-
1
-
-
0033559933
-
Estimates of the worldwide incidence of 25 major cancers in 1990
-
Parkin, D. M., Pisani, P. & Feday, J. Estimates of the worldwide incidence of 25 major cancers in 1990. Int. J. Cancer 80, 827-841 (1999).
-
(1999)
Int. J. Cancer
, vol.80
, pp. 827-841
-
-
Parkin, D.M.1
Pisani, P.2
Feday, J.3
-
3
-
-
0037260139
-
Cancer statistics 2003
-
Jemel, A. et al. Cancer statistics 2003. CA Cancer J. Clin. 53, 5-26 (2003).
-
(2003)
CA Cancer J. Clin.
, vol.53
, pp. 5-26
-
-
Jemel, A.1
-
4
-
-
0003452109
-
-
American Institute for Cancer Research, Washington DC
-
World Cancer Research Fund/American Institute for Cancer Research. Food, Nutrition and the Prevention of Cancer: a Global Perspective (American Institute for Cancer Research, Washington DC, 1997).
-
(1997)
Food, Nutrition and the Prevention of Cancer: A Global Perspective
-
-
-
5
-
-
0032241319
-
Population-based cancer survival in Qidong, People's Republic of China
-
Chen, J.-G. et al. Population-based cancer survival in Qidong, People's Republic of China. IARC Sci. Publ. 145, 27-35 (1998).
-
(1998)
IARC Sci. Publ.
, vol.145
, pp. 27-35
-
-
Chen, J.-G.1
-
6
-
-
0034526950
-
Chronic hepatitis B virus infection in Asian countries
-
Mencan, I. et al. Chronic hepatitis B virus infection in Asian countries. J. Gastroenterol. Hepatol. 15, 1356-1361 (2000).
-
(2000)
J. Gastroenterol. Hepatol.
, vol.15
, pp. 1356-1361
-
-
Mencan, I.1
-
7
-
-
0035045662
-
Hepatocellular carcinoma in the developing world
-
Ogunbiyi, J. O. Hepatocellular carcinoma in the developing world. Semin. Oncol. 28, 179-187 (2001).
-
(2001)
Semin. Oncol.
, vol.28
, pp. 179-187
-
-
Ogunbiyi, J.O.1
-
8
-
-
0037160554
-
Mycotoxins
-
Etzel, R. A. Mycotoxins. JAMA 287, 425-427 (2002).
-
(2002)
JAMA
, vol.287
, pp. 425-427
-
-
Etzel, R.A.1
-
10
-
-
0036561908
-
A Modeling the molecular circuitry of cancer
-
Hahn, W. C. & Weinberg, R. A Modeling the molecular circuitry of cancer. Nature Rev. Cancer 2, 331-341 (2002)
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 331-341
-
-
Hahn, W.C.1
Weinberg, R.2
-
12
-
-
0036894527
-
Hypermethylation pathways to colorectal cancer. Implications for prevention and detection
-
Herman, J. G. Hypermethylation pathways to colorectal cancer. Implications for prevention and detection. Gastroenterol. Clin. North Am. 31, 945-958 (2002).
-
(2002)
Gastroenterol. Clin. North Am.
, vol.31
, pp. 945-958
-
-
Herman, J.G.1
-
13
-
-
0036699940
-
Molecular pathogenesis of human hepatocellular carcinoma
-
Thorgeirsson, A. & Grisham, J. W. Molecular pathogenesis of human hepatocellular carcinoma. Nature Genet. 31, 339-346 (2002).
-
(2002)
Nature Genet.
, vol.31
, pp. 339-346
-
-
Thorgeirsson, A.1
Grisham, J.W.2
-
15
-
-
0022456609
-
Serologic markers of hepatitis B virus infection
-
Hoofnagle, J. H. & Schafer, D. F. Serologic markers of hepatitis B virus infection. Semin. Liver Dis. 6, 1-10 (1986).
-
(1986)
Semin. Liver Dis.
