IL-18 levels and the outcome of innate immune response to lipopolysaccharide: Importance of a positive feedback loop with caspase-1 in IL-18 expression

Journal of Immunology

Volumn 169, Issue 5, 2002, Pages 2536-2544

  Joshi, Vishwas D ^a   Kalvakolanu, Dhananjaya V ^a   Hasday, Jeffrey D ^a   Hebel, Richard J ^a   Cross, Alan S ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA;

ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; GRAM NEGATIVE INFECTION; IMMUNE RESPONSE; IMMUNE SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SURVIVAL RATE;

EID: 0036721805     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.5.2536     Document Type: Article

References (51)

1. A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice
2. Weight loss associated with an endotoxin-induced mediator from peritoneal macrophages: The role of cachectin (tumor necrosis factor)
3. Evidence for IFN-γ as a mediator of the lethality of endotoxin and tumor necrosis factor-α
4. Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-α challenge in mice
5. Endotoxin fails to induce IFN-γ in endotoxin-tolerant mice: Deficiencies in both IL-12 heterodimer production and IL-12 responsiveness
6. Interferon γ receptor deficient mice are resistant to endotoxic shock
7. Mice that lack the interferon-γ receptor have profoundly altered responses to infection with bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide
8. Immunity to intracellular bacteria
9. Anti-interleukin-12 therapy protects mice in lethal endotoxemia but impairs bacterial clearance in murine Escherichia coli peritoneal sepsis
10. Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor α-dependent shock
11. Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia
12. + T cells
13. IL-18 (IFN-γ-inducing factor) regulates early cytokine production in, and promotes resolution of bacterial infection in mice
14. A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on interferon γ production
15. Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice
16. Interleukin-18
17. The regulation and biological activity of interleukin 12
18. IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor
19. IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells
20. Induction of natural killer cell activity and perforin and granzyme B gene expression following continuous culture of short pulse with interleukin-12 in young and old mice
21. Intradermal delivery of IL-12 naked DNA induces systemic NK cell activation and Th1 response in vivo that is independent of endogenous IL-12 production
22. Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12
23. The induction of nitric oxide by interleukin-12 and tumor necrosis factor-α in human natural killer cells: Relationship with the regulation of lytic activity
24. + human blood mononuclear cells
25. Murine macrophages secrete interferon γ upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation
26. The costimulatory effect of IL-18 on the induction of antigen-specific IFN-γ production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor β2 subunit
27. Stimulation of natural immunity to E. coli infection
28. Role of interleukin-18 (IL-18) during lethal shock: Decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice
29. Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme
30. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production
31. Interferon γ induces up-regulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells
32. Interferon regulatory factors regulate interleukin-1β-converting enzyme expression and apoptosis in vascular smooth muscle cells
33. 2 in mouse microglial cells: Involvement of NF-κB pathway in the regulatory processes
34. Role of interferon regulatory factor-1 in the regulation of IL-18 production and activity
35. Cloning of a new cytokine that induces IFN-γ production by T cells
36. An essential role for NF-κB in IL-18-induced IFN-γ expression in KG-1 cells
37. IFN-γ inhibits lipopolysaccharide-induced interleukin-1β in primary murine macrophages via a Stat 1-dependent pathway
38. Interleukin-1β converting enzyme
39. The importance of a lipopolysaccharide-initiated, cytokine-mediated host defense mechanism in mice against extraintestinally invasive Escherichia coli
40. Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-γ
41. Interleukin-18 regulation of interferon γ production and cell proliferation as shown in interleukin-1β-converting enzyme (caspase-1)-deficient mice
42. A synthetic inhibitor of interleukin-1β converting enzyme prevents endotoxin-induced interleukin-1β production in vitro and in vivo
43. Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18
44. IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock
45. Caspase-1 activation of IL-1β and IL-18 are essential for Shigella flexneri-induced inflammation
46. Salmonella-induced cell death: Apoptosis, necrosis or programmed cell death?
47. Pretreatment with recombinant murine tumor necrosis factor α/cachectin and murine interleukin 1α protects mice from lethal bacterial infection
48. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
49. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
50. Expression of murine IL-12 is regulated by translational control of the p35 subunit
51. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit