-
1
-
-
11344292132
-
The role of natural product chemistry in drug discovery
-
Butler, M. S. (2004) The role of natural product chemistry in drug discovery, J. Nat. Prod. 67, 2141-2153.
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 2141-2153
-
-
Butler, M.S.1
-
2
-
-
17844399025
-
Natural products to drugs: Natural product derived compounds in clinical trials
-
Butler, M. S. (2005) Natural products to drugs: natural product derived compounds in clinical trials, Nat. Prod. Rep. 22, 162-195.
-
(2005)
Nat. Prod. Rep.
, vol.22
, pp. 162-195
-
-
Butler, M.S.1
-
3
-
-
33644535147
-
Natural productsthe future scaffolds for novel antibiotics?
-
Butler, M. S., and Buss, A. D. (2006) Natural productsThe future scaffolds for novel antibiotics? Biochem. Pharmacol. 71, 919-929.
-
(2006)
Biochem. Pharmacol.
, vol.71
, pp. 919-929
-
-
Butler, M.S.1
Buss, A.D.2
-
4
-
-
33745041210
-
Drug discovery from natural products
-
Gullo, V. P., McAlpine, J., Lam, K. S., Baker, D., and Petersen, F. (2006) Drug discovery from natural products, J. Ind Microbiol. Biotechnol. 33, 523-531.
-
(2006)
J. Ind Microbiol. Biotechnol.
, vol.33
, pp. 523-531
-
-
Gullo, V.P.1
McAlpine, J.2
Lam, K.S.3
Baker, D.4
Petersen, F.5
-
5
-
-
0031127564
-
The role of carbohydrates in biologically active natural products
-
Weymouth-Wilson, A. C. (1997) The role of carbohydrates in biologically active natural products, Nat. Prod Rep. 14, 99-110.
-
(1997)
Nat. Prod Rep.
, vol.14
, pp. 99-110
-
-
Wilson Weymouth, A.C.1
-
6
-
-
27844587415
-
Sweetening natural products via glycorandomization
-
Griffith, B. R., Langenhan, J. M., and Thorson, J. S. (2005) "Sweetening" natural products via glycorandomization, Curr. Opin. Biotechnol. 16, 622-630.
-
(2005)
Curr. Opin. Biotechnol.
, vol.16
, pp. 622-630
-
-
Griffith, B.R.1
Langenhan, J.M.2
Thorson, J.S.3
-
7
-
-
33744523569
-
Enzymatic tools for engineering natural product glycosylation
-
DOI 10.1016/j.cbpa.2006.04.001, PII S1367593106000524
-
(Pubitemid 43815777) Blanchard, S., and Thorson, J. S. (2006) Enzymatic tools for engineering natural product glycosylation, Curr. Opin. Chem. Biol. 10, 263-271.
-
(2006)
Current Opinion in Chemical Biology
, vol.10
, Issue.3
, pp. 263-271
-
-
Blanchard, S.1
Thorson, J.S.2
-
8
-
-
0033574743
-
Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala
-
DOI 10.1126/science.284.5413.507
-
(Pubitemid 29289628) Ge, M., Chen, Z., Onishi, H. R., Kohler, J., Silver, L. L., Kerns, R., Fukuzawa, S., Thompson, C., and Kahne, D. (1999) Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala, Science 284, 507-511.
-
(1999)
Science
, vol.284
, Issue.5413
, pp. 507-511
-
-
Ge, M.1
Chen, Z.2
Onishi, H.R.3
Kohler, J.4
Silver, L.L.5
Kerns, R.6
Fukuzawa, S.7
Thompson, C.8
Kahne, D.9
-
9
-
-
0031105304
-
Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis
-
(Pubitemid 27188659) Solenberg, P. J., Matsushima, P., Stack, D. R., Wilkie, S. C., Thompson, R. C., and Baltz, R. H. (1997) Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis, Chem. Biol. 4, 195-202.
-
(1997)
Chemistry and Biology
, vol.4
, Issue.3
, pp. 195-202
-
-
Solenberg, P.J.1
Matsushima, P.2
Stack, D.R.3
Wilkie, S.C.4
Thompson, R.C.5
Baltz, R.H.6
-
10
-
-
14844339524
-
Glycopeptide and lipoglycopeptide antibiotics
-
DOI 10.1021/cr030103a
-
(Pubitemid 40356089) Kahne, D., Leimkuhler, C., Lu, W., and Walsh, C. (2005) Glycopeptide and lipoglycopeptide antibiotics, Chem. Rev. 105, 425-448.
-
(2005)
Chemical Reviews
, vol.105
, Issue.2
, pp. 425-448
-
-
Kahne, D.1
Leimkuhler, C.2
Lu, W.3
Walsh, C.4
-
11
-
-
33750712392
-
Colchicine glycorandomization influences cytotoxicity and mechanism of action
-
DOI 10.1021/ja064686s
-
(Pubitemid 44707709) Ahmed. A., Peters, N. R., Fitzgerald, M. K., Watson, J. A., Jr., Hoffmann, F. M., and Thorson, J. S. (2006) Colchicine glycorandomization influences cytotoxicity and mechanism of action, J. Am. Chem. Soc. 128, 14224-14225.
