Tertiary contact formation in α-synuclein probed by electron transfer

Journal of the American Chemical Society

Volumn 127, Issue 47, 2005, Pages 16388-16389

  Lee, Jennifer C ^a   Gray, Harry B ^a   Winkler, Jay R ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BIOPOLYMER; TRYPTOPHAN;

ABSORPTION SPECTROSCOPY; ARTICLE; BETA SHEET; DIFFUSION COEFFICIENT; ELECTRON TRANSPORT; ENERGY TRANSFER; EXCITATION; KINETICS; MODEL; PROTEIN STRUCTURE;

ALPHA-SYNUCLEIN; ELECTRONS; FLUORESCENCE RESONANCE ENERGY TRANSFER; KINETICS; MUTATION; OXIDATION-REDUCTION;

EID: 28444453293     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0561901     Document Type: Article

References (27)

1. Wright, P. E.; Dyson, H. J. J. Mol. Biol. 1999, 293, 321-331.
2. Uversky, V. N. Protein Sci. 2002, 11, 739-756.
3. Baba, M.; Nakajo, S.; Tu, P. H.; Tomita, T.; Nakaya, K.; Lee, V. M. Y.; Trojanowski, J. Q.; Iwatsubo, T. Am. J. Pathol. 1998, 152, 879-884.
4. Clayton, D. F.; George, J. M. Trends Neurosci. 1998, 21, 249-254.
5. Weinreb, P. H.; Zhen, W. G.; Poon, A. W.; Conway, K. A.; Lansbury, P. T. Biochemistry 1996, 35, 13709-13715.
6. Davidson, W. S.; Jonas, A.; Clayton, D. F.; Georges, J. M. J. Biol. Chem. 1998, 273, 9443-9449.
7. Eliezer, D.; Kutluay, E.; Jr., R. B.; Browne, G. J. Mol. Biol. 2001, 307, 1061-1073.
8. Jao, C. C.; Der-Sarkissian, A.; Chen, J.; Langen, R. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 8331-8336.
9. George, J. M.; Jin, H.; Woods, W. S.; Clayton, D. F. Neuron 1995, 15, 361-372.
10. Hsu, L. J.; Mallory, M.; Xia, Y.; Veinbergs, I.; Hashimoto, M.; Yoshimoto, M.; Thai, L. J.; Saitoh, T.; Masliah, E. J. Neurochem. 1998, 71, 338-344.
11. Navon, A.; Ittah, V.; Landsman, P.; Scheraga, H. A.; Hass, E. Biochemistry 2001, 40, 105-118.
12. Lee, J. C.; Engman, K. C.; Tezcan, F. A.; Gray, H. B.; Winkler, J. R. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 14778-14782.
13. Lyubovitsky, J. G.; Gray, H. B.; Winkler, J. R. J. Am. Chem. Soc. 2002, 124, 14840-14841.
14. Pletneva, E. V.; Gray, H. B.; Winkler, J. R. J. Mol. Biol. 2005, 345, 855-867.
15. Lee, J. C.; Langen, R.; Hummel, P. A.; Gray, H. B.; Winkler, J. R. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 16466-16471.
16. Adiabatic ET between two sites in a flexible polypeptide requires the formation of a close-contact encounter complex; for reactions with small intrinsic barriers, observed rates will be limited by the dynamics of intrachain diffusion. Chang, I.-J.; Lee, J. C.; Winkler, J. R.; Gray, H. B. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 3838-3840.
17. Lapidus, L. J.; Eaton, W. A.; Hofrichter, J. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 7220-7225.
18. Gonnelli, M.; Strambini, G. B. Photochem. Photobiol. 2005, 81, 614-622.
19. Szabo, A.; Schulten, K.; Schulten, Z. J. Chem. Phys. 1980, 72, 4350-4357.
20. Wang, X.; Bodunov, E. N.; Nau, W. M. Opt. Spectrosc. 2003, 95, 560-570.
21. Beechem, J. M.; Haas, E. Biophys. J. 1989, 55, 1225-1236.
22. Haas, E. IEEE J. Quantum Electron. 1996, 2, 1088-1106.
23. Flory, P. J. Statistical Mechanics of Chain Molecules; Interscience Pubishers: New York, 1969.
24. Schuler, B.; Lipman, E. A.; Steinbach, P. J.; Kumke, M.; Eaton, W. A. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 2754-2759.
25. Hagen, S. J.; Hofrichter, J.; Eaton, W. A. J. Phys. Chem B 1997, 101, 2352-2365.
26. Thirumalai, D. J. Phys. Chem. B 1999, 103, 608-610.
27. Notably, α-syn rates are significantly lower than end-to-end diffusion rates obtained for Gly-Ser peptides. Krieger, F.; Fierz, B.; Bieri, O.; Drewello, M.; Kiefhaber, T. J. Mol. Biol. 2003, 332, 265-274.