-
1
-
-
0032102455
-
The synucleins: A family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
-
Clayton, D. F., and George, J. M. (1998) The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci. 21, 249-254
-
(1998)
Trends Neurosci
, vol.21
, pp. 249-254
-
-
Clayton, D.F.1
George, J.M.2
-
2
-
-
0023722437
-
Synuclein: A neuron-specific protein localized to the nucleus and presynaptic nerve terminal
-
Maroteaux, L., Campanelli, J. T., and Scheller, R. H. (1988) Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J. Neurosci. 8, 2804-2815
-
(1988)
J. Neurosci
, vol.8
, pp. 2804-2815
-
-
Maroteaux, L.1
Campanelli, J.T.2
Scheller, R.H.3
-
3
-
-
0025943571
-
The rat brain synucleins; family of proteins transiently associated with neuronal membrane
-
Maroteaux, L., and Scheller, R. H. (1991) The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Brain Res. Mol. Brain Res. 11, 335-343
-
(1991)
Brain Res. Mol. Brain Res
, vol.11
, pp. 335-343
-
-
Maroteaux, L.1
Scheller, R.H.2
-
4
-
-
0027429156
-
A new brain-specific 14-kDa protein is a phospho-protein. Its complete amino acid sequence and evidence for phosphorylation
-
Nakajo, S., Tsukada, K., Omata, K., Nakamura, Y., and Nakaya, K (1993) A new brain-specific 14-kDa protein is a phospho-protein. Its complete amino acid sequence and evidence for phosphorylation. Eur. J. Biochem. 217, 1057-1063
-
(1993)
Eur. J. Biochem
, vol.217
, pp. 1057-1063
-
-
Nakajo, S.1
Tsukada, K.2
Omata, K.3
Nakamura, Y.4
Nakaya, K.5
-
5
-
-
0027489773
-
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
-
Ueda, K., Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D. A., Kondo, J., Ihara, Y., and Saitoh, T. (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 90, 11282-11286
-
(1993)
Proc. Natl. Acad. Sci. U. S. A
, vol.90
, pp. 11282-11286
-
-
Ueda, K.1
Fukushima, H.2
Masliah, E.3
Xia, Y.4
Iwai, A.5
Yoshimoto, M.6
Otero, D.A.7
Kondo, J.8
Ihara, Y.9
Saitoh, T.10
-
6
-
-
0029127954
-
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
-
George, J. M., Jin, H., Woods, W. S., and Clayton, D. F. (1995) Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 15, 361-372
-
(1995)
Neuron
, vol.15
, pp. 361-372
-
-
George, J.M.1
Jin, H.2
Woods, W.S.3
Clayton, D.F.4
-
7
-
-
0028277520
-
Identification of two distinct synucleins from human brain
-
Jakes, R., Spillantini, M. G., and Goedert, M. (1994) Identification of two distinct synucleins from human brain. FEBS Lett. 345, 27-32
-
(1994)
FEBS Lett
, vol.345
, pp. 27-32
-
-
Jakes, R.1
Spillantini, M.G.2
Goedert, M.3
-
8
-
-
0032584686
-
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
-
Spillantini, M. G., Crowther, R. A., Jakes, R., Cairns, N. J., Lantos, P. L., and Goedert, M. (1998) Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci. Lett. 251, 205-208
-
(1998)
Neurosci. Lett
, vol.251
, pp. 205-208
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Cairns, N.J.4
Lantos, P.L.5
Goedert, M.6
-
9
-
-
0026523122
-
The amphipathic helix in the exchangeable apolipoproteins: A review of secondary structure and function
-
Segrest, J. P., Jones, M. K., De Loof, H., Brouillette, C. G., Venkatachalapathi, Y. V., and Anantharamaiah, G. M. (1992) The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function. J. Lipid Res. 33, 141-166
-
(1992)
J. Lipid Res
, vol.33
, pp. 141-166
-
-
Segrest, J.P.1
Jones, M.K.2
De Loof, H.3
Brouillette, C.G.4
Venkatachalapathi, Y.V.5
Anantharamaiah, G.M.6
-
10
-
-
0032540327
-
Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes
-
Davidson, W. S., Jonas, A., Clayton, D. F., and George, J. M. (1998) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J. Biol. Chem. 273, 9443-9449
-
(1998)
J. Biol. Chem
, vol.273
, pp. 9443-9449
-
-
Davidson, W.S.1
Jonas, A.2
Clayton, D.F.3
George, J.M.4
-
11
-
-
0034922671
-
Identification of the region of non-Abeta component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity
-
Bodles, A. M., Guthrie, D.J., Greer, B., and Irvine, G. B. (2001) Identification of the region of non-Abeta component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity. J. Neurochem. 78, 384-395
-
(2001)
J. Neurochem
, vol.78
, pp. 384-395
-
-
Bodles, A.M.1
Guthrie, D.J.2
Greer, B.3
Irvine, G.B.4
-
12
-
-
0035951869
-
A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
-
Giasson, B. I., Murray, I. V., Trojanowski, J. Q., and Lee, V. M. (2001) A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. J. Biol. Chem. 276, 2380-2386
-
(2001)
J. Biol. Chem
, vol.276
, pp. 2380-2386
-
-
Giasson, B.I.1
Murray, I.V.2
Trojanowski, J.Q.3
Lee, V.M.4
-
13
-
-
0038116620
-
Role of alpha-synuclein carboxy-terminus on fibril formation in vitro
-
Murray, I. V., Giasson, B. I., Quinn, S. M., Koppaka, V., Axelsen, P. H., Ischiropoulos, H., Trojanowski, J. Q., and Lee, V. M. (2003) Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry 42, 8530-8540
-
(2003)
Biochemistry
, vol.42
, pp. 8530-8540
-
-
Murray, I.V.1
Giasson, B.I.2
Quinn, S.M.3
Koppaka, V.4
Axelsen, P.H.5
Ischiropoulos, H.6
Trojanowski, J.Q.7
Lee, V.M.8
-
14
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
15
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schols, L., and Riess, O. (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 18, 106-108
-
(1998)
Nat. Genet
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
Kosel, S.6
Przuntek, H.7
Epplen, J.T.8
Schols, L.9
Riess, O.10
-
16
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
Zarranz, J. J., Alegre,J., Gomez-Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atares, B., Llorens, V., Gomez Tortosa, E., del Ser, T., Munoz, D. G., and de Yebenes, J. G. (2004) The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55, 164-173
-
(2004)
Ann. Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atares, B.10
Llorens, V.11
Gomez Tortosa, E.12
del Ser, T.13
Munoz, D.G.14
de Yebenes, J.G.15
-
17
-
-
0242300619
-
alpha-Synuclein locus triplication causes Parkinson's disease
-
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., Lincoln, S., Crawley, A., Hanson, M., Maraganore, D., Adler, C., Cookson, M. R., Muenter, M., Baptista, M., Miller, D., Blancato, J., Hardy, J., and Gwinn-Hardy, K. (2003) alpha-Synuclein locus triplication causes Parkinson's disease. Science 302, 841
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Maraganore, D.14
Adler, C.15
Cookson, M.R.16
Muenter, M.17
Baptista, M.18
Miller, D.19
Blancato, J.20
Hardy, J.21
Gwinn-Hardy, K.22
more..
