-
2
-
-
0034644472
-
TGFβ signaling in growth control, cancer and heritable disorders
-
Massagué J, Blain SW, Lo RS: TGFβ signaling in growth control, cancer and heritable disorders. Cell (2000) 103(2):295-309.
-
(2000)
Cell
, vol.103
, Issue.2
, pp. 295-309
-
-
Massagué, J.1
Blain, S.W.2
Lo, R.S.3
-
3
-
-
0242499448
-
Cytostatic and apoptotic actions of TGFβ in homeostasis and cancer
-
Siegel PM, Massagué J: Cytostatic and apoptotic actions of TGFβ in homeostasis and cancer. Nat Rev Cancer (2005) 3(11):807-821.
-
(2005)
Nat Rev Cancer
, vol.3
, Issue.11
, pp. 807-821
-
-
Siegel, P.M.1
Massagué, J.2
-
4
-
-
33745515023
-
Tumour microenvironment: TGFβ: The molecular Jekyll and Hyde of cancer
-
Bierie B, Moses HL: Tumour microenvironment: TGFβ: The molecular Jekyll and Hyde of cancer. Nat Rev Cancer (2006) 6(7):506-520.
-
(2006)
Nat Rev Cancer
, vol.6
, Issue.7
, pp. 506-520
-
-
Bierie, B.1
Moses, H.L.2
-
5
-
-
0033564547
-
Blocking transforming growth factor-β signaling in transgenic epidermis accelerates chemical carcinogenesis: A mechanism associated with increased angiogenesis
-
Go C, Li P, Wang XJ: Blocking transforming growth factor-β signaling in transgenic epidermis accelerates chemical carcinogenesis: A mechanism associated with increased angiogenesis. Cancer Res (1999) 59(12):2861-2868.
-
(1999)
Cancer Res
, vol.59
, Issue.12
, pp. 2861-2868
-
-
Go, C.1
Li, P.2
Wang, X.J.3
-
6
-
-
0034721099
-
Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFRII
-
Go C, He W, Zhong L, Li P, Huang J, Brinkley BR, Wang XJ: Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFRII. Oncogene (2000) 19(32):3623-3631.
-
(2000)
Oncogene
, vol.19
, Issue.32
, pp. 3623-3631
-
-
Go, C.1
He, W.2
Zhong, L.3
Li, P.4
Huang, J.5
Brinkley, B.R.6
Wang, X.J.7
-
7
-
-
0141537150
-
Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-β receptor exhibit impaired mammary development and enhanced mammary tumor formation
-
Gorska AE, Jensen RA, Shyr Y, Aakre ME, Bhowmick NA, Moses HL: Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-β receptor exhibit impaired mammary development and enhanced mammary tumor formation. Am J Pathol (2003) 163(4):1539-1549.
-
(2003)
Am J Pathol
, vol.163
, Issue.4
, pp. 1539-1549
-
-
Gorska, A.E.1
Jensen, R.A.2
Shyr, Y.3
Aakre, M.E.4
Bhowmick, N.A.5
Moses, H.L.6
-
8
-
-
0030598681
-
TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
-
Cui W, Fowlis DJ, Bryson S, Duffie E, Ireland H, Balmain A, Akhurst RJ: TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell (1996) 86(4):531-542.
-
(1996)
Cell
, vol.86
, Issue.4
, pp. 531-542
-
-
Cui, W.1
Fowlis, D.J.2
Bryson, S.3
Duffie, E.4
Ireland, H.5
Balmain, A.6
Akhurst, R.J.7
-
9
-
-
0242285692
-
TGFβ switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
-
Demonstration of the dual role of TGFβ in a breast cancer model, ••
-
Tang B, Vu M, Booker T, Santner SJ, Miller FR, Anver MR, Wakefield LM: TGFβ switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. J Clin Invest (2003) 112(7):1116-1124. •• Demonstration of the dual role of TGFβ in a breast cancer model.
-
(2003)
J Clin Invest
, vol.112
, Issue.7
, pp. 1116-1124
-
-
Tang, B.1
Vu, M.2
Booker, T.3
Santner, S.J.4
Miller, F.R.5
Anver, M.R.6
Wakefield, L.M.7
-
10
-
-
16844373628
-
Effect of conditional knockout of the type II TGF-β receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis
-
Forrester E, Chytil A, Bierie B, Aakre M, Gorska AE, Sharif-Afshar AR, Muller WJ, Moses HL: Effect of conditional knockout of the type II TGF-β receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Cancer Res (2005) 65(6):2296-2302.
-
(2005)
Cancer Res
, vol.65
, Issue.6
, pp. 2296-2302
-
-
Forrester, E.1
Chytil, A.2
Bierie, B.3
Aakre, M.4
Gorska, A.E.5
Sharif-Afshar, A.R.6
Muller, W.J.7
Moses, H.L.8
-
11
-
-
0037816160
-
-
Siegel PM, Shu W, Cardiff RD, Muller WJ, Massagué J: Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci USA (2003) 100(14):8430-8435.
-
Siegel PM, Shu W, Cardiff RD, Muller WJ, Massagué J: Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci USA (2003) 100(14):8430-8435.
-
-
-
-
12
-
-
0242552529
-
Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor-β 1
-
Muraoka RS, Koh Y, Roebuck LR, Sanders ME, Brantley-Sieders D, Gorska AE, Moses HL, Arteaga CL: Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor-β 1. Mol Cell Biol (2003) 23(23):8691-8703.
-
(2003)
Mol Cell Biol
, vol.23
, Issue.23
, pp. 8691-8703
-
-
Muraoka, R.S.1
Koh, Y.2
Roebuck, L.R.3
Sanders, M.E.4
Brantley-Sieders, D.5
Gorska, A.E.6
Moses, H.L.7
Arteaga, C.L.8
-
13
-
-
10844224603
-
Conditional overexpression of active transforming growth factor 1 in vivo accelerates metastases of transgenic mammary tumors
-
Muraoka-Cook RS, Kurokawa H, Koh Y, Forbes JT, Roebuck LR, Barcellos-Hoff MH, Moody SE, Chodosh LA, Arteaga CL: Conditional overexpression of active transforming growth factor 1 in vivo accelerates metastases of transgenic mammary tumors. Cancer Res (2004) 64(24):9002-9011.
-
(2004)
Cancer Res
, vol.64
, Issue.24
, pp. 9002-9011
-
-
Muraoka-Cook, R.S.1
Kurokawa, H.2
Koh, Y.3
Forbes, J.T.4
Roebuck, L.R.5
Barcellos-Hoff, M.H.6
Moody, S.E.7
Chodosh, L.A.8
Arteaga, C.L.9
-
14
-
-
0036086409
-
Blockade of TGFβ inhibits mammary tumor cell viability, migration and metastases
-
Muraoka-Cook RS, Dumont N, Ritter CA, Dugger TC, Brantley DM, Chen J, Easterly E, Roebuck LR, Ryan S, Gotwals PJ, Koteliansky V et al: Blockade of TGFβ inhibits mammary tumor cell viability, migration and metastases. J Clin Invest (2002) 109(12):1551-1559.
-
(2002)
J Clin Invest
, vol.109
, Issue.12
, pp. 1551-1559
-
-
Muraoka-Cook, R.S.1
Dumont, N.2
Ritter, C.A.3
Dugger, T.C.4
Brantley, D.M.5
Chen, J.6
Easterly, E.7
Roebuck, L.R.8
Ryan, S.9
Gotwals, P.J.10
Koteliansky, V.11
-
15
-
-
33745050200
-
Activated type I TGF receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression
-
First demonstration of the existence of cross-talk between TGFβ and the pro-tumorigenic PI3k signaling pathway, •
-
Muraoka-Cook RS, Shin I, Yi JY, Easterly E, Barcellos-Hoff MH, Yingling JM, Zent R, Arteaga CL: Activated type I TGF receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Oncogene (2006) 25(24):3408-3423. • First demonstration of the existence of cross-talk between TGFβ and the pro-tumorigenic PI3k signaling pathway.
-
(2006)
Oncogene
, vol.25
, Issue.24
, pp. 3408-3423
-
-
Muraoka-Cook, R.S.1
Shin, I.2
Yi, J.Y.3
Easterly, E.4
Barcellos-Hoff, M.H.5
Yingling, J.M.6
Zent, R.7
Arteaga, C.L.8
-
16
-
-
10444261212
-
Development of TGFβ signalling inhibitors for cancer therapy
-
An outstanding review of the medicinal chemistry of TGFβ signaling inhibitors in cancer therapy, ••
-
Yingling JM, Blanchard KL, Sawyer JS: Development of TGFβ signalling inhibitors for cancer therapy. Nat Rev Drug Discov (2004) 3(12):1011-1022. •• An outstanding review of the medicinal chemistry of TGFβ signaling inhibitors in cancer therapy.
-
(2004)
Nat Rev Drug Discov
, vol.3
, Issue.12
, pp. 1011-1022
-
-
Yingling, J.M.1
Blanchard, K.L.2
Sawyer, J.S.3
-
17
-
-
15744372725
-
Role of transforming growth factor-β in human cancer
-
Elliot RL, Blobe GC: Role of transforming growth factor-β in human cancer. J Clin Oncol (2005) 23(9):2078-2093.
