New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin

Cancer Treatment Reviews

Volumn 35, Issue 1, 2009, Pages 57-68

  Li Weber, Min ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Anti inflammation; Anti virus; Apoptosis; Cancer therapy; Flavonoids; Herb; Redox

Indexed keywords

BAICALEIN; BAICALIN; CYCLOOXYGENASE 2 INHIBITOR; FLAVONE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; SCUTELLARIA BAICALENSIS EXTRACT; SCUTELLARIAE RADIX; WOGONIN;

ADENOMA; AEROBIC METABOLISM; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; BLADDER TUMOR; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER PREVENTION; CARDIOVASCULAR DISEASE; CELL CYCLE ARREST; CHINESE MEDICINE; CHRONIC INFLAMMATION; CLINICAL TRIAL; COLORECTAL CANCER; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG STRUCTURE; HEAD AND NECK CARCINOMA; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS 1; HYPERTENSION; INFLUENZA; NONHUMAN; PROSTATE CANCER; REVIEW; RISK REDUCTION; SARCOMA; SCUTELLARIA; SKIN INFLAMMATION; SQUAMOUS CELL CARCINOMA; STOMACH CARCINOMA;

DNA TOPOISOMERASES, TYPE II; DRUGS, CHINESE HERBAL; ENZYME INHIBITORS; FLAVANONES; FLAVONOIDS; GLUCURONIDASE; HUMANS; NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; SCUTELLARIA BAICALENSIS;

EID: 58749114381     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2008.09.005     Document Type: Review

References (171)

1. Rhoads C.P. Report on a cooperative study of nitrogen mustard (HN2) therapy of neoplastic disesase. Trans Assoc Am Physicians 60 (1947) 110-111
2. Boik J. Natural Compounds in Cancer Therapy, ISBN 0-9648280-1-4, Oregon Medical 2001.LLC.
3. Abelson P.H. Medicine from plants. Science 247 (1990) 513
4. Newman D.J., Cragg G.M., and Snader K.M. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 66 (2003) 1022-1037
5. Yano H., Mizoguchi A., Fukuda K., Haramaki M., Ogasawara S., Momosaki S., et al. The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase. Cancer Res 54 (1994) 448-454
6. Motoo Y., and Sawabu N. Antitumor effects of saikosaponins, Baicalin and Baicalein on human hepatoma cell lines. Cancer Lett 86 (1994) 91-95
7. Ikemoto S., Sugimura K., Yoshida N., Yasumoto R., Wada S., Yamamoto K., et al. Antitumor effects of Scutellariae radix and its components Baicalein, Baicalin and Wogonin on bladder cancer cell lines. Urology 55 (2000) 951-955
8. Zhang D.Y., Wu J., Ye F., Xue L., Jiang S., Yi J., et al. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Res 63 (2003) 4037-4043
9. Yu J., Liu H., Lei J., Tan W., Hu X., and Zou G. Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. Phytother Res 21 (2007) 817-822
10. Middleton Jr. E., Kandaswami C., and Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52 (2000) 673-751
11. Havsteen B.H. The biochemistry and medical significance of the flavonoids. Pharmacol Ther 96 (2002) 67-202
12. Gao Z., Huang K., Yang X., and Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochim Biophys Acta 1472 (1999) 643-650
13. Wang H.K., Xia Y., Yang Z.Y., Natschke S.L., and Lee K.H. Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents. Adv Exp Med Biol 439 (1998) 191-225
14. Wu J.A., Attele A.S., Zhang L., and Yuan C.S. Anti-HIV activity of medicinal herbs: usage and potential development. Am J Chin Med 29 (2001) 69-81
15. Ma S.C., Du J., But P.P., Deng X.L., Zhang Y.W., Ooi V.E., et al. Anti-viral Chinese medicinal herbs against respiratory syncytial virus. J Ethnopharmacol 79 (2002) 205-211
16. Huang R.L., Chen C.C., Huang H.L., Chang C.G., Chen C.F., Chang C., et al. Anti-hepatitis B virus effects of Wogonin isolated from Scutellaria baicalensis. Planta Med 66 (2000) 694-698