-
18
-
-
4644290985
-
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease
-
Chartier-Harlin, M. C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M., Waucquier, N., Defebvre, L., Amouyel, P., Farrer, M., and Destee, A. (2004) Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 364, 1167-1169
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
Levecque, C.7
Larvor, L.8
Andrieux, J.9
Hulihan, M.10
Waucquier, N.11
Defebvre, L.12
Amouyel, P.13
Farrer, M.14
Destee, A.15
-
19
-
-
0029904487
-
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
-
Weinreb, P. H., Zhen, W., Poon, A. W., Conway, K. A., and Lansbury, P. T., Jr. (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35, 13709-13715
-
(1996)
Biochemistry
, vol.35
, pp. 13709-13715
-
-
Weinreb, P.H.1
Zhen, W.2
Poon, A.W.3
Conway, K.A.4
Lansbury Jr., P.T.5
-
20
-
-
12944304172
-
Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations
-
Dedmon, M. M., Lindorff-Larsen, K., Christodoulou, J., Vendruscolo, M., and Dobson, C. M. (2005) Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations. J. Am. Chem. Soc. 127, 476-477
-
(2005)
J. Am. Chem. Soc
, vol.127
, pp. 476-477
-
-
Dedmon, M.M.1
Lindorff-Larsen, K.2
Christodoulou, J.3
Vendruscolo, M.4
Dobson, C.M.5
-
21
-
-
13444252277
-
Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein
-
Bertoncini, C. W., Jung, Y. S., Fernandez, C. O., Hoyer, W., Griesinger, C., Jovin, T. M., and Zweckstetter, M. (2005) Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. Proc. Natl. Acad. Sci. U. S. A. 102, 1430-1435
-
(2005)
Proc. Natl. Acad. Sci. U. S. A
, vol.102
, pp. 1430-1435
-
-
Bertoncini, C.W.1
Jung, Y.S.2
Fernandez, C.O.3
Hoyer, W.4
Griesinger, C.5
Jovin, T.M.6
Zweckstetter, M.7
-
22
-
-
42649142233
-
Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: Implication for aggregation
-
Wu, K. P., Kim, S., Fela, D. A., and Baum, J. (2008) Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation. J. Mol. Biol. 378, 1104-1115
-
(2008)
J. Mol. Biol
, vol.378
, pp. 1104-1115
-
-
Wu, K.P.1
Kim, S.2
Fela, D.A.3
Baum, J.4
-
23
-
-
34948829554
-
Correlation of amyloid fibril beta-structure with the unfolded state of alpha-synuclein
-
Kim, H. Y., Heise, H., Fernandez, C. O., Baldus, M., and Zweckstetter, M. (2007) Correlation of amyloid fibril beta-structure with the unfolded state of alpha-synuclein. Chembiochem 8, 1671-1674
-
(2007)
Chembiochem
, vol.8
, pp. 1671-1674
-
-
Kim, H.Y.1
Heise, H.2
Fernandez, C.O.3
Baldus, M.4
Zweckstetter, M.5
-
24
-
-
0035815115
-
Conformational properties of alpha-synuclein in its free and lipid-associated states
-
Eliezer, D., Kutluay, E., Bussell, R., Jr., and Browne, G. (2001) Conformational properties of alpha-synuclein in its free and lipid-associated states. J. Mol. Biol. 307, 1061-1073
-
(2001)
J. Mol. Biol
, vol.307
, pp. 1061-1073
-
-
Eliezer, D.1
Kutluay, E.2
Bussell Jr., R.3
Browne, G.4
-
25
-
-
0035824545
-
Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein
-
Bussell, R., Jr., and Eliezer, D. (2001) Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein. J. Biol. Chem. 276, 45996-46003
-
(2001)
J. Biol. Chem
, vol.276
, pp. 45996-46003
-
-
Bussell Jr., R.1
Eliezer, D.2
-
26
-
-
29544433937
-
Macromolecular crowding in the Escherichia coli periplasm maintains alpha-synuclein disorder
-
McNulty, B. C., Young, G. B., and Pielak, G. J. (2006) Macromolecular crowding in the Escherichia coli periplasm maintains alpha-synuclein disorder. J. Mol. Biol. 355, 893-897
-
(2006)
J. Mol. Biol
, vol.355
, pp. 893-897
-
-
McNulty, B.C.1
Young, G.B.2
Pielak, G.J.3
-
27
-
-
48249099670
-
Hydrogen exchange of monomeric {alpha}-synuclein shows unfolded structure persists at physiological temperature and is independent of molecular crowding in Escherichia coli
-
Croke, R. L., Sallum, C. O., Watson, E., Watt, E. D., and Alexandrescu, A. T. (2008) Hydrogen exchange of monomeric {alpha}-synuclein shows unfolded structure persists at physiological temperature and is independent of molecular crowding in Escherichia coli. Protein Sci. 17, 1434-1445
-
(2008)
Protein Sci
, vol.17
, pp. 1434-1445
-
-
Croke, R.L.1
Sallum, C.O.2
Watson, E.3
Watt, E.D.4
Alexandrescu, A.T.5
-
28
-
-
9344230362
-
Alpha-synuclein structures from fluorescence energy-transfer kinetics: Implications for the role of the protein in Parkinson's disease
-
Lee, J. C., Langen, R., Hummel, P. A., Gray, H. B., and Winkler, J. R. (2004) Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 101, 16466-16471
-
(2004)
Proc. Natl. Acad. Sci. U. S. A
, vol.101
, pp. 16466-16471
-
-
Lee, J.C.1
Langen, R.2
Hummel, P.A.3
Gray, H.B.4
Winkler, J.R.5
-
29
-
-
28444453293
-
Tertiary contact formation in alpha-synuclein probed by electron transfer
-
Lee, J. C., Gray, H. B., and Winkler, J. R. (2005) Tertiary contact formation in alpha-synuclein probed by electron transfer.J. Am. Chem. Soc. 127, 16388-16389
-
(2005)
J. Am. Chem. Soc
, vol.127
, pp. 16388-16389
-
-
Lee, J.C.1
Gray, H.B.2
Winkler, J.R.3
-
30
-
-
1542276786
-
Raman spectroscopic characterization of secondary structure in natively unfolded proteins: Alpha-synuclein
-
Maiti, N. C., Apetri, M. M., Zagorski, M. G., Carey, P. R., and Anderson, V. E. (2004) Raman spectroscopic characterization of secondary structure in natively unfolded proteins: alpha-synuclein. J. Am. Chem. Soc. 126, 2399-2408
-
(2004)
J. Am. Chem. Soc
, vol.126
, pp. 2399-2408
-
-
Maiti, N.C.1
Apetri, M.M.2
Zagorski, M.G.3
Carey, P.R.4
Anderson, V.E.5
-
31
-
-
38949139507
-
Conformational equilibria in monomeric alpha-synuclein at the single-molecule level
-
Sandal, M., Valle, F., Tessari, I., Mammi, S., Bergantino, E., Musiani, F., Brucale, M., Bubacco, L., and Samori, B. (2008) Conformational equilibria in monomeric alpha-synuclein at the single-molecule level. PLoS Biol. 6, e6
-
(2008)
PLoS Biol
, vol.6
-
-
Sandal, M.1
Valle, F.2
Tessari, I.3
Mammi, S.4
Bergantino, E.5
Musiani, F.6
Brucale, M.7
Bubacco, L.8
Samori, B.9
-
32
-
-
0036128797
-
Natively unfolded proteins: A point where biology waits for physics
-
Uversky, V. N. (2002) Natively unfolded proteins: a point where biology waits for physics. Protein Sci. 11, 739-756
-
(2002)
Protein Sci
, vol.11
, pp. 739-756
-
-
Uversky, V.N.1