-
(2005)
J Clin Oncol
, vol.23
, Issue.9
, pp. 2078-2093
-
-
Elliot, R.L.1
Blobe, G.C.2
-
18
-
-
0038724672
-
Targeting the TGFβ signaling network in human neoplasia
-
Dumont N, Arteaga CL: Targeting the TGFβ signaling network in human neoplasia. Cancer Cell (2003) 3(6):531-536.
-
(2003)
Cancer Cell
, vol.3
, Issue.6
, pp. 531-536
-
-
Dumont, N.1
Arteaga, C.L.2
-
19
-
-
30644467227
-
Inhibition of TGFβ signaling in cancer therapy
-
Arteaga CL: Inhibition of TGFβ signaling in cancer therapy. Curr Opin Genet Dev (2006) 16(1):30-37.
-
(2006)
Curr Opin Genet Dev
, vol.16
, Issue.1
, pp. 30-37
-
-
Arteaga, C.L.1
-
20
-
-
47549090432
-
TGFβ in cancer
-
An up-to-date review on the knowledge of the mechanistic basis, clinical relevance and therapeutic potential of TGFβ pathway in cancer, ••
-
Massagué J: TGFβ in cancer. Cell (2008) 134(2):215-230. •• An up-to-date review on the knowledge of the mechanistic basis, clinical relevance and therapeutic potential of TGFβ pathway in cancer.
-
(2008)
Cell
, vol.134
, Issue.2
, pp. 215-230
-
-
Massagué, J.1
-
21
-
-
0023652332
-
The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors
-
Cheifetz S, Weatherbee JA, Tsang ML, Anderson JK, Mole JE, Lucas R, Massagué J: The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors. Cell (1987) 48(3):409-415.
-
(1987)
Cell
, vol.48
, Issue.3
, pp. 409-415
-
-
Cheifetz, S.1
Weatherbee, J.A.2
Tsang, M.L.3
Anderson, J.K.4
Mole, J.E.5
Lucas, R.6
Massagué, J.7
-
22
-
-
0030576525
-
The immunophilin FKBP12 functions as a common inhibitor of the TGFβ family type I receptors
-
Wang T, Li BY, Danielson PD, Shah PC, Rockwell S, Lechleider RJ, Martin J, Manganaro T, Donahoe PK: The immunophilin FKBP12 functions as a common inhibitor of the TGFβ family type I receptors. Cell (1996) 86(3):435-444.
-
(1996)
Cell
, vol.86
, Issue.3
, pp. 435-444
-
-
Wang, T.1
Li, B.Y.2
Danielson, P.D.3
Shah, P.C.4
Rockwell, S.5
Lechleider, R.J.6
Martin, J.7
Manganaro, T.8
Donahoe, P.K.9
-
23
-
-
0032527756
-
TGFβ-stimulated cooperation of Smad proteins with the coactivators CBP/p300
-
Janknecht R, Wells NJ, Hunter T: TGFβ-stimulated cooperation of Smad proteins with the coactivators CBP/p300. Genes Dev (1998) 12(14):2114-2119.
-
(1998)
Genes Dev
, vol.12
, Issue.14
, pp. 2114-2119
-
-
Janknecht, R.1
Wells, N.J.2
Hunter, T.3
-
24
-
-
34248384441
-
Dose-dependent cross-talk between the transforming growth factor-β and interleukin-1 signaling pathways
-
Lu T, Tian L, Han Y, Vogelbaum M, Stark GR: Dose-dependent cross-talk between the transforming growth factor-β and interleukin-1 signaling pathways. Proc Natl Acad Sci USA (2007) 104(11):4365-4370.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.11
, pp. 4365-4370
-
-
Lu, T.1
Tian, L.2
Han, Y.3
Vogelbaum, M.4
Stark, G.R.5
-
25
-
-
34248547538
-
Transforming growth factor β signaling via Ras in mesenchymal cells requires p21-activated kinase 2 for extracellular signal-regulated kinase-dependent transcriptional responses
-
Suzuki K, Wilkes MC, Garamszegi N, Edens M, Leof EB: Transforming growth factor β signaling via Ras in mesenchymal cells requires p21-activated kinase 2 for extracellular signal-regulated kinase-dependent transcriptional responses. Cancer Res (2007) 67(8):3673-3682.
-
(2007)
Cancer Res
, vol.67
, Issue.8
, pp. 3673-3682
-
-
Suzuki, K.1
Wilkes, M.C.2
Garamszegi, N.3
Edens, M.4
Leof, E.B.5
-
26
-
-
30944444113
-
Alterations in components of the TGFβ superfamily signaling pathways in human cancer
-
Levy L, Hill CS: Alterations in components of the TGFβ superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev (2006) 17(1-2):41-58.
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, Issue.1-2
, pp. 41-58
-
-
Levy, L.1
Hill, C.S.2
-
27
-
-
1442356678
-
TGFBR1*6A and cancer: A meta-analysis of 12 case-control studies
-
Pasche B, Kaklamani V, Hou N, Young T, Rademaker A, Peterlongo P, Ellis N, Offit K, Caldes T, Reiss M, Zheng T: TGFBR1*6A and cancer: A meta-analysis of 12 case-control studies. J Clin Oncol (2004) 22(4):756-758.
-
(2004)
J Clin Oncol
, vol.22
, Issue.4
, pp. 756-758
-
-
Pasche, B.1
Kaklamani, V.2
Hou, N.3
Young, T.4
Rademaker, A.5
Peterlongo, P.6
Ellis, N.7
Offit, K.8
Caldes, T.9
Reiss, M.10
Zheng, T.11
-
28
-
-
33745082823
-
Role of transforming growth factor-β in hematologic malignancies
-
Dong M, Blobe GC: Role of transforming growth factor-β in hematologic malignancies. Blood (2006) 107(12):4589-4596.
-
(2006)
Blood
, vol.107
, Issue.12
, pp. 4589-4596
-
-
Dong, M.1
Blobe, G.C.2
-
29
-
-
0036654827
-
Focus on pancreas cancer
-
Jaffee EM, Hruban RH, Canto M, Kern SE: Focus on pancreas cancer. Cancer Cell (2002) 2(1):25-28.
-
(2002)
Cancer Cell
, vol.2
, Issue.1
, pp. 25-28
-
-
Jaffee, E.M.1
Hruban, R.H.2
Canto, M.3
Kern, S.E.4
-
30
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S et al: The consensus coding sequences of human breast and colorectal cancers. Science (2006) 314(5797):268-274.
-
(2006)
Science
, vol.314
, Issue.5797
, pp. 268-274
-
-
Sjöblom, T.1
Jones, S.2
Wood, L.D.3
Parsons, D.W.4
Lin, J.5
Barber, T.D.6
Mandelker, D.7
Leary, R.J.8
Ptak, J.9
Silliman, N.10
Szabo, S.11
-
31
-
-
33846821916
-
High TGFβ-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
-
Bruna A, Darken RS, Rojo F, Ocaña A, Peñuelas S, Arias A, Paris R, Tortosa A, Mora J, Baselga J, Seoane J: High TGFβ-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell (2007) 11(2):147-160.
-
(2007)
Cancer Cell
, vol.11
, Issue.2
, pp. 147-160
-
-
Bruna, A.1
Darken, R.S.2
Rojo, F.3
Ocaña, A.4
Peñuelas, S.5
Arias, A.6
Paris, R.7
Tortosa, A.8
Mora, J.9
Baselga, J.10
Seoane, J.11
-
32
-
-
33748208668
-
C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells
-
Gomis RR, Alarcón C, Nadal C, Van Poznak C, Massagué J: C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell (2006) 10(3):203-214.
-
(2006)
Cancer Cell
, vol.10
, Issue.3
, pp. 203-214
-
-
Gomis, R.R.1
Alarcón, C.2
Nadal, C.3
Van Poznak, C.4
Massagué, J.5
-
33
-
-
15444372825
-
Type I transforming growth factor β receptor binds to and activates phosphatidylinositol 3-kinase
-
Yi JY, Shin I, Arteaga CL: Type I transforming growth factor β receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem (2005) 280(11):10870-10876.
-
(2005)
J Biol Chem
, vol.280
, Issue.11
, pp. 10870-10876
-
-
Yi, J.Y.1
Shin, I.2
Arteaga, C.L.3
-
34
-
-
0034671578
-
TGFβ inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest
-
Petritsch C, Beug H, Balmain A, Oft M: TGFβ inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest. Genes Dev (2000) 14(24):3093-3101.
-
(2000)
Genes Dev
, vol.14
, Issue.24
, pp. 3093-3101
-
-
Petritsch, C.1
Beug, H.2
Balmain, A.3
Oft, M.4
-
35
-
-
0035185853
-
Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
-
Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, Arteaga CL, Moses HL: Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell (2001) 12(1):27-36.
-
(2001)
Mol Biol Cell
, vol.12
, Issue.1
, pp. 27-36
-
-
Bhowmick, N.A.1
Ghiassi, M.2
Bakin, A.3
Aakre, M.4
Lundquist, C.A.5
Engel, M.E.6
Arteaga, C.L.7
Moses, H.L.8
-
36
-
-
1642332084
-
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
-
Seoane J, Le HV, Shen L, Anderson SA, Massagué J: Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell (2004) 117(2):211-223.