17. Guo Q., Zhao L., You Q., Yang Y., Gu H., Song G., et al. Anti-hepatitis B virus activity of Wogonin in vitro and in vivo. Antiviral Res 74 (2007) 16-24
18. Kimura Y., Okuda H., and Ogita Z. Effects of flavonoids isolated from scutellaria radix on fibrinolytic system induced by trypsin in human umbilical vein endothelial cells. J Nat Prod 60 (1997) 598-601
19. Huang Y., Tsang S.Y., Yao X., and Chen Z.Y. Biological properties of Baicalein in cardiovascular system. Curr Drug Targets Cardiovasc Haematol Disord 5 (2005) 177-184
20. Chi Y.S., Lim H., Park H., and Kim H.P. Effects of Wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem Pharmacol 66 (2003) 1271-1278
21. Wang C.Z., Mehendale S.R., and Yuan C.S. Commonly used antioxidant botanicals: active constituents and their potential role in cardiovascular illness. Am J Chin Med 35 (2007) 543-558
22. Lee H.H., Yang L.L., Wang C.C., Hu S.Y., Chang S.F., and Lee Y.H. Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. Brain Res 986 (2003) 103-113
23. Lee H., Kim Y.O., Kim H., Kim S.Y., Noh H.S., Kang S.S., et al. Flavonoid Wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J 17 (2003) 1943-1944
24. Son D., Lee P., Lee J., Kim H., and Kim S.Y. Neuroprotective effect of Wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation. Eur J Pharmacol 493 (2004) 99-102
25. Piao H.Z., Jin S.A., Chun H.S., Lee J.C., and Kim W.K. Neuroprotective effect of Wogonin: potential roles of inflammatory cytokines. Arch Pharm Res 27 (2004) 930-936
26. Cho J., and Lee H.K. Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells. Eur J Pharmacol 485 (2004) 105-110
27. Cho J., and Lee H.K. Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Biol Pharm Bull 27 (2004) 1561-1564
28. You K.M., Jong H.G., and Kim H.P. Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants. Arch Pharm Res 22 (1999) 18-24
29. Kim H.K., Cheon B.S., Kim Y.H., Kim S.Y., and Kim H.P. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264. 7 and their structure-activity relationships. Biochem Pharmacol 58 (1999) 759-765
30. Kim H., Kim Y.S., Kim S.Y., and Suk K. The plant flavonoid Wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production. Neurosci Lett 309 (2001) 67-71
31. Wakabayashi I., and Yasui K. Wogonin inhibits inducible prostaglandin E(2) production in macrophages. Eur J Pharmacol 406 (2000) 477-481
32. Chen Y.C., Shen S.C., Chen L.G., Lee T.J., and Yang L.L. Wogonin, Baicalin and Baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochem Pharmacol 61 (2001) 1417-1427
33. Park B.K., Heo M.Y., Park H., and Kim H.P. Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by Wogonin, a plant flavone from Scutellaria radix. Eur J Pharmacol 425 (2001) 153-157
34. Shen S.C., Lee W.R., Lin H.Y., Huang H.C., Ko C.H., Yang L.L., et al. In vitro and in vivo inhibitory activities of rutin, Wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. Eur J Pharmacol 446 (2002) 187-194
35. Haranaka R., Hasegawa R., Nakagawa S., Sakurai A., Satomi N., and Haranaka K. Antitumor activity of combination therapy with traditional Chinese medicine and OK432 or MMC. J Biol Response Mod 7 (1988) 77-90
36. Yamamoto S., Oka H., Kanno T., Mizoguchi Y., and Kobayashi K. Controlled prospective trial to evaluate Syosakiko-to in preventing hepatocellular carcinoma in patients with cirrhosis of the liver. Gan To Kagaku Ryoho 16 (1989) 1519-1524
37. Ma Z., Otsuyama K., Liu S., Abroun S., Ishikawa H., Tsuyama N., et al. Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. Blood 105 (2005) 3312-3318
