-
2
-
-
0035524488
-
Toll-like receptors and innate immunity
-
Medzhitov, R. Toll-like receptors and innate immunity. Nature Rev. Immunol. 1, 135-145 (2001).
-
(2001)
Nature Rev. Immunol.
, vol.1
, pp. 135-145
-
-
Medzhitov, R.1
-
3
-
-
0029979369
-
Biologic basis for interleukin-1 in disease
-
Dinarello, C. A. Biologic basis for interleukin-1 in disease. Blood 87, 2095-2147 (1996).
-
(1996)
Blood
, vol.87
, pp. 2095-2147
-
-
Dinarello, C.A.1
-
4
-
-
0034075754
-
The IL-1 receptor/toll-like receptor superfamily: Crucial receptors for inflammation and host defense
-
O'Neill, L. A. & Dinarello, C. A. The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunol. Today 21, 206-209 (2000).
-
(2000)
Immunol. Today
, vol.21
, pp. 206-209
-
-
O'Neill, L.A.1
Dinarello, C.A.2
-
5
-
-
0032524335
-
MyD 88, an adapter protein involved in interleukin signaling
-
Burns, K. et al. MyD88, an adapter protein involved in interleukin signaling. J. Biol. Chem. 273, 12203-12209 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 12203-12209
-
-
Burns, K.1
-
6
-
-
0030694108
-
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
-
Muzio, M., Ni, J., Feng, P. & Dixil V. M. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278, 1612-1615 (1997).
-
(1997)
Science
, vol.278
, pp. 1612-1615
-
-
Muzio, M.1
Ni, J.2
Feng, P.3
Dixil, V.M.4
-
7
-
-
0032133278
-
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
-
Medzhitov, R. et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2, 253-258 (1998).
-
(1998)
Mol. Cell
, vol.2
, pp. 253-258
-
-
Medzhitov, R.1
-
8
-
-
0031423761
-
MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
-
Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. & Cao, Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7, 837-847 (1997).
-
(1997)
Immunity
, vol.7
, pp. 837-847
-
-
Wesche, H.1
Henzel, W.J.2
Shillinglaw, W.3
Li, S.4
Cao, Z.5
-
9
-
-
0035555301
-
TIRAP an adapter molecule in the Toll signaling pathway
-
Horng, T., Barton, G. M. & Medzhitov, R. TIRAP: an adapter molecule in the Toll signaling pathway. Nature Immunol. 2, 835-841 (2001). This paper (together with reference 10) provides the first evidence for a role of TIRAP in the Toll-like receptor signalling pathway.
-
(2001)
Nature Immunol.
, vol.2
, pp. 835-841
-
-
Horng, T.1
Barton, G.M.2
Medzhitov, R.3
-
10
-
-
0035817925
-
Mai (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
-
Fitzgerald, K. A. et al. Mai (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78-83 (2001).
-
(2001)
Nature
, vol.413
, pp. 78-83
-
-
Fitzgerald, K.A.1
-
11
-
-
0037108346
-
Cutting edge: CATERPILLER: A large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains
-
Harton, J. A., Linhoff, M. W., Zhang, J. & Ting, J. P. Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J. Immunol. 169, 4088-4093 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 4088-4093
-
-
Harton, J.A.1
Linhoff, M.W.2
Zhang, J.3
Ting, J.P.4
-
12
-
-
0036160150
-
Nods: A family of cytosolic proteins that regulate the host response to pathogens
-
Inohara, N., Ogura, Y. & Nuñez, G. Nods: a family of cytosolic proteins that regulate the host response to pathogens. Curr. Opin. Microbiol. 5, 76-80 (2002).
-
(2002)
Curr. Opin. Microbiol.
, vol.5
, pp. 76-80
-
-
Inohara, N.1
Ogura, Y.2
Nuñez, G.3
-
13
-
-
0036239887
-
Genetic control of MHC class II expression
-
Ting, J. P. & Trowsdale, J. Genetic control of MHC class II expression. Cell 109, S21-S33 (2002).
-
(2002)
Cell
, vol.109
-
-
Ting, J.P.1
Trowsdale, J.2
-
14
-
-
0034194079
-
The NACHT family - A new group of predicted NTPases implicated in apoptosis and MHC transcription activation
-
Koonin, E. V. & Aravind, L. The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation. Trends Biochem. Sci 25, 223-224 (2000).