-
(2004)
Cell
, vol.117
, Issue.2
, pp. 211-223
-
-
Seoane, J.1
Le, H.V.2
Shen, L.3
Anderson, S.A.4
Massagué, J.5
-
37
-
-
2342471301
-
Akt interacts directly with Smad3 to regulate the sensitivity to TGFβ induced apoptosis
-
Conery AR, Cao Y, Thompson EA, Townsend CM Jr, Ko TC, Luo K: Akt interacts directly with Smad3 to regulate the sensitivity to TGFβ induced apoptosis. Nat Cell Biol (2004) 6(4):366-372.
-
(2004)
Nat Cell Biol
, vol.6
, Issue.4
, pp. 366-372
-
-
Conery, A.R.1
Cao, Y.2
Thompson, E.A.3
Townsend Jr, C.M.4
Ko, T.C.5
Luo, K.6
-
38
-
-
2342647439
-
PKB/Akt modulates TGFβ signalling through a direct interaction with Smad3
-
Remy I, Montmarquette A, Michnick SW: PKB/Akt modulates TGFβ signalling through a direct interaction with Smad3. Nat Cell Biol (2004) 6(4):358-365.
-
(2004)
Nat Cell Biol
, vol.6
, Issue.4
, pp. 358-365
-
-
Remy, I.1
Montmarquette, A.2
Michnick, S.W.3
-
39
-
-
22144490495
-
Distinct mechanisms of TGFβ1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis
-
Han G, Lu SL, Li AG, He W, Corless CL, Kulesz-Martin M, Wang XJ: Distinct mechanisms of TGFβ1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis. J Clin Invest (2005) 115(7):1714-1723.
-
(2005)
J Clin Invest
, vol.115
, Issue.7
, pp. 1714-1723
-
-
Han, G.1
Lu, S.L.2
Li, A.G.3
He, W.4
Corless, C.L.5
Kulesz-Martin, M.6
Wang, X.J.7
-
40
-
-
33644534795
-
The tumor suppressor Smad4 is required for transforming growth factor-β-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
-
Deckers M, van Dinther M, Buijs J, Que I, Löwik C, van der Pluijm G, ten Dijke P. The tumor suppressor Smad4 is required for transforming growth factor-β-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res (2006) 66(4):2202-2209.
-
(2006)
Cancer Res
, vol.66
, Issue.4
, pp. 2202-2209
-
-
Deckers, M.1
van Dinther, M.2
Buijs, J.3
Que, I.4
Löwik, C.5
van der Pluijm, G.6
ten Dijke, P.7
-
41
-
-
0344845003
-
Epithelial-mesenchymal transitions in development and pathologies
-
Thiery JP: Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol (2003) 15(6):740-746.
-
(2003)
Curr Opin Cell Biol
, vol.15
, Issue.6
, pp. 740-746
-
-
Thiery, J.P.1
-
42
-
-
3142512612
-
Molecular characterization of the tumor microenvironment in breast cancer
-
Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A, Schnitt S et al: Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell (2004) 6(1):17-32.
-
(2004)
Cancer Cell
, vol.6
, Issue.1
, pp. 17-32
-
-
Allinen, M.1
Beroukhim, R.2
Cai, L.3
Brennan, C.4
Lahti-Domenici, J.5
Huang, H.6
Porter, D.7
Hu, M.8
Chin, L.9
Richardson, A.10
Schnitt, S.11
-
43
-
-
0037899253
-
Role of tissue stroma in cancer cell invasion
-
De Wever O, Mareel M: Role of tissue stroma in cancer cell invasion. J Pathol (2003) 200(4):429-447.
-
(2003)
J Pathol
, vol.200
, Issue.4
, pp. 429-447
-
-
De Wever, O.1
Mareel, M.2
-
44
-
-
33646164362
-
Transforming growth factor-β regulation of immune responses
-
Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA: Transforming growth factor-β regulation of immune responses. Annu Rev Immunol (2006) 24:99-146.
-
(2006)
Annu Rev Immunol
, vol.24
, pp. 99-146
-
-
Li, M.O.1
Wan, Y.Y.2
Sanjabi, S.3
Robertson, A.K.4
Flavell, R.A.5
-
45
-
-
0028652327
-
TM-1 cells from an established human malignant glioma cell line produce PDGF, TGFα, and TGFβ which cooperatively play a stimulatory role for an autocrine growth promotion
-
Kurimoto M, Endo S, Arai K, Horie Y, Nogami K, Takaku A: TM-1 cells from an established human malignant glioma cell line produce PDGF, TGFα, and TGFβ which cooperatively play a stimulatory role for an autocrine growth promotion. J Neurooncol (1994) 22(1):33-44.
-
(1994)
J Neurooncol
, vol.22
, Issue.1
, pp. 33-44
-
-
Kurimoto, M.1
Endo, S.2
Arai, K.3
Horie, Y.4
Nogami, K.5
Takaku, A.6
-
46
-
-
0033082525
-
Independent regulation of growth and Smad-mediated transcription by transforming growth factor β in human melanoma cells
-
Rodeck U, Nishiyama T, Mauviel A: Independent regulation of growth and Smad-mediated transcription by transforming growth factor β in human melanoma cells. Cancer Res (1999) 59(3):547-550.
-
(1999)
Cancer Res
, vol.59
, Issue.3
, pp. 547-550
-
-
Rodeck, U.1
Nishiyama, T.2
Mauviel, A.3
-
47
-
-
41149157649
-
TGFβ primes breast tumors for lung metastasis seeding through angiopoietin-like 4
-
Provides clinical, functional, and molecular evidence that TGFβ primes cancer cells in the breast tumor microenvironment for metastasis to the lungs, ••
-
Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, Massagué J: TGFβ primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell (2008) 133(1):66-77. •• Provides clinical, functional, and molecular evidence that TGFβ primes cancer cells in the breast tumor microenvironment for metastasis to the lungs.
-
(2008)
Cell
, vol.133
, Issue.1
, pp. 66-77
-
-
Padua, D.1
Zhang, X.H.2
Wang, Q.3
Nadal, C.4
Gerald, W.L.5
Gomis, R.R.6
Massagué, J.7
-
48
-
-
23144461051
-
Genes that mediate breast cancer metastasis to lung
-
Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, Viale A, Olshen AB, Gerald WL, Massagué J: Genes that mediate breast cancer metastasis to lung. Nature (2005) 436(7050):518-524.
-
(2005)
Nature
, vol.436
, Issue.7050
, pp. 518-524
-
-
Minn, A.J.1
Gupta, G.P.2
Siegel, P.M.3
Bos, P.D.4
Shu, W.5
Giri, D.D.6
Viale, A.7
Olshen, A.B.8
Gerald, W.L.9
Massagué, J.10
-
49
-
-
35848970582
-
Molecular biology of bone metastasis
-
Kingsley LA, Fournier PG, Chirgwin JM, Guise TA: Molecular biology of bone metastasis. Mol Cancer Ther (2007) 6(10):2609-2617.
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.10
, pp. 2609-2617
-
-
Kingsley, L.A.1
Fournier, P.G.2
Chirgwin, J.M.3
Guise, T.A.4
-
50
-
-
33947246042
-
-
Suzuki E, Kim S, Cheung HK, Corbley MJ, Zhang X, Sun L, Shan F, Singh J, Lee WC, Albelda SM, Ling LE: A novel small-molecule inhibitor of transforming growth factor β type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res (2007) 67(5):2351-2359. • The small-molecule TGFβ inhibitor SM-16 demonstrated potent activity against mesothelioma by an immune-mediated mechanism of CD8+ antitumor response.
-
Suzuki E, Kim S, Cheung HK, Corbley MJ, Zhang X, Sun L, Shan F, Singh J, Lee WC, Albelda SM, Ling LE: A novel small-molecule inhibitor of transforming growth factor β type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res (2007) 67(5):2351-2359. • The small-molecule TGFβ inhibitor SM-16 demonstrated potent activity against mesothelioma by an immune-mediated mechanism of CD8+ antitumor response.
-
-
-
-
51
-
-
0042303832
-
Transforming growth factor-1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-κB, JNK, and Ras signaling pathways
-
Park JI, Lee MG, Cho K, Park BJ, Chae KS, Byun DS, Ryu BK, Park YK, Chi SG: Transforming growth factor-1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-κB, JNK, and Ras signaling pathways. Oncogene (2003) 22(28):4314-4332.
-
(2003)
Oncogene
, vol.22
, Issue.28
, pp. 4314-4332
-
-
Park, J.I.1
Lee, M.G.2
Cho, K.3
Park, B.J.4
Chae, K.S.5
Byun, D.S.6
Ryu, B.K.7
Park, Y.K.8
Chi, S.G.9
-
52
-
-
0029963984
-
Coexpression of epidermal growth factor receptor and TGFα and survival in upper aerodigestive tract cancer
-
Issing WJ, Liebich C, Wustrow TP, Ullrich A: Coexpression of epidermal growth factor receptor and TGFα and survival in upper aerodigestive tract cancer. Anticancer Res (1996) 16(1):283-288.
-
(1996)
Anticancer Res
, vol.16
, Issue.1
, pp. 283-288
-
-
Issing, W.J.1
Liebich, C.2
Wustrow, T.P.3
Ullrich, A.4
-
53
-
-
33846564399
-
Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma
-
Kawaguchi Y, Kono K, Mimura K, Sugai H, Akaike H, Fujii H: Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma. Int J Cancer (2007) 120(4):781-787.