38. Han J., Ye M., Xu M., Sun J., Wang B., and Guo D. Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 848 (2007) 355-362
39. Gao J., Sanchez-Medina A., Pendry B.A., Hughes M.J., Webb G.P., and Corcoran O. Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures. J Pharm Pharm Sci 11 (2008) 77-87
40. Wang H.Z., Yu C.H., Gao J., and Zhao G.R. Effects of processing and extracting methods on active components in radix Scutellariae by HPLC analysis. Zhongguo Zhong Yao Za Zhi 32 (2007) 1637-1640
41. Chung H., Jung Y.M., Shin D.H., Lee J.Y., Oh M.Y., Kim H.J., et al. Anticancer effects of Wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. Int J Cancer 122 (2008) 816-822
42. Kuntz S., Wenzel U., and Daniel H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur J Nutr 38 (1999) 133-142
43. So F.V., Guthrie N., Chambers A.F., and Carroll K.K. Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen. Cancer Lett 112 (1997) 127-133
44. Roy M.K., Nakahara K., Na T.V., Trakoontivakorn G., Takenaka M., Isobe S., et al. Baicalein, a flavonoid extracted from a methanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line in vitro via induction of apoptosis. Pharmazie 62 (2007) 149-153
45. Sonoda M., Nishiyama T., Matsukawa Y., and Moriyasu M. Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine. J Ethnopharmacol. 91 (2004) 65-68
46. Himeji M., Ohtsuki T., Fukazawa H., Tanaka M., Yazaki S., Ui S., et al. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid Wogonin among human cancer cells and normal diploid cell. Cancer Lett 245 (2007) 269-274
47. Shieh D.E., Cheng H.Y., Yen M.H., Chiang L.C., and Lin C.C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. Am J Chin Med 34 (2006) 245-261
48. Zhang H.W., Yang Y., Zhang K., Qiang L., Yang L., Yang L., et al. Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation. Eur J Pharmacol 591 (2008) 7-12
49. Yu J.Q., Liu H.B., Tian D.Z., Liu Y.W., Lei J.C., and Zou G.L. Changes in mitochondrial membrane potential and reactive oxygen species during Wogonin-induced cell death in human hepatoma cells. Hepatol Res 37 (2007) 68-76
50. Wang W., Guo Q., You Q., Zhang K., Yang Y., Yu J., et al. Involvement of Bax/Bcl-2 in Wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. Anticancer Drugs 17 (2006) 797-805
51. Wong B.C., Wang W.P., Cho C.H., Fan X.M., Lin M.C., Kung H.F., et al. 12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells. Carcinogenesis 22 (2001) 1349-1354
52. Leung H.W., Yang W.H., Lai M.Y., Lin C.J., and Lee H.Z. Inhibition of 12-lipoxygenase during Baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. Food Chem Toxicol 45 (2007) 403-411
53. Lee H.Z., Leung H.W., Lai M.Y., and Wu C.H. Baicalein-induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells. Anticancer Res 25 (2005) 959-964
54. Li Q.B., You Y., Chen Z.C., Lü J., Shao J., and Zou P. Role of Baicalein in the regulation of proliferation and apoptosis in human myeloma RPMI8226 cells. Chin Med J (Engl) 119 (2006) 948-952
55. Bonham M., Posakony J., Coleman I., Montgomery B., Simon J., and Nelson P.S. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res 11 (2005) 3905-3914
56. Chen S., Ruan Q., Bedner E., Deptala A., Wang X., Hsieh T.C., et al. Effects of the flavonoid Baicalin and its metabolite Baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines. Cell Prolif. 34 (2001) 293-304
57. Pidgeon G.P., Kandouz M., Meram A., and Honn K.V. Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. Cancer Res 62 (2002) 2721-2727
