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Volumn 7, Issue 5, 2005, Pages 509-521

A specific inhibitor of TGF-β receptor kinase, SB-431542, as a potent antitumor agent for human cancers

Author keywords

EMT VEGF; Invasion; Metastasis; SB 431542; TGF

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ANTINEOPLASTIC AGENT; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 20344385003     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1593/neo.04640     Document Type: Article
Times cited : (240)

References (31)
  • 1
    • 0033965260 scopus 로고    scopus 로고
    • Chemoinformatics-predicting the physicochemical properties of 'drug-like' molecules
    • Blake JF (2000). Chemoinformatics-predicting the physicochemical properties of 'drug-like' molecules. Curr Opin Biotechnol 11, 104-107.
    • (2000) Curr Opin Biotechnol , vol.11 , pp. 104-107
    • Blake, J.F.1
  • 2
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • Heldin CH, Miyazono K, and ten Dijke P (1997). TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 3
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massague J (1998). TGF-beta signal transduction. Annu Rev Biochem 67, 753-791.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 4
    • 0034104591 scopus 로고    scopus 로고
    • Smads as transcriptional co-modulators
    • Attisano L and Wrana JL (2000). Smads as transcriptional co-modulators. Curr Opin Cell Biol 12, 235-243.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 235-243
    • Attisano, L.1    Wrana, J.L.2
  • 5
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-beta/Smad signaling system
    • Massague J and Wotton D (2000). Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 19, 1745-1754.
    • (2000) EMBO J , vol.19 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2
  • 6
    • 0033012207 scopus 로고    scopus 로고
    • Signal transduction of the TGF-beta superfamily by Smad proteins
    • Kawabata M and Miyazono K (1999). Signal transduction of the TGF-beta superfamily by Smad proteins. J Biochem (Tokyo) 125, 9-16.
    • (1999) J Biochem (Tokyo) , vol.125 , pp. 9-16
    • Kawabata, M.1    Miyazono, K.2
  • 8
    • 0034612789 scopus 로고    scopus 로고
    • Role of transforming growth factor-beta signaling in cancer
    • de Caestecker MP, Piek E, and Roberts AB (2000). Role of transforming growth factor-beta signaling in cancer. J Natl Cancer Inst 92, 1388-1402.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1388-1402
    • De Caestecker, M.P.1    Piek, E.2    Roberts, A.B.3
  • 9
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • Siegel PM and Massague J (2003). Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 3, 807-821.
    • (2003) Nat Rev Cancer , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 10
    • 0036467496 scopus 로고    scopus 로고
    • TGF-beta signaling: Positive and negative effects on tumorigenesis
    • Wakefield LM and Roberts AB (2002). TGF-beta signaling: positive and negative effects on tumorigenesis, Curr Opin Genet Dev 12, 22-29.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 22-29
    • Wakefield, L.M.1    Roberts, A.B.2
  • 11
    • 0038724672 scopus 로고    scopus 로고
    • Targeting the TGF beta signaling network in human neoplasia
    • Dumont N and Arteaga CL (2003). Targeting the TGF beta signaling network in human neoplasia. Cancer Cell 3, 531-536.
    • (2003) Cancer Cell , vol.3 , pp. 531-536
    • Dumont, N.1    Arteaga, C.L.2
  • 15
    • 0036085920 scopus 로고    scopus 로고
    • SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    • Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, and Hill CS (2002). SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 62, 65-74.
    • (2002) Mol Pharmacol , vol.62 , pp. 65-74
    • Inman, G.J.1    Nicolas, F.J.2    Callahan, J.F.3    Harling, J.D.4    Gaster, L.M.5    Reith, A.D.6    Laping, N.J.7    Hill, C.S.8
  • 16
    • 0036082554 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542
    • Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, Martin W, Fornwald J, Lehr R, Marling J, et al. (2002). Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol 62, 58-64.
    • (2002) Mol Pharmacol , vol.62 , pp. 58-64
    • Laping, N.J.1    Grygielko, E.2    Mathur, A.3    Butter, S.4    Bomberger, J.5    Tweed, C.6    Martin, W.7    Fornwald, J.8    Lehr, R.9    Marling, J.10
  • 17
    • 0034089871 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA
    • Sheng H, Shao J, Dixon DA, Williams CS, Prescott SM, DuBois RD, and Beauchamp RD (2000). Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J Biol Chem 275, 6628-6635.
    • (2000) J Biol Chem , vol.275 , pp. 6628-6635
    • Sheng, H.1    Shao, J.2    Dixon, D.A.3    Williams, C.S.4    Prescott, S.M.5    DuBois, R.D.6    Beauchamp, R.D.7
  • 18
  • 19
    • 0002927539 scopus 로고
    • Type beta transforming growth factor is a growth stimulator and a growth inhibitor
    • Growth Factors and Transformation. J. Feramisco, B. Ozanne, and C. Stiles, eds. (New York: Cold Spring Harbor Press)
    • Moses HL, Tucker RF, Leof EB, Coffey RJ, Halper J, and Shipley GD (1985). Type beta transforming growth factor is a growth stimulator and a growth inhibitor. In Growth factors and Transformation. Cancer Cells 3. J. Feramisco, B. Ozanne, and C. Stiles, eds. (New York: Cold Spring Harbor Press), 65-71.
    • (1985) Cancer Cells 3 , pp. 65-71
    • Moses, H.L.1    Tucker, R.F.2    Leof, E.B.3    Coffey, R.J.4    Halper, J.5    Shipley, G.D.6
  • 20
    • 0031576071 scopus 로고    scopus 로고
    • Protection of 5alpha-dihydrotestosterone against TGF-beta-induced apoptosis in FaO cells and induction of mitosis in HepG2 cells
    • Lim IK, Joo HJ, Choi KS, Sueoka E, Lee MS, Ryu MS, and Fujiki H (1997). Protection of 5alpha-dihydrotestosterone against TGF-beta-induced apoptosis in FaO cells and induction of mitosis in HepG2 cells. Int J Cancer 72, 351-355.
    • (1997) Int J Cancer , vol.72 , pp. 351-355
    • Lim, I.K.1    Joo, H.J.2    Choi, K.S.3    Sueoka, E.4    Lee, M.S.5    Ryu, M.S.6    Fujiki, H.7
  • 21
    • 0035872426 scopus 로고    scopus 로고
    • Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation
    • Ellenrieder V, Hendler SF, Boeck W, Seufferlein T, Menke A, Ruhland C, Adler G, and Gress TM (2001). Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. Cancer Res 61, 4222-4228.
    • (2001) Cancer Res , vol.61 , pp. 4222-4228
    • Ellenrieder, V.1    Hendler, S.F.2    Boeck, W.3    Seufferlein, T.4    Menke, A.5    Ruhland, C.6    Adler, G.7    Gress, T.M.8
  • 23
    • 0023104031 scopus 로고
    • Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta
    • Postlethwaite AE, Keski-Oja J, Moses HL, and Kang AH (1987). Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta. J Exp Med 165, 251-256.
    • (1987) J Exp Med , vol.165 , pp. 251-256
    • Postlethwaite, A.E.1    Keski-Oja, J.2    Moses, H.L.3    Kang, A.H.4
  • 24
    • 0036674213 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration
    • Bakin AV, Rinehart C, Tomlinson AK, and Arteaga CL (2002). p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 115, 3193-3206.
    • (2002) J Cell Sci , vol.115 , pp. 3193-3206
    • Bakin, A.V.1    Rinehart, C.2    Tomlinson, A.K.3    Arteaga, C.L.4
  • 25
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck R, Akhurst RJ, and Balmain A (2001). TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 29, 117-129.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 28
    • 0032547895 scopus 로고    scopus 로고
    • TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis
    • Oft M, Heider KH, and Beug H (1998). TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol 8, 1243-1252.
    • (1998) Curr Biol , vol.8 , pp. 1243-1252
    • Oft, M.1    Heider, K.H.2    Beug, H.3
  • 29
    • 0035890776 scopus 로고    scopus 로고
    • Heterogeneous transforming growth factor (TGF)-beta unresponsiveness and loss of TGF-beta receptor type II expression caused by histone deacetylation in lung cancer cell lines
    • Osada H, Tatematsu Y, Masuda A, Saito T, Sugiyama M, Yanagisawa K, and Takahashi T (2001). Heterogeneous transforming growth factor (TGF)-beta unresponsiveness and loss of TGF-beta receptor type II expression caused by histone deacetylation in lung cancer cell lines. Cancer Res 61, 8331-8339.
    • (2001) Cancer Res , vol.61 , pp. 8331-8339
    • Osada, H.1    Tatematsu, Y.2    Masuda, A.3    Saito, T.4    Sugiyama, M.5    Yanagisawa, K.6    Takahashi, T.7
  • 31
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW and Vogelstein B (1996). Lessons from hereditary colorectal cancer. Cell 87, 159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.