, vol.6
, pp. 1-10
-
-
Hoofnagle, J.H.1
Schafer, D.F.2
-
16
-
-
0026770728
-
Hepatitis C: Virology, epidemiology clinical course, and treatment
-
Weiland, O. & Schvarcz, R. Hepatitis C: virology, epidemiology clinical course, and treatment. Scand. J. Gastroenterol. 27, 337-342 (1992).
-
(1992)
Scand. J. Gastroenterol.
, vol.27
, pp. 337-342
-
-
Weiland, O.1
Schvarcz, R.2
-
17
-
-
0004274773
-
-
(ed. Hayes, A. W.) (Raven Press, New York
-
Plaa, G. L. & Hewitt, W. R. in Principles and Methods of Toxicology 2nd edn (ed. Hayes, A. W.) 599-628 (Raven Press, New York, 1989).
-
(1989)
Principles and Methods of Toxicology 2nd Edn.
, pp. 599-628
-
-
Plaa, G.L.1
Hewitt, W.R.2
-
18
-
-
0033379780
-
Hepatitis C virus and hepatocellular carcinoma
-
Colombo, M. Hepatitis C virus and hepatocellular carcinoma. Baillière's Clin. Gastroenterol. 13, 519-528 (1999).
-
(1999)
Baillière's Clin. Gastroenterol.
, vol.13
, pp. 519-528
-
-
Colombo, M.1
-
19
-
-
0036829856
-
Hepatocellular carcinoma and hepatitis C in the United States
-
El-Serag, H. B. Hepatocellular carcinoma and hepatitis C in the United States. Hepatology 36, S75-S83 (2002).
-
(2002)
Hepatology
, vol.36
-
-
El-Serag, H.B.1
-
20
-
-
0036815957
-
Advances in therapy for hepatitis C infection
-
Zein, C. O. & Zein, N. N. Advances in therapy for hepatitis C infection. Microbes Infect. 4, 1237-1246 (2002).
-
(2002)
Microbes Infect.
, vol.4
, pp. 1237-1246
-
-
Zein, C.O.1
Zein, N.N.2
-
24
-
-
0026566829
-
Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma
-
Ross, R. K. et al. Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet 339, 943-946 (1992). This study was the first to show the synergistic interaction between aflatoxin exposure and infection with hepatitis B virus (HBV) in the aetiology of hepatocellular carcinoma (HCC).
-
(1992)
Lancet
, vol.339
, pp. 943-946
-
-
Ross, R.K.1
-
25
-
-
0028356088
-
A follow-up study of urinary markers of aflatoxin exposure and liver cancer in Shanghai, People's Republic of China
-
Qian, G.-S. et al. A follow-up study of urinary markers of aflatoxin exposure and liver cancer in Shanghai, People's Republic of China. Cancer Epidemiol. Biomarkers Prev. 3, 3-10 (1994).
-
(1994)
Cancer Epidemiol. Biomarkers Prev.
, vol.3
, pp. 3-10
-
-
Qian, G.-S.1
-
26
-
-
0032793909
-
Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen cancers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1
-
Sun, Z.-T. et al. Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen cancers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1. Hepatology 30, 379-383 (1999).
-
(1999)
Hepatology
, vol.30
, pp. 379-383
-
-
Sun, Z.-T.1
-
27
-
-
9544236289
-
Aflatoxin exposure and the risk of hepatocellular carcinoma in Taiwan
-
Wang, L.-Y. et al. Aflatoxin exposure and the risk of hepatocellular carcinoma in Taiwan. Int. J. Cancer 67, 620-625 (1996).
-
(1996)
Int. J. Cancer
, vol.67
, pp. 620-625
-
-
Wang, L.-Y.1
-
28
-
-
0001205434
-
Effect of aflatoxin metabolism and DNA adduct formation on hepatocellular carcinoma among chronic hepatitis B carriers in Taiwan
-
Yu, M. W. et al. Effect of aflatoxin metabolism and DNA adduct formation on hepatocellular carcinoma among chronic hepatitis B carriers in Taiwan. J. Hepatol. 27, 320-330 (1997).