-
(2007)
Int J Cancer
, vol.120
, Issue.4
, pp. 781-787
-
-
Kawaguchi, Y.1
Kono, K.2
Mimura, K.3
Sugai, H.4
Akaike, H.5
Fujii, H.6
-
54
-
-
0027197928
-
Autocrine growth mechanism by transforming growth factor (TGF)-β1 and TGF-β1-receptor regulation by epidermal growth factor in a human endometrial cancer cell line IK-90
-
Sakata M, Kurachi H, Ikegami H, Jikihara H, Morishige K-I, Miyake A, Terakawa N, Tanizawa O: Autocrine growth mechanism by transforming growth factor (TGF)-β1 and TGF-β1-receptor regulation by epidermal growth factor in a human endometrial cancer cell line IK-90. Int J Cancer (2006) 54(5):862-867.
-
(2006)
Int J Cancer
, vol.54
, Issue.5
, pp. 862-867
-
-
Sakata, M.1
Kurachi, H.2
Ikegami, H.3
Jikihara, H.4
Morishige, K.-I.5
Miyake, A.6
Terakawa, N.7
Tanizawa, O.8
-
55
-
-
0030793645
-
Transforming growth factor-β in breast cancer: A working hypothesis
-
Reiss M, Barcellos-Hoff MH: Transforming growth factor-β in breast cancer: A working hypothesis. Breast Cancer Res Treat (1997) 45(1):81-95.
-
(1997)
Breast Cancer Res Treat
, vol.45
, Issue.1
, pp. 81-95
-
-
Reiss, M.1
Barcellos-Hoff, M.H.2
-
56
-
-
37349100945
-
Abrogation of TGFβ signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
-
Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M, Carbone DP, Matrisian LM, Richmond A, Lin PC, Moses HL: Abrogation of TGFβ signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell (2008) 13(1):23-35.
-
(2008)
Cancer Cell
, vol.13
, Issue.1
, pp. 23-35
-
-
Yang, L.1
Huang, J.2
Ren, X.3
Gorska, A.E.4
Chytil, A.5
Aakre, M.6
Carbone, D.P.7
Matrisian, L.M.8
Richmond, A.9
Lin, P.C.10
Moses, H.L.11
-
57
-
-
0027742864
-
Immunocytochemical localization of secreted transforming growth factor-β 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma
-
Dalal BI, Keown PA, Greenberg AH: Immunocytochemical localization of secreted transforming growth factor-β 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma. Am J Pathol (1993) 143(2):381-389.
-
(1993)
Am J Pathol
, vol.143
, Issue.2
, pp. 381-389
-
-
Dalal, B.I.1
Keown, P.A.2
Greenberg, A.H.3
-
58
-
-
25444479744
-
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
-
Demonstration that Smad4 contributes to the formation of osteolytic bone metastases and is essential for the induction of genes implicated in bone metastasis, ••
-
Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen CR, Manova-Todorova K, Blasberg R, Gerald WL, Massagué J: Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci USA (2005) 102(39):13909-13914. •• Demonstration that Smad4 contributes to the formation of osteolytic bone metastases and is essential for the induction of genes implicated in bone metastasis.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.39
, pp. 13909-13914
-
-
Kang, Y.1
He, W.2
Tulley, S.3
Gupta, G.P.4
Serganova, I.5
Chen, C.R.6
Manova-Todorova, K.7
Blasberg, R.8
Gerald, W.L.9
Massagué, J.10
-
59
-
-
0029096747
-
Cardiac and vascular morbidity in women receiving adjuvant tamoxifen for breast cancer in a randomised trial
-
McDonald CC, Alexander FE, Whyte BW, Forrest AP, Stewart HJ: Cardiac and vascular morbidity in women receiving adjuvant tamoxifen for breast cancer in a randomised trial. Br Med J (1995) 311(7011):977-980.
-
(1995)
Br Med J
, vol.311
, Issue.7011
, pp. 977-980
-
-
McDonald, C.C.1
Alexander, F.E.2
Whyte, B.W.3
Forrest, A.P.4
Stewart, H.J.5
-
60
-
-
0031026647
-
Induction of transforming growth factor β-1 in cervical intraepithelial neoplasia in vivo after treatment with β-carotene
-
Comerci JT Jr, Runowicz CD, Fields AL, Romney SL, Palan PR, Kadish AS, Goldberg GL: Induction of transforming growth factor β-1 in cervical intraepithelial neoplasia in vivo after treatment with β-carotene. Clin Cancer Res (1997) 3(2):157-160.
-
(1997)
Clin Cancer Res
, vol.3
, Issue.2
, pp. 157-160
-
-
Comerci Jr, J.T.1
Runowicz, C.D.2
Fields, A.L.3
Romney, S.L.4
Palan, P.R.5
Kadish, A.S.6
Goldberg, G.L.7
-
61
-
-
0041379638
-
Potential role of transforming growth factor β1 in drug resistance of tumor cells
-
Stoika R, Yakymovych M, Souchelnytskyi S, Yakymovych I: Potential role of transforming growth factor β1 in drug resistance of tumor cells. Acta Biochim Pol (2003) 50(2):497-508.
-
(2003)
Acta Biochim Pol
, vol.50
, Issue.2
, pp. 497-508
-
-
Stoika, R.1
Yakymovych, M.2
Souchelnytskyi, S.3
Yakymovych, I.4
-
62
-
-
46849115402
-
The effect of FK506 on transforming growth factor β signaling and apoptosis in chronic lymphocytic leukemia B cells
-
Romano S, Mallardo M, Chiurazzi F, Bisogni R, D'Angelillo A, Liuzzi R, Compare G, Romano MF: The effect of FK506 on transforming growth factor β signaling and apoptosis in chronic lymphocytic leukemia B cells. Haematologica (2008) 93(7):1039-1048.
-
(2008)
Haematologica
, vol.93
, Issue.7
, pp. 1039-1048
-
-
Romano, S.1
Mallardo, M.2
Chiurazzi, F.3
Bisogni, R.4
D'Angelillo, A.5
Liuzzi, R.6
Compare, G.7
Romano, M.F.8
-
63
-
-
0037085474
-
Transcriptional regulation of the transforming growth factor β type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells
-
Park SH, Lee SR, Kim BC, Cho EA, Patel SP, Kang HB, Sausville EA, Nakanishi O, Trepel JB, Lee BI, Kim SJ: Transcriptional regulation of the transforming growth factor β type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. J Biol Chem (2002) 277(7):5168-5174.
-
(2002)
J Biol Chem
, vol.277
, Issue.7
, pp. 5168-5174
-
-
Park, S.H.1
Lee, S.R.2
Kim, B.C.3
Cho, E.A.4
Patel, S.P.5
Kang, H.B.6
Sausville, E.A.7
Nakanishi, O.8
Trepel, J.B.9
Lee, B.I.10
Kim, S.J.11
-
64
-
-
0035190076
-
Captopril restores transforming growth factor-β type II receptor and sensitivity to transforming growth factor-β in murine renal cell cancer cells
-
Miyajima A, Asano T, Hayakawa M: Captopril restores transforming growth factor-β type II receptor and sensitivity to transforming growth factor-β in murine renal cell cancer cells. J Urol (2001) 165(2):616-620.
-
(2001)
J Urol
, vol.165
, Issue.2
, pp. 616-620
-
-
Miyajima, A.1
Asano, T.2
Hayakawa, M.3
-
65
-
-
0034676340
-
Inhibition of farnesyltransferase increases TGFβ type II receptor expression and enhances the responsiveness of human cancer cells to TGFβ
-
Adnane J, Bizouarn FA, Chen Z, Ohkanda J, Hamilton AD, Munoz-Antonia T, Sebti SM: Inhibition of farnesyltransferase increases TGFβ type II receptor expression and enhances the responsiveness of human cancer cells to TGFβ. Oncogene (2000) 19(48):5525-5533.
-
(2000)
Oncogene
, vol.19
, Issue.48
, pp. 5525-5533
-
-
Adnane, J.1
Bizouarn, F.A.2
Chen, Z.3
Ohkanda, J.4
Hamilton, A.D.5
Munoz-Antonia, T.6
Sebti, S.M.7
-
66
-
-
0035881295
-
Reversion of transcriptional repression of Sp1 by 5 aza-2 deoxycytidine restores TGFβ type II receptor expression in the pancreatic cancer cell line MIA PaCa-2
-
Venkatasubbarao K, Ammanamanchi S, Brattain MG, Mimari D, Freeman JW: Reversion of transcriptional repression of Sp1 by 5 aza-2 deoxycytidine restores TGFβ type II receptor expression in the pancreatic cancer cell line MIA PaCa-2. Cancer Res (2001) 61(16):6239-6247.
-
(2001)
Cancer Res
, vol.61
, Issue.16
, pp. 6239-6247
-
-
Venkatasubbarao, K.1
Ammanamanchi, S.2
Brattain, M.G.3
Mimari, D.4
Freeman, J.W.5
-
67
-
-
0034770605
-
Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells
-
Gorelik L, Flavell RA: Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells. Nat Med (2001) 7(10):1118-1122.