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 223-224
-
-
Koonin, E.V.1
Aravind, L.2
-
15
-
-
0036187036
-
Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
-
Acehan, D. et al. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol. Cell 9, 423-432 (2002). This excellent study proposes a three-dimensional model of the apoptosome.
-
(2002)
Mol. Cell
, vol.9
, pp. 423-432
-
-
Acehan, D.1
-
16
-
-
0035692811
-
The leucine-rich repeat as a protein recognition motif
-
Kobe, B. & Kajava, A. V. The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol. 11, 725-732 (2001).
-
(2001)
Curr. Opin. Struct. Biol.
, vol.11
, pp. 725-732
-
-
Kobe, B.1
Kajava, A.V.2
-
17
-
-
0035379670
-
Dendritic cell-specific MHC class II transactivator contains a caspase recruitment domain that confers potent transactivation activity
-
Nickerson, K. et al. Dendritic cell-specific MHC class II transactivator contains a caspase recruitment domain that confers potent transactivation activity. J. Biol. Chem. 276, 19089-19093 (2001)
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 19089-19093
-
-
Nickerson, K.1
-
18
-
-
0035050491
-
Two distinct domains within CIITA mediate self-association: Involvement of the GTP-binding and leucine-rich repeat domains
-
Linhoff, M. W., Harton, J. A., Cressman, D. E., Martin, B. K. & Ting, J. P. Two distinct domains within CIITA mediate self-association: involvement of the GTP-binding and leucine- rich repeat domains. Mol. Cell. Biol. 21, 3001-3011 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3001-3011
-
-
Linhoff, M.W.1
Harton, J.A.2
Cressman, D.E.3
Martin, B.K.4
Ting, J.P.5
-
19
-
-
0033591330
-
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κ
-
Inohara, N. et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κ. J. Biol. Chem. 274, 14560-14567 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 14560-14567
-
-
Inohara, N.1
-
20
-
-
0033532091
-
Human CARD4 protein is a novel CED- 4/Apaf-1 cell death family member that activates NF-κB
-
Bertin, J. et al. Human CARD4 protein is a novel CED- 4/Apaf-1 cell death family member that activates NF-κB. J. Biol. Chem. 274, 12955-12958 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12955-12958
-
-
Bertin, J.1
-
21
-
-
0035895992
-
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
-
Ogura, Y. et al. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J. Biol. Chem. 276, 4812-4818 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 4812-4818
-
-
Ogura, Y.1
-
22
-
-
0035951792
-
Human Nod1 confers responsiveness to bacterial lipopolysaccharides
-
Inohara, N., Ogura, Y., Chen, F. F., Muto, A. & Nuñez, G. Human Nod1 confers responsiveness to bacterial lipopolysaccharides. J. Biol. Chem. 276, 2551-2554 (2001). This Study provides evidence that the LRRs of NOD1 and NOD2 bind LPS.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 2551-2554
-
-
Inohara, N.1
Ogura, Y.2
Chen, F.F.3
Muto, A.4
Nuñez, G.5
-
23
-
-
17944380130
-
CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri
-
Girardin, S. E. et al. CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri. EMBO Rep. 2, 736-742 (2001).
-
(2001)
EMBO Rep.
, vol.2
, pp. 736-742
-
-
Girardin, S.E.1
-
24
-
-
13344259990
-
Mapping of a susceptibility locus for Crohn's disease on chromosome 16
-
Hugot, J. P. et al. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 379, 821-823 (1996). First evidence for an association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
(1996)
Nature
, vol.379
, pp. 821-823
-
-
Hugot, J.P.1
-
25
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura, Y. et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603-606 (2001).
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
-
26
-
-
17944372335
-
CARD 15 mutations in Blau syndrome
-
Miceli-Richard, C et al. CARD15 mutations in Blau syndrome. Nature Genet. 29, 19-20 (2001).
-
(2001)
Nature Genet.
