-
1
-
-
0030700891
-
Commentary: Rethinking genotype and phenotype correlations in polyglutamine expansion disorders
-
Andrew, S.E., Y.P. Goldberg, and M.R. Hayden. 1997. Commentary: rethinking genotype and phenotype correlations in polyglutamine expansion disorders. Hum. Mol. Genet. 6:2005-2010.
-
(1997)
Hum. Mol. Genet.
, vol.6
, pp. 2005-2010
-
-
Andrew, S.E.1
Goldberg, Y.P.2
Hayden, M.R.3
-
2
-
-
0031918640
-
Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and palidoluysian atrophy: Correlation between the density of inclusions and IT15 CAG triplet repeat length
-
In press
-
Becher, M.W., J.A. Kotzuk, A.H. Sharp, S.W. Davies, G.P. Bates, D.L. Price, and C.A. Ross. 1997. Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and palidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length. Neurobiol. Dis. In press.
-
(1997)
Neurobiol. Dis.
-
-
Becher, M.W.1
Kotzuk, J.A.2
Sharp, A.H.3
Davies, S.W.4
Bates, G.P.5
Price, D.L.6
Ross, C.A.7
-
3
-
-
0023130372
-
Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
-
Carmichael, J., W.G. DeGraff, A.F. Gazdar, J.D. Minna, and J.B. Mitchell. 1987. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 47:936-942.
-
(1987)
Cancer Res.
, vol.47
, pp. 936-942
-
-
Carmichael, J.1
DeGraff, W.G.2
Gazdar, A.F.3
Minna, J.D.4
Mitchell, J.B.5
-
4
-
-
12644270610
-
The nuclear localization sequences of the BRCA1 protein interact with the importin-α subunit of the nuclear transport signal receptor
-
Chen, C.F., S. Li, Y. Chen, P.L. Chen, Z.D. Sharp, and W.H. Lee. 1996. The nuclear localization sequences of the BRCA1 protein interact with the importin-α subunit of the nuclear transport signal receptor. J. Biol. Chem. 271: 32863-32868.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32863-32868
-
-
Chen, C.F.1
Li, S.2
Chen, Y.3
Chen, P.L.4
Sharp, Z.D.5
Lee, W.H.6
-
5
-
-
7144253143
-
Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture
-
Cooper, J.K., G. Schilling, M.F. Peters, W.J. Herring, A.H. Sharp, Z. Kaminsky, J. Masone, F.A. Khan, M. Delanoy, D.R. Borchelt, et al. 1998. Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Hum. Mol. Genet. 7:783-790.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 783-790
-
-
Cooper, J.K.1
Schilling, G.2
Peters, M.F.3
Herring, W.J.4
Sharp, A.H.5
Kaminsky, Z.6
Masone, J.7
Khan, F.A.8
Delanoy, M.9
Borchelt, D.R.10
-
6
-
-
0028242089
-
Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines
-
Couldwell, W.T., D.R. Hinton, S. He, T.C. Chen, I. Sebat, M.H. Weiss, and R.E. Law. 1994. Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines. FEBS (Fed. Euro. Biochem. Soc.) Lett. 345:43-46.
-
(1994)
FEBS (Fed. Euro. Biochem. Soc.) Lett.
, vol.345
, pp. 43-46
-
-
Couldwell, W.T.1
Hinton, D.R.2
He, S.3
Chen, T.C.4
Sebat, I.5
Weiss, M.H.6
Law, R.E.7
-
7
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
Davies, S.W., M. Turmaine, B.A. Cozens, M. DiFiglia, A.H. Sharp, C.A. Ross, E. Scherzinger, E.E. Wanker, L. Mangiarini, and G.P. Bates. 1997. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell. 90:537-548.
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.W.1
Turmaine, M.2
Cozens, B.A.3
DiFiglia, M.4
Sharp, A.H.5
Ross, C.A.6
Scherzinger, E.7
Wanker, E.E.8
Mangiarini, L.9
Bates, G.P.10
-
8
-
-
0030752709
-
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
-
DiFiglia, M., E. Sapp, K.O. Chase, S.W. Davies, G.P. Bates, J.P. Vonsattel, and N. Aronin. 1997. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science. 277:1990-1993.
