Design of an N-methylated peptide inhibitor of α-synuclein aggregation guided by solid-state NMR

Journal of the American Chemical Society

Volumn 130, Issue 25, 2008, Pages 7873-7881

  Madine, Jillian ^a   Doig, Andrew J ^b   Middleton, David A ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; ARCHITECTURAL DESIGN; BIOCHEMICAL ENGINEERING; DRUG THERAPY; GLYCOPROTEINS; HYDROCARBONS; MAGNETIC FIELDS; MAGNETIC RESONANCE; MAGNETISM; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERS; POLYMERS; PROTEINS; RESONANCE; STABILIZERS (AGENTS); TELLURIUM COMPOUNDS; WEIGHT CONTROL;

AMERICAN CHEMICAL SOCIETY (ACS); AMYLOID DISEASES; AMYLOID FORMATION; BIOCHEMICAL DATA; LEWY BODIES; METHYL GROUPS; MISFOLDED PROTEINS; NEURO-DEGENERATIVE DISEASE; PARKINSON'S DISEASE (PD); PATHOLOGICAL LESIONS; PROTEIN AGGREGATION; PROTEIN SEQUENCING; SELF AGGREGATION; SOLID STATE NMR (SSNMR); SOLID STATE NUCLEAR MAGNETIC RESONANCE (NMR); STRUCTURAL DATA; STRUCTURAL INFORMATIONS; SYNUCLEIN; SYNUCLEIN AGGREGATION;

HEALTH;

ALPHA SYNUCLEIN; AMYLOID PROTEIN; METHYL GROUP;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; DEGENERATIVE DISEASE; DRUG DESIGN; LEWY BODY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARKINSON DISEASE; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN MODIFICATION; SOLID STATE;

ALPHA-SYNUCLEIN; AMINO ACID SEQUENCE; DRUG DESIGN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; MOLECULAR SEQUENCE DATA; PEPTIDES; SOLUBILITY;

EID: 45749101292     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja075356q     Document Type: Article

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