-
(2001)
Nat Med
, vol.7
, Issue.10
, pp. 1118-1122
-
-
Gorelik, L.1
Flavell, R.A.2
-
68
-
-
7444226411
-
SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo
-
Uhl M, Aulwurm S, Wischhusen J, Weiler M, Ma JY, Almirez R, Mangadu R, Liu YW, Platten M, Herrlinger U, Murphy A et al: SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res (2004) 64(21):7954-7961.
-
(2004)
Cancer Res
, vol.64
, Issue.21
, pp. 7954-7961
-
-
Uhl, M.1
Aulwurm, S.2
Wischhusen, J.3
Weiler, M.4
Ma, J.Y.5
Almirez, R.6
Mangadu, R.7
Liu, Y.W.8
Platten, M.9
Herrlinger, U.10
Murphy, A.11
-
69
-
-
5644248080
-
RNA interference targeting transforming growth factor-β enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo
-
Friese MA, Wischhusen J, Wick W, Weiler M, Eisele G, Steinle A, Weller M: RNA interference targeting transforming growth factor-β enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo. Cancer Res (2004) 64(20):7596-7603.
-
(2004)
Cancer Res
, vol.64
, Issue.20
, pp. 7596-7603
-
-
Friese, M.A.1
Wischhusen, J.2
Wick, W.3
Weiler, M.4
Eisele, G.5
Steinle, A.6
Weller, M.7
-
70
-
-
44249100929
-
TGFβ secreted by B16 melanoma antagonizes cancer gene immunotherapy bystander effect
-
Penafuerte C, Galipeau J: TGFβ secreted by B16 melanoma antagonizes cancer gene immunotherapy bystander effect. Cancer Immunol Immunother (2008) 57(8):1197-1206.
-
(2008)
Cancer Immunol Immunother
, vol.57
, Issue.8
, pp. 1197-1206
-
-
Penafuerte, C.1
Galipeau, J.2
-
71
-
-
33750586798
-
Phase II study of belagenpumatucel-L, a transforming growth factor β-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer
-
Nemunaitis J, Dillman RO, Schwarzenberger PO, Senzer N, Cunningham C, Cutler J, Tong A, Kumar P, Pappen B, Hamilton C, DeVol E et al: Phase II study of belagenpumatucel-L, a transforming growth factor β-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer. J Clin Oncol (2006) 24(29):4721-4730.
-
(2006)
J Clin Oncol
, vol.24
, Issue.29
, pp. 4721-4730
-
-
Nemunaitis, J.1
Dillman, R.O.2
Schwarzenberger, P.O.3
Senzer, N.4
Cunningham, C.5
Cutler, J.6
Tong, A.7
Kumar, P.8
Pappen, B.9
Hamilton, C.10
DeVol, E.11
-
72
-
-
52449122955
-
Transforming growth factor-β receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers
-
Wallace A, Kapoor V, Sun J, Mrass P, Weninger W, Heitjan DF, June C, Kaiser LR, Ling LE, Albelda SM: Transforming growth factor-β receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers. Clin Cancer Res (2008) 14(12):3966-3974.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.12
, pp. 3966-3974
-
-
Wallace, A.1
Kapoor, V.2
Sun, J.3
Mrass, P.4
Weninger, W.5
Heitjan, D.F.6
June, C.7
Kaiser, L.R.8
Ling, L.E.9
Albelda, S.M.10
-
73
-
-
34248185926
-
-
Biswas S, Guix M, Rinehart C, Dugger TC, Chytil A, Moses HL, Freeman ML, Arteaga CL: Inhibition of TGFβ with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. J Clin Invest (2007) 117(5):1305-1313. •• Administration of ionizing radiation or doxorubicin in a mouse model of metastatic breast cancer caused increased circulating levels of TGFβ1 as well as increased circulating tumor cells and lung metastases. These effects were abrogated by administration of a neutralizing pan-TGFβ antibody.
-
Biswas S, Guix M, Rinehart C, Dugger TC, Chytil A, Moses HL, Freeman ML, Arteaga CL: Inhibition of TGFβ with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. J Clin Invest (2007) 117(5):1305-1313. •• Administration of ionizing radiation or doxorubicin in a mouse model of metastatic breast cancer caused increased circulating levels of TGFβ1 as well as increased circulating tumor cells and lung metastases. These effects were abrogated by administration of a neutralizing pan-TGFβ antibody.
-
-
-
-
74
-
-
0024553650
-
Monoclonal antibodies recognizing transforming growth factor-β. Bioactivity neutralization and transforming growth factor β 2 affinity purification
-
Dasch JR, Pace DR, Waegell W, Inenaga D, Ellingsworth L: Monoclonal antibodies recognizing transforming growth factor-β. Bioactivity neutralization and transforming growth factor β 2 affinity purification. J Immunol (1989) 142(5):1536-1541.
-
(1989)
J Immunol
, vol.142
, Issue.5
, pp. 1536-1541
-
-
Dasch, J.R.1
Pace, D.R.2
Waegell, W.3
Inenaga, D.4
Ellingsworth, L.5
-
75
-
-
0032821129
-
Human anti-transforming growth factor-β2 antibody: A new glaucoma anti-scarring agent
-
Cordeiro MF, Gay JA, Khaw PT: Human anti-transforming growth factor-β2 antibody: A new glaucoma anti-scarring agent. Invest Ophthalmol Vis Sci (1999) 40(10):2225-2234.
-
(1999)
Invest Ophthalmol Vis Sci
, vol.40
, Issue.10
, pp. 2225-2234
-
-
Cordeiro, M.F.1
Gay, J.A.2
Khaw, P.T.3
-
76
-
-
0032867293
-
A fully human antibody neutralising biologically active human TGFβ2 for use in therapy
-
Thompson JE, Vaughan TJ, Williams AJ, Wilton J, Johnson KS, Bacon L, Green JA, Field R, Ruddock S, Martins M, Pope AR: A fully human antibody neutralising biologically active human TGFβ2 for use in therapy. J Immunol Methods (1999) 227(1-2):17-29.
-
(1999)
J Immunol Methods
, vol.227
, Issue.1-2
, pp. 17-29
-
-
Thompson, J.E.1
Vaughan, T.J.2
Williams, A.J.3
Wilton, J.4
Johnson, K.S.5
Bacon, L.6
Green, J.A.7
Field, R.8
Ruddock, S.9
Martins, M.10
Pope, A.R.11
-
77
-
-
0025179010
-
The autocrine production of transforming growth factor-β 1 during lymphocyte activation. A study with a monoclonal antibody-based ELISA
-
Lucas C, Bald LN, Fendly BM, Mora-Worms M, Figari IS, Patzer EJ, Palladino MA: The autocrine production of transforming growth factor-β 1 during lymphocyte activation. A study with a monoclonal antibody-based ELISA. J Immunol (1990) 145(5):1415-1422.
-
(1990)
J Immunol
, vol.145
, Issue.5
, pp. 1415-1422
-
-
Lucas, C.1
Bald, L.N.2
Fendly, B.M.3
Mora-Worms, M.4
Figari, I.S.5
Patzer, E.J.6
Palladino, M.A.7
-
78
-
-
33745685865
-
Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor β in a mouse model of breast cancer
-
Nam JS, Suchar AM, Kang MJ, Stuelten CH, Tang B, Michalowska AM, Fisher LW, Fedarko NS, Jain A, Pinkas J, Lonning S et al: Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor β in a mouse model of breast cancer. Cancer Res (2006) 66(12):6327-6335.
-
(2006)
Cancer Res
, vol.66
, Issue.12
, pp. 6327-6335
-
-
Nam, J.S.1
Suchar, A.M.2
Kang, M.J.3
Stuelten, C.H.4
Tang, B.5
Michalowska, A.M.6
Fisher, L.W.7
Fedarko, N.S.8
Jain, A.9
Pinkas, J.10
Lonning, S.11
-
79
-
-
45549085803
-
An anti-transforming growth factor β antibody suppresses metastasis via cooperative effects on multiple cell compartments
-
Nam JS, Terabe M, Mamura M, Kang MJ, Chae H, Stuelten C, Kohn E, Tang B, Sabzevari H, Anver MR, Lawrence S et al: An anti-transforming growth factor β antibody suppresses metastasis via cooperative effects on multiple cell compartments. Cancer Res (2008) 68(10):3835-3843.
-
(2008)
Cancer Res
, vol.68
, Issue.10
, pp. 3835-3843
-
-
Nam, J.S.1
Terabe, M.2
Mamura, M.3
Kang, M.J.4
Chae, H.5
Stuelten, C.6
Kohn, E.7
Tang, B.8
Sabzevari, H.9
Anver, M.R.10
Lawrence, S.11
-
80
-
-
0041342109
-
Evaluation of anti-TGFβ2 antibody as a new postoperative anti-scarring agent in glaucoma surgery
-
Mead AL, Wong TT, Cordeiro MF, Anderson IK, Khaw PT: Evaluation of anti-TGFβ2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Invest Ophthalmol Vis Sci (2003) 44(8):3394-3401.
-
(2003)
Invest Ophthalmol Vis Sci
, vol.44
, Issue.8
, pp. 3394-3401
-
-
Mead, A.L.1
Wong, T.T.2
Cordeiro, M.F.3
Anderson, I.K.4
Khaw, P.T.5
-
81
-
-
34748861947
-
A phase III study of subconjunctival human antitransforming growth factor β(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy
-
Khaw P, Grehn F, Holló G, Overton B, Wilson R, Vogel R, Smith Z: A phase III study of subconjunctival human antitransforming growth factor β(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. Ophthalmology (2007) 114(10):1822-1830.
