-
1
-
-
33750288937
-
Apoptosis and caspases regulate death and inflammation in sepsis
-
Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 2006; 6:813-822.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 813-822
-
-
Hotchkiss, R.S.1
Nicholson, D.W.2
-
2
-
-
33846120985
-
Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa
-
Gastrointest Liver Physiol, This study describes the microbial virulence strategy in hypoxic conditions
-
Patel NJ, Zaborina O, Wu L, et al. Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol 2007; 292:G134-G142. This study describes the microbial virulence strategy in hypoxic conditions.
-
(2007)
Am J Physiol
, vol.292
-
-
Patel, N.J.1
Zaborina, O.2
Wu, L.3
-
3
-
-
33745847180
-
TLRs, NLRs and RLRs: A trinity of pathogen sensors that co-operate in innate immunity
-
Creagh EM, O'Neill LA. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 2006; 27:352-357.
-
(2006)
Trends Immunol
, vol.27
, pp. 352-357
-
-
Creagh, E.M.1
O'Neill, L.A.2
-
4
-
-
33748308787
-
Toll-like receptors and innate immunity
-
Uematsu S, Akira S. Toll-like receptors and innate immunity. J Mol Med 2007; 84:712-725.
-
(2007)
J Mol Med
, vol.84
, pp. 712-725
-
-
Uematsu, S.1
Akira, S.2
-
5
-
-
20644450804
-
Negative regulation of toll-like receptor-mediated immune responses
-
Liew FY, Xu D, Brint EK, O'Neill LA. Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 2005; 5:446-458.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 446-458
-
-
Liew, F.Y.1
Xu, D.2
Brint, E.K.3
O'Neill, L.A.4
-
7
-
-
33845697586
-
Effects of combining inducible nitric oxide synthase inhibitor and radical scavenger during porcine bacteremia
-
Matejovic M, Krouzecky A, Rokyta R Jr, et al. Effects of combining inducible nitric oxide synthase inhibitor and radical scavenger during porcine bacteremia. Shock 2007; 27:61-68.
-
(2007)
Shock
, vol.27
, pp. 61-68
-
-
Matejovic, M.1
Krouzecky, A.2
Rokyta Jr, R.3
-
8
-
-
0036417213
-
The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis
-
Cinel I, Buyukafsar K, Cinel L, et al. The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis. Pharmacol Res 2002; 46:119-127.
-
(2002)
Pharmacol Res
, vol.46
, pp. 119-127
-
-
Cinel, I.1
Buyukafsar, K.2
Cinel, L.3
-
9
-
-
0035431101
-
Poly(ADP-ribose) synthetase inhibition reduces bacterial translocation in rats after endotoxin challenge
-
Taner S, Cinel I, Ozer L, et al. Poly(ADP-ribose) synthetase inhibition reduces bacterial translocation in rats after endotoxin challenge. Shock 2001; 16:159-162.
-
(2001)
Shock
, vol.16
, pp. 159-162
-
-
Taner, S.1
Cinel, I.2
Ozer, L.3
-
10
-
-
33645805025
-
Potential role of poly(adenosine 5′-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock
-
Soriano FG, Nogueira AC, Caldini EG, et al. Potential role of poly(adenosine 5′-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock. Crit Care Med 2006; 34:1073-1079.
-
(2006)
Crit Care Med
, vol.34
, pp. 1073-1079
-
-
Soriano, F.G.1
Nogueira, A.C.2
Caldini, E.G.3
-
11
-
-
12544252469
-
The effect of preventive use of alanylglutamine on diaphragm muscle function in cecal ligation and puncture-induced sepsis model
-
Doruk N, Buyukakilli B, Cinel I, et al. The effect of preventive use of alanylglutamine on diaphragm muscle function in cecal ligation and puncture-induced sepsis model. J Parenter Enteral Nutr 2005; 29:36-43.
-
(2005)
J Parenter Enteral Nutr
, vol.29
, pp. 36-43
-
-
Doruk, N.1
Buyukakilli, B.2
Cinel, I.3
-
13
-
-
0037508533
-
Inflammation and coagulation: Implications for the septic patients
-
Dellinger RP. Inflammation and coagulation: implications for the septic patients. Clin Infect Dis 2003; 36:1259-1265.
