Potential role of poly(adenosine 5′-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock

Critical Care Medicine

Volumn 34, Issue 4, 2006, Pages 1073-1079

  Soriano, Francisco G ^a   Nogueira, Antonio C ^a   Caldini, Elia G ^a   Lins, Marcelo H ^a   Teixeira, Ana C ^a   Cappi, Sylas B ^a   Lotufo, Paulo A ^a   Bernik, Márcia M S ^a   Zsengellér, Zsuzsanna ^b   Chen, Min ^b   Szabó, Csaba ^b,c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b INOTEK CORPORATION   (United States)

^c SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

Heart dysfunction; Oxidative and nitrosative stress; Peroxynitrite; Poly(ADP ribose) polymerase; Sepsis

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; EOSIN; HEMATOXYLIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TROPONIN; TROPONIN I;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; DENSITOMETRY; DISEASE ASSOCIATION; DISEASE MARKER; DISEASE SEVERITY; ELECTRON MICROSCOPY; ENZYME ACTIVATION; FOLLOW UP; HEART INDEX; HEART INJURY; HEART LEFT VENTRICLE CONTRACTILITY; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE NECROSIS; HEART STROKE VOLUME; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTENSIVE CARE UNIT; MYOCARDIAL CONTRACTILE DYSFUNCTION; MYOCARDIAL DISEASE; PATIENT INFORMATION; PATIENT SELECTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SAMPLE SIZE; SEPSIS; SEPTIC SHOCK; SURGICAL PATIENT; SURVIVAL RATE; SYSTOLE; TISSUE SECTION; UNIVERSITY HOSPITAL;

CARDIOMYOPATHIES; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; POLY(ADP-RIBOSE) POLYMERASES; PROSPECTIVE STUDIES; SHOCK, SEPTIC;

EID: 33645805025     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000206470.47721.8D     Document Type: Article

References (36)