, vol.29
, pp. 19-20
-
-
Miceli-Richard, C.1
-
27
-
-
0035958867
-
Identification of lpaf, a human caspase-1-activating protein related to Apaf-1
-
Poyet, J. L. et al. Identification of lpaf, a human caspase-1-activating protein related to Apaf-1. J. Biol. Chem. 276, 28309-28313 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 28309-28313
-
-
Poyet, J.L.1
-
28
-
-
0034964518
-
CLAN a novel human CED-4-like gene
-
Damiano, J. S., Stehlik, C., Pio, F., Godzik, A. & Reed, J. C. CLAN, a novel human CED-4-like gene. Genomics 75, 77-83 (2001).
-
(2001)
Genomics
, vol.75
, pp. 77-83
-
-
Damiano, J.S.1
Stehlik, C.2
Pio, F.3
Godzik, A.4
Reed, J.C.5
-
29
-
-
0034815799
-
Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis
-
Geddes, B. J. et al Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. Biochem. Biophys. Res. Commun. 284, 77-82 (2001).
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.284
, pp. 77-82
-
-
Geddes, B.J.1
-
30
-
-
0028896092
-
The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy
-
Roy, N. et al. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 80, 167-178 (1995). First evidence for an association of NAIP variants with susceptibility to spinal muscular atrophy.
-
(1995)
Cell
, vol.80
, pp. 167-178
-
-
Roy, N.1
-
31
-
-
13344278692
-
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
-
Liston, P. et al. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379, 349-353 (1996).
-
(1996)
Nature
, vol.379
, pp. 349-353
-
-
Liston, P.1
-
33
-
-
0034142264
-
The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila
-
Diez, E., Yaraghi, Z., MacKenzie, A & Gros, P. The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila. J. Immunol. 164, 1470-1477 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 1470-1477
-
-
Diez, E.1
Yaraghi, Z.2
MacKenzie, A.3
Gros, P.4
-
34
-
-
0031231588
-
Genetic and physical mapping of the mouse host resistance locus Lgn 1
-
Diez, E. et al. Genetic and physical mapping of the mouse host resistance locus Lgn1. Mamm. Genome 8, 682-685 (1997).
-
(1997)
Mamm. Genome
, vol.8
, pp. 682-685
-
-
Diez, E.1
-
35
-
-
0036671894
-
The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-1β
-
Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-1β. Mol. Cell 10, 417-426 (2002). This paper describes the existence of the inflammasome.
-
(2002)
Mol. Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
36
-
-
0035253123
-
PAAD - A new protein domain associated with apoptosis, cancer and autoimmune diseases
-
Pawlowski, K., Pio, F., Chu, Z., Reed, J. C. & Godzik, A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem. Sci. 26, 85-87 (2001).
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 85-87
-
-
Pawlowski, K.1
Pio, F.2
Chu, Z.3
Reed, J.C.4
Godzik, A.5
-
37
-
-
0037192793
-
PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-κB
-
Manji, G. A. et al. PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-κB. J. Biol. Chem. 277, 11570-11575 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 11570-11575
-
-
Manji, G.A.1
-
38
-
-
0030856668
-
Imprinting in clusters: Lessons from Beckwith-Wiedemann syndrome
-
Reik, W. & Maher, E. R. Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome. Trends Genet. 13, 330-334 (1997).
-
(1997)
Trends Genet.
, vol.13
, pp. 330-334
-
-
Reik, W.1
Maher, E.R.2
-
39
-
-
0035937775
-
Molecular cloning and characterization of DEFCAP-L and-S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins
-
Hlaing, T. et al. Molecular cloning and characterization of DEFCAP-L and-S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J. Biol. Chem. 276, 9230-9238 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9230-9238
-
-
Hlaing, T.1
-
40
-
-
0035937797
-
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis
-
Chu, Z. L. et al. A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. J. Biol. Chem. 276, 9239-9245 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9239-9245
-
-
Chu, Z.L.1
-
41
-
-
0035916324
-
The Pyrin domain: A possible member of the death domain-fold family implicated in apoptosis and inflammation
-
Martinon, F., Hofmann, K. & Tschopp, J. The Pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr. Biol. 10, R118-R120 (2001).
-
(2001)
Curr. Biol.