-
(2006)
Journal of the American Chemical Society
, vol.128
, Issue.44
, pp. 14224-14225
-
-
Ahmed, A.1
Peters, N.R.2
Fitzgerald, M.K.3
Watson Jr., J.A.4
Hoffmann, F.M.5
Thorson, J.S.6
-
12
-
-
24644484805
-
Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization
-
USA
-
Langenhan, J. M., Peters, N. R., Guzei, I. A., Hoffmann, F. M., and Thorson, J. S. (2005) Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization, Proc. Natl. Acad. Sci. USA 102, 12305-12310.
-
(2005)
Proc. Natl. Acad. Sci.
, vol.102
, pp. 12305-12310
-
-
Langenhan, J.M.1
Peters, N.R.2
Guzei, I.A.3
Hoffmann, F.M.4
Thorson, J.S.5
-
13
-
-
27544456829
-
Syntheses and biological activities of daunorubicin analogs with uncommon sugars
-
DOI 10.1016/j.bmc.2005.06.053, PII S0968089605005894
-
(Pubitemid 41539302) Zhu, L., Cao, X., Chen, W., Zhang, G., Sun, D., and Wang, P. G. (2005) Syntheses and biological activities of daunorubicin analogs with uncommon sugars, Bioorg. Med. Chem. 13, 6381-6387.
-
(2005)
Bioorganic and Medicinal Chemistry
, vol.13
, Issue.23
, pp. 6381-6387
-
-
Zhu, L.1
Cao, X.2
Chen, W.3
Zhang, G.4
Sun, D.5
Wang, P.G.6
-
14
-
-
20444370281
-
Synthesis of new, potent avermectin-like insecticidal agents
-
DOI 10.1016/j.carres.2005.04.019, PII S0008621505002193
-
(Pubitemid 40798023) Wei, L., Wei, G., Zhang, H., Wang, P. G., and Du, Y. (2005) Synthesis of new, potent avermectin-like insecticidal agents, Carbohydr. Res. 340, 1583-1590.
-
(2005)
Carbohydrate Research
, vol.340
, Issue.9
, pp. 1583-1590
-
-
Wei, L.1
Wei, G.2
Zhang, H.3
Wang, P.G.4
Du, Y.5
-
15
-
-
33644851237
-
Syntheses and biological activities of 3′-azido disaccharide analogues of daunorubicin against drug-resistant leukemia
-
DOI 10.1021/jm050916m
-
(Pubitemid 43376522) Zhang, G., Fang, L., Zhu, L., Zhong, Y., Wang, P. G., and Sun, D. (2006) Syntheses and biological activities of 3'-azido disaccharide analogues of daunorubicin against drugresistant leukemia, J. Med. Chem. 49, 1792-1799.
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.5
, pp. 1792-1799
-
-
Zhang, G.1
Fang, L.2
Zhu, L.3
Zhong, Y.4
Wang, P.G.5
Sun, D.6
-
16
-
-
33750921265
-
De novo asymmetric syntheses of SL0101 and its analogues via a palladium-catalyzed glycosylation
-
DOI 10.1021/o1062076r
-
(Pubitemid 44728900) Shan, M., and O'Doherty. G. A. (2006) De novo asymmetric syntheses of SL0101 and its analogues via a palladium-catalyzed glycosylation, Org. Lett. 8, 5149-5152.
-
(2006)
Organic Letters
, vol.8
, Issue.22
, pp. 5149-5152
-
-
Shan, M.1
O'Doherty, G.A.2
-
17
-
-
34447313701
-
De novo asymmetric synthesis of the anthrax tetrasaccharide by a palladium-catalyzed glycosylation reaction
-
DOI 10.1002/anie.200701354
-
(Pubitemid 47051290) Guo, H., and O'Doherty, G. A. (2007) De novo asymmetric synthesis of the anthrax tetrasaccharide by a palladium-catalyzed glycosylation reaction, Angew. Chem. Int. Ed. Engl. 46, 5206-5208.
-
(2007)
Angewandte Chemie - International Edition
, vol.46
, Issue.27
, pp. 5206-5208
-
-
Guo, H.1
O'Doherty, G.A.2
-
18
-
-
34047220599
-
De novo approach to 2-deoxy--glycosides: Asymmetric syntheses of digoxose and digitoxin
-
DOI 10.1021/jo062534+
-
(Pubitemid 46536179) Zhou, M, and O'Doherty, G. A. (2007) De novo approach to 2-deoxy-glycosides: Asymmetric syntheses of digoxose and digitoxin, J. Org. Chem. 72, 2485-2493.
-
(2007)
Journal of Organic Chemistry
, vol.72
, Issue.7
, pp. 2485-2493
-
-
Zhou, M.1
O'Doherty, G.A.2
-
19
-
-
29044436566
-
Neoglycorandomization and chemoenzymatic glycorandomization: Two complementary tools for natural product diversification
-
Langenhan, J. M., Griffith, B. R., and Thorson, J. S. (2005) Neoglycorandomization and chemoenzymatic glycorandomization: Two complementary tools for natural product diversification, J. Nat. Prod. 68, 1696-1711.