-
33
-
-
20444376186
-
The interplay between structure and function in intrinsically unstructured proteins
-
Tompa, P. (2005) The interplay between structure and function in intrinsically unstructured proteins. FEBS Lett. 579, 3346-3354
-
(2005)
FEBS Lett
, vol.579
, pp. 3346-3354
-
-
Tompa, P.1
-
34
-
-
0038460184
-
Part II: Alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease
-
Dev, K. K., Hofele, K., Barbieri, S., Buchman, V. L., and van der Putten, H. (2003) Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease. Neuropharmacology 45, 14-44
-
(2003)
Neuropharmacology
, vol.45
, pp. 14-44
-
-
Dev, K.K.1
Hofele, K.2
Barbieri, S.3
Buchman, V.L.4
van der Putten, H.5
-
35
-
-
4644291645
-
Analysis of alpha-synuclein-associated proteins by quantitative proteomics
-
Zhou, Y., Gu, G., Goodlett, D. R., Zhang, T., Pan, C., Montine, T. J., Montine, K. S., Aebersold, R. H., and Zhang, J. (2004) Analysis of alpha-synuclein-associated proteins by quantitative proteomics. J. Biol. Chem. 279, 39155-39164
-
(2004)
J. Biol. Chem
, vol.279
, pp. 39155-39164
-
-
Zhou, Y.1
Gu, G.2
Goodlett, D.R.3
Zhang, T.4
Pan, C.5
Montine, T.J.6
Montine, K.S.7
Aebersold, R.H.8
Zhang, J.9
-
36
-
-
0033565874
-
alpha-Synuclein shares physical and functional homology with 14-3-3 proteins
-
Ostrerova, N., Petrucelli, L., Farrer, M., Mehta, N., Choi, P., Hardy, J., and Wolozin, B. (1999) alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. J. Neurosci. 19, 5782-5791
-
(1999)
J. Neurosci
, vol.19
, pp. 5782-5791
-
-
Ostrerova, N.1
Petrucelli, L.2
Farrer, M.3
Mehta, N.4
Choi, P.5
Hardy, J.6
Wolozin, B.7
-
37
-
-
0034492520
-
Structural changes in alpha-synuclein affect its chaperone-like activity in vitro
-
Kim, T. D., Paik, S. R., Yang, C. H., and Kim, J. (2000) Structural changes in alpha-synuclein affect its chaperone-like activity in vitro. Protein Sci. 9, 2489-2496
-
(2000)
Protein Sci
, vol.9
, pp. 2489-2496
-
-
Kim, T.D.1
Paik, S.R.2
Yang, C.H.3
Kim, J.4
-
38
-
-
0034716979
-
Chaperone-like activity of synucleins
-
Souza, J. M., Giasson, B. I., Lee, V. M., and Ischiropoulos, H. (2000) Chaperone-like activity of synucleins. FEBS Lett. 474, 116-119
-
(2000)
FEBS Lett
, vol.474
, pp. 116-119
-
-
Souza, J.M.1
Giasson, B.I.2
Lee, V.M.3
Ischiropoulos, H.4
-
39
-
-
0037177241
-
Stress-induced aggregation profiles of GST-alpha-synuclein fusion proteins: Role of the C-terminal acidic tail of alpha-synuclein in protein thermosolubility and stability
-
Park, S. M., Jung, H. Y., Chung, K. C., Rhim, H., Park, J. H., and Kim, J. (2002) Stress-induced aggregation profiles of GST-alpha-synuclein fusion proteins: role of the C-terminal acidic tail of alpha-synuclein in protein thermosolubility and stability. Biochemistry 41, 4137-4146
-
(2002)
Biochemistry
, vol.41
, pp. 4137-4146
-
-
Park, S.M.1
Jung, H.Y.2
Chung, K.C.3
Rhim, H.4
Park, J.H.5
Kim, J.6
-
40
-
-
0037092442
-
A role for alpha-synuclein in the regulation of dopamine biosynthesis
-
Perez, R. G., Waymire, J. C., Lin, E., Liu, J. J., Guo, F., and Zigmond, M. J. (2002) A role for alpha-synuclein in the regulation of dopamine biosynthesis. J. Neurosci. 22, 3090-3099
-
(2002)
J. Neurosci
, vol.22
, pp. 3090-3099
-
-
Perez, R.G.1
Waymire, J.C.2
Lin, E.3
Liu, J.J.4
Guo, F.5
Zigmond, M.J.6
-
41
-
-
33750461646
-
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
-
Tehranian, R., Montoya, S. E., Van Laar, A. D., Hastings, T. G., and Perez, R. G. (2006) Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells. J. Neurochem. 99, 1188-1196
-
(2006)
J. Neurochem
, vol.99
, pp. 1188-1196
-
-
Tehranian, R.1
Montoya, S.E.2
Van Laar, A.D.3
Hastings, T.G.4
Perez, R.G.5
-
42
-
-
34548620297
-
Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation
-
Uversky, V. N. (2007) Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation. J. Neurochem. 103, 17-37
-
(2007)
J. Neurochem
, vol.103
, pp. 17-37
-
-
Uversky, V.N.1
-
43
-
-
38849091518
-
Alpha-synuclein and its role in metal binding: Relevance to Parkinson's disease
-
Wright, J. A., and Brown, D. R. (2008) Alpha-synuclein and its role in metal binding: relevance to Parkinson's disease. J. Neurosci. Res. 86, 496-503
-
(2008)
J. Neurosci. Res
, vol.86
, pp. 496-503
-
-
Wright, J.A.1
Brown, D.R.2
-
44
-
-
0035144618
-
Cortical neurons expressing calcium binding proteins are spared in dementia with Lewy bodies
-
Gomez-Tortosa, E., Sanders, J. L., Newell, K., and Hyman, B. T. (2001) Cortical neurons expressing calcium binding proteins are spared in dementia with Lewy bodies. Acta Neuropathol. (Berl.) 101, 36-42
-
(2001)
Acta Neuropathol. (Berl.)
, vol.101
, pp. 36-42
-
-
Gomez-Tortosa, E.1
Sanders, J.L.2
Newell, K.3
Hyman, B.T.4
-
45
-
-
0025061059
-
The Lewy body variant of Alzheimer's disease: A clinical and pathologic entity
-
Hansen, L., Salmon, D., Galasko, D., Masliah, E., Katzman, R., DeTeresa, R., Thal, L., Pay, M. M., Hofstetter, R., Klauber, M., Rice, V., Butters, N., and Alford, M. (1990) The Lewy body variant of Alzheimer's disease: a clinical and pathologic entity. Neurology 40, 1-8
-
(1990)
Neurology
, vol.40
, pp. 1-8
-
-
Hansen, L.1
Salmon, D.2
Galasko, D.3
Masliah, E.4
Katzman, R.5
DeTeresa, R.6
Thal, L.7
Pay, M.M.8
Hofstetter, R.9
Klauber, M.10
Rice, V.11
Butters, N.12
Alford, M.13
-
46
-
-
0032990543
-
Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease
-
Lippa, C. F., Schmidt, M. L., Lee, V. M., and Trojanowski, J. Q. (1999) Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Ann. Neurol. 45, 353-357
-
(1999)
Ann. Neurol
, vol.45
, pp. 353-357
-
-
Lippa, C.F.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
-
47
-
-
0032568534
-
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
-
Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., and Goedert, M. (1998) alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc. Natl. Acad. Sci. U. S. A. 95, 6469-6473
-
(1998)
Proc. Natl. Acad. Sci. U. S. A
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
48
-
-
0023028576
-
Lewy bodies of Parkinson's disease. Immune electron microscopic demonstration of neurofilament antigens in constituent filaments
-
Pappolla, M. A. (1986) Lewy bodies of Parkinson's disease. Immune electron microscopic demonstration of neurofilament antigens in constituent filaments. Arch. Pathol. Lab. Med. 110, 1160-1163