-
(2003)
Clin Infect Dis
, vol.36
, pp. 1259-1265
-
-
Dellinger, R.P.1
-
14
-
-
34247550884
-
Protein C concentrations in severe sepsis: An early directional change in plasma levels predicts outcome
-
Shorr AF, Bernard GR, Dhainaut JF, et al. Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome. Crit Care 2006; 10:R92-R100.
-
(2006)
Crit Care
, vol.10
-
-
Shorr, A.F.1
Bernard, G.R.2
Dhainaut, J.F.3
-
15
-
-
0030896981
-
The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection
-
Aupeix K, Hugel B, Martin T, et al. The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection. J Clin Invest 1997; 99:1546-1554.
-
(1997)
J Clin Invest
, vol.99
, pp. 1546-1554
-
-
Aupeix, K.1
Hugel, B.2
Martin, T.3
-
16
-
-
2442661930
-
Endothelial microparticles as markers of endothelial dysfunction
-
Horstman LL, Jy W, Jimenez JJ, Ahn YS. Endothelial microparticles as markers of endothelial dysfunction. Front Biosci 2004; 9:1118-1135.
-
(2004)
Front Biosci
, vol.9
, pp. 1118-1135
-
-
Horstman, L.L.1
Jy, W.2
Jimenez, J.J.3
Ahn, Y.S.4
-
18
-
-
33845872563
-
-
Trzeciak S, Dellinger RP, Parrillo JE, et al., Microcirculatory Alterations in Resuscitation and Shock Investigators. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 2007; 49:88-98. This was a study of the early microcirculatory perfusion derangements in patients with severe sepsis/septic shock and the microcirculation difference between survivors and nonsurvivors.
-
Trzeciak S, Dellinger RP, Parrillo JE, et al., Microcirculatory Alterations in Resuscitation and Shock Investigators. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 2007; 49:88-98. This was a study of the early microcirculatory perfusion derangements in patients with severe sepsis/septic shock and the microcirculation difference between survivors and nonsurvivors.
-
-
-
-
19
-
-
0036119842
-
Activated polymorphonuclear leukocytes enhance production of leukocyte microparticles with increased adhesion molecules in patients with sepsis
-
Fujimi S, Ogura H, Tanaka H, et al. Activated polymorphonuclear leukocytes enhance production of leukocyte microparticles with increased adhesion molecules in patients with sepsis. J Trauma 2002; 52:443-448.
-
(2002)
J Trauma
, vol.52
, pp. 443-448
-
-
Fujimi, S.1
Ogura, H.2
Tanaka, H.3
-
20
-
-
27944507708
-
Levels of endothelial and platelet microparticles and their interactions with leukocytes negatively correlate with organ dysfunction and predict mortality in severe sepsis
-
Soriano AO, Jy W, Chirinos JA, et al. Levels of endothelial and platelet microparticles and their interactions with leukocytes negatively correlate with organ dysfunction and predict mortality in severe sepsis. Crit Care Med 2005; 33:2540-2546.
-
(2005)
Crit Care Med
, vol.33
, pp. 2540-2546
-
-
Soriano, A.O.1
Jy, W.2
Chirinos, J.A.3
-
21
-
-
34249083324
-
Mechanisms of critical illness - classifying microcirculatory flow abnormalities in distributive shock
-
Elbers PE, Ince C. Mechanisms of critical illness - classifying microcirculatory flow abnormalities in distributive shock. Crit Care 2006; 10:221-228.
-
(2006)
Crit Care
, vol.10
, pp. 221-228
-
-
Elbers, P.E.1
Ince, C.2
-
22
-
-
0027255030
-
Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock
-
Kreymann G, Grosser S, Buggisch P, et al. Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock. Crit Care Med 1993; 21:1012-1019.
-
(1993)
Crit Care Med
, vol.21
, pp. 1012-1019
-
-
Kreymann, G.1
Grosser, S.2
Buggisch, P.3
-
23
-
-
0032770246
-
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
-
Hotchkiss RS, Swanson PE, Freeman BD, et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999; 27:1230-1251.
