메뉴 건너뛰기




Volumn 174, Issue 6, 2005, Pages 3633-3642

Inhibition of neutrophil apoptosis by TLR agonists in whole blood: Involvement of the phosphoinositide 3-kinase/Akt and NF-κB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated bad

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; CYCLOHEXIMIDE; DIPHENYLIODONIUM SALT; DNA; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FLAGELLIN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GENISTEIN; HEAT SHOCK PROTEIN 27; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOXORIBINE; MACROPHAGE ACTIVATING LIPOPEPTIDE 2; MONOCLONAL ANTIBODY; PEPTIDOGLYCAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN MCL 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SYNTHETIC PEPTIDE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 14844362908     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.6.3633     Document Type: Article
Times cited : (210)

References (59)
  • 1
    • 0021739838 scopus 로고
    • Oxidants from phagocytes: Agents of defense and destruction
    • Babior, B. M. 1984. Oxidants from phagocytes: agents of defense and destruction. Blood 64:959.
    • (1984) Blood , vol.64 , pp. 959
    • Babior, B.M.1
  • 3
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov, R., P. Preston-Hurlburt, and C. A. Janeway Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394.
    • (1997) Nature , vol.388 , pp. 394
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 4
    • 0141705297 scopus 로고    scopus 로고
    • Toll-like receptors stimulate human neutrophil function
    • Hayashi, F., T. K. Means, and A. D. Luster. 2003. Toll-like receptors stimulate human neutrophil function. Blood 102:2660.
    • (2003) Blood , vol.102 , pp. 2660
    • Hayashi, F.1    Means, T.K.2    Luster, A.D.3
  • 5
    • 0033952703 scopus 로고    scopus 로고
    • TLR4: Central component of the sole mammalian LPS sensor
    • Beutler, B. 2000. TLR4: central component of the sole mammalian LPS sensor. Curr. Opin. Immunol. 12:20.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 20
    • Beutler, B.1
  • 7
    • 2142652249 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils
    • Strassheim, D., K. Asehnoune, J. S. Park, J. Y. Kim, Q. He, D. Richter, K. Kuhn, S. Mitra, and E. Abraham. 2004. Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils. J. Immunol. 172:5727.
    • (2004) J. Immunol. , vol.172 , pp. 5727
    • Strassheim, D.1    Asehnoune, K.2    Park, J.S.3    Kim, J.Y.4    He, Q.5    Richter, D.6    Kuhn, K.7    Mitra, S.8    Abraham, E.9
  • 9
    • 0036884424 scopus 로고    scopus 로고
    • A blast from the past: Clearance of apoptotic cells regulates immune responses
    • Savill, J., I. Dransfield, C. Gregory, and C. Haslett. 2002. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat. Rev. Immunol. 2:965.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 965
    • Savill, J.1    Dransfield, I.2    Gregory, C.3    Haslett, C.4
  • 10
    • 0026795415 scopus 로고
    • Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products
    • Colotta, F., F. Re, N. Polentarutti, S. Sozzani, and A. Mantovani. 1992. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 80:2012.
    • (1992) Blood , vol.80 , pp. 2012
    • Colotta, F.1    Re, F.2    Polentarutti, N.3    Sozzani, S.4    Mantovani, A.5
  • 12
    • 0032189802 scopus 로고    scopus 로고
    • Mcl-1 expression in human neutrophils: Regulation by cytokines and correlation with cell survival
    • Moulding, D. A., J. A. Quayle, C. A. Hart, and S. W. Edwards. 1998. Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival. Blood 92:2495.
    • (1998) Blood , vol.92 , pp. 2495
    • Moulding, D.A.1    Quayle, J.A.2    Hart, C.A.3    Edwards, S.W.4
  • 13
    • 0036786958 scopus 로고    scopus 로고
    • Role of PI3-kinase-dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival
    • Cowburn, A. S., K. A. Cadwallader, B. J. Reed, N. Farahi, and E. R. Chilvers. 2002. Role of PI3-kinase-dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival. Blood 100:2607.