-
(1986)
Arch. Pathol. Lab. Med
, vol.110
, pp. 1160-1163
-
-
Pappolla, M.A.1
-
49
-
-
0034712918
-
Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation
-
Serpell, L. C., Berriman, J., Jakes, R., Goedert, M., and Crowther, R. A. (2000) Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation. Proc. Natl. Acad. Sci. U. S. A. 97, 4897-4902
-
(2000)
Proc. Natl. Acad. Sci. U. S. A
, vol.97
, pp. 4897-4902
-
-
Serpell, L.C.1
Berriman, J.2
Jakes, R.3
Goedert, M.4
Crowther, R.A.5
-
50
-
-
0036386364
-
Dependence of alpha-synuclein aggregate morphology on solution conditions
-
Hoyer, W., Antony, T., Cherny, D., Heim, G., Jovin, T. M., and Subramaniam, V. (2002) Dependence of alpha-synuclein aggregate morphology on solution conditions. J. Mol. Biol. 322, 383-393
-
(2002)
J. Mol. Biol
, vol.322
, pp. 383-393
-
-
Hoyer, W.1
Antony, T.2
Cherny, D.3
Heim, G.4
Jovin, T.M.5
Subramaniam, V.6
-
51
-
-
0141733169
-
Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling
-
Der-Sarkissian, A., Jao, C. C., Chen, J., and Langen, R. (2003) Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling. J. Biol. Chem. 278, 37530-37535
-
(2003)
J. Biol. Chem
, vol.278
, pp. 37530-37535
-
-
Der-Sarkissian, A.1
Jao, C.C.2
Chen, J.3
Langen, R.4
-
52
-
-
34548359337
-
Investigation of alpha-synuclein fibril structure by site-directed spin labeling
-
Chen, M., Margittai, M., Chen, J., and Langen, R. (2007) Investigation of alpha-synuclein fibril structure by site-directed spin labeling. J. Biol. Chem. 282, 24970-24979
-
(2007)
J. Biol. Chem
, vol.282
, pp. 24970-24979
-
-
Chen, M.1
Margittai, M.2
Chen, J.3
Langen, R.4
-
53
-
-
27644518721
-
Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR
-
Heise, H., Hoyer, W., Becker, S., Andronesi, O. C., Riedel, D., and Baldus, M. (2005) Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR. Proc. Natl. Acad. Sci. U. S. A. 102, 15871-15876
-
(2005)
Proc. Natl. Acad. Sci. U. S. A
, vol.102
, pp. 15871-15876
-
-
Heise, H.1
Hoyer, W.2
Becker, S.3
Andronesi, O.C.4
Riedel, D.5
Baldus, M.6
-
54
-
-
47249110199
-
The fold of alpha-synuclein fibrils
-
Vilar, M., Chou, H. T., Luhrs, T., Maji, S. K., Riek-Loher, D., Verel, R., Manning, G., Stahlberg, H., and Riek, R. (2008) The fold of alpha-synuclein fibrils. Proc. Natl. Acad. Sci. U. S. A. 105, 8637-8642
-
(2008)
Proc. Natl. Acad. Sci. U. S. A
, vol.105
, pp. 8637-8642
-
-
Vilar, M.1
Chou, H.T.2
Luhrs, T.3
Maji, S.K.4
Riek-Loher, D.5
Verel, R.6
Manning, G.7
Stahlberg, H.8
Riek, R.9
-
55
-
-
0033538541
-
alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease
-
Wood, S. J., Wypych, J., Steavenson, S., Louis, J. C., Citron, M., and Biere, A. L. (1999) alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. J. Biol. Chem. 274, 19509-19512
-
(1999)
J. Biol. Chem
, vol.274
, pp. 19509-19512
-
-
Wood, S.J.1
Wypych, J.2
Steavenson, S.3
Louis, J.C.4
Citron, M.5
Biere, A.L.6
-
56
-
-
0034681163
-
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
-
Conway, K. A., Lee, S. J., Rochet, J. C., Ding, T. T., Williamson, R. E., and Lansbury, P. T., Jr. (2000) Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc. Natl. Acad. Sci. U. S. A. 97, 571-576
-
(2000)
Proc. Natl. Acad. Sci. U. S. A
, vol.97
, pp. 571-576
-
-
Conway, K.A.1
Lee, S.J.2
Rochet, J.C.3
Ding, T.T.4
Williamson, R.E.5
Lansbury Jr., P.T.6
-
57
-
-
25444433798
-
Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein
-
Kaylor, J., Bodner, N., Edridge, S., Yamin, G., Hong, D. P., and Fink, A. L. (2005) Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein. J. Mol. Biol. 353, 357-372
-
(2005)
J. Mol. Biol
, vol.353
, pp. 357-372
-
-
Kaylor, J.1
Bodner, N.2
Edridge, S.3
Yamin, G.4
Hong, D.P.5
Fink, A.L.6
-
58
-
-
33644527256
-
Characterization of oligomers during alpha-synuclein aggregation using intrinsic tryptophan fluorescence
-
Dusa, A., Kaylor, J., Edridge, S., Bodner, N., Hong, D. P., and Fink, A. L. (2006) Characterization of oligomers during alpha-synuclein aggregation using intrinsic tryptophan fluorescence. Biochemistry 45, 2752-2760
-
(2006)
Biochemistry
, vol.45
, pp. 2752-2760
-
-
Dusa, A.1
Kaylor, J.2
Edridge, S.3
Bodner, N.4
Hong, D.P.5
Fink, A.L.6
-
59
-
-
0037072284
-
Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes
-
Ding, T. T., Lee, S. J., Rochet, J. C., and Lansbury, P. T., Jr. (2002) Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes. Biochemistry 41, 10209-10217
-
(2002)
Biochemistry
, vol.41
, pp. 10209-10217
-
-
Ding, T.T.1
Lee, S.J.2
Rochet, J.C.3
Lansbury Jr., P.T.4
-
60
-
-
33749841522
-
The aggregation and fibrillation of alpha-synuclein
-
Fink, A. L. (2006) The aggregation and fibrillation of alpha-synuclein. Acc. Chem. Res. 39, 628-634
-
(2006)
Acc. Chem. Res
, vol.39
, pp. 628-634
-
-
Fink, A.L.1
-
61
-
-
0035834360
-
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
-
Conway, K. A., Rochet, J. C., Bieganski, R. M., and Lansbury, P. T., Jr. (2001) Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 294, 1346-1349
-
(2001)
Science
, vol.294
, pp. 1346-1349
-
-
Conway, K.A.1
Rochet, J.C.2
Bieganski, R.M.3
Lansbury Jr., P.T.4
-
62
-
-
0029981526
-
Neuropathology of Parkinson's disease
-
Forno, L. S. (1996) Neuropathology of Parkinson's disease. J. Neuropathol. Exp. Neurol. 55, 259-272
-
(1996)
J. Neuropathol. Exp. Neurol
, vol.55
, pp. 259-272
-
-
Forno, L.S.1
-
63
-
-
0031013141
-
Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons
-
Tompkins, M. M., Basgall, E. J., Zamrini, E., and Hill, W. D. (1997) Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons. Am. J. Pathol. 150, 119-131
-
(1997)
Am. J. Pathol
, vol.150
, pp. 119-131
-
-
Tompkins, M.M.1
Basgall, E.J.2
Zamrini, E.3
Hill, W.D.4
-
64
-
-
0037046163
-
Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism
-
Volles, M. J., and Lansbury, P. T., Jr. (2002) Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism. Biochemistry 41, 4595-4602
-
(2002)
Biochemistry
, vol.41
, pp. 4595-4602
-
-
Volles, M.J.1
Lansbury Jr., P.T.2
-
65
-
-
0037130174
-
Neurodegenerative disease: Amyloid pores from pathogenic mutations
-
Lashuel, H. A., Hartley, D., Petre, B. M., Walz, T., and Lansbury, P. T., Jr. (2002) Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature 418, 291