-
(2007)
Ophthalmology
, vol.114
, Issue.10
, pp. 1822-1830
-
-
Khaw, P.1
Grehn, F.2
Holló, G.3
Overton, B.4
Wilson, R.5
Vogel, R.6
Smith, Z.7
-
82
-
-
0038205926
-
Add-on anti-TGFβ antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat
-
Benigni A, Zoja C, Corna D, Zatelli C, Conti S, Campana M, Gagliardini E, Rottoli D, Zanchi C, Abbate M, Ledbetter S et al: Add-on anti-TGFβ antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat. J Am Soc Nephrol (2003) 14(7):1816- 1824.
-
(2003)
J Am Soc Nephrol
, vol.14
, Issue.7
, pp. 1816-1824
-
-
Benigni, A.1
Zoja, C.2
Corna, D.3
Zatelli, C.4
Conti, S.5
Campana, M.6
Gagliardini, E.7
Rottoli, D.8
Zanchi, C.9
Abbate, M.10
Ledbetter, S.11
-
83
-
-
33846250366
-
Recombinant human anti-transforming growth factor β1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
-
Denton CP, Merkel PA, Furst DE, Khanna D, Emery P, Hsu VM, Silliman N, Streisand J, Powell J, Akesson A, Coppock J et al: Recombinant human anti-transforming growth factor β1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum (2007) 56(1):323-333.
-
(2007)
Arthritis Rheum
, vol.56
, Issue.1
, pp. 323-333
-
-
Denton, C.P.1
Merkel, P.A.2
Furst, D.E.3
Khanna, D.4
Emery, P.5
Hsu, V.M.6
Silliman, N.7
Streisand, J.8
Powell, J.9
Akesson, A.10
Coppock, J.11
-
85
-
-
0033623532
-
Integrin α1β1 and transforming growth factor-β1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy
-
Cosgrove D, Rodgers K, Meehan D, Miller C, Bovard K, Gilroy A, Gardner H, Kotelianski V, Gotwals P, Amatucci A, Kalluri R: Integrin α1β1 and transforming growth factor-β1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy. Am J Pathol (2000) 157(5):1649-1659.
-
(2000)
Am J Pathol
, vol.157
, Issue.5
, pp. 1649-1659
-
-
Cosgrove, D.1
Rodgers, K.2
Meehan, D.3
Miller, C.4
Bovard, K.5
Gilroy, A.6
Gardner, H.7
Kotelianski, V.8
Gotwals, P.9
Amatucci, A.10
Kalluri, R.11
-
86
-
-
0033215194
-
A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells
-
Bandyopadhyay A, Zhu Y, Cibull ML, Bao L, Chen C, Sun L: A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells. Cancer Res (1999) 59(19):5041-5046.
-
(1999)
Cancer Res
, vol.59
, Issue.19
, pp. 5041-5046
-
-
Bandyopadhyay, A.1
Zhu, Y.2
Cibull, M.L.3
Bao, L.4
Chen, C.5
Sun, L.6
-
87
-
-
0036086409
-
Blockade of TGFβ inhibits mammary tumor cell viability, migration and metastases
-
Muraoka RS, Dumont N, Ritter CA, Dugger TC, Brantley DM, Chen J, Easterly E, Roebuck LR, Ryan S, Gotwals PJ, Koteliansky V et al: Blockade of TGFβ inhibits mammary tumor cell viability, migration and metastases. Clin Invest (2002) 109(12):1551-1559.
-
(2002)
Clin Invest
, vol.109
, Issue.12
, pp. 1551-1559
-
-
Muraoka, R.S.1
Dumont, N.2
Ritter, C.A.3
Dugger, T.C.4
Brantley, D.M.5
Chen, J.6
Easterly, E.7
Roebuck, L.R.8
Ryan, S.9
Gotwals, P.J.10
Koteliansky, V.11
-
88
-
-
0036087521
-
Lifetime exposure to a soluble TGFβ antagonist protects mice against metastasis without adverse side effects
-
Yang YA, Dukhanina O, Tang B, Mamura M, Letterio JJ, MacGregor J, Patel SC, Khozin S, Liu ZY, Green J, Anver MR et al: Lifetime exposure to a soluble TGFβ antagonist protects mice against metastasis without adverse side effects. J Clin Invest (2002) 109(12):1607-1615.
-
(2002)
J Clin Invest
, vol.109
, Issue.12
, pp. 1607-1615
-
-
Yang, Y.A.1
Dukhanina, O.2
Tang, B.3
Mamura, M.4
Letterio, J.J.5
MacGregor, J.6
Patel, S.C.7
Khozin, S.8
Liu, Z.Y.9
Green, J.10
Anver, M.R.11
-
89
-
-
0037102289
-
Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft
-
Bandyopadhyay A, López-Casillas F, Malik SN, Montiel JL, Mendoza V, Yang J, Sun LZ: Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft. Cancer Res (2002) 62(16):4690- 4695.
-
(2002)
Cancer Res
, vol.62
, Issue.16
, pp. 4690-4695
-
-
Bandyopadhyay, A.1
López-Casillas, F.2
Malik, S.N.3
Montiel, J.L.4
Mendoza, V.5
Yang, J.6
Sun, L.Z.7
-
90
-
-
14944363173
-
Systemic administration of a soluble betaglycan suppresses tumor growth, angiogenesis, and matrix metalloproteinase-9 expression in a human xenograft model of prostate cancer
-
Bandyopadhyay A, Wang L, López-Casillas F, Mendoza V, Yeh IT, Sun L: Systemic administration of a soluble betaglycan suppresses tumor growth, angiogenesis, and matrix metalloproteinase-9 expression in a human xenograft model of prostate cancer. Prostate (2005) 63(1):81-90.
-
(2005)
Prostate
, vol.63
, Issue.1
, pp. 81-90
-
-
Bandyopadhyay, A.1
Wang, L.2
López-Casillas, F.3
Mendoza, V.4
Yeh, I.T.5
Sun, L.6
-
91
-
-
25444497522
-
The TGFβ1 antisense oligonucleotide AP 11014 for the treatment of non-small cell lung, colorectal and prostate cancer: Preclinical studies
-
Abs 3132
-
Schlingensiepen KH, Bischof A, Egger T, Hafner M, Herrmuth H, Jachimczak P, Kielmanowicz M, Niewel M, Zavadova E, Stauder G: The TGFβ1 antisense oligonucleotide AP 11014 for the treatment of non-small cell lung, colorectal and prostate cancer: Preclinical studies. J Clin Oncol (2004) 22(14 Suppl): Abs 3132.
-
(2004)
J Clin Oncol
, vol.22
, Issue.14 SUPPL.
-
-
Schlingensiepen, K.H.1
Bischof, A.2
Egger, T.3
Hafner, M.4
Herrmuth, H.5
Jachimczak, P.6
Kielmanowicz, M.7
Niewel, M.8
Zavadova, E.9
Stauder, G.10
-
92
-
-
34547187636
-
Inhibition of TGFβ2 with AP 12009 in recurrent malignant gliomas: From preclinical to phase I/II studies
-
Hau P, Jachimczak P, Schlingensiepen R, Schulmeyer F, Jauch T, Steinbrecher A, Brawanski A, Proescholdt M, Schlaier J, Buchroithner J, Pichler J et al: Inhibition of TGFβ2 with AP 12009 in recurrent malignant gliomas: From preclinical to phase I/II studies. Oligonucleotides (2007) 17(2):201-212.
-
(2007)
Oligonucleotides
, vol.17
, Issue.2
, pp. 201-212
-
-
Hau, P.1
Jachimczak, P.2
Schlingensiepen, R.3
Schulmeyer, F.4
Jauch, T.5
Steinbrecher, A.6
Brawanski, A.7
Proescholdt, M.8
Schlaier, J.9
Buchroithner, J.10
Pichler, J.11
-
93
-
-
38449103630
-
Antisense therapeutics for tumor treatment: The TGFβ2 inhibitor AP 12009 in clinical development against malignant tumors
-
Schlingensiepen KH, Fischer-Blass B, Schmaus S, Ludwig S: Antisense therapeutics for tumor treatment: The TGFβ2 inhibitor AP 12009 in clinical development against malignant tumors. Recent Results Cancer Res (2008) 177:137-150.
-
(2008)
Recent Results Cancer Res
, vol.177
, pp. 137-150
-
-
Schlingensiepen, K.H.1
Fischer-Blass, B.2
Schmaus, S.3
Ludwig, S.4
-
94
-
-
0029865486
-
Eradication of established intracranial rat gliomas by transforming growth factor β antisense gene therapy
-
Fakhrai H, Dorigo O, Shawler DL, Lin H, Mercola D, Black KL, Royston I, Sobol RE: Eradication of established intracranial rat gliomas by transforming growth factor β antisense gene therapy. Proc Natl Acad Sci USA (1996) 93(7):2909-2914.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, Issue.7
, pp. 2909-2914
-
-
Fakhrai, H.1
Dorigo, O.2
Shawler, D.L.3
Lin, H.4
Mercola, D.5
Black, K.L.6
Royston, I.7
Sobol, R.E.8
-
95
-
-
0031698247
-
Prolonged survival of rats with intracranial C6 gliomas by treatment with TGFβ antisense gene
-
Liau LM, Fakhrai H, Black KL: Prolonged survival of rats with intracranial C6 gliomas by treatment with TGFβ antisense gene. Neurol Res (1998) 20(8):742-747.
-
(1998)
Neurol Res
, vol.20
, Issue.8
, pp. 742-747
-
-
Liau, L.M.1
Fakhrai, H.2
Black, K.L.3
-
96
-
-
4644243836
-
Transforming the TGFβ pathway: Convergence of distinct lead generation strategies on a novel kinase pharmacophore for TβRI (ALK5)
-
Singh J, Ling LE, Sawyer JS, Lee WC, Zhang F, Yingling JM: Transforming the TGFβ pathway: Convergence of distinct lead generation strategies on a novel kinase pharmacophore for TβRI (ALK5). Curr Opin Drug Discov Devel (2004) 7(4):437-445.
-
(2004)
Curr Opin Drug Discov Devel
, vol.7
, Issue.4
, pp. 437-445
-
-
Singh, J.1
Ling, L.E.2
Sawyer, J.S.3
Lee, W.C.4
Zhang, F.5
Yingling, J.M.6
-
97
-
-
2942589081
-
Synthesis and activity of new aryl- and heteroarylsubstituted 5,6-dihydro-4H-pyrrolo[1,2-b] pyrazole inhibitors of the transforming growth factor- type I receptor kinase domain
-
Sawyer JS, Beight DW, Britt KS, Anderson BD, Campbell RM, Goodson T Jr, Herron DK, Li HY, McMillen WT, Mort N, Parsons S et al: Synthesis and activity of new aryl- and heteroarylsubstituted 5,6-dihydro-4H-pyrrolo[1,2-b] pyrazole inhibitors of the transforming growth factor- type I receptor kinase domain. Bioorg Med Chem Lett (2004) 14(13):3581-3584.
-
(2004)
Bioorg Med Chem Lett
, vol.14
, Issue.13
, pp. 3581-3584
-
-
Sawyer, J.S.1
Beight, D.W.2
Britt, K.S.3
Anderson, B.D.4
Campbell, R.M.5
Goodson Jr, T.6
Herron, D.K.7
Li, H.Y.8
McMillen, W.T.9
Mort, N.10
Parsons, S.11
-
98
-
-
41849147494
-
Optimization of a dihydropyrrolopyrazole series of transforming growth factor-β type I receptor kinase domain inhibitors: Discovery of an orally bioavailable transforming growth factor-β receptor type I inhibitor as antitumor agent
-
Li HY, McMillen WT, Heap CR, McCann DJ, Yan L, Campbell RM, Mundla SR, King CH, Dierks EA, Anderson BD, Britt KS et al: Optimization of a dihydropyrrolopyrazole series of transforming growth factor-β type I receptor kinase domain inhibitors: Discovery of an orally bioavailable transforming growth factor-β receptor type I inhibitor as antitumor agent. J Med Chem (2008) 51(7):2302-2306.
-
(2008)
J Med Chem
, vol.51
, Issue.7
, pp. 2302-2306
-
-
Li, H.Y.1
McMillen, W.T.2
Heap, C.R.3
McCann, D.J.4
Yan, L.5
Campbell, R.M.6
Mundla, S.R.7
King, C.H.8
Dierks, E.A.9
Anderson, B.D.10
Britt, K.S.11
-
99
-
-
42249099019
-
-
Melisi D, Ishiyama S, Sclabas GM, Fleming JB, Xia Q, Tortora G, Abbruzzese JL, Chiao PJ: LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther (2008) 7(4):829-840. • LY-2109761, in combination with gemcitabine, significantly decreased tumor burden, prolonged survival, and reduced spontaneous abdominal metastases in an orthotopic murine model of metastatic pancreatic cancer.
-
Melisi D, Ishiyama S, Sclabas GM, Fleming JB, Xia Q, Tortora G, Abbruzzese JL, Chiao PJ: LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther (2008) 7(4):829-840. • LY-2109761, in combination with gemcitabine, significantly decreased tumor burden, prolonged survival, and reduced spontaneous abdominal metastases in an orthotopic murine model of metastatic pancreatic cancer.
-
-
-
-
100
-
-
20044375562
-
Kinetic characterization of novel pyrazole TGFβ receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition
-
Peng SB, Yan L, Xia X, Watkins SA, Brooks HB, Beight D, Herron DK, Jones ML, Lampe JW, McMillen WT, Mort N et al: Kinetic characterization of novel pyrazole TGFβ receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition. Biochemistry (2005) 44(7):2293-2304.
-
(2005)
Biochemistry
, vol.44
, Issue.7
, pp. 2293-2304
-
-
Peng, S.B.1
Yan, L.2
Xia, X.3
Watkins, S.A.4
Brooks, H.B.5
Beight, D.6
Herron, D.K.7
Jones, M.L.8
Lampe, J.W.9
McMillen, W.T.10
Mort, N.11
-
101
-
-
3442894138
-
Targeting endogenous transforming growth factor β receptor signaling in Smad4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1
-
Subramanian G, Schwarz RE, Higgins L, McEnroe G, Chakravarty S, Dugar S, Reiss M: Targeting endogenous transforming growth factor β receptor signaling in Smad4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1. Cancer Res (2004) 64(15):5200-5211.
-
(2004)
Cancer Res
, vol.64
, Issue.15
, pp. 5200-5211
-
-
Subramanian, G.1
Schwarz, R.E.2
Higgins, L.3
McEnroe, G.4
Chakravarty, S.5
Dugar, S.6
Reiss, M.7
-
102
-
-
1342265719
-
SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7
-
DaCosta Byfield S, Major C, Laping NJ, Roberts AB: SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol (2004) 65(3):744-752.
-
(2004)
Mol Pharmacol
, vol.65
, Issue.3
, pp. 744-752
-
-
DaCosta Byfield, S.1
Major, C.2
Laping, N.J.3
Roberts, A.B.4
-
103
-
-
0030611757
-
Identification of Smad7, a TGFβ-inducible antagonist of TGFβ signalling
-
Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P: Identification of Smad7, a TGFβ-inducible antagonist of TGFβ signalling. Nature (1997) 389(6651):631-635.
-
(1997)
Nature
, vol.389
, Issue.6651
, pp. 631-635
-
-
Nakao, A.1
Afrakhte, M.2
Morén, A.3
Nakayama, T.4
Christian, J.L.5
Heuchel, R.6
Itoh, S.7
Kawabata, M.8
Heldin, N.E.9
Heldin, C.H.10
ten Dijke, P.11
-
104
-
-
0034710545
-
Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas
-
Iglesias M, Frontelo P, Gamallo C, Quintanilla M: Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas. Oncogene (2000) 19(36):4134-4145.
-
(2000)
Oncogene
, vol.19
, Issue.36
, pp. 4134-4145
-
-
Iglesias, M.1
Frontelo, P.2
Gamallo, C.3
Quintanilla, M.4
-
105
-
-
20544444943
-
Selective inhibition of TGFβ responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1, and CBP
-
Cui Q, Lim SK, Zhao B, Hoffmann FM: Selective inhibition of TGFβ responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1, and CBP. Oncogene (2005) 24(24):3864-3874.
-
(2005)
Oncogene
, vol.24
, Issue.24
, pp. 3864-3874
-
-
Cui, Q.1
Lim, S.K.2
Zhao, B.3
Hoffmann, F.M.4
-
106
-
-
0033598408
-
The TGFβ signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer
-
Kleeff J, Ishiwata T, Maruyama H, Friess H, Truong P, Büchler MW, Falb D, Korc M: The TGFβ signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. Oncogene (1999) 18(39):5363-5372.
-
(1999)
Oncogene
, vol.18
, Issue.39
, pp. 5363-5372
-
-
Kleeff, J.1
Ishiwata, T.2
Maruyama, H.3
Friess, H.4
Truong, P.5
Büchler, M.W.6
Falb, D.7
Korc, M.8
-
107
-
-
0035415661
-
Human antibodies as next generation therapeutics
-
van Dijk MA, van de Winkel JG: Human antibodies as next generation therapeutics. Curr Opin Chem Biol (2001) 5(4):368-374.
-
(2001)
Curr Opin Chem Biol
, vol.5
, Issue.4
, pp. 368-374
-
-
van Dijk, M.A.1
van de Winkel, J.G.2
-
108
-
-
62149130350
-
The use of virtual screening in Alk5 kinase inhibitor discovery and validation of orally active Alk5 kinase inhibitors in oncology
-
Jakowlew SB Ed, Humana Press, Totowa, NJ, USA
-
Ling LE, Singh J, Chuaqui CE, Boriack-Sjodin PA, Lepage DJ, Silverio EL, Corbley MJ, Sun L, Papadatos JL, Shan F, Pontz T et al: The use of virtual screening in Alk5 kinase inhibitor discovery and validation of orally active Alk5 kinase inhibitors in oncology. In: Transforming Growth Factor-β in Cancer Therapy Vol II. Jakowlew SB (Ed), Humana Press, Totowa, NJ, USA (2008).