, vol.10
-
-
Martinon, F.1
Hofmann, K.2
Tschopp, J.3
-
42
-
-
0037134457
-
CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis
-
Razmara, M. et al. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J. Biol. Chem. 277, 13952-13958 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13952-13958
-
-
Razmara, M.1
-
43
-
-
0035943736
-
TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer
-
Pathan, N. et al. TUCAN, an antiapoptotic caspase- associated recruitment domain family protein overexpressed in cancer. J. Biol. Chem. 276, 32220-32229 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 32220-32229
-
-
Pathan, N.1
-
44
-
-
0035941220
-
CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-κB activation pathways
-
Bouchier-Hayes, L. et al. CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-κB activation pathways. J. Biol. Chem. 276, 44069-44077 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 44069-44077
-
-
Bouchier-Hayes, L.1
-
45
-
-
0035179970
-
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
-
Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A. & Kolodner, R. D. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nature Genet. 29, 301-305 (2001).
-
(2001)
Nature Genet.
, vol.29
, pp. 301-305
-
-
Hoffman, H.M.1
Mueller, J.L.2
Broide, D.H.3
Wanderer, A.A.4
Kolodner, R.D.5
-
46
-
-
0036745064
-
Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis
-
Aganna, E. et al. Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum. 46, 2445-2452 (2002).
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 2445-2452
-
-
Aganna, E.1
-
47
-
-
0036271829
-
Oocyte-specific genes regulate follicle formation, fertility and early mouse development
-
Dean, J. Oocyte-specific genes regulate follicle formation, fertility and early mouse development. J. Reprod. Immunol. 63, 171-180 (2002).
-
(2002)
J. Reprod. Immunol.
, vol.63
, pp. 171-180
-
-
Dean, J.1
-
48
-
-
0033757582
-
Mater, a maternal effect gene required for early embryonic development in mice
-
Tong, Z. B. et al. Mater, a maternal effect gene required for early embryonic development in mice. Nature Genet. 26, 267-268 (2000).
-
(2000)
Nature Genet.
, vol.26
, pp. 267-268
-
-
Tong, Z.B.1
-
49
-
-
0037144586
-
A novel PAAD-containing protein that modulates NF-κB induction by cytokines TNFα and IL-1β
-
Fiorentino, L. et al. A novel PAAD-containing protein that modulates NF-κB induction by cytokines TNFα and IL-1β. J. Biol. Chem. 277, 35333-35340 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35333-35340
-
-
Fiorentino, L.1
-
50
-
-
0010464874
-
PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-κB and caspase-1-dependent cytokine processing
-
Wang, L. et al. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-κB and caspase-1-dependent cytokine processing. J. Biol. Chem. 277, 29874-29880 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29874-29880
-
-
Wang, L.1
-
51
-
-
0037077283
-
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1
-
Srinivasula, S. M. et al. The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J. Biol. Chem. 277, 21119-21122 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 21119-21122
-
-
Srinivasula, S.M.1
-
52
-
-
0033607768
-
ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells
-
Masumoto, J. et al. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J. Biol. Chem. 274, 33835-33838 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33835-33838
-
-
Masumoto, J.1
-
53
-
-
0035914452
-
Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis
-
Richards, N. et al. Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis. J. Biol. Chem. 276, 39320-39329 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39320-39329
-
-
Richards, N.1
-
54
-
-
0034831010
-
Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues
-
Masumoto, J. et al. Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues. J. Histochem. Cytochem. 49, 1269-1275 (2001).
-
(2001)
J. Histochem. Cytochem.
, vol.49
, pp. 1269-1275
-
-
Masumoto, J.1
-
55
-
-
0036079120
-
ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils
-
Shiohara, M. et al. ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils. Biochem. Biophys. Res. Commun. 293, 1314-1318 (2002).
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.293
, pp. 1314-1318
-
-
Shiohara, M.1
-
56
-
-
0033676843
-
TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers
-
Conway, K. E. et al. TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. Cancer Res. 60, 6236-6242 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 6236-6242
-
-
Conway, K.E.1
-
57
-
-
0026507126
-
A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes
-
Thornberry, N. A. et al. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature 356, 768-774 (1992).
