Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system

Antiviral Research

Volumn 68, Issue 2, 2005, Pages 75-83

  Romero, Marta R ^a   Efferth, Thomas ^b   Serrano, Maria A ^a   Castaño, Beatriz ^a   MacIas, Rocio I R ^a   Briz, Oscar ^a   Marin, Jose J G ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Artemisinin; Artesunate; Curcumin; Hepatitis B; Traditional Chinese medicine

Indexed keywords

ARTEMISININ; ARTESUNATE; BAICALEIN; BAICALIN; BERBERINE; BUFALIN; CHINESE DRUG; CURCUMIN; DAIDZEIN; DAIDZIN; DIALLYL DISULFIDE; GLYCYRRHIZIC ACID; HEPATITIS B SURFACE ANTIGEN; ISONARDOSINON; LAMIVUDINE; NARDOFURAN; NARDOSINON; NEUTRAL RED; PUERARIN; QUERCETIN; TANNIN; TETRAHYDRONARDOSINON; UNCLASSIFIED DRUG; VIRUS DNA;

ANTIVIRAL ACTIVITY; ARTICLE; CELL STRAIN; CHINESE MEDICINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG EXPOSURE; DRUG POTENTIATION; DRUG PURIFICATION; DRUG SCREENING; HEPATITIS B VIRUS; HOST CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SOUTHERN BLOTTING; VIRUS REPLICATION;

ANTI-HIV AGENTS; ANTIVIRAL AGENTS; ARTEMISININS; CELL LINE; CULTURE MEDIA; DNA, VIRAL; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; INDICATORS AND REAGENTS; LAMIVUDINE; PLANT EXTRACTS; SESQUITERPENES; VIRUS REPLICATION;

ARTESUNATE; DNA VIRUSES; HEPATITIS B VIRUS;

EID: 27644565158     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2005.07.005     Document Type: Article

References (39)

1. G. Acs, M.A. Sells, R.H. Purcell, P. Price, R. Engle, M. Shapiro, and H. Popper Hepatitis B virus produced by transfected HepG2 cells causes hepatitis in chimpanzees Proc. Natl. Acad. Sci. U.S.A. 84 1987 4641 4644
2. A. Bartholomeusz, and S. Locarnini Hepatitis B virus mutants and fulminant hepatitis B: fitness plus phenotype Hepatology 34 2001 432 435
3. K.T. Batty, T.M. Davis, L.T. Thu, T.Q. Binh, T.K. Anh, and K.F. Ilett Selective high-performance liquid chromatographic determination of artesunate and alpha- and beta-dihydroartemisinin in patients with falciparum malaria J. Chromatogr. B. Biomed. Appl. 677 1996 345 350
4. R.P. Beasley, and L.Y. Hwang Overview on the epidemiology of hepatocellular carcinoma F.B. Hollinger S.M. Lemon M. Margolis Viral Hepatitis and Liver Disease 1991 Williams and Willkins Baltimore 532 535
5. I.M. Chang Liver-protective activities of aucubin derived from traditional oriental medicine Res. Comm. Mol. Pathol. Pharmcol. 102 1998 189 204
6. T.S.N. Chen, and P.S. Chen The liver in traditional Chinese medicine J. Gastroenterol. Hepatol. 13 1998 437 442
7. P. Chouteau, J. Le Seyec, B. Saulier-Le Drean, I. Cannie, P. Brissot, G. Lescoat, C. Guguen-Guillouzo, and P. Gripon Inhibition of hepatitis B virus production associated with high levels of intracellular viral DNA intermediates in iron-depleted HepG2 2.2.15 cells J. Hepatol. 34 2001 108 113
8. A.D. Dayan Neurotoxicity and artemisinin compounds: do the observations in animals justify limitation of clinical use? Med. Trop. 58 1998 32 37
9. S.L. Doong, C.H. Tsai, R.F. Schinazi, D.C. Liotta, and Y.C. Cheng Inhibition of the replication of hepatitis B virus in vitro by 2′,3′-dideoxy-3′-thiacytidine and related analogues Proc. Natl. Acad. Sci. U.S.A. 88 1991 8495 8499
10. T. Efferth, H. Dunstan, A. Saurbrey, H. Miyachi, and C. Chitambar The anti-malarial artesunate is also active against cancer Int. J. Oncol. 18 2001 767 773
11. T. Efferth, M. Davey, A. Olbrich, G. Rücker, E. Gebhart, and R. Davey Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells Blood Cells Mol. Dis. 28 2002 160 168
12. T. Efferth, M. Marschall, X. Wang, S.M. Huong, I. Hauber, A. Olbrich, M. Kronschnabl, T. Stamminger, and E.S. Huang Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses J. Mol. Med. 80 2002 233 242
13. T. Efferth, A. Olbrich, and R. Bauer mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether Biochem. Pharmacol. 64 2002 617 623
14. T. Efferth, A. Sauerbrey, A. Olbrich, E. Gebhart, P. Rauch, H.O. Weber, J.G. Hengstler, M.E. Halatsch, M. Volm, K.D. Tew, D.D. Ross, and J.O. Funk Molecular modes of action of artesunate in tumor cell lines Mol. Pharmacol. 64 2003 382 394
15. C.T. Fang, N. Nath, M. Pielech, and R.Y. Dodd A modified technique for the detection of hepatitis B virus-specific DNA polymerase J. Virol. Methods 2 1981 349 356
16. R. Fautz, B. Husein, and C. Hechenberger Application of the Neutral Red assay (NR assay) to monolayer cultures of primary hepatocytes: rapid colorimetric viability determination for the unscheduled DNA synthesis test (UDS) Mutat. Res. 253 1991 173 179
17. J. Han Traditional Chinese medicine and the search for new antineoplastic drugs J. Ethnopharmacol. 24 1988 1 17
18. S. Iino Natural history of hepatitis B and C virus infections Oncology 62 Suppl. 1 2002 18 23
19. J.B. Jiang, G.Q. Li, X.B. Guo, Y.C. Kong, and K. Arnold Antimalarial activity of mefloquine and qinghaosu Lancet 2 1982 285 288
20. T. Kalinina, A. Riu, L. Fischer, H. Will, and M. Sterneck A dominant hepatitis B virus population defective in virus secretion because of several S-gene mutations from a patient with fulminant hepatitis Hepatology 34 2001 385 394
21. S. Kaneko, S.M. Feinstone, and R.H. Miller Rapid and sensitive method for the detection of serum hepatitis B virus DNA using the polymerase chain reaction technique J. Clin. Microbiol. 27 1989 1930 1933
22. J. Lien, D.J. Petcu, C.E. Aldrich, and W.S. Mason Initiation of termination of duck hepatitis B virus DNA synthesis during virus maturation J. Virol. 61 1987 3832 3840
23. R. McGready, T. Cho, J.J. Cho, J.A. Simpsom, C. Luxemburger, L. Dubowitz, S. Looareesuwan, N.J. White, and F. Nosten Artemisinin derivatives in the treatment of falciparum malaria in pregnancy Trans. R. Soc. Trop. Med. Hyg. 92 1998 430 433
24. S.R. Meshnick Artemisinin: mechanisms of action, resistance and toxicity Int. J. Parasitol. 32 2002 1655 1660
25. K.L. Molnar-Kimber, J.W. Summers, and W.S. Mason Mapping of the cohesive overlap of duck hepatitis B virus DNA and of the site of initiation of reverse transcription J. Virol. 51 1984 181 191
26. F. Nosten, and R.N. Price New antimalarials. A risk-benefit analysis Drug Saf. 12 1995 264 273
27. L. Placidi, A. Faraj, A.G. Loi, C. Pierra, D. Egron, E. Cretton-Scott, G. Gosselin, C. Perigaud, L.T. Martin, R.F. Schinazi, J.L. Imbach, M.H. el Kouni, M.L. Bryant, and J.P. Sommadossi Antiviral activity and intracellular metabolism of bis(tButylSATE) phosphotriester of beta-l-2′,3′- dideoxyadenosine, a potent inhibitor of HIV and HBV replication Antivir. Chem. Chemother. 12 2001 99 108
28. R. Price, M. van Vugt, L. Phaipun, C. Luxemburger, J. Simpsom, R. McGready, F. ter Kuile, A. Kham, T. Chongsuphajaisiddhi, N.J. White, and F. Nosten Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives Am. J. Trop. Med. Hyg. 60 1999 547 555
29. J.C. Pugh, and M.F. Bassendine Molecular biology of hepadnavirus replication Br. Med. Bull. 46 1990 329 353
30. M.R. Romero, M.C. Martinez-Diez, M.G. Larena, R.I.R. Macias, M. Domínguez, C. Garcia-Monzon, M.A. Serrano, and J.J.G. Marin Evidence for dual effects of DNA-reactive bile acid derivatives (Bamets) on hepatitis B virus life cycle in an in vitro replicative system Antivir. Chem. Chemother. 13 2002 371 380
31. S.W. Schalm, R.A. de Man, R.A. Heijtink, and H.G.M. Niesters New nucleoside analogues for chronic hepatitis B J. Hepatol. 22 Suppl. 1995 52 56
32. L.B. Seeff, K.L. Lindsay, B.R. Bacon, T.F. Kresina, and J.H. Hoofnagle Complementary and alternative medicine in chronic liver disease Hepatology 34 2001 595 603
33. M.A. Sells, M.L. Chen, and G. Acs Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA Proc. Natl. Acad. Sci. U.S.A. 84 1987 1005 1009
34. M.A. Sells, A. Zelent, M. Shvartsman, and G. Acs Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions J. Virol. 62 1988 2836 2844
35. The EASL Jury, 2003. EASL International Consensus Conference on Hepatitis B. J. Hepatol. 38, 533-540.
36. B.E. Wang Treatment of chronic liver diseases with traditional Chinese medicine J. Gastroenterol. Hepatol. 15 Suppl. 2000 E67 E70
37. G.H. Wang, and C. Seeger Novel mechanism for reverse transcription in hepatitis B viruses J. Virol. 67 1993 6507 6512
38. Y.Z. Yang, B. Little, and S.R. Meshnick Alkylation of proteins by artemisinin. Effects of heme, pH and drug structure Biochem. Pharmacol. 48 1994 569 573
39. F. Zhang, D.K. Gosser Jr., and S.R. Meshnick Hemin-catalyzed decomposition of artemisinin Biochem. Pharmacol. 43 1992 1805 1809