Cutting edge: TGF-β inhibits Th type 2 development through inhibition of GATA-3 expression

Journal of Immunology

Volumn 165, Issue 9, 2000, Pages 4773-4777

  Gorelik, L ^a   Fields, P E ^a   Flavell, R A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; TRANSCRIPTION FACTOR GATA 3; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

EID: 0034327176     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.9.4773     Document Type: Article

References (15)

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4. Transcription factor GATA-3 is differentially expressed in murine Thl and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
5. Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype
6. Transforming growth factor-/3 and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pat temand cell surface phenotype
7. Production of transforming growth factor/3 by human T lymphocytes and its potential role in the regulation of T cell growth
8. Abrogation of TGF/3 signaiing in T cells leads to spontaneous T cell differentiation and autoimmune disease
9. Helper T cell differentiation is controlled by the cell cycle
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11. Transcription factor GATA-3 is required for development of the T-cell lineage
12. In vivo analysis using variants of zebrafish BMPR-IA: Range of action and involvement of BMP in ectoderm patterning
13. Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
14. The type II activin receptors are essential for egg cylinder Growth, gastrulation, and rostral head development in mice
15. TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis