Activated type I TGFβ receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

Oncogene

Volumn 25, Issue 24, 2006, Pages 3408-3423

  Muraoka Cook, R S ^a   Shin, I ^a,f   Yi, J Y ^a   Easterly, E ^a   Barcellos Hoff, M H ^b   Yingling, J M ^c   Zent, R ^a,d   Arteaga, C L ^a,e  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e VANDERBILT INGRAM CANCER CENTER   (United States)

^f Hanyang University   (South Korea)

Author keywords

Involution; Mammary cancer; Oncogenes; PI 3 kinase; TGF ; Transgenic mice

Indexed keywords

MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME INHIBITOR; PROTEIN KINASE B; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; BREAST METASTASIS; BREAST TUMOR; CANCER SURVIVAL; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; INHIBITION KINETICS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENE; TUMOR GROWTH;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTIVIN RECEPTORS, TYPE I; ANIMALS; APOPTOSIS; CELL SURVIVAL; DISEASE PROGRESSION; GENES, REPORTER; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, ANIMAL; MICE; NEOPLASM METASTASIS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA;

MOUSE MAMMARY TUMOR VIRUS; MUS MUSCULUS;

EID: 33745050200     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1208964     Document Type: Article

References (58)

1. Ackler S, Ahmad S, Tobias C, Johnson MD, Glazer RI. (2002). Oncogene 21: 198-206.
2. Adams J. (2004). Cancer Cell 5: 417-421.
3. Alexandrow MG, Moses HL. (1995). Cancer Res 55: 1452-1457.
4. Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL. (2000). J Biol Chem 275: 36803-36810.
5. Bhowmick NA, Neilson EG, Moses HL. (2004). Nature 432: 332-337.
6. Bottinger EP, Jakubczak JL, Haines DC, Bagnal K, Wakefield LM. (1997). Cancer Res 57: 5564-5570.
7. Boulanger CA, Wagner KU, Smith GH. (2005). Oncogene 24: 552-560.
8. Carpenter CL, Tolias KF, Couvillon AC, Hartwig JH. (1997). Adv Enzyme Regul 37: 377-390.
9. Charng MJ, Kinnunen P, Hawker J, Brand T, Schneider MD. (1996). J Biol Chem 271: 22941-22944.
10. Chen CR, Kang Y, Massague J. (2001). Proc Natl Acad Sci USA 98: 992-999.
11. Chen CR, Kang Y, Siegel PM, Massague J. (2002). Cell 110: 19-32.
12. Conery AR, Cao Y, Thompson EA, Townsend Jr CM, Ko TC, Luo K. (2004). Nat Cell Biol 6: 366-372.
13. Datto MB, Frederick JP, Pan L, Borton AJ, Zhuang Y, Wang XF. (1999). Mol Cell Biol 19: 2495-2504.
14. D'Cruz CM, Gunther EJ, Boxer RB, Hartman JL, Sintasath L, Moody SE et al. (2001). Nat Med 7: 235-239.
15. Derynck R, Zhang YE. (2003). Nature 425: 577-584.
16. Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL. (2003). Nat Cell Biol 5: 410-421.
17. Dumont N, Bakin AV, Arteaga CL. (2003). J Biol Chem 278: 3275-3285.
18. Ehrhart EJ, Segarini P, Tsang ML, Carroll AG, Barcellos-Hoff MH. (1997). FASEB J 11: 991-1002.
19. Engle SJ, Hoying JB, Boivin GP, Ormsby I, Gartside PS, Doetschman T. (1999). Cancer Res 59: 3379-3386.
20. Ewan KB, Shyamala G, Ravani SA, Tang Y, Akhurst R, Wakefield L et al. (2002). Am J Pathol 160: 2081-2093.
21. Forrester E, Chytil A, Bierie B, Aakre M, Gorska A, Sharif-Afshar AR et al. (2005). Cancer Res 65: 2295-2302.
22. Glick AB, Weinberg WC, Wu IH, Quan W, Yuspa SH. (1996). Cancer Res 56: 3645-3650.
23. Gorska AE, Jensen RA, Shyr Y, Aakre ME, Bhowmick NA, Moses HL. (2003). Am J Pathol 163: 1539-1549.