-
(1992)
Nature
, vol.356
, pp. 768-774
-
-
Thornberry, N.A.1
-
58
-
-
0026517239
-
Molecular cloning of the interleukin-1β converting enzyme
-
Cerretti, D. P. et al. Molecular cloning of the interleukin-1β converting enzyme. Science 256, 97-100 (1992).
-
(1992)
Science
, vol.256
, pp. 97-100
-
-
Cerretti, D.P.1
-
59
-
-
0032548919
-
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
-
Wang, S. et al. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92, 501-509 (1998).
-
(1998)
Cell
, vol.92
, pp. 501-509
-
-
Wang, S.1
-
60
-
-
0028984948
-
Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
-
Li, P. et al. Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell 80, 401-411 (1995).
-
(1995)
Cell
, vol.80
, pp. 401-411
-
-
Li, P.1
-
61
-
-
0028920863
-
Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme
-
Kuida, K. et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267, 2000-2003 (1995). References 60 and 61 provide the first genetic evidence for a role of caspase-1 in the processing of IL-1β.
-
(1995)
Science
, vol.267
, pp. 2000-2003
-
-
Kuida, K.1
-
62
-
-
0028970610
-
The interleukin-1β-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy
-
Singer, I.I. et al. The interleukin-1β-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy. J. Exp. Med. 182, 1447-1459 (1995).
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1447-1459
-
-
Singer, I.I.1
-
63
-
-
0035142618
-
Structure-function analysis of the Shigella virulence factor IpaB
-
Guichon, A., Hersh, D., Smith, M. R. & Zychlinsky, A. Structure-function analysis of the Shigella virulence factor IpaB. J. Bacteriol. 183, 1269-1276 (2001).
-
(2001)
J. Bacteriol.
, vol.183
, pp. 1269-1276
-
-
Guichon, A.1
Hersh, D.2
Smith, M.R.3
Zychlinsky, A.4
-
64
-
-
0033515032
-
The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1
-
Hersh, D. et al. The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Proc. Natl. Acad. Sci. USA 96, 2396-2401 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2396-2401
-
-
Hersh, D.1
-
65
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li, P. et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489 (1997).
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
-
66
-
-
0032695108
-
Natural adjuvants: Endogenous activators of dendritic cells
-
Gallucci, S., Lolkema, M. & Matzinger, P. Natural adjuvants: endogenous activators of dendritic cells. Nature Med. 5, 1249-1255 (1999).
-
(1999)
Nature Med.
, vol.5
, pp. 1249-1255
-
-
Gallucci, S.1
Lolkema, M.2
Matzinger, P.3
-
67
-
-
0037036369
-
The endoplesmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway
-
Vabulas, R. M. et al. The endoplesmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J. Biol. Chem. 277, 20847-20853 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 20847-20853
-
-
Vabulas, R.M.1
-
68
-
-
0037066427
-
The danger model: A renewed sense of self
-
Matzinger P. The danger model: a renewed sense of self. Science 296, 301-305 (2002).
-
(2002)
Science
, vol.296
, pp. 301-305
-
-
Matzinger, P.1
-
69
-
-
0023188695
-
The endogenous mediator of endotoxic shock
-
Beutler, B. & Cerami, A. The endogenous mediator of endotoxic shock. Clin. Res. 35, 192-197 (1987).
-
(1987)
Clin. Res.
, vol.35
, pp. 192-197
-
-
Beutler, B.1
Cerami, A.2
-
70
-
-
0034743434
-
Regulation of IL-1β generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins
-
Druilhe, A., Srinivasula, S. M., Razmara, M., Ahmad, M. & Alnemri, E. S. Regulation of IL-1β generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Cell Death Differ. 8, 649-657 (2001).
-
(2001)
Cell Death Differ.
, vol.8
, pp. 649-657
-
-
Druilhe, A.1
Srinivasula, S.M.2
Razmara, M.3
Ahmad, M.4
Alnemri, E.S.5
-
72
-
-
0033568456
-
Caspase-1 (interleukin-1β-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9
-
Annand, R. R. et al. Caspase-1 (interleukin-1β-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9. Biochem. J. 342, 655-665 (1999).
-
(1999)
Biochem. J.