-
(1997)
Science
, vol.277
, pp. 1990-1993
-
-
DiFiglia, M.1
Sapp, E.2
Chase, K.O.3
Davies, S.W.4
Bates, G.P.5
Vonsattel, J.P.6
Aronin, N.7
-
9
-
-
0025949412
-
Nuclear targeting sequences - A consensus?
-
Dingwall, C., and R.A. Laskey. 1991. Nuclear targeting sequences - a consensus? Trends Biochem. Sci. 16:478-481.
-
(1991)
Trends Biochem. Sci.
, vol.16
, pp. 478-481
-
-
Dingwall, C.1
Laskey, R.A.2
-
10
-
-
0030875858
-
Kinetic characterization of the human retinoblastoma protein bipartite nuclear localization sequence (NLS) in vivo and in vitro. A comparison with the SV40 large T-antigen NLS
-
Efthymiadis, A., H. Shao, S. Hubner, and D.A. Jans. 1997. Kinetic characterization of the human retinoblastoma protein bipartite nuclear localization sequence (NLS) in vivo and in vitro. A comparison with the SV40 large T-antigen NLS. J. Biol. Chem. 272:22134-22139.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22134-22139
-
-
Efthymiadis, A.1
Shao, H.2
Hubner, S.3
Jans, D.A.4
-
11
-
-
9044229711
-
Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript
-
Goldberg, Y.P., M.A. Kalchman, M. Metzler, J. Nasir, J. Zeisler, R. Graham, H.B. Koide, J. O'Kusky, A.H. Sharp, C.A. Ross, et al. 1996. Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript. Hum. Mol. Genet. 5:177-185.
-
(1996)
Hum. Mol. Genet.
, vol.5
, pp. 177-185
-
-
Goldberg, Y.P.1
Kalchman, M.A.2
Metzler, M.3
Nasir, J.4
Zeisler, J.5
Graham, R.6
Koide, H.B.7
O'Kusky, J.8
Sharp, A.H.9
Ross, C.A.10
-
12
-
-
0022516246
-
Synthetic peptides as nuclear localization signals
-
Goldfarb, D.S., J. Gariepy, G. Schoolnik, and R.D. Kornberg. 1986. Synthetic peptides as nuclear localization signals. Nature. 322:641-644.
-
(1986)
Nature
, vol.322
, pp. 641-644
-
-
Goldfarb, D.S.1
Gariepy, J.2
Schoolnik, G.3
Kornberg, R.D.4
-
13
-
-
0029984570
-
Nucleocytoplasmic transport
-
Gorlich, D., and I.W. Mattaj. 1996. Nucleocytoplasmic transport. Science. 271: 1513-1518.
-
(1996)
Science
, vol.271
, pp. 1513-1518
-
-
Gorlich, D.1
Mattaj, I.W.2
-
14
-
-
10544222019
-
Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype
-
Hodgson, J.G., D.J. Smith, K. McCutcheon, H.B. Koide, K. Nishiyama, M.B. Dinulos, M.E. Stevens, N. Bissada, J. Nasir, K. Kanazawa, et al. 1996. Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype. Hum. Mol. Genet. 5:1875-1885.
-
(1996)
Hum. Mol. Genet.
, vol.5
, pp. 1875-1885
-
-
Hodgson, J.G.1
Smith, D.J.2
McCutcheon, K.3
Koide, H.B.4
Nishiyama, K.5
Dinulos, M.B.6
Stevens, M.E.7
Bissada, N.8
Nasir, J.9
Kanazawa, K.10
-
15
-
-
17344362229
-
Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch
-
Igarashi, S., R. Koide, T. Shimohata, M. Yamada, Y. Hayashi, H. Takano, H. Date, M. Oyake, T. Sato, A. Sato, et al. 1998. Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch. Nat. Genet. 18:111-117.
-
(1998)
Nat. Genet.
, vol.18
, pp. 111-117
-
-
Igarashi, S.1
Koide, R.2
Shimohata, T.3
Yamada, M.4
Hayashi, Y.5
Takano, H.6
Date, H.7
Oyake, M.8
Sato, T.9
Sato, A.10
-
16
-
-
0030986659
-
HIP1, a human homolog of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain
-
Kalchman, M.A., H.B. Koide, K. McCutcheon, R.K. Graham, K. Nichol, K. Nishiyama, F.C. Lynn, P. Kazemi-Esfarjani, C.L. Wellington, M. Metzler, et al. 1997. HIP1, a human homolog of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain. Nat. Genet. 16:44-53.