-
(1997)
J. Hepatol.
, vol.27
, pp. 320-330
-
-
Yu, M.W.1
-
29
-
-
0036091794
-
Clinical and public health challenges of cancer. Natural history of hepatocellular carcinoma including fibrolamellar and hepato-cholangiocarcinoma vanants
-
Okuda, K. Clinical and public health challenges of cancer. Natural history of hepatocellular carcinoma including fibrolamellar and hepato-cholangiocarcinoma vanants. J. Gastroenterol. Hepatol. 17, 401-405 (2002).
-
(2002)
J. Gastroenterol. Hepatol.
, vol.17
, pp. 401-405
-
-
Okuda, K.1
-
30
-
-
0035143887
-
The role of serum α-fetoprotein estimation in the diagnosis and management of hepatocellular carcinoma
-
Johnson, P. J. The role of serum α-fetoprotein estimation in the diagnosis and management of hepatocellular carcinoma. Clin. Liver Dis. 5, 145-159 (2001).
-
(2001)
Clin. Liver Dis.
, vol.5
, pp. 145-159
-
-
Johnson, P.J.1
-
31
-
-
0142206339
-
Screening for liver cancer: Results of a randomised controlled trial in Qidong, China
-
in the press
-
Chen, J.-G. et al. Screening for liver cancer: results of a randomised controlled trial in Qidong, China. J. Med. Screening (in the press).
-
J. Med. Screening
-
-
Chen, J.-G.1
-
32
-
-
0037357427
-
Gene expression profiling of preneoplastic liver disease and liver cancer: A new era for improved early detection and treatment of these deadly diseases?
-
Kim, J. W. & Wang, X. W. Gene expression profiling of preneoplastic liver disease and liver cancer: a new era for improved early detection and treatment of these deadly diseases? Carcinogenesis 24, 363-369 (2003).
-
(2003)
Carcinogenesis
, vol.24
, pp. 363-369
-
-
Kim, J.W.1
Wang, X.W.2
-
33
-
-
0029836445
-
Microsatellite alterations in serum DNA of head and neck cancer patients
-
Nawroz, H. et al. Microsatellite alterations in serum DNA of head and neck cancer patients. Nature Med. 2, 1035-1037 (1996).
-
(1996)
Nature Med.
, vol.2
, pp. 1035-1037
-
-
Nawroz, H.1
-
34
-
-
17344377380
-
Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: Correlation with clinicopathological features
-
Yamada, T. et al. Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features. Clin. Cancer Res. 4, 1527-1532 (1998).
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 1527-1532
-
-
Yamada, T.1
-
35
-
-
0032894125
-
Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients
-
Esteller, M. et al. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res. 59, 67-70 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 67-70
-
-
Esteller, M.1
-
36
-
-
0032893755
-
Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients
-
Wong, I. H. et al. Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients. Cancer Res. 59, 71-73 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 71-73
-
-
Wong, I.H.1
-
37
-
-
0002832039
-
Detection of circulating tumor DNA in the blood (plasma/serum) of cancer patients
-
Anker, P., Mulcahy, H., Chen, X. Q. & Stroun, M. Detection of circulating tumor DNA in the blood (plasma/serum) of cancer patients. Cancer Metastasis Rev. 18, 65-73 (1999).
-
(1999)
Cancer Metastasis Rev.
, vol.18
, pp. 65-73
-
-
Anker, P.1
Mulcahy, H.2
Chen, X.Q.3
Stroun, M.4
-
38
-
-
0033818628
-
Frequent p15 promoter methylation in tumor and peripheral blood from hepatocellular carcinoma patients
-
Wong, I. H., Lo, Y. M., Yeo, W., Lau, W. Y. & Johnson, P. J. Frequent p15 promoter methylation in tumor and peripheral blood from hepatocellular carcinoma patients. Clin. Cancer Res. 6, 3516-3521 (2000).
