Flavonoid-induced glutathione depletion: Potential implications for cancer treatment

Free Radical Biology and Medicine

Volumn 41, Issue 1, 2006, Pages 65-76

  Kachadourian, Remy ^a   Day, Brian J ^a,b  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Flow cytometry; Glutathione (GSH); HPLC EC; Manganese porphyrin; Multidrug resistance protein 1 (MRP1); Reactive oxygen species (ROS)

Indexed keywords

2 METHOXYESTRADIOL; ANTIOXIDANT; APIGENIN; BIOCHANIN A; CHRYSIN; CURCUMIN; CYTOCHROME C; DIHYDROXYCHALCONE; ETOPOSIDE; FLAVONE; FLAVONOID; GALANGIN; GENISTEIN; GLUTATHIONE; HYDROXYCHALCONE; INDOMETACIN; KAEMPFEROL; MANGANESE TETRAKIS(N ETHYLPYRIDINIUM 2 YL)PORPHYRIN; MULTIDRUG RESISTANCE PROTEIN 1; PORPHYRIN DERIVATIVE; QUERCETIN; ROTENONE; UNCLASSIFIED DRUG; VERAPAMIL; VERLUKAST;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER THERAPY; CELL CULTURE; CELL LEVEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ANTAGONISM; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; ENZYME RELEASE; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PHARMACODYNAMICS; PRIORITY JOURNAL; TUMOR CELL CULTURE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; CHALCONES; DRUG SYNERGISM; FLAVONOIDS; GLUTATHIONE; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID; LUNG NEOPLASMS; MALE; NEOPLASMS; OXIDANTS; PROSTATIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33744996911     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.03.002     Document Type: Article

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