-
(1997)
Nat. Genet.
, vol.16
, pp. 44-53
-
-
Kalchman, M.A.1
Koide, H.B.2
McCutcheon, K.3
Graham, R.K.4
Nichol, K.5
Nishiyama, K.6
Lynn, F.C.7
Kazemi-Esfarjani, P.8
Wellington, C.L.9
Metzler, M.10
-
17
-
-
17344363559
-
Length of the protein and polyglutamine tract influence localization and frequency of intracellular aggregates of huntingtin
-
Martindale, D., A.S. Hackam, A. Wieczorek, L. Ellerby, C.L. Wellington, K. McCutcheon, R. Singaraja, P. Kazemi-Esfarjani, R. Devon, D.E. Bredesen, et al. 1998. Length of the protein and polyglutamine tract influence localization and frequency of intracellular aggregates of huntingtin. Nat. Genet. 18: 150-154.
-
(1998)
Nat. Genet.
, vol.18
, pp. 150-154
-
-
Martindale, D.1
Hackam, A.S.2
Wieczorek, A.3
Ellerby, L.4
Wellington, C.L.5
McCutcheon, K.6
Singaraja, R.7
Kazemi-Esfarjani, P.8
Devon, R.9
Bredesen, D.E.10
-
18
-
-
0028213962
-
Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development
-
Metzler, M., A. Gertz, M. Sarkar, H. Schachter, J.W. Schrader, and J.D. Marth. 1994. Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development. EMBO (Eur. Mol. Biol. Organ.) J. 13:2056-2065.
-
(1994)
EMBO (Eur. Mol. Biol. Organ.) J.
, vol.13
, pp. 2056-2065
-
-
Metzler, M.1
Gertz, A.2
Sarkar, M.3
Schachter, H.4
Schrader, J.W.5
Marth, J.D.6
-
19
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65: 55-63.
-
(1983)
J. Immunol. Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
20
-
-
0029055717
-
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
-
Nasir, J., S.B. Floresco, J.R. O'Kusky, V.M. Diewert, J.M. Richman, J. Zeisler, A. Borowski, J.D. Marth, A.G. Phillips, and M.R. Hayden. 1995. Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell. 81:811-823.
-
(1995)
Cell
, vol.81
, pp. 811-823
-
-
Nasir, J.1
Floresco, S.B.2
O'Kusky, J.R.3
Diewert, V.M.4
Richman, J.M.5
Zeisler, J.6
Borowski, A.7
Marth, J.D.8
Phillips, A.G.9
Hayden, M.R.10
-
21
-
-
0022687260
-
Assembly in vitro of nuclei active in nuclear protein transport: ATP is required for nucleoplasmin accumulation
-
Newmeyer, D.D., J.M. Lucocq, T.R. Burglin, and E.M. De Robertis. 1986. Assembly in vitro of nuclei active in nuclear protein transport: ATP is required for nucleoplasmin accumulation. EMBO (Eur. Mol. Biol. Organ.) J. 5:501-510.
-
(1986)
EMBO (Eur. Mol. Biol. Organ.) J.
, vol.5
, pp. 501-510
-
-
Newmeyer, D.D.1
Lucocq, J.M.2
Burglin, T.R.3
De Robertis, E.M.4
-
22
-
-
0030850412
-
Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3
-
Paulson, H.L., M.K. Perez, Y. Trottier, J.Q. Trojanowski, S.H. Subramony, S.S. Das, P. Vig, J.-L. Mandel, K.H. Fischbeck, and R.N. Pittman. 1997. Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3. Neuron. 19:333-344.
-
(1997)
Neuron.
, vol.19
, pp. 333-344
-
-
Paulson, H.L.1
Perez, M.K.2
Trottier, Y.3
Trojanowski, J.Q.4
Subramony, S.H.5
Das, S.S.6
Vig, P.7
Mandel, J.-L.8
Fischbeck, K.H.9
Pittman, R.N.10
-
23
-
-
0029089172
-
When more is less: Pathogenesis of glutamine repeat neurodegenerative diseases
-
Ross, C.A. 1995. When more is less: pathogenesis of glutamine repeat neurodegenerative diseases. Neuron. 15:491-496.