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 3516-3521
-
-
Wong, I.H.1
Lo, Y.M.2
Yeo, W.3
Lau, W.Y.4
Johnson, P.J.5
-
39
-
-
0036554834
-
Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinomas
-
Zhong, S. et al. Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinomas. Clin. Cancer Res. 8, 1087-1092 (2002). Epigenetic silencing of a gene encoding a carcinogen-detoxification enzyme, GSTP1, is associated with the pathogenesis of HCC.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 1087-1092
-
-
Zhong, S.1
-
40
-
-
0029813585
-
Hot-spot mutations in hepatitis B virus X gene in hepatocellular carcinoma
-
Hsia, C. C., Yowen, H. & Tabor, E. Hot-spot mutations in hepatitis B virus X gene in hepatocellular carcinoma. Lancet 348, 625-626 (1996).
-
(1996)
Lancet
, vol.348
, pp. 625-626
-
-
Hsia, C.C.1
Yowen, H.2
Tabor, E.3
-
41
-
-
0036828782
-
Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China
-
Ming, L. et al. Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China. Hepatology 36, 1214-1220 (2002). A comprehensive assessment of the separate and combined effects of HBV, hepatitis C virus (HCV) and aflatoxin in causing HCC in Qidong, China.
-
(2002)
Hepatology
, vol.36
, pp. 1214-1220
-
-
Ming, L.1
-
42
-
-
0142206338
-
Detection of specific mutations in the hepatitis B virus X-gene associated with codon 249 mutations in p53 in hepatocellular carcinoma patients
-
Kuang, S.-Y. et al. Detection of specific mutations in the hepatitis B virus X-gene associated with codon 249 mutations in p53 in hepatocellular carcinoma patients. Proc. Am. Assoc. Cancer Res. 44, 593 (2003).
-
(2003)
Proc. Am. Assoc. Cancer Res.
, vol.44
, pp. 593
-
-
Kuang, S.-Y.1
-
43
-
-
0037184718
-
Molecular pathogenesis of human hepatocellular carcinoma
-
Wang, X. W. et al. Molecular pathogenesis of human hepatocellular carcinoma. Toxicology 181-182, 43-47 (2002).
-
(2002)
Toxicology
, vol.181-182
, pp. 43-47
-
-
Wang, X.W.1
-
44
-
-
0036856464
-
The toxicology of aflatoxins as a basis for public health decisions
-
Wild, C. P. & Turner, P. C. The toxicology of aflatoxins as a basis for public health decisions. Mutagenesis 17, 471-481 (2002).
-
(2002)
Mutagenesis
, vol.17
, pp. 471-481
-
-
Wild, C.P.1
Turner, P.C.2
-
45
-
-
0037222429
-
TP 53 and liver carcinogenesis
-
Staib, F. et al. TP53 and liver carcinogenesis. Hum. Mutat. 21, 201-216 (2003).
-
(2003)
Hum. Mutat.
, vol.21
, pp. 201-216
-
-
Staib, F.1
-
46
-
-
0034684954
-
Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia
-
Kirk, G. D. et al. Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia. J. Natl Cancer Inst. 92, 148-153 (2000). The first demonstration that mutations of TP53 can be detected in plasma samples of patients with HCC.
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 148-153
-
-
Kirk, G.D.1
-
47
-
-
0035137702
-
Specific p53 mutation detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry
-
Jackson, P. E. et al. Specific p53 mutation detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry. Cancer Res. 61, 33-35 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 33-35
-
-
Jackson, P.E.1
-
48
-
-
85099525751
-
Prospective detection of codon 249 mutations in p53 in plasma of hepatocellular carcinoma patients
-
in the press
-
Jackson, P. E. et al. Prospective detection of codon 249 mutations in p53 in plasma of hepatocellular carcinoma patients. Carcinogenesis (in the press).
-
Carcinogenesis
-
-
Jackson, P.E.1
-
49
-
-
0035234125
-
-
(eds Miller, A. B. et al.) (International Agency for Research on Cancer by Oxford University Press, UK)
-
Wild, C. P. & Turner, P. C. in Biomarkers in Cancer Chemopruevention (eds Miller, A. B. et al.) 154, 215-222 (International Agency for Research on Cancer by Oxford University Press, UK, 2001).