-
(1999)
Crit Care Med
, vol.27
, pp. 1230-1251
-
-
Hotchkiss, R.S.1
Swanson, P.E.2
Freeman, B.D.3
-
24
-
-
33745685397
-
Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality
-
Recent publication showing the role of mitochondrial permeability transition in sepsis-induced organ dysfunction
-
Larche J, Lancel S, Hassoun SM, et al. Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality. J Am Coll Cardiol 2006; 48:377-385. Recent publication showing the role of mitochondrial permeability transition in sepsis-induced organ dysfunction.
-
(2006)
J Am Coll Cardiol
, vol.48
, pp. 377-385
-
-
Larche, J.1
Lancel, S.2
Hassoun, S.M.3
-
25
-
-
0037142987
-
Association between mitochondrial dysfunction and severity and outcome of septic shock
-
Brealey D, Brand M, Hargreaves I, et al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002; 360:219-223.
-
(2002)
Lancet
, vol.360
, pp. 219-223
-
-
Brealey, D.1
Brand, M.2
Hargreaves, I.3
-
26
-
-
33847401104
-
Multiple triggers of cell death in sepsis: Death receptor and mitochondrial-mediated apoptosis
-
Chang KC, Unsinger J, Davis CG, et al. Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J 2007; 21:708-719.
-
(2007)
FASEB J
, vol.21
, pp. 708-719
-
-
Chang, K.C.1
Unsinger, J.2
Davis, C.G.3
-
27
-
-
14844343217
-
Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure
-
Felmet KA, Hall MW, Clark RS, et al. Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure. J Immunol 2005; 174:3765-3772.
-
(2005)
J Immunol
, vol.174
, pp. 3765-3772
-
-
Felmet, K.A.1
Hall, M.W.2
Clark, R.S.3
-
28
-
-
85047692486
-
Spleen depletion in neonatal sepsis and chorioamnionitis
-
Toti P, De Felice C, Occhini R, et al. Spleen depletion in neonatal sepsis and chorioamnionitis. Am J Clin Pathol 2004; 122:765-771.
-
(2004)
Am J Clin Pathol
, vol.122
, pp. 765-771
-
-
Toti, P.1
De Felice, C.2
Occhini, R.3
-
29
-
-
17044413706
-
Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways
-
Hotchkiss RS, Osmon SB, Chang KC, et al. Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J Immunol 2005; 174:5110-5118.
-
(2005)
J Immunol
, vol.174
, pp. 5110-5118
-
-
Hotchkiss, R.S.1
Osmon, S.B.2
Chang, K.C.3
-
30
-
-
0038113408
-
The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model
-
Ozdulger A, Cinel I, Koksel O, et al. The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model. Shock 2003; 19:366-372.
-
(2003)
Shock
, vol.19
, pp. 366-372
-
-
Ozdulger, A.1
Cinel, I.2
Koksel, O.3
-
31
-
-
6444244641
-
Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome
-
Le Tulzo Y, Pangault C, Gacouin A, et al. Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome. Shock 2002; 18:487-494.
-
(2002)
Shock
, vol.18
, pp. 487-494
-
-
Le Tulzo, Y.1
Pangault, C.2
Gacouin, A.3
-
32
-
-
33846292157
-
Decrease in circulating dendritic cells predicts fatal outcome in septic shock
-
This recent study demonstrates the importance of blood dendritic cell count for the assessment of the severity of the host response against infection in septic shock patients
-
Guisset O, Dilhuydy MS, Thiebaut R, et al. Decrease in circulating dendritic cells predicts fatal outcome in septic shock. Intensive Care Med 2007; 33:148-152. This recent study demonstrates the importance of blood dendritic cell count for the assessment of the severity of the host response against infection in septic shock patients.
-
(2007)
Intensive Care Med
, vol.33
, pp. 148-152
-
-
Guisset, O.1
Dilhuydy, M.S.2
Thiebaut, R.3
-
33
-
-
3242775982
-
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
-
Dellinger RP, Carlet JM, Masur H, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32:858-873.
-
(2004)
Crit Care Med
, vol.32
, pp. 858-873
-
-
Dellinger, R.P.1
Carlet, J.M.2
Masur, H.3
-
34
-
-
33748422918
-
Current treatment of severe sepsis
-
The authors recommended evidence-based protocolized care in the treatment of severe sepsis and septic shock
-
Cinel I, Dellinger RP. Current treatment of severe sepsis. Curr Infect Dis Rep 2006; 8:358-365. The authors recommended evidence-based protocolized care in the treatment of severe sepsis and septic shock.
