Induction of transforming growth factor β-1 in cervical intraepithelial neoplasia in vivo after treatment with β-carotene

Clinical Cancer Research

Volumn 3, Issue 2, 1997, Pages 157-160

  Comerci Jr , John T ^a,b   Runowicz, Carolyn D ^a   Fields, Abbie L ^a   Romney, Seymour L ^a   Palan, Prabhudas R ^a   Kadish, Anna S ^a   Goldberg, Gary L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CAROTENE; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; UTERINE CERVIX DYSPLASIA;

BETA CAROTENE; CERVICAL INTRAEPITHELIAL NEOPLASIA; CHEMOPREVENTION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; TRANSFORMING GROWTH FACTOR BETA; UTERINE CERVICAL NEOPLASMS;

EID: 0031026647     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Parkin, D. M., Muir, C. S., and Whelan, S. (eds) Cancer in Five Continents. VI. IARC Scientific Publ. No. 120. Lyon, France: IARC, 1992.
2. Parkin, D. M., Caara, E., and Muir, C. S. Estimates of the world wide frequency of sixteen major cancers in 1980. Int. J. Cancer, 41: 184-197, 1988.
3. Kaufman, R. H. Dysplasia and carcinoma in situ of the cervix. Clin. Obstet. Gynecol., 10: 748-784, 1967.
4. Darwiche, N., Celli, G., and De Luca, L. M. Specificity of retinoid receptor gene expression in mouse cervical epithelium. Endocrinology, 134: 2018-2025, 1994.
5. Palan, P. R., Romney, S. L., Mikhail, M. S., Basu, J., and Vermund, S. H. Decreased plasma beta-carotene levels in women with uterine dysplasia and cancer. J. Natl. Cancer Inst., 80: 454-455, 1988.
6. Palan, P. R., Mikhail, M. S., Basu, J., and Romney, S. L. β-carotene levels in exfoliated cervicovaginal epithelial cells in cervical intraepithelial neoplasia and cervical cancer. Am. J. Obstet. Gynecol., 767: 1899-1903, 1992.
7. Meyskens, F. L., Surwit, E., Moon, T. E., Childers, J. M., Davis, J. R., Dorr, R. T., Johnson, C. S., and Alberts, D. S. Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-trans retinoic acid: a randomized trial. J. Natl. Cancer Inst., 86: 539-543, 1994.
8. Lippman, S. M., Kavanagh, J. J., Paredes-Espinoza, M., Delgadillo-Madrueno, F., Paredes-Casillas, P., Hong, W. K., Massimini, G., Holdener, E. E., and Krakoff, I. H. 13-Cis-retinoic acid plus interferon-α2A in locally advanced squamous cell carcinoma of the cervix. J. Natl. Cancer Inst., 85: 499-500, 1993.
9. Lippman, S. M., Kavanagh, J. J., Paredes-Espinoza, M., Delgadillo-Madrueno, F., Paredes-Casillas, P., Hong, W. K, Massimini, G., Holdener, E. E., and Krakoff, I. H. 13-Cis-retinoic acid (13cRA), interferon-α2A (IFN-α2A) and radiotherapy for locally advanced cancer of the cervix. Proc. Am. Soc. Clin. Oncol., 12: 257, 1993.
10. Roberts, A. B., Thompson, N. L., Hein, U., Flanders, K. C., and Spom, M. B. Transforming growth factor-β: possible roles in carcinogenesis. Br. J. Cancer, 57: 594-600, 1988.
11. Shipely, G. D., Pittelkow, M. R., Wille, J. J., Scott, R. E., and Moses, H. L. Reversible inhibition of normal human prokeratinocyte proliferation by type β transforming growth factor inhibition in serum-free medium. Cancer Res., 46: 2068-2071, 1986.
12. Bascom, C. C., Wolfshohl, R. J., Coffey, R. J., Madisen, L., Webb, N. R., Purchio, A. R., Derynck, R., and Moses, H. L, Complex regulation of transforming growth factor β1, β2, and β3m RNA expression in mouse fibroblasts and keratinocytes by transforming growth factors β1 and β2. Mol. Cell. Biol., 9: 5508-5515, 1989.
13. Braun, L., Durst, M., Mikumo, R., and Gruppuso, P. Differential response of nontumorigenic and tumorigenic human papilloma virus type 16-positive epithelial cells to transforming growth factor-β1. Cancer Res., 50: 7324-7332, 1990.