-
(2001)
Biomarkers in Cancer Chemoprevention
, vol.154
, pp. 215-222
-
-
Wild, C.P.1
Turner, P.C.2
-
50
-
-
84989646554
-
A pilot study on universal immunization of newborn infants in an area of hepatitis B virus and primary hepatocellular carcinoma prevalence with a low dose of hepatitis B vaccine
-
Sun, T.-T. et al. A pilot study on universal immunization of newborn infants in an area of hepatitis B virus and primary hepatocellular carcinoma prevalence with a low dose of hepatitis B vaccine. J. Cell. Physiol. 4, 83-90 (1986).
-
(1986)
J. Cell. Physiol.
, vol.4
, pp. 83-90
-
-
Sun, T.-T.1
-
51
-
-
0030965103
-
Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children
-
Taiwan Childhood Hepatoma Study Group
-
Chang, M.-H. et al. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group. N. Engl. J. Med. 336, 1855-1859 (1997). The initial report describing the efficacy of HBV vaccination in reducing the incidence of HCC.
-
(1997)
N. Engl. J. Med.
, vol.336
, pp. 1855-1859
-
-
Chang, M.-H.1
-
52
-
-
0037237706
-
Trends in the incidence of hepatocellular carcinoma in boys and girls in Taiwan after large-scale hepatitis B vaccination
-
Lee, C.-L., Hsieh, K.-S. & Ko, Y.-C. Trends in the incidence of hepatocellular carcinoma in boys and girls in Taiwan after large-scale hepatitis B vaccination. Cancer Epidemiol. Biomarkers Prev. 12, 57-59 (2003).
-
(2003)
Cancer Epidemiol. Biomarkers Prev.
, vol.12
, pp. 57-59
-
-
Lee, C.-L.1
Hsieh, K.-S.2
Ko, Y.-C.3
-
53
-
-
0000613334
-
-
(ed. Searle, C. E.) (ACS, Washington DC)
-
Busby, W. F. Jr & Wogan, G. N. in Chemical Carcinogenesis 2nd edn, Vol. 2 (ed. Searle, C. E.) 945-1136 (ACS, Washington DC, 1984).
-
(1984)
Chemical Carcinogenesis 2nd Edn.
, vol.2
, pp. 945-1136
-
-
Busby W.F., Jr.1
Wogan, G.N.2
-
54
-
-
12244286810
-
The role of aflatoxins and hepatitis viruses in the etiopathogenesis of hepatocellular carcinoma: A basis for primary prevention in Guinea-Conakry, West Africa
-
Turner, P. C. et al. The role of aflatoxins and hepatitis viruses in the etiopathogenesis of hepatocellular carcinoma: a basis for primary prevention in Guinea-Conakry, West Africa. J. Gastroenterol. Hepatol. 17, S441-S448 (2002). This study describes the development and use of biomarkers to assess the impact of reduction of aflatoxin exposure on the development of HCC in high-risk populations.
-
(2002)
J. Gastroenterol. Hepatol.
, vol.17
-
-
Turner, P.C.1
-
55
-
-
0036637235
-
Chemoprevention: An essential approach to controlling cancer
-
Sporn, M. B. & Suh, N. Chemoprevention: an essential approach to controlling cancer. Nature Rev. Cancer 2, 537-543 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 537-543
-
-
Sporn, M.B.1
Suh, N.2
-
56
-
-
0035496616
-
Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
-
Gupta, R. A. & DuBois, R. N. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nature Rev. Cancer 1, 11-21 (2001).
-
(2001)
Nature Rev. Cancer
, vol.1
, pp. 11-21
-
-
Gupta, R.A.1
DuBois, R.N.2
-
57
-
-
0032549474
-
1. A review of the antimutagenicity and anticarcinogenicity data in rainbow trout
-
1. A review of the antimutagenicity and anticarcinogenicity data in rainbow trout. Mutat. Res. 399, 245-253 (1998).
-
(1998)
Mutat. Res.
, vol.399
, pp. 245-253
-
-
Dashwood, R.1
-
58
-
-
0002472283
-
Chlorophyll derivatives - Their chemistry, commercial preparation and uses
-
Kephart, J. C. Chlorophyll derivatives - their chemistry, commercial preparation and uses. Econ. Bot. 9, 3-38 (1955).
-
(1955)
Econ. Bot.
, vol.9
, pp. 3-38
-
-
Kephart, J.C.1
-
59
-
-
0018921340
-
Use of chlorophyllin in the care of geriatric patients
-
Young, R. W. & Bergel, J. S. Use of chlorophyllin in the care of geriatric patients. J. Am. Geriat. Soc. 24, 46-47 (1980).
-
(1980)
J. Am. Geriat. Soc.
, vol.24
, pp. 46-47
-
-
Young, R.W.1
Bergel, J.S.2
-
61
-
-
0035807837
-
Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer
-
Egner, P. A. et al. Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Proc. Natl Acad. Sci. USA 98, 14601-14606 (2001). A pivotal clinical trial showing that an 'interceptor' molecule, chlorophyllin, can be used to reduce the bioavailability of aflatoxin in humans.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 14601-14606
-
-
Egner, P.A.1
-
62
-
-
0036630087
-
Schistosomiasis: From risk assessment to control
-
Bergquist, N. R. Schistosomiasis: from risk assessment to control. Trends Parasitol. 18, 309-314 (2002).
-
(2002)
Trends Parasitol.
, vol.18
, pp. 309-314
-
-
Bergquist, N.R.1
-
63
-
-
0033577057
-
1 by oltipraz in residents of Qidong, People's Republic of China
-
1 by oltipraz in residents of Qidong, People's Republic of China. J. Natl. Cancer Inst. 91, 347-354 (1999). This study showed that oltipraz can modulate the effects of aflatoxin in humans through the induction of carcinogen-detoxification enzymes.
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 347-354
-
-
Wang, J.-S.1
-
64
-
-
0343545529
-
Oltipraz chemoprevention trial in Qidong, People's Republic of China: Modulation of serum aflatoxin albumin adduct biomarkers
-
Kensler, T. W. et al. Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers. Cancer Epidemiol. Biomarkers Prev. 7, 127-134 (1998).
-
(1998)
Cancer Epidemiol. Biomarkers Prev.
, vol.7
, pp. 127-134
-
-
Kensler, T.W.1
-
65
-
-
0035098686
-
The importance of using scientific principles in the development of medicinal agents from plants
-
Talalay, P. & Talalay, P. The importance of using scientific principles in the development of medicinal agents from plants. Acad. Med. 76, 238-247 (2001).
-
(2001)
Acad. Med.
, vol.76
, pp. 238-247
-
-
Talalay, P.1
Talalay, P.2
-
66
-
-
0035808553
-
The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
-
Fahey, J. W., Zalcmann, A. T. & Talalay, P. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry 56, 5-51 (2001).
-
(2001)
Phytochemistry
, vol.56
, pp. 5-51
-
-
Fahey, J.W.1
Zalcmann, A.T.2
Talalay, P.3
-
67
-
-
0026577605
-
A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
-
Zhang, Y., Talalay, P., Cho, C. G. & Posner, G. H. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl Acad. Sci. USA 89, 2399-2403 (1992).
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 2399-2403
-
-
Zhang, Y.1
Talalay, P.2
Cho, C.G.3
Posner, G.H.4
-
68
-
-
0030931522
-
Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
-
Fahey, J. W., Zhang, Y. & Talalay, P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl Acad. Sci. USA 94, 10367-10372 (1997). The initial demonstration that high levels of the anticarcinogen isothiocyanate sulphoraphane can be found in 3-day-old broccoli sprouts.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 10367-10372
-
-
Fahey, J.W.1
Zhang, Y.2
Talalay, P.3
-
69
-
-
0034928041
-
Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: Metabolism and excretion in humans
-
Shapiro, T. et al. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol. Biomarkers Prev. 10, 501-508 (2001).
-
(2001)
Cancer Epidemiol. Biomarkers Prev.
, vol.10
, pp. 501-508
-
-
Shapiro, T.1
-
70
-
-
0028179830
-
Consumption of Brussels sprouts results in elevated α-class glutathione S-transferase levels in human blood plasma
-
Bogaards, J. J., Verhagen, H., Willems, M. I., van Poppel, G. & van Bladdern, P. J. Consumption of Brussels sprouts results in elevated α-class glutathione S-transferase levels in human blood plasma. Carcinogenesis 15, 1073-1075 (1994).
-
(1994)
Carcinogenesis
, vol.15
, pp. 1073-1075
-
-
Bogaards, J.J.1
Verhagen, H.2
Willems, M.I.3
Van Poppel, G.4
Van Bladdern, P.J.5
-
71
-
-
0033839333
-
Modulation of human glutathione S-transferases by botanically defined vegetable diets
-
Lampe, J. W. et al. Modulation of human glutathione S-transferases by botanically defined vegetable diets. Cancer Epidemiol. Biomarkers Prev. 9, 787-793 (2000).
-
(2000)
Cancer Epidemiol. Biomarkers Prev.
, vol.9
, pp. 787-793
-
-
Lampe, J.W.1
-
72
-
-
0029048396
-
Intermittent dosing with oltipraz: Relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases
-
Primiano, T. et al. Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases. Cancer Res. 55, 4319-4324 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 4319-4324
-
-
Primiano, T.1
-
73
-
-
0034494832
-
Preventive effects of drinking green tea on cancer and cardiovascular disease: Epidemiological evidence for multiple targeting prevention
-
Nakachi, K., Matsuyama, S., Miyake, S., Suganuma, M. & Imai, K. Preventive effects of drinking green tea on cancer and cardiovascular disease: epidemiological evidence for multiple targeting prevention. BioFactors 13, 49-54 (2000).
-
(2000)
BioFactors
, vol.13
, pp. 49-54
-
-
Nakachi, K.1
Matsuyama, S.2
Miyake, S.3
Suganuma, M.4
Imai, K.5
-
74
-
-
0037114363
-
Green tea: Cancer preventive beverage and/or drug
-
Fujiki, H., Suganuma, M., Imai, K. & Nakachi, K. Green tea: cancer preventive beverage and/or drug. Cancer Lett. 188, 9-13 (2002).
-
(2002)
Cancer Lett.
, vol.188
, pp. 9-13
-
-
Fujiki, H.1
Suganuma, M.2
Imai, K.3
Nakachi, K.4
-
75
-
-
0142144311
-
Chemoprevention trial of green tea polyphenols in high-risk population of liver cancer
-
Wang, J.-S. et al. Chemoprevention trial of green tea polyphenols in high-risk population of liver cancer. Proc. Am. Assoc. Cancer Res. 44, 1101 (2003).
-
(2003)
Proc. Am. Assoc. Cancer Res.
, vol.44
, pp. 1101
-
-
Wang, J.-S.1
-
76
-
-
0033038336
-
The effect of tea consumption on oxidative stress in smokers and nonsmokers
-
Klaunig, J. E. et al. The effect of tea consumption on oxidative stress in smokers and nonsmokers. Proc. Soc. Exp. Biol. Med. 220, 249-254 (1999).
-
(1999)
Proc. Soc. Exp. Biol. Med.
, vol.220
, pp. 249-254
-
-
Klaunig, J.E.1
-
77
-
-
0036884409
-
Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation
-
Kang, K. W. et al. Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation. FASEB J. 16, 1988-1990 (2002).
-
(2002)
FASEB J.
, vol.16
, pp. 1988-1990
-
-
Kang, K.W.1
-
78
-
-
5844370499
-
Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma: Hepatoma prevention study group
-
Muto, Y. et al. Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma: hepatoma prevention study group. N. Engl. J. Med. 334, 1561-1567 (1996). This study describes a clinical chemoprevention trial of polyprenoic acid in a Japanese cohort. HCV infection was the main cause of HCC in more than 70% of patients in the study population. Minimal side effects were reported for 600 mg of polyprenoic acid per day - a treatment that significantly prevented second primary tumours.
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 1561-1567
-
-
Muto, Y.1
-
79
-
-
0035702637
-
Chemoprevention of hepatocellular carcinoma: Concept, progress and perspectives
-
Okuno, M., Kojima, S. & Moriwaki, H. Chemoprevention of hepatocellular carcinoma: concept, progress and perspectives. J. Gastroenterol. Hepatol. 16, 1329-1335 (2001).