-
(2002)
Nature
, vol.418
, pp. 291
-
-
Lashuel, H.A.1
Hartley, D.2
Petre, B.M.3
Walz, T.4
Lansbury Jr., P.T.5
-
66
-
-
45849128342
-
Fluorescent N-arylaminonaphthalene sulfonate probes for amyloid aggregation of alpha-synuclein
-
Celej, M. S., Jares-Erijman, E. A., and Jovin, T. M. (2008) Fluorescent N-arylaminonaphthalene sulfonate probes for amyloid aggregation of alpha-synuclein. Biophys. J. 94, 4867-4879
-
(2008)
Biophys. J
, vol.94
, pp. 4867-4879
-
-
Celej, M.S.1
Jares-Erijman, E.A.2
Jovin, T.M.3
-
67
-
-
45749101292
-
Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR
-
Madine, J., Doig, A. J., and Middleton, D. A. (2008) Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR. J. Am. Chem. Soc. 130, 7873-7881
-
(2008)
J. Am. Chem. Soc
, vol.130
, pp. 7873-7881
-
-
Madine, J.1
Doig, A.J.2
Middleton, D.A.3
-
68
-
-
35848966149
-
Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors
-
Luk, K. C., Hyde, E. G., Trojanowski, J. Q., and Lee, V. M. (2007) Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors. Biochemistry 46, 12522-12529
-
(2007)
Biochemistry
, vol.46
, pp. 12522-12529
-
-
Luk, K.C.1
Hyde, E.G.2
Trojanowski, J.Q.3
Lee, V.M.4
-
69
-
-
42649135877
-
Multiparametric fluorescence detection of early stages in the amyloid protein aggregation of pyrene-labeled alpha-synuclein
-
Thirunavukkuarasu, S., Jares-Erijman, E. A., and Jovin, T. M. (2008) Multiparametric fluorescence detection of early stages in the amyloid protein aggregation of pyrene-labeled alpha-synuclein. J. Mol. Biol. 378, 1064-1073
-
(2008)
J. Mol. Biol
, vol.378
, pp. 1064-1073
-
-
Thirunavukkuarasu, S.1
Jares-Erijman, E.A.2
Jovin, T.M.3
-
70
-
-
42349111633
-
Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules
-
Rao, J. N., Dua, V., and Ulmer, T. S. (2008) Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules. Biochemistry 47, 4651-4656
-
(2008)
Biochemistry
, vol.47
, pp. 4651-4656
-
-
Rao, J.N.1
Dua, V.2
Ulmer, T.S.3
-
71
-
-
0034602296
-
alpha-Synuclein membrane interactions and lipid specificity
-
Jo, E., McLaurin, J., Yip, C. M., St George-Hyslop, P., and Fraser, P. E. (2000) alpha-Synuclein membrane interactions and lipid specificity. J. Biol. Chem. 275, 34328-34334
-
(2000)
J. Biol. Chem
, vol.275
, pp. 34328-34334
-
-
Jo, E.1
McLaurin, J.2
Yip, C.M.3
St George-Hyslop, P.4
Fraser, P.E.5
-
72
-
-
0037930855
-
Lipid binding inhibits alpha-synuclein fibril formation
-
Zhu, M., and Fink, A. L. (2003) Lipid binding inhibits alpha-synuclein fibril formation. J. Biol. Chem. 278, 16873-16877
-
(2003)
J. Biol. Chem
, vol.278
, pp. 16873-16877
-
-
Zhu, M.1
Fink, A.L.2
-
73
-
-
0141891097
-
The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation
-
Zhu, M., Li, J., and Fink, A. L. (2003) The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation. J. Biol. Chem. 278, 40186-40197
-
(2003)
J. Biol. Chem
, vol.278
, pp. 40186-40197
-
-
Zhu, M.1
Li, J.2
Fink, A.L.3
-
74
-
-
33744788870
-
Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy
-
Rhoades, E., Ramlall, T. F., Webb, W. W., and Eliezer, D. (2006) Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy. Biophys. J. 90, 4692-4700
-
(2006)
Biophys. J
, vol.90
, pp. 4692-4700
-
-
Rhoades, E.1
Ramlall, T.F.2
Webb, W.W.3
Eliezer, D.4
-
75
-
-
0035928748
-
Membrane binding and self-association of alpha-synucleins
-
Narayanan, V., and Scarlata, S. (2001) Membrane binding and self-association of alpha-synucleins. Biochemistry 40, 9927-9934
-
(2001)
Biochemistry
, vol.40
, pp. 9927-9934
-
-
Narayanan, V.1
Scarlata, S.2
-
76
-
-
37549068169
-
Alpha-synuclein selectively binds to anionic phospholipids embedded in liquid-disordered domains
-
Stockl, M., Fischer, P., Wanker, E., and Herrmann, A. (2008) Alpha-synuclein selectively binds to anionic phospholipids embedded in liquid-disordered domains. J. Mol. Biol. 375, 1394-1404
-
(2008)
J. Mol. Biol
, vol.375
, pp. 1394-1404
-
-
Stockl, M.1
Fischer, P.2
Wanker, E.3
Herrmann, A.4
-
77
-
-
3342951965
-
Lipid rafts mediate the synaptic localization of alpha-synuclein
-
Fortin, D. L., Troyer, M. D., Nakamura, K., Kubo, S., Anthony, M. D., and Edwards, R. H. (2004) Lipid rafts mediate the synaptic localization of alpha-synuclein. J. Neurosci. 24, 6715-6723
-
(2004)
J. Neurosci
, vol.24
, pp. 6715-6723
-
-
Fortin, D.L.1
Troyer, M.D.2
Nakamura, K.3
Kubo, S.4
Anthony, M.D.5
Edwards, R.H.6
-
78
-
-
24744432079
-
A combinatorial code for the interaction of alpha-synuclein with membranes
-
Kubo, S., Nemani, V. M., Chalkley, R. J., Anthony, M. D., Hattori, N., Mizuno, Y., Edwards, R. H., and Fortin, D. L. (2005) A combinatorial code for the interaction of alpha-synuclein with membranes. J. Biol. Chem. 280, 31664-31672
-
(2005)
J. Biol. Chem
, vol.280
, pp. 31664-31672
-
-
Kubo, S.1
Nemani, V.M.2
Chalkley, R.J.3
Anthony, M.D.4
Hattori, N.5
Mizuno, Y.6
Edwards, R.H.7
Fortin, D.L.8
-
79
-
-
33745279409
-
A novel mechanism of interaction between alpha-synuclein and biological membranes
-
Kim, Y. S., Laurine, E., Woods, W., and Lee, S.J. (2006) A novel mechanism of interaction between alpha-synuclein and biological membranes. J. Mol. Biol. 360, 386-397
-
(2006)
J. Mol. Biol
, vol.360
, pp. 386-397
-
-
Kim, Y.S.1
Laurine, E.2
Woods, W.3
Lee, S.J.4
-
80
-
-
33748496027
-
Calcium-triggered membrane interaction of the alpha-synuclein acidic tail
-
Tamamizu-Kato, S., Kosaraju, M. G., Kato, H., Raussens, V., Ruysschaert, J. M., and Narayanaswami, V. (2006) Calcium-triggered membrane interaction of the alpha-synuclein acidic tail. Biochemistry 45, 10947-10956
-
(2006)
Biochemistry
, vol.45
, pp. 10947-10956
-
-
Tamamizu-Kato, S.1
Kosaraju, M.G.2
Kato, H.3
Raussens, V.4
Ruysschaert, J.M.5
Narayanaswami, V.6
-
81
-
-
33749028479
-
Conformational properties of the SDS-bound state of alpha-synuclein probed by limited proteolysis: Unexpected rigidity of the acidic C-terminal tail
-
De Laureto, P. P., Tosatto, L., Frare, E., Marin, O., Uversky, V. N., and Fontana, A. (2006) Conformational properties of the SDS-bound state of alpha-synuclein probed by limited proteolysis: unexpected rigidity of the acidic C-terminal tail. Biochemistry 45, 11523-11531
-
(2006)