1. Thijs LG, Groeneveld AB, Hack CE: Multiple organ failure in septic shock. Curr Top Microbiol Immunol 1996; 216:209-237
2. Garcia Soriano F, Liaudet L, Marton A, et al: Inosine improves gut permeability and vascular reactivity in endotoxic shock. Crit Care Med 2001; 29:703-708
3. Liaudet L, Soriano FG, Szabo C: Biology of nitric oxide signaling. Crit Care Med 2000; 28:N37-N52
4. Portoles MT, Catala M, Anton A, et al: Hepatic response to the oxidative stress induced by E. coli endotoxin: Glutathione as an index of the acute phase during the endotoxic shock. Mol Cell Biochem 1996; 159:115-121
5. Bautista AP, Meszaros K, Bojta J, et al: Superoxide anion generation in the liver during the early stage of endotoxemia in rats. J Leukoc Biol 1990; 48:123-128
6. Sewerynek E, Reiter RJ, Melchiorri D, et al: Oxidative damage in the liver induced by ischemia-reperfusion: Protection by melatonin. Hepatogastroenterology 1996; 43:898-905
7. Xiao CY, Chen M, Zsengeller Z, et al: Poly-(ADP-ribose) polymerase promotes cardiac remodeling, contractile failure and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure. J Pharmacol Exp Ther 2005; 312:891-898
8. Muller-Werdan U, Schumann H, Fuchs R, et al: Tumor necrosis factor alpha (tumor necrosis factor alpha) is cardiodepressant in pathophysiologically relevant concentrations without inducing inducible nitric oxide-(NO)-synthase (iNOS) or triggering serious cytotoxicity. J Mol Cell Cardiol 1997; 29:2915-2923
9. Parrillo JE, Parker MM, Natanson C, et al: Septic shock in humans: Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med 1990; 113:227-242
10. Scirica BM, Morrow DA: Troponins in acute coronary syndromes. Semin Vasc Med 2003; 3:363-374
11. Parker MM, Shelhamer JH, Natanson C, et al: Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: Heart rate as an early predictor of prognosis. Crit Care Med 1987; 15:923-929
12. Roch A, Allardet-Servent J, Michelet P, et al: NH2 terminal pro-brain natriuretic peptide plasma level as an early marker of prognosis and cardiac dysfunction in septic shock patients. Crit Care Med 2005; 33:1001-1007
13. Parrillo JE, Burch C, Shelhamer JH, et al: A circulating myocardial depressant substance in humans with septic shock: Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. J Clin Invest 1985; 76:1539-1553
14. Guest TM, Ramanathan AV, Tuteur PG, et al: Myocardial injury in critically ill patients: A frequently unrecognized complication. JAMA 1995; 273:1945-1949
15. Suzuki T, Morisaki H, Serita R, et al: Infusion of the beta-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rats. Crit Care Med 2005; 33:2294-2301
16. Turner A, Tsamitros M, Bellomo R: Myocardial cell injury in septic shock. Crit Care Med 1999; 27:1775-1780
17. Kroner A, Seitelberger R, Schirnhofer J, et al: Diltiazem during reperfusion preserves high energy phosphates by protection of mitochondrial integrity. Eur J Cardiothorac Surg 2002; 21:224-231
18. Lancel S, Petillot P, Favory R, et al: Expression of apoptosis regulatory factors during myocardial dysfunction in endotoxemic rats. Crit Care Med 2005; 33:492-496
19. Quezado ZN, Keiser HR, Parker MM: Reversible myocardial depression after massive catecholamine release from a pheochromocytoma. Crit Care Med 1992; 20:549-551
20. Szabo G, Liaudet L, Hagl S, et al: Poly(ADP-ribose) polymerase activation in the reperfused myocardium. Cardiovasc Res 2004; 61:471-480
21. Ben-Shaul V, Lomnitski L, Nyska A, et al: The effect of natural antioxidants, NAO and apocynin, on oxidative stress in the rat heart following LPS challenge. Toxicol Lett 2001; 123:1-10
22. Mungrue IN, Gros R, You X, et al: Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. J Clin Invest 2002; 09:735-743
23. Goldfarb RD, Marton A, Szabo E, et al: Protective effect of a novel, potent inhibitor of poly(adenosine 5′-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis. Crit Care Med 2002; 30:974-980
24. Salvemini D, Cuzzocrea S: Oxidative stress in septic shock and disseminated intravascular coagulation. Free Radic Biol Med 2002; 33:1173-1185
25. Mihm MJ, Coyle CM, Schanbacher BL, et al: Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure. Cardiovasc Res 2001; 49:798-807
26. Liaudet L, Szabo C, Evgenov OV, et al: Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis. Shock 2003; 19:131-137
27. Liaudet L, Murthy KG, Mabley JG, et al: Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide. Infect Immun 2002; 70:192-198
28. Boulos M, Astiz ME, Barua RS, et al: Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase. Crit Care Med 2003; 31:353-358
29. Szabo C, Zingarelli B, Salzman AL: Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ Res 1996; 78:1051-1063
30. Szabo A, Salzman AL, Szabo C: Poly (ADP-ribose) synthetase activation mediates pulmonary microvascular and intestinal mucosal dysfunction in endotoxin shock. Life Sci 1998; 63:2133-2139
31. Veres B, Gallyas F Jr, Varbiro G, et al: Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock. Biochem Pharmacol 2003; 65:1373-1382
32. Pacher P, Cziraki A, Mabley JG, et al: Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents. Biochem Pharmacol 2002; 64:1785-1791
33. Ivanyi Z, Hauser B, Pittner A, et al: Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia. Shock 2003; 19:415-421
34. Murakami K, Enkhbaatar P, Shimoda K, et al: Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. Shock 2004; 21:126-133
35. Southan GJ, Szabo C: Poly(ADP-ribose) polymerase inhibitors. Curr Med Chem 2003; 10:321-340
36. Peukert S, Schwann U: New inhibitors of poly(ADP-ribose) polymerase. Expert Op Therap Patents 2004; 15:1531-1551