-
(2008)
Transforming Growth Factor-β in Cancer Therapy
, vol.2
-
-
Ling, L.E.1
Singh, J.2
Chuaqui, C.E.3
Boriack-Sjodin, P.A.4
Lepage, D.J.5
Silverio, E.L.6
Corbley, M.J.7
Sun, L.8
Papadatos, J.L.9
Shan, F.10
Pontz, T.11
-
109
-
-
43949140575
-
-
Hepatology
-
Fransvea E, Angelotti U, Antonaci S, Giannelli G: Blocking transforming growth factor-β up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. (Hepatology) (2008) 47(5):1557-1566.
-
(2008)
Blocking transforming growth factor-β up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells
, vol.47
, Issue.5
, pp. 1557-1566
-
-
Fransvea, E.1
Angelotti, U.2
Antonaci, S.3
Giannelli, G.4
-
110
-
-
44149115681
-
TGFβ1 induced MMP-9 expression in HNSCC cell lines via Smad/MLCK pathway
-
Sinpitaksakul SN, Pimkhaokham A, Sanchavanakit N, Pavasant P: TGFβ1 induced MMP-9 expression in HNSCC cell lines via Smad/MLCK pathway. Biochem Biophys Res Commun (2008) 371(4):713-718.
-
(2008)
Biochem Biophys Res Commun
, vol.371
, Issue.4
, pp. 713-718
-
-
Sinpitaksakul, S.N.1
Pimkhaokham, A.2
Sanchavanakit, N.3
Pavasant, P.4
-
111
-
-
44849127372
-
The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis
-
Noma K, Smalley KS, Lioni M, Naomoto Y, Tanaka N, El-Deiry W, King AJ, Nakagawa H, Herlyn M: The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology (2008) 134(7):1981-1993.
-
(2008)
Gastroenterology
, vol.134
, Issue.7
, pp. 1981-1993
-
-
Noma, K.1
Smalley, K.S.2
Lioni, M.3
Naomoto, Y.4
Tanaka, N.5
El-Deiry, W.6
King, A.J.7
Nakagawa, H.8
Herlyn, M.9
-
112
-
-
20344385003
-
-
TGFβ receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia (2005) 7(5):509-521.
-
TGFβ receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia (2005) 7(5):509-521.
-
-
-
-
113
-
-
4444341835
-
SB-431542, a small molecule transforming growth factor-β-receptor antagonist, inhibits human glioma cell line proliferation and motility
-
Hjelmeland MD, Hjelmeland AB, Sathornsumetee S, Reese ED, Herbstreith MH, Laping NJ, Friedman HS, Bigner DD, Wang XF, Rich JN: SB-431542, a small molecule transforming growth factor-β-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol Cancer Ther (2004) 3(6):737-745.
-
(2004)
Mol Cancer Ther
, vol.3
, Issue.6
, pp. 737-745
-
-
Hjelmeland, M.D.1
Hjelmeland, A.B.2
Sathornsumetee, S.3
Reese, E.D.4
Herbstreith, M.H.5
Laping, N.J.6
Friedman, H.S.7
Bigner, D.D.8
Wang, X.F.9
Rich, J.N.10
-
114
-
-
42249113861
-
SM16, an orally active tgfβ type I receptor inhibitor, prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model
-
Fu K, Corbley MJ, Sun L, Friedman JE, Shan F, Papadatos JL, Costa D, Lutterodt F, Sweigard H, Bowes S, Choi M et al: SM16, an orally active tgfβ type I receptor inhibitor, prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol (2008) 28(4):665-671.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, Issue.4
, pp. 665-671
-
-
Fu, K.1
Corbley, M.J.2
Sun, L.3
Friedman, J.E.4
Shan, F.5
Papadatos, J.L.6
Costa, D.7
Lutterodt, F.8
Sweigard, H.9
Bowes, S.10
Choi, M.11
-
115
-
-
4143066817
-
Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGFβ type I receptor inhibitors
-
Gellibert F, Woolven J, Fouchet MH, Mathews N, Goodland H, Lovegrove V, Laroze A, Nguyen VL, Sautet S, Wang R, Janson C et al: Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGFβ type I receptor inhibitors. J Med Chem (2004) 47(18):4494-4506.
-
(2004)
J Med Chem
, vol.47
, Issue.18
, pp. 4494-4506
-
-
Gellibert, F.1
Woolven, J.2
Fouchet, M.H.3
Mathews, N.4
Goodland, H.5
Lovegrove, V.6
Laroze, A.7
Nguyen, V.L.8
Sautet, S.9
Wang, R.10
Janson, C.11
-
116
-
-
0037620888
-
Synthesis and activity of new aryland heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain
-
Sawyer JS, Anderson BD, Beight DW, Campbell RM, Jones ML, Herron DK, Lampe JW, McCowan JR, McMillen WT, Mort N, Parsons S et al: Synthesis and activity of new aryland heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain. J Med Chem (2003) 46(19):3953-3956.
-
(2003)
J Med Chem
, vol.46
, Issue.19
, pp. 3953-3956
-
-
Sawyer, J.S.1
Anderson, B.D.2
Beight, D.W.3
Campbell, R.M.4
Jones, M.L.5
Herron, D.K.6
Lampe, J.W.7
McCowan, J.R.8
McMillen, W.T.9
Mort, N.10
Parsons, S.11
-
117
-
-
0344496021
-
Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)
-
Singh J, Chuaqui CE, Boriack-Sjodin PA, Lee WC, Pontz T, Corbley MJ, Cheung HK, Arduini RM, Mead JN, Newman MN, Papadatos JL et al: Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI). Bioorg Med Chem Lett (2003) 13(24):4355-4359.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, Issue.24
, pp. 4355-4359
-
-
Singh, J.1
Chuaqui, C.E.2
Boriack-Sjodin, P.A.3
Lee, W.C.4
Pontz, T.5
Corbley, M.J.6
Cheung, H.K.7
Arduini, R.M.8
Mead, J.N.9
Newman, M.N.10
Papadatos, J.L.11
-
118
-
-
33751320565
-
Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-β type I receptor kinase in vivo
-
Ge R, Rajeev V, Ray P, Lattime E, Rittling S, Medicherla S, Protter A, Murphy A, Chakravarty J, Dugar S, Schreiner G et al: Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-β type I receptor kinase in vivo. Clin Cancer Res (2006) 12(14 Pt 1):4315-4330.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.14 PART 1
, pp. 4315-4330
-
-
Ge, R.1
Rajeev, V.2
Ray, P.3
Lattime, E.4
Rittling, S.5
Medicherla, S.6
Protter, A.7
Murphy, A.8
Chakravarty, J.9
Dugar, S.10
Schreiner, G.11
-
119
-
-
62149093504
-
-
NATIONAL INSTITUTES OF HEALTH (Terabe M, Takaku S, Berzofsky JA): Synergistic effect of TGFβR; blockade and immunogenic agents on tumors. WO-2006089251 (2006).
-
NATIONAL INSTITUTES OF HEALTH (Terabe M, Takaku S, Berzofsky JA): Synergistic effect of TGFβR; blockade and immunogenic agents on tumors. WO-2006089251 (2006).
-
-
-
-
120
-
-
62149093170
-
-
BIOGEN INC (Lee WC, Carter MB, Sun L, Chuaqui C, Singh J, Boriack-Sjodin P, Choi MS): Preparation of (pyridinyl) (pyrimidinyl) imidazo[1,2-a]pyridines as TGFβ receptor type I antagonists for treatment of fibrotic disorders and tumors. WO-2004021989 (2004).
-
BIOGEN INC (Lee WC, Carter MB, Sun L, Chuaqui C, Singh J, Boriack-Sjodin P, Choi MS): Preparation of (pyridinyl) (pyrimidinyl) imidazo[1,2-a]pyridines as TGFβ receptor type I antagonists for treatment of fibrotic disorders and tumors. WO-2004021989 (2004).
-
-
-
-
121
-
-
62149099473
-
-
PFIZER PRODUCTS INC (Blumberg LC, Munchhof MJ) Preparation of 2-(triazolyl)pyridines and related compounds as transforming growth factor (TGF) inhibitors for the treatment of cancer and fibrotic diseases. WO-2004026307 (2004).
-
PFIZER PRODUCTS INC (Blumberg LC, Munchhof MJ) Preparation of 2-(triazolyl)pyridines and related compounds as transforming growth factor (TGF) inhibitors for the treatment of cancer and fibrotic diseases. WO-2004026307 (2004).
-
-
-
-
122
-
-
62149140112
-
-
SCIOS INC (Chakravarty S, Dugar S, Perumattam JJ, Schreiner GF, Liu DY, Lewicki JA) Preparation of quinazolines as p38-β kinase and TGFβ inhibitors. WO-2000012497 (2000).
-
SCIOS INC (Chakravarty S, Dugar S, Perumattam JJ, Schreiner GF, Liu DY, Lewicki JA) Preparation of quinazolines as p38-β kinase and TGFβ inhibitors. WO-2000012497 (2000).
-
-
-
-
123
-
-
62149122521
-
-
Munchhof MJ, Isothiazole derivatives. WO-2004067530 2004
-
(Munchhof MJ): Isothiazole derivatives. WO-2004067530 (2004).
-
-
-
|