-
(2001)
J. Gastroenterol. Hepatol.
, vol.16
, pp. 1329-1335
-
-
Okuno, M.1
Kojima, S.2
Moriwaki, H.3
-
81
-
-
0030814179
-
Predictive value of molecular dosimetry: Individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of hepatocellular carcinoma
-
Kensler, T. W. et al. Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of hepatocellular carcinoma. Cancer Epidemiol. Biomarkers Prev. 6, 603-610 (1997).
-
(1997)
Cancer Epidemiol. Biomarkers Prev.
, vol.6
, pp. 603-610
-
-
Kensler, T.W.1
-
82
-
-
0037417954
-
Multiple mutations and cancer
-
Loeb, L. A., Loeb, K. A. & Anderson, J. P. Multiple mutations and cancer. Proc. Natl Acad. Sci. USA 100, 776-781 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 776-781
-
-
Loeb, L.A.1
Loeb, K.A.2
Anderson, J.P.3
-
83
-
-
0024847084
-
Multifactorial etiology and multifaceted prevention strategy of hepatocellular carcinoma
-
Sun, Z. & Zhu, Y.-R. Multifactorial etiology and multifaceted prevention strategy of hepatocellular carcinoma. Cancer Detect. Prev. 14, 285-289 (1989).
-
(1989)
Cancer Detect. Prev.
, vol.14
, pp. 285-289
-
-
Sun, Z.1
Zhu, Y.-R.2
-
84
-
-
0033012855
-
Development of cancer chemopreventive agents: Oltipraz as a paradigm
-
Kensler, T. W., Groopman, J. D., Sutter, T. R., Curphey, T. J. & Roebuck, B. D. Development of cancer chemopreventive agents: oltipraz as a paradigm. Chem. Res. Toxicol. 12, 113-126 (1999).
-
(1999)
Chem. Res. Toxicol.
, vol.12
, pp. 113-126
-
-
Kensler, T.W.1
Groopman, J.D.2
Sutter, T.R.3
Curphey, T.J.4
Roebuck, B.D.5
-
85
-
-
0037424262
-
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival
-
Kwak, M.-K. et al. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J. Biol. Chem. 278, 8135-8145 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 8135-8145
-
-
Kwak, M.-K.1
-
86
-
-
0031577292
-
A Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh, K. et al. A Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys Res. Commun. 236, 313-322 (1997).
-
(1997)
Biochem. Biophys Res. Commun.
, vol.236
, pp. 313-322
-
-
Itoh, K.1
-
87
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the aminoterminal Neh2 domain
-
Itoh, K. et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the aminoterminal Neh2 domain. Genes Dev. 13, 76-86 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 76-86
-
-
Itoh, K.1
-
88
-
-
0037015035
-
Direct evidence that sulfnydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
Dinkova-Kostova, A. T. et al. Direct evidence that sulfnydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl Acad. Sci. USA 99, 11908-11913 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
-
89
-
-
0037356451
-
Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice
-
Ramos-Gomez, M., Dolan, P. M., Itoh, K., Yamamoto, M. & Kensler, T. W. Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice. Carcinogenesis 24, 461-467 (2003).
-
(2003)
Carcinogenesis
, vol.24
, pp. 461-467
-
-
Ramos-Gomez, M.1
Dolan, P.M.2
Itoh, K.3
Yamamoto, M.4
Kensler, T.W.5
-
90
-
-
0035853157
-
Sensitivity to carcinogenesis is increased and chemoprotectrve efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
-
Ramos-Gomez, M. et al. Sensitivity to carcinogenesis is increased and chemoprotectrve efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc. Natl Acad. Sci. USA 98, 3410-3415 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 3410-3415
-
-
Ramos-Gomez, M.1
-
91
-
-
0037188518
-
Sulforaphane inhibits extracellular, intracellular, and antiobiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
-
Fahey, J. W. et al. Sulforaphane inhibits extracellular, intracellular, and antiobiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc. Natl. Acad. Sci. USA 99, 7610-7615 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 7610-7615
-
-
Fahey, J.W.1
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