c-Jun and the transcriptional control of neuronal apoptosis

Biochemical Pharmacology

Volumn 60, Issue 8, 2000, Pages 1015-1021

  Ham, Jonathan ^a   Eilers, Andreas ^b   Whitfield, Jonathan ^c   Neame, Stephen J ^c   Shah, Bina ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; c Jun; Caspase; Cytochrome c; Development; Jun N terminal kinase; Nerve growth factor; Sympathetic neurons

Indexed keywords

NEUROTROPHIN; NEUROTROPHIN RECEPTOR; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; CELL STRAIN; DEGENERATIVE DISEASE; MOUSE; NERVE CELL; NERVOUS SYSTEM; NEURAL TUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVIEW; SYMPATHETIC NERVE CELL;

EID: 0034668184     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00372-5     Document Type: Article

References (48)

1. Oppenheim R.W. Cell death during the development of the nervous system. Annu Rev Neurosci. 14:1991;453-501.
2. Jacobson M.D., Weil M., Raff M.C. Programmed cell death in animal development. Cell. 88:1997;347-354.
3. Pettmann B., Henderson C.E. Neuronal cell death. Neuron. 20:1998;633-647.
4. Wright L.L., Cunningham T.J., Smolen A.J. Developmental neuron death in the rat superior cervical sympathetic ganglion Cell counts and ultrastructure . J Neurocytol. 12:1983;727-738.
5. Martin D.P., Schmidt R.E., DiStefano P.S., Lowry O.H., Carter J.G., Johnson E.M. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J Cell Biol. 106:1988;829-844.
6. Deckwerth T.L., Johnson E.M. Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J Cell Biol. 123:1993;1207-1222.
7. Edwards S.N., Tolkovsky A.M. Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal. J Cell Biol. 124:1994;537-546.
8. Rimon G., Bazenet C.E., Philpott K.L., Rubin L.L. Increased surface phosphatidylserine is an early marker of neuronal apoptosis. J Neurosci Res. 48:1997;563-570.
9. Martinou I., Fernandez P.-A., Missotten M., White E., Allet B., Sadoul R., Martinou J.-C. Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation. J Cell Biol. 128:1995;201-208.
10. Deshmukh M., Vasilakos J., Deckwerth T.L., Lampe P.A., Shivers B.D., Johnson E.M. Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases. J Cell Biol. 135:1996;1341-1354.
11. McCarthy M.J., Rubin L.L., Philpott K.L. Involvement of caspases in sympathetic neuron apoptosis. J Cell Sci. 110:1997;2165-2173.
12. Neame S.J., Rubin L.L., Philpott K.L. Blocking cytochrome c activity within intact neurons inhibits apoptosis. J Cell Biol. 142:1998;1583-1593.
13. Deshmukh M., Johnson E.M. Evidence of a novel event during neuronal death Development of competence-to-die in response to cytoplasmic cytochrome c . Neuron. 21:1998;695-705.
14. Ham J., Babij C., Whitfield J., Pfarr C.M., Lallemand D., Yaniv M., Rubin L.L. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron. 14:1995;927-939.
15. Karin M., Liu Z.-G., Zandi E. AP-1 function and regulation. Curr Opin Cell Biol. 9:1997;240-246.
16. Estus S., Zaks W.J., Freeman R.S., Gruda M., Bravo R., Johnson E.M. Altered gene expression in neurons during programmed cell death Identification of c-jun as necessary for neuronal apoptosis . J Cell Biol. 127:1994;1717-1727.
17. Ip Y.T., Davis R.J. Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Curr Opin Cell Biol. 10:1998;205-219.
18. Eilers A., Whitfield J., Babij C., Rubin L.L., Ham J. Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons. J Neurosci. 18:1998;1713-1724.
19. Herr I., van Dam H., Angel P. Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation. Carcinogenesis. 15:1994;1105-1113.
20. Lallemand D., Ham J., Garbay S., Bakiri L., Traincard F., Jeannequin O., Pfarr C.M., Yaniv M. Stress-activated protein kinases are negatively regulated by cell density. EMBO J. 17:1998;5615-5626.
21. Virdee K., Bannister A.J., Hunt S.P., Tolkovsky A.M. Comparison between the timing of JNK activation, c-Jun phosphorylation and onset of death commitment in sympathetic neurons. J Neurochem. 69:1997;550-561.
22. Yan M., Dai T., Deak J.C., Kyriakis J.M., Zon L.I., Woodgett J.R., Templeton D.J. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature. 372:1994;798-800.
23. Whitmarsh A.J., Cavanagh J., Tournier C., Yasuda J., Davis R.J. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science. 281:1998;1671-1674.
24. Dickens M., Rogers J.S., Cavanagh J., Raitano A., Xia Z., Halpern J.R., Greenberg M.E., Sawyers C.L., Davis R.J. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science. 277:1997;693-696.
25. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
26. Bazenet C.E., Mota M.A., Rubin L.L. The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death. Proc Natl Acad Sci USA. 95:1998;3984-3989.
27. Kanamoto T., Mota M.A., Takeda K., Rubin L.L., Miyazono K., Ichijo H., Bazenet C.E. Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons. Mol Cell Biol. 20:2000;196-204.
28. Bamji S.X., Majdan M., Pozniak C.D., Belliveau D.J., Aloyz R., Kohn J., Causing C.G., Miller F.D. The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J Cell Biol. 140:1998;911-923.
29. Mazzoni I.E., Said F.A., Aloyz R., Miller F.D., Kaplan D. Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway. J Neurosci. 19:1999;9716-9727.
30. Watson A., Eilers A., Lallemand D., Kyriakis J., Rubin L.L., Ham J. Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J Neurosci. 18:1998;751-762.
31. D'Mello S.R., Galli C., Ciotti T., Calissano P. Induction of apoptosis in cerebellar granule neurons by low potassium Inhibition of death by insulin-like growth factor 1 and cAMP . Proc Natl Acad Sci USA. 90:1993;10989-10993.
32. Papavassiliou A.G., Treier M., Bohmann D. Intramolecular signal transduction in c-Jun. EMBO J. 14:1995;2014-2019.
33. Luo Y., Umegaki H., Wang X., Abe R., Roth G.S. Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway. J Biol Chem. 273:1998;3756-3764.
34. Liu Y.F. Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line. J Biol Chem. 273:1998;28873-28877.
35. Bossy-Wetzel E., Bakiri L., Yaniv M. Induction of apoptosis by the transcription factor c-Jun. EMBO J. 16:1997;1695-1709.
36. Hilberg F., Aguzzi A., Howells N., Wagner E.F. c-Jun is essential for normal mouse development and hepatogenesis. Nature. 365:1993;179-181.
37. 3F12 kinase A novel MAP kinase expressed in a subset of neurons in the human nervous system . Neuron. 14:1995;67-78.
38. Yang D.D., Kuan C.-Y., Whitmarsh A.J., Rincon M., Zheng T.S., Davis R.J., Rakic P., Flavell R.A. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature. 389:1997;865-870.
39. Behrens A., Sibilia M., Wagner E.F. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet. 21:1999;326-329.
40. Kuan C.-Y., Yang D.D., Samanta Roy D.R., Davis R.J., Rakic P., Flavell R.A. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron. 22:1999;667-676.
41. Sabapathy K., Jochum W., Hochedlinger K., Chang L., Karin M., Wagner E.F. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev. 89:1999;115-124.
42. Herdegen T., Skene P., Bahr M. The c-Jun transcription factor - bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci. 20:1997;227-231.
43. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:1997;479-489.
44. Martinou J.-C. Key to the mitochondrial gate. Nature. 399:1999;411-412.
45. Slack R.S., Miller F.D. Viral vectors for modulating gene expression in neurons. Curr Opin Neurobiol. 6:1996;576-583.
46. Kasibhatla S., Brunner T., Genestier L., Echeverri F., Mahboubi A., Green D.R. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kB and AP-1. Mol Cell. 1:1998;543-551.
47. Le-Niculescu H., Bonfoco E., Kasuya Y., Claret F.-X., Green D.R., Karin M. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol. 19:1999;751-763.
48. Raoul C., Henderson C.E., Pettmann B. Programmed cell death of embryonic motoneurons triggered through the Fas death receptor. J Cell Biol. 147:1999;1049-1061.