-
(2006)
Curr Infect Dis Rep
, vol.8
, pp. 358-365
-
-
Cinel, I.1
Dellinger, R.P.2
-
35
-
-
4043110513
-
Lactate metabolism - a new paradigm for the third millennium
-
Gladden LB. Lactate metabolism - a new paradigm for the third millennium. J Physiol 2004; 558:5-30.
-
(2004)
J Physiol
, vol.558
, pp. 5-30
-
-
Gladden, L.B.1
-
36
-
-
14744301896
-
+ATPase activity and raised lactate concentrations in septic shock: A prospective study
-
+ATPase activity and raised lactate concentrations in septic shock: a prospective study. Lancet 2005; 365:871-875.
-
(2005)
Lancet
, vol.365
, pp. 871-875
-
-
Levy, B.1
Gibot, S.2
Franck, P.3
-
37
-
-
26444464969
-
Lactate and glucose metabolism in severe sepsis and septic shock
-
Revelly JP, Tappy L, Martinez A, et al. Lactate and glucose metabolism in severe sepsis and septic shock. Crit Care Med 2005; 33:2235-2240.
-
(2005)
Crit Care Med
, vol.33
, pp. 2235-2240
-
-
Revelly, J.P.1
Tappy, L.2
Martinez, A.3
-
38
-
-
33747621364
-
C-reactive protein concentrations during bacteraemia: A comparison between patients with and without liver dysfunction
-
Mackenzie I, Woodhouse J. C-reactive protein concentrations during bacteraemia: A comparison between patients with and without liver dysfunction. Intensive Care Med 2006; 32:1344-1351.
-
(2006)
Intensive Care Med
, vol.32
, pp. 1344-1351
-
-
Mackenzie, I.1
Woodhouse, J.2
-
39
-
-
33745622134
-
-
Uzzan B, Cohen R, Nicolas P, et al. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med 2006; 34:1996-2003. A meta-analysis of 32 published studies, summarizing the current knowledge on procalcitonin as a biological diagnostic marker for sepsis, severe sepsis or septic shock.
-
Uzzan B, Cohen R, Nicolas P, et al. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med 2006; 34:1996-2003. A meta-analysis of 32 published studies, summarizing the current knowledge on procalcitonin as a biological diagnostic marker for sepsis, severe sepsis or septic shock.
-
-
-
-
40
-
-
1342265610
-
Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: Cluster-randomised, single-blinded intervention trial
-
Christ-Crain M, Jaccard-Stolz D, Bingisser R, et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial. Lancet 2004; 363:600-607.
-
(2004)
Lancet
, vol.363
, pp. 600-607
-
-
Christ-Crain, M.1
Jaccard-Stolz, D.2
Bingisser, R.3
-
41
-
-
11144234176
-
Procalcitonin kinetics as a prognostic marker of ventilator-associated pneumonia
-
Luyt CE, Guerin V, Combes A, et al. Procalcitonin kinetics as a prognostic marker of ventilator-associated pneumonia. Am J Respir Crit Care Med 2005; 171:48-53.
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 48-53
-
-
Luyt, C.E.1
Guerin, V.2
Combes, A.3
-
42
-
-
33748782250
-
Procalcitonin increase in early identi-fication of critically ill patients at high risk of mortality
-
Jensen JU, Heslet L, Jensen TH, et al. Procalcitonin increase in early identi-fication of critically ill patients at high risk of mortality. Crit Care Med 2006; 34:2596-2602.
-
(2006)
Crit Care Med
, vol.34
, pp. 2596-2602
-
-
Jensen, J.U.1
Heslet, L.2
Jensen, T.H.3
-
43
-
-
33744527833
-
Duration of hypotension prior to initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
-
This is an investigation showing the importance of early intravenous antibiotic therapy in sepsis
-
Kumar A, Roberts D, Wood KE, et al. Duration of hypotension prior to initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34:1589-1596. This is an investigation showing the importance of early intravenous antibiotic therapy in sepsis.