24. Gotzmann J, Huber H, Thallinger C, Wolschek M, Jansen B, Schulte-Hermann R et al. (2002). J Cell Sci 115: 1189-1202.
25. Guy CT, Webster MA, Schaller M, Parsons TJ, Cardiff RD, Muller WJ. (1992). Proc Natl Acad Sci USA 89: 10578-10582.
26. Higaki M, Shimokado K. (1999). Arterioscler Thromb Vasc Biol 19: 2127-2132.
27. Horowitz JC, Lee DY, Waghray M, Keshamouni VG, Thomas PE, Zhang H et al. (2004). J Biol Chem 279: 1359-1367.
28. Huang Y, Hutter D, Liu Y, Wang X, Sheikh MS, Chan AM et al. (2000). J Biol Chem 275: 18234-18242.
29. Hutchinson J, Jin J, Cardiff RD, Woodgett JR, Muller WJ. (2001). Mol Cell Biol 21: 2203-2212.
30. Jhappan C, Geiser AG, Kordon EC, Bagheri D, Hennighausen L, Roberts AB et al. (1993). EMBO J 12: 1835-1845.
31. Kordon EC, McKnight RA, Jhappan C, Hennighausen L, Merlino G, Smith GH. (1995). Dev Biol 168: 47-61.
32. Liu X, Sun Y, Constantinescu SN, Karam E, Weinberg RA, Lodish HF. (1997). Proc Natl Acad Sci USA 94: 10669-10674.
33. Lo RS, Massague J. (1999). Nat Cell Biol 1: 472-478.
34. Massague J. (1998). Annu Rev Biochem 67: 753-791.
35. Massague J, Blain SW, Lo RS. (2000). Cell 103: 295-309.
36. Muraoka RS, Dumont N, Ritter CA, Dugger TC, Brantley DM, Chen J et al. (2002a). J Clin Invest 109: 1551-1559.
37. Muraoka RS, Koh Y, Roebuck LR, Sanders ME, Brantley-Sieders D, Gorska AE et al. (2003). Mol Cell Biol 23: 8691-8703.
38. Muraoka RS, Lenferink AE, Law B, Hamilton E, Brantley DM, Roebuck LR et al. (2002b). Mol Cell Biol 22: 2204-2219.
39. Muraoka RS, Lenferink AE, Simpson J, Brantley DM, Roebuck LR, Yakes FM et al. (2001). J Cell Biol 153: 917-932.
40. Muraoka-Cook RS, Kurokawa H, Koh Y, Forbes JT, Roebuck LR, Barcellos-Hoff MH et al (2004). Cancer Res 64: 9002-9011.
41. Nguyen AV, Pollard JW. (2000). Development 127: 3107-3118.
42. Peng S-H, Yan L, Xia X, Watkins SA, Brooks HB, Beight D et al. (2005). Biochemistry 44: 2293-2304.
43. Pierce DF, Gorska AE, Chytil A, Meise KS, Page DL, Coffey Jr RJ et al. (1995). Proc Natl Acad Sci USA 92: 4254-4258.
44. Pierce Jr DF, Johnson MD, Matsui Y, Robinson SD, Gold LI, Purchio AF et al. (1993). Genes Dev 7: 2308-2317.
45. Remy I, Montmarquette A, Michnick SW. (2004). Nat Cell Biol 6: 358-365.
46. Sawyer JS, Beight DW, Britt KS, Anderson BD, Campbell RM, Goodson Jr T et al. (2004). Bioorg Med Chem Lett 14: 3581-3584.
47. Schwertfeger KL, Richert MM, Anderson SM. (2001). Mol Endocrinol 15: 867-881.
48. Seoane J, Le HV, Shen L, Anderson SA, Massague J. (2004). Cell 117: 211-223.
49. Shi Y, Massague J. (2003). Cell 113: 685-700.
50. Shin I, Bakin AV, Rodeck U, Brunet A, Arteaga CL. (2001). Mol Biol Cell 12: 3328-3339.
51. Siegel PM, Massague J. (2003). Nat Rev Cancer 3: 807-820.
52. Siegel PM, Shu W, Cardiff RD, Muller WJ, Massague J. (2003). Proc Natl Acad Sci USA 100: 8430-8435.
53. Stambolic V, Tsao MS, Macpherson D, Suzuki A, Chapman WB, Mak TW. (2000). Cancer Res 60: 3605-3611.
54. Vivanco I, Sawyers CL. (2002). Nat Rev Cancer 2: 489-501.
55. Wakefield LM, Roberts AB. (2002). Curr Opin Genet Dev 12: 22-29.
56. Wieser R, Wrana JL, Massague J. (1995). EMBO J 14: 2199-2208.
57. Yang YA, Tang B, Robinson G, Hennighausen L, Brodie SG, Deng CX et al. (2002). Cell Growth Differ 13: 123-130.
58. Yi JY, Shin I, Arteaga CL. (2005). J Biol Chem 280: 2870-2876.