Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: A microarray analysis

Journal of Neurochemistry

Volumn 94, Issue 4, 2005, Pages 943-956

  Yew, Elaine Hau Jin ^a   Cheung, Nam Sang ^a   Choy, Meng Shyan ^a   Qi, Robert Z ^b   Lee, Alan Yiu Wah ^a   Peng, Zhao Feng ^a   Melendez, Alirio J ^a   Manikandan, Jayapal ^a   Koay, Evelyn Siew Chuan ^a,c   Chiu, Lily Lily ^c   Ng, Wooi Loon ^c   Whiteman, Matthew ^a   Kandiah, Jeyaseelan ^a   Halliwell, Barry ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^c NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

Apoptosis; Heat shock proteins; Lactacystin; Neurons; Proteasome inhibition

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CELL CYCLE PROTEIN; CYCLOOXYGENASE 2 INHIBITOR; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 22; HEAT SHOCK PROTEIN 70; LACTACYSTIN; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NERVE GROWTH FACTOR; PROTEASOME; PROTEASOME INHIBITOR; SULINDAC SULFIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; INFLAMMATION; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CYSTEINE PROTEINASE INHIBITORS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEAT-SHOCK PROTEINS; HSP20 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; LEUPEPTINS; MICE; MUSCLE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PC12 CELLS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; TRANSCRIPTION, GENETIC; TRANSFECTION; UP-REGULATION;

EID: 23844516979     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03220.x     Document Type: Article

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