    • (2002) Blood , vol.100 , pp. 2607
    • Cowburn, A.S.1    Cadwallader, K.A.2    Reed, B.J.3    Farahi, N.4    Chilvers, E.R.5
  • 14
    • 0035036669 scopus 로고    scopus 로고
    • Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis
    • Klein, J. B., A. Buridi, P. Y. Coxon, M. J. Rane, T. Manning. R. Kettritz, and K. R. McLeish. 2001. Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis. Cell. Signal. 13:335.
    • (2001) Cell. Signal. , vol.13 , pp. 335
    • Klein, J.B.1    Buridi, A.2    Coxon, P.Y.3    Rane, M.J.4    Manning, T.5    Kettritz, R.6    McLeish, K.R.7
  • 15
  • 16
    • 0030031340 scopus 로고    scopus 로고
    • Sodium butyrate delays neutrophil apoptosis: Role of protein biosynthesis in neutrophil survival
    • Stringer, R. E., C. A. Hart, and S. W. Edwards. 1996. Sodium butyrate delays neutrophil apoptosis: role of protein biosynthesis in neutrophil survival. Br. J. Haematol. 92:169.
    • (1996) Br. J. Haematol. , vol.92 , pp. 169
    • Stringer, R.E.1    Hart, C.A.2    Edwards, S.W.3
  • 18
  • 19
    • 0034431166 scopus 로고    scopus 로고
    • Membrane potential estimation by flow cytometry
    • Shapiro, H. M. 2000. Membrane potential estimation by flow cytometry. Methods 21:271.
    • (2000) Methods , vol.21 , pp. 271
    • Shapiro, H.M.1
  • 20
    • 0035871720 scopus 로고    scopus 로고
    • Intracellular pool of IL-10 receptors in specific granules of human neutrophils: Differential mobilization by proinflammatory mediators
    • Elbim, C., H. Reglier, M. Fay, C. Delarche, V. Andrieu, J. El Benna, and M. A. Gougerot-Pocidalo. 2001. Intracellular pool of IL-10 receptors in specific granules of human neutrophils: differential mobilization by proinflammatory mediators. J. Immunol. 166:5201.
    • (2001) J. Immunol. , vol.166 , pp. 5201
    • Elbim, C.1    Reglier, H.2    Fay, M.3    Delarche, C.4    Andrieu, V.5    El Benna, J.6    Gougerot-Pocidalo, M.A.7
  • 21
    • 0025218905 scopus 로고
    • Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′,7′-dichlorofluorescin
    • Rothe, G., and G. Valet. 1990. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′,7′- dichlorofluorescin. J. Leukocyte Biol. 47:440.
    • (1990) J. Leukocyte Biol. , vol.47 , pp. 440
    • Rothe, G.1    Valet, G.2
  • 22
    • 0036569658 scopus 로고    scopus 로고
    • Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: A critical role for monocytes in leukocyte lipopolysaccharide responses
    • Sabroe, I., E. C. Jones, L. R. Usher, M. K. Whyte, and S. K. Dower. 2002. Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses. J. Immunol. 168:4701.
    • (2002) J. Immunol. , vol.168 , pp. 4701
    • Sabroe, I.1    Jones, E.C.2    Usher, L.R.3    Whyte, M.K.4    Dower, S.K.5
  • 24
    • 0034655090 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways
    • Klein, J. B., M. J. Rane, J. A. Scherzer, P. Y. Coxon, R. Kettritz, J. M. Mathiesen, A. Buridi, and K. R. McLeish. 2000. Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways. J. Immunol. 164:4286.
    • (2000) J. Immunol. , vol.164 , pp. 4286
    • Klein, J.B.1    Rane, M.J.2    Scherzer, J.A.3    Coxon, P.Y.4    Kettritz, R.5    Mathiesen, J.M.6    Buridi, A.7    McLeish, K.R.8
  • 26
    • 0036356391 scopus 로고    scopus 로고
    • P38 Mitogen-activated protein kinase and phosphatidylinositol 3-kinase activities have opposite effects on human neutrophil apoptosis
    • Alvarado-Kristensson, M., M. I. Porn-Ares, S. Grethe, D. Smith, L. Zheng, and T. Andersson. 2002. P38 Mitogen-activated protein kinase and phosphatidylinositol 3-kinase activities have opposite effects on human neutrophil apoptosis. FASEB J. 16:129.
    • (2002) FASEB J. , vol.16 , pp. 129
    • Alvarado-Kristensson, M.1    Porn-Ares, M.I.2    Grethe, S.3    Smith, D.4    Zheng, L.5    Andersson, T.6
  • 27
    • 0037771321 scopus 로고    scopus 로고
    • Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-δ, and NF-κB signaling pathways
    • Wang, K., D. Scheel-Toellner, S. H. Wong, R. Craddock, J. Caamano, A. N. Akbar, M. Salmon, and J. M. Lord. 2003. Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-δ, and NF-κB signaling pathways. J. Immunol. 171:1035.
    • (2003) J. Immunol. , vol.171 , pp. 1035
    • Wang, K.1    Scheel-Toellner, D.2    Wong, S.H.3    Craddock, R.4    Caamano, J.5    Akbar, A.N.6    Salmon, M.7    Lord, J.M.8
  • 28
    • 0031843222 scopus 로고    scopus 로고
    • Lipopolysaccharide protects polymorphonuclear leukocytes from apoptosis via tyrosine phosphorylation-dependent signal transduction pathways
    • Sweeney, J. F., P. K. Nguyen, G. M. Omann, and D. B. Hinshaw. 1998. Lipopolysaccharide protects polymorphonuclear leukocytes from apoptosis via tyrosine phosphorylation-dependent signal transduction pathways. J. Surg. Res. 74:64.
    • (1998) J. Surg. Res. , vol.74 , pp. 64
    • Sweeney, J.F.1    Nguyen, P.K.2    Omann, G.M.3    Hinshaw, D.B.4
  • 30
    • 0030785701 scopus 로고    scopus 로고
    • Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27
    • Konishi, H., H. Matsuzaki, M. Tanaka, Y. Takemura, S. Kuroda, Y. Ono, and U. Kikkawa. 1997. Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett. 410:493.
    • (1997) FEBS Lett. , vol.410 , pp. 493
    • Konishi, H.1    Matsuzaki, H.2    Tanaka, M.3    Takemura, Y.4    Kuroda, S.5    Ono, Y.6    Kikkawa, U.7
  • 32
    • 0035808270 scopus 로고    scopus 로고
    • Molecular control of neutrophil apoptosis
    • Akgul, C., D. A. Moulding, and S. W. Edwards. 2001. Molecular control of neutrophil apoptosis. FEBS Lett. 487:318.
    • (2001) FEBS Lett. , vol.487 , pp. 318
    • Akgul, C.1    Moulding, D.A.2    Edwards, S.W.3
  • 33
    • 0037021446 scopus 로고    scopus 로고
    • Mechanisms involved in interleukin-15-induced suppression of human neutrophil apoptosis: Role of the anti-apoptotic Mcl-1 protein and several kinases including Janus kinase-2, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2
    • Pelletier, M., C. Ratthe, and D. Girard. 2002. Mechanisms involved in interleukin-15-induced suppression of human neutrophil apoptosis: role of the anti-apoptotic Mcl-1 protein and several kinases including Janus kinase-2, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2. FEBS Lett. 532:164.
    • (2002) FEBS Lett. , vol.532 , pp. 164
    • Pelletier, M.1    Ratthe, C.2    Girard, D.3
  • 35
    • 1242292337 scopus 로고    scopus 로고
    • C5a delays apoptosis of human neutrophils via an extracellular signal-regulated kinase and Bad-mediated signalling pathway
    • Perianayagam, M. C., V. S. Balakrishnan, B. J. Pereira, and B. L. Jaber. 2004. C5a delays apoptosis of human neutrophils via an extracellular signal-regulated kinase and Bad-mediated signalling pathway. Eur. J. Clin. Invest. 34:50.
    • (2004) Eur. J. Clin. Invest. , vol.34 , pp. 50
    • Perianayagam, M.C.1    Balakrishnan, V.S.2    Pereira, B.J.3    Jaber, B.L.4
  • 36
    • 0028928480 scopus 로고
    • Effects of cell purification methods on CD11b and L-seleclin expression as well as the adherence and activation of leucocytes
    • Macey, M. G., D. A. McCarthy, S. Vordermeier, A. C. Newland, and K. A. Brown. 1995. Effects of cell purification methods on CD11b and L-seleclin expression as well as the adherence and activation of leucocytes. J. Immunol. Methods. 181:211.
    • (1995) J. Immunol. Methods , vol.181 , pp. 211
    • Macey, M.G.1    McCarthy, D.A.2    Vordermeier, S.3    Newland, A.C.4    Brown, K.A.5
  • 37
    • 0034537417 scopus 로고    scopus 로고
    • Increased levels of apoptosis of leukocyte subsets in cultured PBMCs compared to whole blood as shown by annexin V binding: Relevance to cytokine production
    • Hodge, G., S. Hodge, and P. Han. 2000. Increased levels of apoptosis of leukocyte subsets in cultured PBMCs compared to whole blood as shown by annexin V binding: relevance to cytokine production. Cytokine 12:1763.
    • (2000) Cytokine , vol.12 , pp. 1763
    • Hodge, G.1    Hodge, S.2    Han, P.3
  • 38
    • 7244219855 scopus 로고    scopus 로고
    • The role of interleukin-1β in direct and Toll-like receptor 4-mediated neutrophil activation and survival
    • Prince, L. R., L. Allen, E. C. Jones, P. G. Hellewell, S. K. Dower, M. K. B. Whyte, and I. Sabroe. 2004. The role of interleukin-1β in direct and Toll-like receptor 4-mediated neutrophil activation and survival. Am. J. Pathol. 165:1819.
    • (2004) Am. J. Pathol. , vol.165 , pp. 1819
    • Prince, L.R.1    Allen, L.2    Jones, E.C.3    Hellewell, P.G.4    Dower, S.K.5    Whyte, M.K.B.6    Sabroe, I.7
  • 39
    • 0033124896 scopus 로고    scopus 로고
    • Porphyromonas gingivalis lipopolysaccharide delays human polymorphonuclear leukocyte apoptosis in vitro
    • Preshaw, P. M., R. E. Schifferle, and J. D. Walters. 1999. Porphyromonas gingivalis lipopolysaccharide delays human polymorphonuclear leukocyte apoptosis in vitro. J. Periodontal Res. 34:197.
    • (1999) J. Periodontal Res. , vol.34 , pp. 197
    • Preshaw, P.M.1    Schifferle, R.E.2    Walters, J.D.3
  • 40
    • 0035165287 scopus 로고    scopus 로고
    • Cutting edge: Functional interactions between Toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
    • Hajjar, A. M., D. S. O'Mahony, A. Ozinsky, D. M. Underhill, A. Aderem, S. J. Klebanoff, and C. B. Wilson. 2001. Cutting edge: functional interactions between Toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. J. Immunol. 166:15.
    • (2001) J. Immunol. , vol.166 , pp. 15
    • Hajjar, A.M.1    O'Mahony, D.S.2    Ozinsky, A.3    Underhill, D.M.4    Aderem, A.5    Klebanoff, S.J.6    Wilson, C.B.7
  • 41
    • 0037080024 scopus 로고    scopus 로고
    • Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
    • Zarember, K. A., and P. J. Godowski. 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J. Immunol. 168:554.
    • (2002) J. Immunol. , vol.168 , pp. 554
    • Zarember, K.A.1    Godowski, P.J.2
  • 44
    • 0029006149 scopus 로고
    • Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
    • Lin, Y. Z., S. Y. Yao, R. A. Veach, T. R. Torgerson, and J. Hawinger. 1995. Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J. Biol. Chem. 270:14255.
    • (1995) J. Biol. Chem. , vol.270 , pp. 14255
    • Lin, Y.Z.1    Yao, S.Y.2    Veach, R.A.3    Torgerson, T.R.4    Hawinger, J.5
  • 46
    • 0442307969 scopus 로고    scopus 로고
    • IκB kinases: Key regulators of the NF-κB pathway
    • Yamamoto, Y., and R. B. Gaynor. 2004. IκB kinases: key regulators of the NF-κB pathway. TRENDS Biochem. Sci. 29:72.
    • (2004) TRENDS Biochem. Sci. , vol.29 , pp. 72
    • Yamamoto, Y.1    Gaynor, R.B.2
  • 47
    • 0030992837 scopus 로고    scopus 로고
    • Signalling through the lipid products of phosphoinositide-3-OH kinase
    • Toker, A., and L. C. Cantley. 1997. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387:673.
    • (1997) Nature , vol.387 , pp. 673
    • Toker, A.1    Cantley, L.C.2
  • 48
    • 0032053709 scopus 로고    scopus 로고
    • Mechanisms and consequences of activation of protein kinase B/Akt
    • Downward, J. 1998. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell. Biol. 10:262.
    • (1998) Curr. Opin. Cell. Biol. , vol.10 , pp. 262
    • Downward, J.1
  • 51
    • 0043267638 scopus 로고    scopus 로고
    • Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-κB in endothelial cells
    • Li, X., J. C. Tupper, D. D. Bannerman, R. K. Winn, C. J. Rhodes, and J. M. Harlan. 2003. Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-κB in endothelial cells. Infect. Immun. 71:4414.
    • (2003) Infect. Immun. , vol.71 , pp. 4414
    • Li, X.1    Tupper, J.C.2    Bannerman, D.D.3    Winn, R.K.4    Rhodes, C.J.5    Harlan, J.M.6
  • 52
    • 0742289969 scopus 로고    scopus 로고
    • Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9
    • Takeshita, F., I. Gursel, K. J. Ishii, K. Suzuki, M. Gursel, and D. M. Klinman. 2004. Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9. Semin. Immunol. 16:17.
    • (2004) Semin. Immunol. , vol.16 , pp. 17
    • Takeshita, F.1    Gursel, I.2    Ishii, K.J.3    Suzuki, K.4    Gursel, M.5    Klinman, D.M.6
  • 53
    • 0035876931 scopus 로고    scopus 로고
    • Cooperative regulation of Mcl-1 by Janus kinase/Stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils
    • Epling-Burnette, P. K., B. Zhong, F. Bai, K. Jiang, R. D. Bailey, R. Garcia, R. Jove, J. Y. Djeu, T. P. Loughran Jr., and S. Wei. 2001. Cooperative regulation of Mcl-1 by Janus kinase/Stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils. J. Immunol. 166:7486.
    • (2001) J. Immunol. , vol.166 , pp. 7486
    • Epling-Burnette, P.K.1    Zhong, B.2    Bai, F.3    Jiang, K.4    Bailey, R.D.5    Garcia, R.6    Jove, R.7    Djeu, J.Y.8    Loughran Jr., T.P.9    Wei, S.10
  • 54
    • 3042686666 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1
    • Derouet, M., L. Thomas, A. Cross, R. J. Moots, and S. W. Edwards. 2004. Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1. J. Biol. 7 Chem. 279:26915.
    • (2004) J. Biol. Chem. , vol.279 , pp. 26915
    • Derouet, M.1    Thomas, L.2    Cross, A.3    Moots, R.J.4    Edwards, S.W.5
  • 55
    • 0035368020 scopus 로고    scopus 로고
    • Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesis
    • Schubert, K. M., and V. Duronio. 2001. Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesis. Biochem. J. 356:473.
    • (2001) Biochem. J. , vol.356 , pp. 473
    • Schubert, K.M.1    Duronio, V.2
  • 56
    • 0033529416 scopus 로고    scopus 로고
    • NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes
    • Lee, H. H., H. Dadgostar, Q. Cheng, J. Shu, and G. Cheng. 1999. NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc. Natl. Acad. Sci. USA 96:9136.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9136
    • Lee, H.H.1    Dadgostar, H.2    Cheng, Q.3    Shu, J.4    Cheng, G.5
  • 57
    • 2142721829 scopus 로고    scopus 로고
    • Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11
    • Hsu, S. Y., A. Kaipia, L. Zhu, and A. J. Hsueh. 1997. Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11. Mol. Endocrinol. 11:1858.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1858
    • Hsu, S.Y.1    Kaipia, A.2    Zhu, L.3    Hsueh, A.J.4
  • 58
    • 0034811108 scopus 로고    scopus 로고
    • Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis
    • Bae, J., S. Y. Hsu, C. P. Leo, K. Zell, and A. J. Hsueh. 2001. Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis. Apoptosis 6:319.
    • (2001) Apoptosis , vol.6 , pp. 319
    • Bae, J.1    Hsu, S.Y.2    Leo, C.P.3    Zell, K.4    Hsueh, A.J.5
  • 59
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • del Peso, L., M. Gonzalez-Garcia, C. Page, R. Herrera, and G. Nunez. 1997. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687.
    • (1997) Science , vol.278 , pp. 687
    • Del Peso, L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.