Biochemistry
, vol.45
, pp. 11523-11531
-
-
De Laureto, P.P.1
Tosatto, L.2
Frare, E.3
Marin, O.4
Uversky, V.N.5
Fontana, A.6
-
82
-
-
33646228610
-
The 11-mer repeats of human alpha-synuclein in vesicle interactions and lipid composition discrimination: A cooperative role
-
Bisaglia, M., Schievano, E., Caporale, A., Peggion, E., and Mammi, S. (2006) The 11-mer repeats of human alpha-synuclein in vesicle interactions and lipid composition discrimination: a cooperative role. Biopolymers 84, 310-316
-
(2006)
Biopolymers
, vol.84
, pp. 310-316
-
-
Bisaglia, M.1
Schievano, E.2
Caporale, A.3
Peggion, E.4
Mammi, S.5
-
83
-
-
15744362063
-
Structure and dynamics of micelle-bound human alpha-synuclein
-
Ulmer, T. S., Bax, A., Cole, N. B., and Nussbaum, R. L. (2005) Structure and dynamics of micelle-bound human alpha-synuclein. J. Biol. Chem. 280, 9595-9603
-
(2005)
J. Biol. Chem
, vol.280
, pp. 9595-9603
-
-
Ulmer, T.S.1
Bax, A.2
Cole, N.B.3
Nussbaum, R.L.4
-
84
-
-
0038341134
-
A broken alpha-helix in folded alpha-Synuclein
-
Chandra, S., Chen, X., Rizo, J., Jahn, R., and Sudhof, T. C. (2003) A broken alpha-helix in folded alpha-Synuclein. J. Biol. Chem. 278, 15313-15318
-
(2003)
J. Biol. Chem
, vol.278
, pp. 15313-15318
-
-
Chandra, S.1
Chen, X.2
Rizo, J.3
Jahn, R.4
Sudhof, T.C.5
-
85
-
-
11844251247
-
A topological model of the interaction between alpha-synuclein and sodium dodecyl sulfate micelles
-
Bisaglia, M., Tessari, I., Pinato, L., Bellanda, M., Giraudo, S., Fasano, M., Bergantino, E., Bubacco, L., and Mammi, S. (2005) A topological model of the interaction between alpha-synuclein and sodium dodecyl sulfate micelles. Biochemistry 44, 329-339
-
(2005)
Biochemistry
, vol.44
, pp. 329-339
-
-
Bisaglia, M.1
Tessari, I.2
Pinato, L.3
Bellanda, M.4
Giraudo, S.5
Fasano, M.6
Bergantino, E.7
Bubacco, L.8
Mammi, S.9
-
86
-
-
33744500490
-
Structure and topology of the non-amyloid-beta component fragment of human alpha-synuclein bound to micelles: Implications for the aggregation process
-
Bisaglia, M., Trolio, A., Bellanda, M., Bergantino, E., Bubacco, L., and Mammi, S. (2006) Structure and topology of the non-amyloid-beta component fragment of human alpha-synuclein bound to micelles: implications for the aggregation process. Protein Sci. 15, 1408-1416
-
(2006)
Protein Sci
, vol.15
, pp. 1408-1416
-
-
Bisaglia, M.1
Trolio, A.2
Bellanda, M.3
Bergantino, E.4
Bubacco, L.5
Mammi, S.6
-
87
-
-
15244347219
-
Helix periodicity, topology, and dynamics of membrane-associated alpha-synuclein
-
Bussell, R., Jr., Ramlall, T. F., and Eliezer, D. (2005) Helix periodicity, topology, and dynamics of membrane-associated alpha-synuclein. Protein Sci. 14, 862-872
-
(2005)
Protein Sci
, vol.14
, pp. 862-872
-
-
Bussell Jr., R.1
Ramlall, T.F.2
Eliezer, D.3
-
88
-
-
0242424112
-
Alpha-synuclein association with phosphatidylglycerol probed by lipid spin labels
-
Ramakrishnan, M., Jensen, P. H., and Marsh, D. (2003) Alpha-synuclein association with phosphatidylglycerol probed by lipid spin labels. Biochemistry 42, 12919-12926
-
(2003)
Biochemistry
, vol.42
, pp. 12919-12926
-
-
Ramakrishnan, M.1
Jensen, P.H.2
Marsh, D.3
-
89
-
-
2942555022
-
Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling
-
Jao, C. C., Der-Sarkissian, A., Chen, J., and Langen, R. (2004) Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling. Proc. Natl. Acad. Sci. U. S. A. 101, 8331-8336
-
(2004)
Proc. Natl. Acad. Sci. U. S. A
, vol.101
, pp. 8331-8336
-
-
Jao, C.C.1
Der-Sarkissian, A.2
Chen, J.3
Langen, R.4
-
90
-
-
0038054286
-
A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins
-
Bussell, R., Jr., and Eliezer, D. (2003) A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins. J. Mol. Biol. 329, 763-778
-
(2003)
J. Mol. Biol
, vol.329
, pp. 763-778
-
-
Bussell Jr., R.1
Eliezer, D.2
-
91
-
-
38549099683
-
Membrane-bound structure and energetics of alpha-synuclein
-
Mihajlovic, M., and Lazaridis, T. (2007) Membrane-bound structure and energetics of alpha-synuclein. Proteins 70, 761-778
-
(2007)
Proteins
, vol.70
, pp. 761-778
-
-
Mihajlovic, M.1
Lazaridis, T.2
-
92
-
-
44349100972
-
Broken helix in vesicle and micelle-bound alpha-synuclein: Insights from site-directed spin labeling-EPR experiments and MD simulations
-
Bortolus, M., Tombolato, F., Tessari, I., Bisaglia, M., Mammi, S., Bubacco, L., Ferrarini, A., and Maniero, A. L. (2008) Broken helix in vesicle and micelle-bound alpha-synuclein: insights from site-directed spin labeling-EPR experiments and MD simulations. J. Am. Chem. Soc. 130, 6690-6691
-
(2008)
J. Am. Chem. Soc
, vol.130
, pp. 6690-6691
-
-
Bortolus, M.1
Tombolato, F.2
Tessari, I.3
Bisaglia, M.4
Mammi, S.5
Bubacco, L.6
Ferrarini, A.7
Maniero, A.L.8
-
93
-
-
45749089759
-
Antiparallel arrangement of the helices of vesicle-bound alpha-synuclein
-
Drescher, M., Veldhuis, G., van Rooijen, B. D., Milikisyants, S., Subramaniam, V., and Huber, M. (2008) Antiparallel arrangement of the helices of vesicle-bound alpha-synuclein. J. Am. Chem. Soc. 130, 7796-7797
-
(2008)
J. Am. Chem. Soc
, vol.130
, pp. 7796-7797
-
-
Drescher, M.1
Veldhuis, G.2
van Rooijen, B.D.3
Milikisyants, S.4
Subramaniam, V.5
Huber, M.6
-
94
-
-
58149173445
-
Membrane-bound alpha-synuclein forms an extended helix: Long-distance pulsed ESR measurements using vesicles, bicelles, and rodlike micelles
-
Georgieva, E. R., Ramlall, T. F., Borbat, P. P., Freed, J. H., and Eliezer, D. (2008) Membrane-bound alpha-synuclein forms an extended helix: long-distance pulsed ESR measurements using vesicles, bicelles, and rodlike micelles. J. Am. Chem. Soc. 130, 12856-12857
-
(2008)
J. Am. Chem. Soc
, vol.130
, pp. 12856-12857
-
-
Georgieva, E.R.1
Ramlall, T.F.2
Borbat, P.P.3
Freed, J.H.4
Eliezer, D.5
-
95
-
-
0028985267
-
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
-
Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., Flanagan, L., de Silva, H. A., Kittel, A., and Saitoh, T. (1995) The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14, 467-475
-
(1995)
Neuron
, vol.14
, pp. 467-475
-
-
Iwai, A.1
Masliah, E.2
Yoshimoto, M.3
Ge, N.4
Flanagan, L.5
de Silva, H.A.6
Kittel, A.7
Saitoh, T.8
-
96
-
-
0034077041
-