58. Chan F.L., Choi H.L., Chen Z.Y., Chan P.S., and Huang Y. Induction of apoptosis in prostate cancer cell lines by a flavonoid, Baicalin. Cancer Lett 160 (2000) 219-228
59. Lee J.H., Li Y.C., Ip S.W., Hsu S.C., Chang N.W., Tang N.Y., et al. The role of Ca2+ in Baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway. Anticancer Res 28 (2008) 1701-1711
60. Chow J.M., Huang G.C., Shen S.C., Wu C.Y., Lin C.W., and Chen Y.C. Differential apoptotic effect of Wogonin and nor-Wogonin via stimulation of ROS production in human leukemia cells. J Cell Biochem 103 (2008) 1394-1404
61. Lee W.R., Shen S.C., Lin H.Y., Hou W.C., Yang L.L., and Chen Y.C. Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. Biochem Pharmacol 63 (2002) 225-236
62. Baumann S., Fas S.C., Giaisi M., Müller W.W., Merling A., Gülow K., et al. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLC{gamma}1- and Ca2+-dependent apoptosis. Blood 111 (2008) 2354-2363
63. Chang W.H., Chen C.H., and Lu F.J. Different effects of Baicalein, Baicalin and Wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. Planta Med 68 (2002) 128-132
64. Chen Y.C., Shen S.C., Lee W.R., Lin H.Y., Ko C.H., Shih C.M., et al. Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. Arch Toxicol 76 (2002) 351-359
65. Lee D.H., Kim C., Zhang L., and Lee Y.J. Role of p53, PUMA, and Bax in Wogonin-induced apoptosis in human cancer cells. Biochem Pharmacol 75 (2008) 2020-2033
66. Wang W., Guo Q.L., You Q.D., Zhang K., Yang Y., Yu J., et al. The anticancer activities of Wogonin in murine sarcoma S180 both in vitro and in vivo. Biol Pharm Bull 29 (2006) 1132-1137
67. Lu N., Gao Y., Ling Y., Chen Y., Yang Y., Gu H.Y., et al. Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. Life Sci 82 (2008) 956-963
68. Enomoto R., Sugahara C., Suzuki C., Nagase I., Takamura Y., Yoshikawa A., et al. Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action. J Pharmacol Sci 104 (2007) 355-365
69. Kawai M., Hirano T., Higa S., Arimitsu J., Maruta M., Kuwahara Y., et al. Flavonoids and related compounds as anti-allergic substances. Allergol Int 56 (2007) 113-123
70. Hausen B.M. Evaluation of the main contact allergens in propolis (1995 to 2005). Dermatitis 16 (2005) 127-129
71. Schuler T.M., and Frosch P.J. Propolis-induced contact allergy. Hautarzt 39 (1988) 139-142
72. Lee B.S., Shim S.M., Heo J., Pae H.O., Seo B.Y., Han S.Y., et al. Wogonin suppresses TARC expression induced by mite antigen via heme oxygenase 1 in human keratinocytes Suppressive effect of Wogonin on mite antigen-induced TARC expression. J Dermatol Sci 46 (2007) 31-40
73. Taniguchi C., Homma M., Takano O., Hirano T., Oka K., Aoyagi Y., et al. Pharmacological effects of urinary products obtained after treatment with saiboku-to, a herbal medicine for bronchial asthma, on type IV allergic reaction. Planta Med 66 (2000) 607-611
74. Curtin J.F., Donovan M., and Cotter T.G. Regulation and measurement of oxidative stress in apoptosis. J Immunol Metohods 265 (2002) 49-72
75. Storz P. Reactive oxygen species in tumor progression. Front Biosci 10 (2005) 1881-1896
76. Rice-Evans C.A., Miller N.J., and Paganga G. Structure-antioxidant activity relationships of flavonoids and phenlic acids. Free Radic Biol Med 20 (1996) 933-956
77. Cao G., Sofic E., and Prior R.L. Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic Biol Med 22 (1997) 749-760
78. Valko M., Rhodes C.J., Moncol J., Izakovic M., and Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160 (2006) 1-40
79. 2+ ions: implications for their antioxidant properties. Biochem. J (1998) 1173-1178
