D.3
  • 101
    • 55049118394 scopus 로고    scopus 로고
    • Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction
    • Ogura, H., Murakami, M., Okuyama, Y. et al. 2008. Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity 29:628.
    • (2008) Immunity , vol.29 , pp. 628
    • Ogura, H.1    Murakami, M.2    Okuyama, Y.3
  • 102
    • 17644368573 scopus 로고    scopus 로고
    • Interleukin-6: From basic science to medicine-40 years in immunology
    • Kishimoto, T. 2005. Interleukin-6: From basic science to medicine-40 years in immunology. Annu. Rev. Immunol. 23:1.
    • (2005) Annu. Rev. Immunol , vol.23 , pp. 1
    • Kishimoto, T.1
  • 103
  • 104
    • 34249869268 scopus 로고    scopus 로고
    • Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection
    • Rudner, X. L., Happel, K. I., Young, E. A. and Shellito, J. E. 2007. Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection. Infect. Immun. 75:3055.
    • (2007) Infect. Immun , vol.75 , pp. 3055
    • Rudner, X.L.1    Happel, K.I.2    Young, E.A.3    Shellito, J.E.4
  • 105
    • 40049098958 scopus 로고    scopus 로고
    • IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
    • Aujla, S. J., Chan, Y. R., Zheng, M. et al. 2008. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med. 14:275.
    • (2008) Nat. Med , vol.14 , pp. 275
    • Aujla, S.J.1    Chan, Y.R.2    Zheng, M.3
  • 106
    • 38949133035 scopus 로고    scopus 로고
    • IL-23 and IL-17 in tuberculosis
    • Khader, S. A. and Cooper, A. M. 2008. IL-23 and IL-17 in tuberculosis. Cytokine 41:79.
    • (2008) Cytokine , vol.41 , pp. 79
    • Khader, S.A.1    Cooper, A.M.2
  • 107
    • 33749138039 scopus 로고    scopus 로고
    • IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection
    • Lockhart, E., Green, A. M. and Flynn, J. L. 2006. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J. Immunol. 177:4662.
    • (2006) J. Immunol , vol.177 , pp. 4662
    • Lockhart, E.1    Green, A.M.2    Flynn, J.L.3
  • 108
    • 34248562792 scopus 로고    scopus 로고
    • IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    • Khader, S. A., Bell, G. K., Pearl, J. E. et al. 2007. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat. Immunol. 8:369.
    • (2007) Nat. Immunol , vol.8 , pp. 369
    • Khader, S.A.1    Bell, G.K.2    Pearl, J.E.3
  • 109
    • 55849118788 scopus 로고    scopus 로고
    • Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme arthritis
    • Codolo, G., Amedei, A., Steere, A. C. et al. 2008. Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme arthritis. Arthritis Rheum. 58:3609.
    • (2008) Arthritis Rheum , vol.58 , pp. 3609
    • Codolo, G.1    Amedei, A.2    Steere, A.C.3
  • 110
    • 41449110468 scopus 로고    scopus 로고
    • Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
    • Milner, J. D., Brenchley, J. M., Laurence, A. et al. 2008. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 452:773.
    • (2008) Nature , vol.452 , pp. 773
    • Milner, J.D.1    Brenchley, J.M.2    Laurence, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.