-
(2006)
Crit Care Med
, vol.34
, pp. 1589-1596
-
-
Kumar, A.1
Roberts, D.2
Wood, K.E.3
-
44
-
-
29844454995
-
Selection of resistance during sequential use of preferential antibiotic classes
-
Damas P, Canivet JL, Ledoux D, et al. Selection of resistance during sequential use of preferential antibiotic classes. Intensive Care Med 2006; 32:67-74.
-
(2006)
Intensive Care Med
, vol.32
, pp. 67-74
-
-
Damas, P.1
Canivet, J.L.2
Ledoux, D.3
-
45
-
-
0035829842
-
Early goal-directed therapy in the treatment of severe sepsis and septic shock
-
Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl JMed 2001; 345:1368-1377.
-
(2001)
N Engl JMed
, vol.345
, pp. 1368-1377
-
-
Rivers, E.1
Nguyen, B.2
Havstad, S.3
-
46
-
-
31744440688
-
Sepsis Occurrence in Acutely Ill Patients' Investigators. Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study
-
Vincent JL, Sakr Y, Reinhart K, et al., 'Sepsis Occurrence in Acutely Ill Patients' Investigators. Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study. Crit Care 2005; 9:R745-R754.
-
(2005)
Crit Care
, vol.9
-
-
Vincent, J.L.1
Sakr, Y.2
Reinhart, K.3
-
47
-
-
23444461703
-
Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): A randomised controlled trial
-
Harvey S, Harrison DA, Singer M, et al. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. Lancet 2005; 366:472-477.
-
(2005)
Lancet
, vol.366
, pp. 472-477
-
-
Harvey, S.1
Harrison, D.A.2
Singer, M.3
-
48
-
-
33646859471
-
Pulmonary artery versus central venous catheter to guide treatment of acute lung injury
-
Wheeler AP, Bernard GR, Thompson BT, et al. Pulmonary artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med 2006; 354:2213-2224.
-
(2006)
N Engl J Med
, vol.354
, pp. 2213-2224
-
-
Wheeler, A.P.1
Bernard, G.R.2
Thompson, B.T.3
-
49
-
-
23744484147
-
Hemodynamic variables related to outcome in septic shock
-
Varpula M, Tallgren M, Saukkonen K, et al. Hemodynamic variables related to outcome in septic shock. Intensive Care Med 2005; 31:1066-1071.
-
(2005)
Intensive Care Med
, vol.31
, pp. 1066-1071
-
-
Varpula, M.1
Tallgren, M.2
Saukkonen, K.3
-
50
-
-
4143058000
-
Continuous central venous and pulmonary artery oxygen saturation monitoring in the critically ill
-
Reinhart K, Kuhn HJ, Hartog C, Bredle DL. Continuous central venous and pulmonary artery oxygen saturation monitoring in the critically ill. Intensive Care Med 2004; 30:1572-1578.
-
(2004)
Intensive Care Med
, vol.30
, pp. 1572-1578
-
-
Reinhart, K.1
Kuhn, H.J.2
Hartog, C.3
Bredle, D.L.4
-
51
-
-
0034950453
-
Central venous and mixed venous oxygen saturation in critically ill patients
-
Ladakis C, Myrianthefs P, Karabinis A, et al. Central venous and mixed venous oxygen saturation in critically ill patients. Respiration 2001; 68:279-285.
-
(2001)
Respiration
, vol.68
, pp. 279-285
-
-
Ladakis, C.1
Myrianthefs, P.2
Karabinis, A.3
-
52
-
-
84926232888
-
A comparison of albumin and saline for fluid resuscitation in the intensive care unit
-
Finfer S, Bellomo R, Boyce N, et al. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 2004; 350:2247-2256.
-
(2004)
N Engl J Med
, vol.350
, pp. 2247-2256
-
-
Finfer, S.1
Bellomo, R.2
Boyce, N.3
-
53
-
-
34347325784
-
Corticosteroid therapy of septic shock (CORTICUS) [abstract B97]
-
Sprung CL, Annane D, Briegel J, et al. Corticosteroid therapy of septic shock (CORTICUS) [abstract B97]. Am J Respir Crit Care Med 2007; 175:A507.
-
(2007)
Am J Respir Crit Care Med
, vol.175
-
-
Sprung, C.L.1
Annane, D.2
Briegel, J.3
-
54
-
-
0037151571
-
Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
-
Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. J Am Med Assoc 2002; 288:862-871.