80. Morel I., Lescoat G., Cillard P., and Cillard J. Role of flavonoids and iron chelation in antioxidant action. Methods Enzymol 234 (1994) 437-443
81. Williams R.J., Spencer J.P., and Rice-Evans C. Flavonoids: antioxidants or signaling molecules?. Free Radic Biol Med 36 (2004) 838-849
82. Kagan V.E., Kuzmenko A.I., Tyurina Y.Y., Shvedova A.A., Matsura T., and Yalowich J.C. Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase. Cancer Res 61 (2001) 7777-7784
83. Modriansky M., Tyurina Y.Y., Tyurin V.A., Matsura T., Shvedova A.A., Yalowich J.C., et al. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?. Toxicology 177 (2002) 105-117
84. Miyoshi N., Naniwa K., Yamada T., Osawa T., and Nakamura Y. Dietary flavonoid apigenin is a potential inducer of intracellular oxidative stress: the role in the interruptive apoptotic signal. Arch Biochem Biophys 466 (2007) 274-282
85. Kachadourian R., Leitner H.M., and Day B.J. Selected flavonoids potentiate the toxicity of cisplatin in human lung adenocarcinoma cells: a role for glutathione depletion. Int J Oncol 31 (2007) 161-168
86. Kachadourian R., and Day B.J. Flavonoid-induced glutathione depletion: potential implications for cancer treatment. Free Radic Biol Med 41 (2006) 65-76
87. Pantano C., Reynaert N.L., van der Vliet A., and Janssen-Heininger Y.M. Redox-sensitive kinases of the nuclear factor-kappaB signaling pathway. Antioxid Redox Signal 8 (2006) 1791-1806
88. Nakano H., Nakajima A., Sakon-Komazawa S., Piao J.H., Xue X., and Okumura K. Reactive oxygen species mediate crosstalk between NF-kappaB and JNK. Cell Death Differ 13 (2006) 730-737
89. Jost P.J., and Ruland J. Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood 109 (2007) 2700-2707
90. Suh J., and Rabson A.B. NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon?. J Cell Biochem 91 (2004) 100-117
91. François S., El Benna J., Dang P.M., Pedruzzi E., Gougerot-Pocidalo M.A., and Elbim C. Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad. J Immunol 174 (2005) 3633-3642
92. Szatrowski T.P., and Nathan C.F. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 51 (1991) 794-798
93. Toyokuni S., Okamoto K., Yodoi J., and Hiai H. Persistent oxidative stress in cancer. FEBS Lett 358 (1995) 1-3
94. Portakal O., Ozkaya O., Erden Inal M., Bozan B., Kosan M., and Sayek I. (2000) Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 33 (2000) 279-284
95. Fas S.C., Baumann S., Zhu J.Y., Giaisi M., Treiber M.K., Mahlknecht U., et al. Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis. Blood 108 (2006) 3700-3706
96. Schwartz G.K., and Shah M.A. Targeting the cell cycle: a new approach to cancer therapy. J Clin Oncol 23 (2005) 9408-9421
97. Shapiro G.I. Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol 24 (2006) 1770-1783
98. Blagosklonny M.V., and Pardee A.B. The restriction point of the cell cycle. Cell cycle 1 (2002) 103-110
99. Roy P.G., and Thompson A.M. Cyclin D1 and breast cancer. Breast 15 (2006) 718-727
100. Hideshima T., Bergsagel P.L., Kuehl W.M., and Anderson K.C. Advances in biology of multiple myeloma: clinical applications. Blood 104 (2004) 607-618
101. Hinz M., Krappmann D., Eichten A., Heder A., Scheidereit C., and Strauss M. NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 19 (1999) 2690-2698
102. Guttridge D.C., Albanese C., Reuther J.Y., Pestell R.G., and Baldwin Jr. A.S. NF-κB controls cell growth ad differentiation through the transcriptional regulation of cyclin D1. Mol Cell Biol 19 (1999) 5785-5799
103. Joyce D., Albanese C., Steer J., Fu M., Bouzahzah B., and Pestell R.G. NF-kappaB and cell-cycle regulation: the cyclin connection. Cytokine Growth Factor Rev 12 (2001) 73-90
104. Galluzzi L., Larochette N., Zamzami N., and Kroemer G. Mitochondria as therapeutic targets for cancer chemotherapy. Oncogene 25 (2006) 4812-4830
105. Debatin K.M., and Krammer P.H. Death receptors in chemotherapy and cancer. Oncogene 23 (2004) 2950-2966
106. Budd R.C., Yeh W.C., and Tschopp J. CFLIP regulation of lymphocyte activation and development. Nat Rev Immunol 6 (2006) 196-204
107. Krammer P.H., Arnold R., and Lavrik I.N. Life and death in peripheral T-cells. Nat Rev Immunol 7 (2007) 532-542
108. Barnhart B.C., Alappat E.C., and Peter M.E. The CD95 type I/type II model. Semin Immunol 15 (2003) 185-193
109. Beg A.A., and Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 274 (1996) 782-784
110. Van Antwerp D.J., Martin S.J., Kafri T., Green D.R., and Verma I.M. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 274 (1996) 787-789
111. Wang C.Y., Mayo M.W., and ASJr Baldwin. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 274 (1996) 784-787
112. Gulow K., Kaminski M., Darvas K., Suss D., Li-Weber M., and Krammer P.H. HIV-1 trans-activator of transcription substitutes for oxidative signaling in activation-induced T-cell death. J Immunol 174 (2005) 5249-5260
113. Kaminski M., Kießling M., Suss D., Krammer P.H., and Gulow G. Novel role for mitochondria: protein kinase c theta dependent oxidative signaling organelles in activation induced T-cell death. Mol Cell Biol 27 (2007) 3625-3639
114. Akaishi T., Nakazawa K., Sato K., Saito H., Ohno Y., and Ito Y. Hydrogen peroxide modulates whole cell Ca2+ currents through L-type channels in cultured rat dentate granule cells. Neurosci Lett 356 (2004) 25-28
115. Redondo P.C., Salido G.M., Rosado J.A., and Pariente J.A. Effect of hydrogen peroxide on Ca2+ mobilization in human platelets through sulphydryl oxidation dependent and independent mechanisms. Biochem Pharmacol 67 (2004) 491-502
116. Hong J.H., Moon S.J., Byun H.M., Kim M.S., Jo H., Bae Y.S., et al. Critical role of phospholipase Cgamma1 in the generation of H2O2-evoked [Ca2+]i oscillations in cultured rat cortical astrocytes. J Biol Chem 281 (2006) 13057-13067
117. Rizzuto R., Pinton P., Carrington W., Fay F.S., Fogarty K.E., Lifshitz L.M., et al. Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. Science 280 (1998) 1763-1766
118. Csordas G., Thomas A.P., and Hajnoczky G. Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria. EMBO J 18 (1999) 96-108
119. Montero M., Lobatón C.D., Hernández-Sanmiguel E., Santodomingo J., Vay L., Moreno A., et al. Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids. Biochem J 384 (2004) 19-24
120. Wang H.G., Pathan N., Ethell I.M., Krajewski S., Yamaguchi Y., Shibasaki F., et al. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 284 (1999) 339-343
121. Springer J.E., Azbill R.D., Nottingham S.A., and Kennedy S.E. Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury. J Neurosci 20 (2000) 7246-7251
122. Datta S.R., Ranger A.M., Lin M.Z., Sturgill J.F., Ma Y.C., Cowan C.W., et al. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell 3 (2002) 631-643
123. Kotturi M.F., Carlow D.A., Lee J.C., Ziltener H.J., and Jefferies W.A. Identification and functional characterization of voltage-dependent calcium channels in T lymphocytes. J Biol Chem 278 (2003) 46949-46960
124. Badou A., Basavappa S., Desai R., Peng Y.Q., Matza D., Mehal W.Z., et al. Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions. Science 307 (2005) 117-121
125. Coussens L.M., and Werb Z. Inflammation and cancer. Nature 420 (2002) 860-867