, vol.342
, pp. 655-665
-
-
Annand, R.R.1
-
73
-
-
0037174880
-
Modulators of inflammation use NF-κB and AP-1 sites to induce the caspase-1 and granzyme B inhibttor, proteinase inhibitor 9
-
Kannan-Thulasiraman, P. & Shapiro, D. J. Modulators of inflammation use NF-κB and AP-1 sites to induce the caspase-1 and granzyme B inhibttor, proteinase inhibitor 9. J. Biol. Chem. 277, 41230-41239 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 41230-41239
-
-
Kannan-Thulasiraman, P.1
Shapiro, D.J.2
-
74
-
-
0036302235
-
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS 1, a gene highly expressed in polymorphonuclear cells and chondrocytes
-
Feldmann, J. et al. Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am. J. Hum. Genet. 71, 198-203 (2002).
-
(2002)
Am. J. Hum. Genet.
, vol.71
, pp. 198-203
-
-
Feldmann, J.1
-
75
-
-
18344385660
-
New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: A novel mutation underlies both syndromes
-
Dode, C. et al. New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes. Am. J. Hum. Genet. 70, 1498-1506 (2002).
-
(2002)
Am. J. Hum. Genet.
, vol.70
, pp. 1498-1506
-
-
Dode, C.1
-
76
-
-
0034802261
-
Hereditary periodic fever syndromes
-
McDermott, M. F. & Frenkel, J. Hereditary periodic fever syndromes. Neth. J. Med. 59, 118-125 (2001).
-
(2001)
Neth. J. Med.
, vol.59
, pp. 118-125
-
-
McDermott, M.F.1
Frenkel, J.2
-
77
-
-
16944365196
-
A candidate gene for familial Mediterranean fever. The French FMF Consortium
-
French FMF Consortium. A candidate gene for familial Mediterranean fever. The French FMF Consortium. Nature Genet. 17, 25-31 (1997).
-
(1997)
Nature Genet.
, vol.17
, pp. 25-31
-
-
-
78
-
-
0030745449
-
Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever
-
International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90, 797-807 (1997).
-
(1997)
Cell
, vol.90
, pp. 797-807
-
-
-
79
-
-
0033358561
-
Genetic linkage of the Muckle-Wells syndrome to chromosome 1q44
-
Cuisset, L. et al. Genetic linkage of the Muckle-Wells syndrome to chromosome 1q44. Am. J. Hum. Genet. 65, 1054-1059 (1999).
-
(1999)
Am. J. Hum. Genet.
, vol.65
, pp. 1054-1059
-
-
Cuisset, L.1
-
80
-
-
0033696045
-
An autosomal dominant periodic fever associated with AA amyloidosis in a north Indian family maps to distal chromosome 1q
-
McDermott, M. F. et al. An autosomal dominant periodic fever associated with AA amyloidosis in a north Indian family maps to distal chromosome 1q. Arthritis Rheum. 43, 2034-2040 (2000).
-
(2000)
Arthritis Rheum.
, vol.43
, pp. 2034-2040
-
-
McDermott, M.F.1
-
81
-
-
0033940611
-
Identification of a locus on chromosome 1q44 for familial cold urticaria
-
Hoffman, H. M., Wright, F. A., Broide, D. H., Wanderer, A. A. & Kolodner, R. D. Identification of a locus on chromosome 1q44 for familial cold urticaria. Am. J. Hum. Genet. 66, 1693-1698 (2000). First evidence for an association of NAbP3/Cryopyrin variants with Muckle-Wells syndrome.
-
(2000)
Am. J. Hum. Genet.
, vol.66
, pp. 1693-1698
-
-
Hoffman, H.M.1
Wright, F.A.2
Broide, D.H.3
Wanderer, A.A.4
Kolodner, R.D.5
-
82
-
-
0035098521
-
A recently recognised chronic inflammatory disease of early onset characterised by the triad of rash, central nervous system involvement and arthropathy
-
Prieur, A. M. A recently recognised chronic inflammatory disease of early onset characterised by the triad of rash, central nervous system involvement and arthropathy. Clin. Exp. Rheumatol. 19, 103-106 (2001)
-
(2001)
Clin. Exp. Rheumatol.
, vol.19
, pp. 103-106
-
-
Prieur, A.M.1
-
83
-
-
0027275490
-
A novel domain within the 55kd TNF receptor signals cell death
-
Tartaglia, L. A., Ayres, T. M., Wong, G. H. & Goeddel, D. V. A novel domain within the 55kd TNF receptor signals cell death. Cell 74, 845-853 (1993).
-
(1993)
Cell
, vol.74
, pp. 845-853
-
-
Tartaglia, L.A.1
Ayres, T.M.2
Wong, G.H.3
Goeddel, D.V.4
-
84
-
-
0027281373
-
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen
-
Itoh, N. & Nagata, S. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J. Biol. Chem. 268, 10932-10937 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 10932-10937
-
-
Itoh, N.1
Nagata, S.2
-
85
-
-
0029965280
-
FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
-
Chinnaiyan, A. M. et al. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J. Biol. Chem. 271, 4961-4965 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4961-4965
-
-
Chinnaiyan, A.M.1
-
86
-
-
0030954209
-
The CARD domain: A new apoptotic signalling motif
-
Hofmann, K., Bucher, P. & Tschopp, J. The CARD domain: a new apoptotic signalling motif. Trends Biochem. Sci. 22, 155-156 (1997).
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 155-156
-
-
Hofmann, K.1
Bucher, P.2
Tschopp, J.3
-
87
-
-
0034520137
-
The PYRIN domain: A novel motif found in apoptosis and inflammation proteins
-
Bertin, J. & DiStefano, P. S. The PYRIN domain: a novel motif found in apoptosis and inflammation proteins. Cell Death Differ. 7, 1273-1274 (2000).
-
(2000)
Cell Death Differ.
, vol.7
, pp. 1273-1274
-
-
Bertin, J.1
DiStefano, P.S.2
-
88
-
-
0035253022
-
The DAPIN family: A novel domain links apoptotic and interferon response proteins
-
Staub, E., Dahl, E. & Rosenthal, A. The DAPIN family: a novel domain links apoptotic and interferon response proteins. Trends Biochem. Sci. 26, 83-85 (2001).
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 83-85
-
-
Staub, E.1
Dahl, E.2
Rosenthal, A.3
-
89
-
-
0032809592
-
Transcription and growth regulatory functions of the HIN-200 family of proteins
-
Johnstone, R. W. & Trapani, J. A. Transcription and growth regulatory functions of the HIN-200 family of proteins. Mol. Cell. Biol. 19, 5833-5838 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5833-5838
-
-
Johnstone, R.W.1
Trapani, J.A.2
-
90
-
-
0036101735
-
A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development
-
Tong, Z. B., Bondy, C. A., Zhou, J. & Nelson, L. M. A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development. Hum. Reprod. 17, 903-911 (2002).
-
(2002)
Hum. Reprod.
, vol.17
, pp. 903-911
-
-
Tong, Z.B.1
Bondy, C.A.2
Zhou, J.3
Nelson, L.M.4
-
91
-
-
18644368579
-
Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-κB and caspase-1
-
Grenier, J. M. et al. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-κB and caspase-1. FEBS Lett. 580, 73-78 (2002).
-
(2002)
FEBS Lett.
, vol.580
, pp. 73-78
-
-
Grenier, J.M.1
-
92
-
-
0032127922
-
Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein)
-
Yaraghi, Z., Korneluk, R. G. & MacKenzie, A. Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein). Genomics 51, 107-113 (1998).
-
(1998)
Genomics
, vol.51
, pp. 107-113
-
-
Yaraghi, Z.1
Korneluk, R.G.2
MacKenzie, A.3
-
93
-
-
0035064073
-
The bare lymphocyte syndrome and the regulation of MHC expression
-
Reith, W. & Mach, B. The bare lymphocyte syndrome and the regulation of MHC expression. Annu. Rev. Immunol. 19, 331-373 (2001).
-
(2001)
Annu. Rev. Immunol.
, vol.19
, pp. 331-373
-
-
Reith, W.1
Mach, B.2
-
94
-
-
0034658465
-
The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators
-
Centola, M. et al. The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators. Blood 95, 3223-3231 (2000).
-
(2000)
Blood
, vol.95
, pp. 3223-3231
-
-
Centola, M.1
|