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W. H., Castillo, P. E., Shinsky, N., Verdugo, J. M., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., and Rosenthal, A. (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25, 239-252
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Farinas, I.3
Choi-Lundberg, D.4
Ho, W.H.5
Castillo, P.E.6
Shinsky, N.7
Verdugo, J.M.8
Armanini, M.9
Ryan, A.10
Hynes, M.11
Phillips, H.12
Sulzer, D.13
Rosenthal, A.14
-
97
-
-
0034193399
-
Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
-
Murphy, D. D., Rueter, S. M., Trojanowski, J. Q., and Lee, V. M. (2000) Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J. Neurosci. 20, 3214-3220
-
(2000)
J. Neurosci
, vol.20
, pp. 3214-3220
-
-
Murphy, D.D.1
Rueter, S.M.2
Trojanowski, J.Q.3
Lee, V.M.4
-
98
-
-
0037109727
-
Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein
-
Cabin, D. E., Shimazu, K., Murphy, D., Cole, N. B., Gottschalk, W., McIlwain, K. L., Orrison, B., Chen, A., Ellis, C. E., Paylor, R., Lu, B., and Nussbaum, R. L. (2002) Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J. Neurosci. 22, 8797-8807
-
(2002)
J. Neurosci
, vol.22
, pp. 8797-8807
-
-
Cabin, D.E.1
Shimazu, K.2
Murphy, D.3
Cole, N.B.4
Gottschalk, W.5
McIlwain, K.L.6
Orrison, B.7
Chen, A.8
Ellis, C.E.9
Paylor, R.10
Lu, B.11
Nussbaum, R.L.12
-
99
-
-
10944243102
-
Role of alpha-synuclein in presynaptic dopamine recruitment
-
Yavich, L., Tanila, H., Vepsalainen, S., and Jakala, P. (2004) Role of alpha-synuclein in presynaptic dopamine recruitment. J. Neurosci. 24, 11165-11170
-
(2004)
J. Neurosci
, vol.24
, pp. 11165-11170
-
-
Yavich, L.1
Tanila, H.2
Vepsalainen, S.3
Jakala, P.4
-
100
-
-
20844456402
-
alpha-Synuclein produces a long-lasting increase in neurotransmitter release
-
Liu, S., Ninan, I., Antonova, I., Battaglia, F., Trinchese, F., Narasanna, A., Kolodilov, N., Dauer, W., Hawkins, R. D., and Arancio, O. (2004) alpha-Synuclein produces a long-lasting increase in neurotransmitter release. EMBO J. 23, 4506-4516
-
(2004)
EMBO J
, vol.23
, pp. 4506-4516
-
-
Liu, S.1
Ninan, I.2
Antonova, I.3
Battaglia, F.4
Trinchese, F.5
Narasanna, A.6
Kolodilov, N.7
Dauer, W.8
Hawkins, R.D.9
Arancio, O.10
-
101
-
-
0345189365
-
Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein
-
Willingham, S., Outeiro, T. F., DeVit, M. J., Lindquist, S. L., and Muchowski, P. J. (2003) Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science 302, 1769-1772
-
(2003)
Science
, vol.302
, pp. 1769-1772
-
-
Willingham, S.1
Outeiro, T.F.2
DeVit, M.J.3
Lindquist, S.L.4
Muchowski, P.J.5
-
102
-
-
0141841634
-
Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease
-
Scherzer, C. R., Jensen, R. V., Gullans, S. R., and Feany, M. B. (2003) Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease. Hum. Mol. Genet. 12, 2457-2466
-
(2003)
Hum. Mol. Genet
, vol.12
, pp. 2457-2466
-
-
Scherzer, C.R.1
Jensen, R.V.2
Gullans, S.R.3
Feany, M.B.4
-
103
-
-
0035979233
-
alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins
-
Sharon, R., Goldberg, M. S., Bar-Josef, I., Betensky, R. A., Shen, J., and Selkoe, D. J. (2001) alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc. Natl. Acad. Sci. U. S. A. 98, 9110-9115
-
(2001)
Proc. Natl. Acad. Sci. U. S. A
, vol.98
, pp. 9110-9115
-
-
Sharon, R.1
Goldberg, M.S.2
Bar-Josef, I.3
Betensky, R.A.4
Shen, J.5
Selkoe, D.J.6
-
104
-
-
20444400627
-
Alpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of alpha-synuclein palmitate binding
-
Golovko, M. Y., Faergeman, N. J., Cole, N. B., Castagnet, P. I., Nussbaum, R. L., and Murphy, E. J. (2005) Alpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of alpha-synuclein palmitate binding. Biochemistry 44, 8251-8259
-
(2005)
Biochemistry
, vol.44
, pp. 8251-8259
-
-
Golovko, M.Y.1
Faergeman, N.J.2
Cole, N.B.3
Castagnet, P.I.4
Nussbaum, R.L.5
Murphy, E.J.6
-
105
-
-
33744949939
-
Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism
-
Golovko, M. Y., Rosenberger, T. A., Faergeman, N. J., Feddersen, S., Cole, N. B., Pribill, I., Berger, J., Nussbaum, R. L., and Murphy, E. J. (2006) Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism. Biochemistry 45, 6956-6966
-
(2006)
Biochemistry
, vol.45
, pp. 6956-6966
-
-
Golovko, M.Y.1
Rosenberger, T.A.2
Faergeman, N.J.3
Feddersen, S.4
Cole, N.B.5
Pribill, I.6
Berger, J.7
Nussbaum, R.L.8
Murphy, E.J.9
-
106
-
-
33947280424
-
Alpha-synuclein gene ablation increases docosahexaenoic acid incorporation and turnover in brain phospholipids
-
Golovko, M. Y., Rosenberger, T. A., Feddersen, S., Faergeman, N. J., and Murphy, E. J. (2007) Alpha-synuclein gene ablation increases docosahexaenoic acid incorporation and turnover in brain phospholipids. J. Neurochem. 101, 201-211
-
(2007)
J. Neurochem
, vol.101
, pp. 201-211
-
-
Golovko, M.Y.1
Rosenberger, T.A.2
Feddersen, S.3
Faergeman, N.J.4
Murphy, E.J.5
-
107
-
-
0032492689
-
Regulation of phospholipase D2: Selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins
-
Jenco, J. M., Rawlingson, A., Daniels, B., and Morris, A. J. (1998) Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins. Biochemistry 37, 4901-4909
-
(1998)
Biochemistry
, vol.37
, pp. 4901-4909
-
-
Jenco, J.M.1
Rawlingson, A.2
Daniels, B.3
Morris, A.J.4
-
108
-
-
18544364794
-
alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells
-
Ahn, B. H., Rhim, H., Kim, S. Y., Sung, Y. M., Lee, M. Y., Choi, J. Y., Wolozin, B., Chang, J. S., Lee, Y. H., Kwon, T. K., Chung, K. C., Yoon, S. H., Hahn, S. J., Kim, M. S., Jo, Y. H., and Min, D. S. (2002) alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. J. Biol. Chem. 277, 12334-12342
-
(2002)
J. Biol. Chem
, vol.277
, pp. 12334-12342
-
-
Ahn, B.H.1
Rhim, H.2
Kim, S.Y.3
Sung, Y.M.4
Lee, M.Y.5
Choi, J.Y.6
Wolozin, B.7
Chang, J.S.8
Lee, Y.H.9
Kwon, T.K.10
Chung, K.C.11
Yoon, S.H.12
Hahn, S.J.13
Kim, M.S.14
Jo, Y.H.15
Min, D.S.16
-
109
-
-
0036797552
-
Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease
-
Lotharius, J., and Brundin, P. (2002) Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease. Hum. Mol. Genet. 11, 2395-2407
-
(2002)
Hum. Mol. Genet
, vol.11
, pp. 2395-2407
-
-
Lotharius, J.1
Brundin, P.2
-
110
-
-
0029781368
-
Synaptic vesicle recycling in synapsin I knock-out mice
-