126. Balkwill F., Charles K.A., and Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7 (2005) 211-217
127. Lim H., Park H., and Kim H.P. Inhibition of contact dermatitis in animal models and suppression of proinflammatory gene expression by topically applied flavonoid, Wogonin. Arch Pharm Res. 27 (2004) 442-448
128. Lin C.C., and Shieh D.E. The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, Baicalin, Baicalein and Wogonin. Am J Chin Med 24 (1996) 31-36
129. Van Dien M., Takahashi K., Mu M.M., Koide N., Sugiyama T., Mori I., et al. Protective effect of Wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice. Microbiol Immunol 45 (2001) 751-756
130. Hong T., Jin G.B., Cho S., and Cyong J.C. Evaluation of the anti-inflammatory effect of Baicalein on dextran sulfate sodium-induced colitis in mice. Planta Med 68 (2002) 268-271
131. Fukumura D., Kashiwagi S., and Jain R.K. The role of nitric oxide in tumor progression. Nature Reviews Cancer 6 (2006) 521-534
132. Hussain S.P., Hofseth L.J., and Harris C.C. Radical causes of cancer. Nat Rev Cancer 3 (2003) 276-285
133. Chen C.J., Raung S.L., Liao S.L., and Chen S.Y. Inhibition of inducible nitric oxide synthase expression by Baicalein in endotoxin/cytokine-stimulated microglia. Biochem Pharmacol 67 (2004) 957-965
134. Chen T.J., Shen S.C., Lin H.Y., Chien L.L., and Chen Y.C. Lipopolysaccharide enhancement of 12-o-tetradecanoylphorbol 13-acetate-mediated transformation in rat glioma C6, accompanied by induction of inducible nitric oxide synthase. Toxicol Lett 147 (2004) 1-3
135. Lo Y.C., Lin Y.L., Yu K.L., Lai Y.H., Wu Y.C., Ann L.M., et al. San-Huang-Xie-Xin-Tang attenuates inflammatory responses in lipopolysaccharide-exposed rat lungs. J Ethnopharmacol 101 (2005) 68-74
136. Cheng P.Y., Lee Y.M., Wu Y.S., Chang T.W., Jin J.S., and Yen M.H. Protective effect of Baicalein against endotoxic shock in rats in vivo and in vitro. Biochem Pharmacol 73 (2007) 793-804
137. Shih Y.T., Wu D.C., Liu C.M., Yang Y.C., Chen I.J., and Lo Y.C. San-Huang-Xie-Xin-Tang inhibits Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells. J Ethnopharmacol 112 (2007) 537-544
138. Park S.W., Lee C.H., Kim Y.S., Kang S.S., Jeon S.J., Son K.H., et al. Protective effect of Baicalin against carbon tetrachloride-induced acute hepatic injury in mice. J Pharmacol Sci 106 (2008) 136-143
139. Shen S.C., Lin C.W., Lee H.M., Chien L.L., and Chen Y.C. Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: differential inhibitory effects of flavonoids. Neuroscience 140 (2006) 477-489
140. Hull M.A., Ko S.C., and Hawcroft G. Prostaglandin EP receptors: targets for treatment and prevention of colorectal cancer?. Mol Cancer Ther 3 (2004) 1031-1039
141. Subbaramaiah K., and Dannenberg A.J. Cyclooxygenase 2: a molecular target for cancer revention and treatment. Trends Pharmacol Sci 24 (2003) 96-102
142. Vane J.R., Bakhle Y.S., and Botting R.M. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38 (1998) 97-120
143. Castellone M.D., Teramoto H., and Gutkind J.S. Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection. Cancer Res 66 (2006) 11085-11088
144. Torrance C.J., Jackson P.E., Montgomery E., Kinzler K.W., Vogelstein B., Wissner A., et al. Combinatorial chemoprevention of intestinal neoplasia. Nat Med 6 (2000) 1024-1028
145. Brown J.R., and DuBois R.N. COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol. 23 (2005) 2840-2855
146. Chen LG, Hung LY, Tsai KW, Pan YS, Tsai YD, Li YZ, Liu YW. Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells. Mol Nutr Food Res. 2008 May 21. [Epub ahead of print].
147. Li B.Q., Fu T., Gong W.H., Dunlop N., Kung H., Yan Y., et al. The flavonoid Baicalin exhibits anti-inflammatory activity by binding to chemokines. Immunopharmacology 49 (2000) 295-306
148. zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nature Reviews Cancer 2 (2002) 342-350
149. Young L.S., and Rickinson A.B. Epstein-Barr virus: 40 years on. Nat Rev Cancer 4 (2004) 757-768
150. Kensler T.W., Qian G., and Chen J. Translational strategies for cancer prevention in liver. Nat Rev Cancer 3 (2003) 321-329
151. Farazi Paraskevi.A., and PA De.Pinho.R.A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6 (2006) 674-687
152. Matsuoka M., and Jeang K. Human T-cell leukemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 7 (2007) 270-280
153. Monini P., Sgadari C., Toschi E., Giovanni Barillari G., and Ensoli B. Antitumor effects of antiretroviral therapy. Nat Rev Cancer 4 (2004) 861-875
154. Nagai T., Miyaichi Y., Tomimori T., Suzuki Y., and Yamada H. Inhibition of influenza virus sialidase and anti-influenza virus activity by plant flavonoids. Chem Pharm Bull (Tokyo) 38 (1990) 1329-1332
155. Li Y., Ooi L.S., Wang H., But P.P., and Ooi V.E. Anti-viral activities of medicinal herbs traditionally used in Southern Mainland China. Phytother Res 18 (2004) 718-722
156. Nunnari G., Smith J.A., and Daniel R. HIV-1 Tat and AIDS-associated cancer: targeting the cellular anticancer barrier?. J Exp Clin Cancer Res 27 (2008) 3
157. Baylor N.W., Fu T., Yan Y.D., and Ruscetti F.W. Inhibition of human T-cell leukemia virus by the plant flavonoid Baicalin (7-glucuronic acid, 5, 6-dihydroxyflavone). J Infect Dis 165 3 (1992 Mar) 433-437
158. Ono K., Nakane H., Fukushima M., Chermann J.C., and Barré-Sinoussi F. Inhibition of reverse transcriptase activity by a flavonoid compound, 5, 6, 7-trihydroxyflavone. Biochem Biophys Res Commun 160 (1989) 982-987
159. Tang X., Chen H., and Zhang X. Inhibition of human immunodeficiency virus reverse transcriptase by Chinese medicines in vitro. Proc Chin Acad Med Sci Peking Union Med Coll. 5 (1990) 140-144
160. Li B.Q., Fu T., Yan Y.D., Baylor N.W., Ruscetti F.W., and Kung H.F. Inhibition of HIV infection by Baicalin-a flavonoid compound purified from Chinese herbal medicine. Cell Mol Biol Res 39 (1993) 119-124
161. Kitamura K., Honda M., Yoshizaki H., Yamamoto S., Nakane H., Fukushima M., et al. Baicalin, an inhibitor of HIV-1 production in vitro. Antiviral Res 37 (1998) 131-140
162. Li B.Q., Fu T., Dongyan Y., Mikovits J.A., Ruscetti F.W., and Wang J.M. Flavonoid Baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun 276 (2000) 534-538
163. De Clercq E. Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection. Med Res Rev 20 (2000) 323-349
164. Hussain S.P., Schwank J., Staib F., Wang X.W., and Harris C.C. TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene 26 (2007) 2166-2176
165. Romero M.R., Efferth T., Serrano M.A., Castaño B., Macias R.I., Briz O., et al. Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. Antiviral Res 68 (2005) 75-83
166. Tang Z.M., Peng M., and Zhan C.J. Screening 20 Chinese herbs often used for clearing heat and dissipating toxin with nude mice model of hepatitis C viral infection. Zhongguo Zhong Xi Yi Jie He Za Zhi 23 (2003) 447-448
167. Kutok J.L., and Wang F. Spectrum of Epstein-Barr virus-associated diseases. Annu Rev Pathol 1 (2006) 375-404
168. Konoshima T., Kokumai M., Kozuka M., Iinuma M., Mizuno M., Tanaka T., et al. Studies on inhibitors of skin tumor promotion. XI. Inhibitory effects of flavonoids from Scutellaria baicalensis on Epstein-Barr virus activation and their antitumor-promoting activities. Chem Pharm Bull (Tokyo) 40 (1992) 531-533
169. Wang H.W., Lin C.P., Chiu J.H., Chow K.C., Kuo K.T., Lin C.S., et al. Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by Wogonin and chrysin. Int J Cancer 120 (2007) 2019-2027
170. Lee S.J., Yoon J.H., and Song K.S. Chrysin inhibited stem cell factor (SCF)/c-Kit complex-induced cell proliferation in human myeloid leukemia cells. Biochem Pharmacol 74 (2007) 215-225
171. Kim J.H., Lee E.O., Lee H.J., Ku J.S., Lee M.H., Yang D.C., et al. Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung