Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis

Critical Care Medicine

Volumn 31, Issue 7, 2003, Pages 2068-2071

  Monneret, Guillaume ^a   Debard, Anne Lise ^a   Venet, Fabienne ^a   Bohe, Julien ^a   Hequet, Olivier ^a   Bienvenu, Jacques ^a   Lepape, Alain ^a  

^a CENTRE HOSPITALIER LYON SUD   (France)

Author keywords

CD4+CD25+ T cells; Human leukocyte antigen DR; Immunoparalysis; Septic shock; T lymphocytes

Indexed keywords

CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HOSPITAL ADMISSION; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOPARALYSIS; INTENSIVE CARE; LYMPHOCYTE COUNT; MALE; MORTALITY; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; SUPPRESSOR CELL; T LYMPHOCYTE;

EID: 0041365362     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000069345.78884.0F     Document Type: Article

References (12)

1. Kox WJ, Volk T, Kox SN, et al: Immunomodulatory therapies in sepsis. Intensive Care Med 2000; 26:S124-S128
2. Munford RS, Pugin J: Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am J Respir Crit Care Med 2001; 163:316-321
3. Docke WD, Randow F, Syrbe U, et al: Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment. Nat Med 1997; 3:678-681
4. Dieckmann D, Bruett CH, Ploettner H, et al: Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce Interleukin1-producing, contact-independent type 1-like regulatory T cells. J Exp Med 2002; 196:247-253
5. Jonuleit H, Schmitt E, Kakirman H, et al: Infectious tolerance: Human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med 2002; 196:255-260
6. Shevach EM: Certified professionals: CD4+CD25+ suppressor T cells. J Exp Med 2001; 193:F41-F45
7. Suto A, Nakajima H, Kagami SI, et al: Role of CD4+CD25+ regulatory T cells in TH2 cell-mediated allergic inflammation in the airways. Am J Respir Crit Care Med 2001; 164:680
8. Zelenika D, Adams E, Humm S, et al: Regulatory T cells overexpress a subset of TH2 gene transcripts. J Immunol 2002; 168:1069
9. Iellem A, Mariani M, Lang R, et al: Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4+CD25+ regulatory T cells. J Exp Med 2001; 194:847-853
10. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101:1644-1655
11. Le Gall JR, Lemeshow S, Saulnier F: A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993; 270:2957-2963
12. Monneret G, Elmenkouri N, Bohe J, et al: Analytical requirements for measuring monocytic HLA-DR by flow cytometry: Application to the monitoring of patients with septic shock. Clin Chem 2002; 48:1589-1592