14. DeBenedetti, F., Falk, L., Ruscetti, F. U., Cobum, N. H., Faltynek, C. R., and Oppenheim, J. J. Synergistic inhibition of phorbol esterinduced transformation of JB6 cells by transforming growth factor-beta and retinoic acid. Cancer Res., 51: 1158-1164, 1991.
15. Glick, A. B., Flanders, K. C., Danielpour, D., Yuspa, S. H., and Sporn, M. B. Retinoic acid induces transforming growth factor-beta-2 in cultured keratinocytes and mouse epidermis. Cell Regul., 1: 87-97, 1989.
16. Ferenczy, A., and Winkler, B. Cervical intraepithelial neoplasia and condyloma. In: R. J. Kurman (ed.), Blaustein's Pathology of the Female Genital Tract, pp. 177-217. New York; Springer-Verlag, 1987.
17. Flanders, K. C., Thompson, N. L., Cissel, D. S., van Obberghen-Schilling, E., Baker, C. C., Kass, M. E., Ellingsworth, L. R., Roberts, A. B., and Sporn, M. B. Transforming growth factor-β1: histochemical localization with antibodies to different epitopes. J. Cell Biol., 108: 653-660, 1989.
18. Comerci, J. T., Runowicz, C. D., Flanders, K. C., De Victoria, C., Fields, A. L., Romney, S. L., Kadish, A. S., and Goldberg, G. L. Altered expression of transforming growth factor beta-1 in cervical neoplasia as an early biomarker in carcinogenesis of the uterine cervix. Cancer (Phila.), 77: 1107-1114, 1996.
19. Glick, A. B., Kulkarni, A. B., Tennenbaum, T., Hennings, H., Flanders, K. C., O'Reilly, M., Sporn, M. B., Karlsson, S., and Yuspa, S. H. Loss of expression of transforming growth factor β in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proc. Natl. Acad. Sci. USA, 90: 6076-6080, 1993.
20. Braun, L., Durst, M., Mikumo, R., Crowley, A., and Robinson, M. Regulation of growth and gene expression in human papilloma virus-transformed keratinocytes by transforming growth factor β: implications for the control of papilloma virus infection. Mol. Carcinog., 6: 100-111, 1992.
21. Gorodeski, G. I., Eckert, R. L., Utian, W. H., Sheean, L., and Rorke, E. A. Cultured human ectocervical epithelial cell differentiation is regulated by the combined direct actions of sex steroids, glucocorticoids, and retinoids, J. Clin. Endocrinol. Metab., 70: 1624-1630, 1990.
22. Colletta, A. A., Wakefield, L. M., Howell, F. V., Danielpour, D., Baum, M., and Sporn, M. B. The growth inhibition of human breast cancer cells by a novel synthetic progestin involves the induction of transforming growth factor beta. J. Clin. Invest., 87: 277-283, 1991.
23. Butta, A., MacLennan, K., Flanders, K. C., Sacks, N. P. M., Smith, I., McKinna, A., Dowsett, M., Wakefield, L. M., Sporn, M. B., and Baum, M. Induction of transforming growth factor β, in human breast cancer in vivo following tamoxifen treatment. Cancer Res., 52: 4261-4264, 1992.
24. Foster, C. S. Structural and functional aspects of transforming growth factor-β in prostate cancer and other human malignancies. Hum. Pathol., 24: 1-3, 1993.
25. Colletta, A. A., Wakefield, L. M., Howell, F. V., Danielpour, D., Baum, M., and Sporn, M. B. The growth inhibition of human breast cancer cells by a novel synthetic progestin involves the induction of transforming growth factor beta. J. Clin. Invest., 87: 277-283, 1991.
26. Roberts, A. B., and Sporn, M. B. Mechanistic interrelationships between two super-families: the steroid/retinoid receptors and transforming growth factor-β. Cancer Surv., 14: 205-220, 1992.
27. Lippman, S. M., Lee, J. J., Lotan, R., Hittelman, W., Wargovich, M. J., and Hong, W. K. Biomarkers as intermediate endpoints in chemoprevention trials. J. Natl. Cancer Inst., 82: 555-560, 1990.