-
(1995)
Neuron.
, vol.15
, pp. 491-496
-
-
Ross, C.A.1
-
24
-
-
0030771894
-
Huntingtin localization in brains of normal and Huntington's disease patients
-
Sapp, E., C. Schwarz, K. Chase, P.G. Bhide, A.B. Young, J. Penney, J.P. Vonsattel, N. Aronin, and M. DiFiglia. 1997. Huntingtin localization in brains of normal and Huntington's disease patients. Ann. Neurol. 42:604-612.
-
(1997)
Ann. Neurol.
, vol.42
, pp. 604-612
-
-
Sapp, E.1
Schwarz, C.2
Chase, K.3
Bhide, P.G.4
Young, A.B.5
Penney, J.6
Vonsattel, J.P.7
Aronin, N.8
DiFiglia, M.9
-
25
-
-
18544400323
-
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
-
Scherzinger, E., R. Lurz, M. Turmaine, L. Mangiarini, B. Hollenbach, R. Hasenbank, G.P. Bates, S.W. Davies, H. Lehrach, and E.E. Wanker. 1997. Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Cell. 90:549-558.
-
(1997)
Cell
, vol.90
, pp. 549-558
-
-
Scherzinger, E.1
Lurz, R.2
Turmaine, M.3
Mangiarini, L.4
Hollenbach, B.5
Hasenbank, R.6
Bates, G.P.7
Davies, S.W.8
Lehrach, H.9
Wanker, E.E.10
-
26
-
-
0030666001
-
Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures
-
Skinner, V.J., B.T. Koshy, C.J. Cummings, I.A. Klement, K. Helin, A. Servadio, H.Y. Zoghbi, and H.T. Orr. 1997. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures. Nature. 389:971-974.
-
(1997)
Nature
, vol.389
, pp. 971-974
-
-
Skinner, V.J.1
Koshy, B.T.2
Cummings, C.J.3
Klement, I.A.4
Helin, K.5
Servadio, A.6
Zoghbi, H.Y.7
Orr, H.T.8
-
27
-
-
0025738516
-
Tetrazolium-based assays for cellular viability: A critical examination of selected parameters affecting formazan production
-
Vistica, D.T., P. Skehan, D. Scudiero, A. Monks, A. Pittman, and M.R. Boyd. 1991. Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production. Cancer Res. 51:2515-2520.
-
(1991)
Cancer Res.
, vol.51
, pp. 2515-2520
-
-
Vistica, D.T.1
Skehan, P.2
Scudiero, D.3
Monks, A.4
Pittman, A.5
Boyd, M.R.6
-
28
-
-
0030791305
-
Of molecular interactions, mice and mechanisms: New insights into Huntington's disease
-
Wellington, C.L., and M.R. Hayden. 1997. Of molecular interactions, mice and mechanisms: new insights into Huntington's disease. Curr. Opin. Neurol. 10: 291-298.
-
(1997)
Curr. Opin. Neurol.
, vol.10
, pp. 291-298
-
-
Wellington, C.L.1
Hayden, M.R.2
-
29
-
-
0032502715
-
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
-
Wellington, C.L., L.M. Ellerby, A.S. Hackam, R.L. Margolis, M.A. Trifiro, R. Singaraja, K. McCutcheon, G.S. Salvesen, S.S. Propp, M. Bromm, et al. 1998. Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J. Biol. Chem. 273:9159-9167.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9159-9167
-
-
Wellington, C.L.1
Ellerby, L.M.2
Hackam, A.S.3
Margolis, R.L.4
Trifiro, M.A.5
Singaraja, R.6
McCutcheon, K.7
Salvesen, G.S.8
Propp, S.S.9
Bromm, M.10
-
30
-
-
0021052942
-
tRNA transport from the nucleus in a eukaryotic cell: Carrier-mediated translocation process
-
Zasloff, M. 1983. tRNA transport from the nucleus in a eukaryotic cell: carrier-mediated translocation process. Proc. Natl. Acad. Sci. USA. 80:6436-6440.
-
(1983)
Proc. Natl. Acad. Sci. USA
, vol.80
, pp. 6436-6440
-
-
Zasloff, M.1
|