Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25- lymphocytes

Critical Care Medicine

Volumn 32, Issue 11, 2004, Pages 2329-2331

  Venet, Fabienne ^a   Pachot, Alexandre ^b   Debard, Anne Lise ^a   Bohé, Julien ^a   Bienvenu, Jacques ^a   Lepape, Alain ^a   Monneret, Guillaume ^a  

^a CENTRE HOSPITALIER LYON SUD   (France)

^b BIOMÉRIEUX   (France)

Author keywords

CD4+CD25+; Foxp3; Immunosuppression; Regulatory T cells; Sepsis; Septic shock

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR; MESSENGER RNA;

ADULT; AGED; APOPTOSIS; ARTICLE; BLOOD DISEASE; CELL LINEAGE; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HEART FAILURE; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEPTIC SHOCK; T LYMPHOCYTE; UNIVERSITY HOSPITAL;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; APACHE; APOPTOSIS; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; DNA-BINDING PROTEINS; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SHOCK, SEPTIC; STATISTICS, NONPARAMETRIC; T-LYMPHOCYTES, REGULATORY; TIME FACTORS;

EID: 8544236263     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000145999.42971.4B     Document Type: Article

References (15)

1. Hotchkiss RS, Karl EI: The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348:138-150
2. Munford RS, Pugin J: Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am J Respir Crit Care Med 2001; 163:316-321
3. Monneret G, Debard AL, Venet F, et al: Marked elevation of circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis. Crit Care Med 2003; 31:2068-2071
4. Gavin M, Rudensky A: Control of immune homeostasis by naturally arising regulatory CD4+ T cells. Curr Opin Immunol 2003; 15:690-696
5. Mittrücker HV, Kaufmann S: Regulatory T cells and infections: Suppression revisited. Eur J Immunol 2004; 34:306-312
6. Ramsdell F: Foxp3 and natural regulatory T cells: Key to a cell lineage? Immunity 2003; 19:165-168
7. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101:1644-1655
8. Le Gall JR, Lemeshow S, Saulnier F: A new Simplified Acute Physiology Score [SAPS II] based on a European/North American multicenter study. JAMA 1993; 270:2957-2963
9. Sotiriou C, Powles TJ, Dowsett M, et al: Gene expression profiles derived from fine needle aspiration correlate with response to systemic chemotherapy in breast cancer. Breast Cancer Res 2002; 4:R3
10. Sasada T, Kimura M, Yoshida Y, et al: CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies. Cancer 2003; 98:1089-1099
11. Le Tulzo Y, Pangault C, Amiot L, et al: Monocyte human leukocyte antigen-DR transcriptional downregulation by cortisol during septic shock. Am J Respir Crit Care Med 2004; 169:1144-1151
12. Pachot A, Monneret G, Mougin B, et al: Time-related transcriptional signature of survivor and non-survivor septic shock patients. Abstr. Shock 2003; 21:105
13. Bone RC, Grodzin CJ, Balk RA: Sepsis: A new hypothesis for pathogenesis of the disease process. Chest 1997; 112:235-243
14. Chen X, Murakami T, Oppenheim JJ, et al: Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death. Eur J Immunol 2004; 34:859-869
15. Banz A, Pontoux C, Papiernik M: Modulation of Fas-dependent apoptosis: A dynamic process controlling both the persistence and death of regulatory T cells and effector T cells. J Immunol 2002; 169:750-757