Cytoplasmic inclusions of Htt exon1 containing an expanded polyglutamine tract suppress execution of apoptosis in sympathetic neurons

Journal of Neuroscience

Volumn 28, Issue 53, 2008, Pages 14401-14415

  King, Matthew A ^a,c   Goemans, Christoph G ^a,e   Hafiz, Farida ^a   Prehn, Jochen H M ^c   Wyttenbach, Andreas ^a,b   Tolkovsky, Aviva M ^a,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Bim; Cell death; Hsp70; Lysosome; Proteasome; Puma

Indexed keywords

GREEN FLUORESCENT PROTEIN; HEAT SHOCK PROTEIN 70; POLYGLUTAMINE; PROTEIN BAX; PUMA PROTEIN;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; EXON; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE CELL;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CYCLOSPORINE; ENZYME INHIBITORS; EXONS; GREEN FLUORESCENT PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INCLUSION BODIES; LYSOSOMES; NERVE GROWTH FACTOR; NEURONS; PEPTIDES; RATS; RATS, WISTAR; RECEPTOR, TRKA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SIGNAL TRANSDUCTION; SUPERIOR CERVICAL GANGLION; TIME FACTORS; TRANSFECTION;

EID: 58149400159     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4751-08.2008     Document Type: Article

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