Ryan, T. A., Li, L., Chin, L. S., Greengard, P., and Smith, S. J. (1996) Synaptic vesicle recycling in synapsin I knock-out mice. J. Cell Biol. 134, 1219-1227
-
(1996)
J. Cell Biol
, vol.134
, pp. 1219-1227
-
-
Ryan, T.A.1
Li, L.2
Chin, L.S.3
Greengard, P.4
Smith, S.J.5
-
111
-
-
33746445842
-
Activity-related redistribution of pre-synaptic proteins at the active zone
-
Tao-Cheng, J. H. (2006) Activity-related redistribution of pre-synaptic proteins at the active zone. Neuroscience 141, 1217-1224
-
(2006)
Neuroscience
, vol.141
, pp. 1217-1224
-
-
Tao-Cheng, J.H.1
-
112
-
-
36348950454
-
Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy
-
Woods, W. S., Boettcher, J. M., Zhou, D. H., Kloepper, K. D., Hartman, K. L., Ladror, D. T., Qi, Z., Rienstra, C. M., and George, J. M. (2007) Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy. J. Biol. Chem. 282, 34555-34567
-
(2007)
J. Biol. Chem
, vol.282
, pp. 34555-34567
-
-
Woods, W.S.1
Boettcher, J.M.2
Zhou, D.H.3
Kloepper, K.D.4
Hartman, K.L.5
Ladror, D.T.6
Qi, Z.7
Rienstra, C.M.8
George, J.M.9
-
113
-
-
0035066885
-
Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis
-
Lee, F. J., Liu, F., Pristupa, Z. B., and Niznik, H. B. (2001) Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. FASEB J. 15, 916-926
-
(2001)
FASEB J
, vol.15
, pp. 916-926
-
-
Lee, F.J.1
Liu, F.2
Pristupa, Z.B.3
Niznik, H.B.4
-
114
-
-
0642364992
-
Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress
-
Wersinger, C., Prou, D., Vernier, P., and Sidhu, A. (2003) Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress. FASEB J. 17, 2151-2153
-
(2003)
FASEB J
, vol.17
, pp. 2151-2153
-
-
Wersinger, C.1
Prou, D.2
Vernier, P.3
Sidhu, A.4
-
115
-
-
0037451858
-
Attenuation of dopamine transporter activity by alpha-synuclein
-
Wersinger, C., and Sidhu, A. (2003) Attenuation of dopamine transporter activity by alpha-synuclein. Neurosci. Lett. 340, 189-192
-
(2003)
Neurosci. Lett
, vol.340
, pp. 189-192
-
-
Wersinger, C.1
Sidhu, A.2
-
116
-
-
34548689113
-
Regulation of the norepinephrine transporter by alpha-synuclein-mediated interactions with microtubules
-
Jeannotte, A. M., and Sidhu, A. (2007) Regulation of the norepinephrine transporter by alpha-synuclein-mediated interactions with microtubules. Eur. J. Neurosci. 26, 1509-1520
-
(2007)
Eur. J. Neurosci
, vol.26
, pp. 1509-1520
-
-
Jeannotte, A.M.1
Sidhu, A.2
-
117
-
-
0031787871
-
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
-
Conway, K. A., Harper, J. D., and Lansbury, P. T. (1998) Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat. Med. 4, 1318-1320
-
(1998)
Nat. Med
, vol.4
, pp. 1318-1320
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury, P.T.3
-
118
-
-
6344228684
-
Mutation E46K increases phospholipid binding and assembly into filaments of human α-synuclein
-
Choi, W., Zibaee, S., Jakes, R., Serpell, L. C., Davletov, B., Crowther, R. A., and Goedert, M. (2004) Mutation E46K increases phospholipid binding and assembly into filaments of human α-synuclein. FEBS Lett. 576, 363-368
-
(2004)
FEBS Lett
, vol.576
, pp. 363-368
-
-
Choi, W.1
Zibaee, S.2
Jakes, R.3
Serpell, L.C.4
Davletov, B.5
Crowther, R.A.6
Goedert, M.7
-
119
-
-
34250796802
-
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states
-
Fredenburg, R. A., Rospigliosi, C., Meray, R. K., Kessler, J. C., Lashuel, H. A., Eliezer, D., and Lansbury, P. T., Jr. (2007) The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states. Biochemistry 46, 7107-7118
-
(2007)
Biochemistry
, vol.46
, pp. 7107-7118
-
-
Fredenburg, R.A.1
Rospigliosi, C.2
Meray, R.K.3
Kessler, J.C.4
Lashuel, H.A.5
Eliezer, D.6
Lansbury Jr., P.T.7
-
120
-
-
24744461907
-
Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation
-
Bertoncini, C. W., Fernandez, C. O., Griesinger, C., Jovin, T. M., and Zweckstetter, M. (2005) Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation. J. Biol. Chem. 280, 30649-30652
-
(2005)
J. Biol. Chem
, vol.280
, pp. 30649-30652
-
-
Bertoncini, C.W.1
Fernandez, C.O.2
Griesinger, C.3
Jovin, T.M.4
Zweckstetter, M.5
-
121
-
-
0034602271
-
Interaction of human alpha-synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis
-
Perrin, R. J., Woods, W. S., Clayton, D. F., and George, J. M. (2000) Interaction of human alpha-synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis. J. Biol. Chem. 275, 34393-34398
-
(2000)
J. Biol. Chem
, vol.275
, pp. 34393-34398
-
-
Perrin, R.J.1
Woods, W.S.2
Clayton, D.F.3
George, J.M.4
-
122
-
-
1942534598
-
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein
-
Bussell, R., Jr., and Eliezer, D. (2004) Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein. Biochemistry 43, 4810-4818
-
(2004)
Biochemistry
, vol.43
, pp. 4810-4818
-
-
Bussell Jr., R.1
Eliezer, D.2
-
123
-
-
0036307753
-
Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein
-
Jo, E., Fuller, N., Rand, R. P., St George-Hyslop, P., and Fraser, P. E. (2002) Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein. J. Mol. Biol. 315, 799-807
-
(2002)
J. Mol. Biol
, vol.315
, pp. 799-807
-
-
Jo, E.1
Fuller, N.2
Rand, R.P.3
St George-Hyslop, P.4
Fraser, P.E.5
-
124
-
-
0032500599
-
Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
-
Jensen, P. H., Nielsen, M. S., Jakes, R., Dotti, C. G., and Goedert, M. (1998) Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. J. Biol. Chem. 273, 26292-26294
-
(1998)
J. Biol. Chem
, vol.273
, pp. 26292-26294
-
-
Jensen, P.H.1
Nielsen, M.S.2
Jakes, R.3
Dotti, C.G.4
Goedert, M.5
-
125
-
-
30044450420
-
Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants
-
Ulmer, T. S., and Bax, A. (2005) Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants. J. Biol. Chem. 280, 43179-43187
-
(2005)
J. Biol. Chem
, vol.280
, pp. 43179-43187
-
-
Ulmer, T.S.1
Bax, A.2
-
126
-
-
37249003742
-
Helical alpha-synuclein forms highly conductive ion channels
-
Zakharov, S. D., Hulleman, J. D., Dutseva, E. A., Antonenko, Y. N., Rochet, J. C., and Cramer, W. A. (2007) Helical alpha-synuclein forms highly conductive ion channels. Biochemistry 46, 14369-14379
-
(2007)
Biochemistry
, vol.46
, pp. 14369-14379
-
-
Zakharov, S.D.1
Hulleman, J.D.2
Dutseva, E.A.3
Antonenko, Y.N.4
Rochet, J.C.5
Cramer, W.A.6
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