-
(2002)
J Am Med Assoc
, vol.288
, pp. 862-871
-
-
Annane, D.1
Sebille, V.2
Charpentier, C.3
-
55
-
-
0035826096
-
Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group: Efficacy and safety of recombinant human activated protein Cfor severe sepsis
-
Bernard GR, Vincent JL, Laterre PF, et al. Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group: efficacy and safety of recombinant human activated protein Cfor severe sepsis. N Engl J Med 2001; 344:699-709.
-
(2001)
N Engl J Med
, vol.344
, pp. 699-709
-
-
Bernard, G.R.1
Vincent, J.L.2
Laterre, P.F.3
-
56
-
-
25444492831
-
Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death
-
Abraham E, Laterre PF, Garg R, et al. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med 2005; 353:1332-1341.
-
(2005)
N Engl J Med
, vol.353
, pp. 1332-1341
-
-
Abraham, E.1
Laterre, P.F.2
Garg, R.3
-
57
-
-
31344447152
-
Recombinant activated protein C: Decisions for administration
-
Dellinger RP. Recombinant activated protein C: decisions for administration. Crit Care Med 2006; 34:530-531.
-
(2006)
Crit Care Med
, vol.34
, pp. 530-531
-
-
Dellinger, R.P.1
-
58
-
-
33847355615
-
Increadsing evidence that the risks of rhAPC may outweigh its benefits
-
Eichacker PQ, Natanson C. Increadsing evidence that the risks of rhAPC may outweigh its benefits. Intensive Care Med 2007; 33:396-399.
-
(2007)
Intensive Care Med
, vol.33
, pp. 396-399
-
-
Eichacker, P.Q.1
Natanson, C.2
-
59
-
-
34247882129
-
Engineering a disulfide bond to stabilize the calcium binding loop of activated protein C eliminates its anticoagulant but not protective signaling properties
-
Recent study which provides activated protein C mutant as an important tool for in-vivo studies to examine the role of anticoagulant versus anti-inflammatory function of activated protein C
-
Bae JS, Yang L, Manithody C, Rezaie AR. Engineering a disulfide bond to stabilize the calcium binding loop of activated protein C eliminates its anticoagulant but not protective signaling properties. J Biol Chem 2007; 282:9251-9259. Recent study which provides activated protein C mutant as an important tool for in-vivo studies to examine the role of anticoagulant versus anti-inflammatory function of activated protein C.
-
(2007)
J Biol Chem
, vol.282
, pp. 9251-9259
-
-
Bae, J.S.1
Yang, L.2
Manithody, C.3
Rezaie, A.R.4
-
60
-
-
33748421260
-
Guidelines for severe infections: Are they useful? Curr Opin
-
Cinel I, Dellinger RP. Guidelines for severe infections: Are they useful? Curr Opin Crit Care Med 2006; 12:483-488.
-
(2006)
Crit Care Med
, vol.12
, pp. 483-488
-
-
Cinel, I.1
Dellinger, R.P.2
-
61
-
-
8444230449
-
Sepsis change bundles: Converting guidelines into meaningful change in behavior and clinical outcome
-
Levy MM, Pronovost PJ, Dellinger RP, et al. Sepsis change bundles: Converting guidelines into meaningful change in behavior and clinical outcome. Crit Care Med 2004; 32:S595-S597.
-
(2004)
Crit Care Med
, vol.32
-
-
Levy, M.M.1
Pronovost, P.J.2
Dellinger, R.P.3
-
62
-
-
34347381519
-
Will sepsis care bundles improve patient outcome?
-
Gao F. Will sepsis care bundles improve patient outcome? Adv Sepsis 2006; 5:94-96.
-
(2006)
Adv Sepsis
, vol.5
, pp. 94-96
-
-
Gao, F.1
-
63
-
-
34347391695
-
Surviving Sepsis Campaign (SSC) performance improvement program: Demonstration of process change [abstract]
-
Schorr C, Trzeciak S, Fakorede F, et al. Surviving Sepsis Campaign (SSC) performance improvement program: demonstration of process change [abstract]. Crit Care Med 2006; 34 (Suppl.):A107.
-
(2006)
Crit Care Med
, vol.34
, Issue.SUPPL.
-
-
Schorr, C.1
Trzeciak, S.2
Fakorede, F.3
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