-
(2005)
J. Nat. Prod
, vol.68
, pp. 1696-1711
-
-
Langenhan, J.M.1
Griffith, B.R.2
Thorson, J.S.3
-
20
-
-
34247626294
-
Unusual sugar biosynthesis and natural product glycodiversification
-
Thibodeaux, C. J., Melancon, C. E., and Liu, H. W. (2007) Unusual sugar biosynthesis and natural product glycodiversification, Nature 446, 1008-1016.
-
(2007)
Nature
, vol.446
, pp. 1008-1016
-
-
Thibodeaux, C.J.1
Melancon, C.E.2
Liu, H.W.3
-
21
-
-
34247511117
-
Engineering the glycosylation of natural products in actinomycetes
-
DOI 10.1016/j.tim.2007.03.004, PII S0966842X07000479
-
(Pubitemid 46660603) Salas, J. A., and Mendez, C. (2007) Engineering the glycosylation of natural products in actinomycetes, Trends. Microbiol. 15, 219-232.
-
(2007)
Trends in Microbiology
, vol.15
, Issue.5
, pp. 219-232
-
-
Salas, J.A.1
Mendez, C.2
-
22
-
-
0035986693
-
Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms: A tool to produce novel glycosylated bioactive compounds
-
DOI 10.1016/S1074-5521(02)00154-0, PII S1074552102001540
-
(Pubitemid 34653067) Rodriguez, L., Aguirrezabalaga, I., Allende, N., Brana, A. F., Mendez, C., and Salas, J. A. (2002) Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds, Chem. Biol. 9, 721-729.
-
(2002)
Chemistry and Biology
, vol.9
, Issue.6
, pp. 721-729
-
-
Rodriguez, L.1
Aguirrezabalaga, I.2
Allende, N.3
Brana, A.F.4
Mendez, C.5
Salas, J.A.6
-
23
-
-
17444374633
-
Combining sugar biosynthesis genes for the generation of L-and D-amicetose and formation of two novel antitumor tetracenomycins
-
DOI 10.1039/b417815g
-
(Pubitemid 40543559) Perez, M., Lombo, F., Zhu, L., Gibson, M., Brana, A. F., Rohr, J., Salas, J. A., and Mendez, C. (2005) Combining sugar biosynthesis genes for the generation of l-and damicetose and formation of two novel antitumor tetracenomycins, Chem. Common. (Comb). 1604-1606.
-
(2005)
Chemical Communications
, Issue.12
, pp. 1604-1606
-
-
Perez, M.1
Lombo, F.2
Zhu, L.3
Gibson, M.4
Brana, A.F.5
Rohr, J.6
Salas, J.A.7
Mendez, C.8
-
24
-
-
10644221353
-
Engineering biosynthetic pathways for deoxysugars: Branched-chain sugar pathways and derivatives from the antitumor tetracenomycin
-
DOI 10.1016/j.chembiol.2004.10.007, PII S1074552104002996
-
(Pubitemid 39651305) Lombo, F., Gibson, M., Greenwell, L., Brana, A. F., Rohr, J., Salas, J. A., and Mendez, C. (2004) Engineering biosynthetic pathways for deoxysugars: Branched-chain sugar pathways and derivatives from the antitumor tetracenomycin, Chem. Biol. 11, 1709-1718.
-
(2004)
Chemistry and Biology
, vol.11
, Issue.12
, pp. 1709-1718
-
-
Lombo, F.1
Gibson, M.2
Greenwell, L.3
Brana, A.F.4
Rohr, J.5
Salas, J.A.6
Mendez, C.7
-
25
-
-
33750087290
-
Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses
-
DOI 10.1128/AEM.01266-06
-
(Pubitemid 44582905) Perez, M., Lombo, F., Baig, I., Brana, A. F., Rohr, J., Salas, J. A., and Mendez, C. (2006) Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2, 6-ddideoxyhexoses, Appl. Environ. Microbiol. 72, 6644-6652.
-
(2006)
Applied and Environmental Microbiology
, vol.72
, Issue.10
, pp. 6644-6652
-
-
Perez, M.1
Lombo, F.2
Baig, I.3
Brana, A.F.4
Rohr, J.5
Salas, J.A.6
Mendez, C.7
-
26
-
-
0035075686
-
Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin
-
DOI 10.1016/S1074-5521(01)00010-2, PII S1074552101000102
-
(Pubitemid 32296115) Blanco, G., Patallo, E. P., Brana, A. F., Trefzer, A., Bechthold, A., Rohr, J., Mendez, C., and Salas, J. A. (2001) Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin, Chem. Biol. 8, 253-263.
-
(2001)
Chemistry and Biology
, vol.8
, Issue.3
, pp. 253-263
-
-
Blanco, G.1
Patallo, E.P.2
Braa, A.F.3
Trefzer, A.4
Bechthold, A.5
Rohr, J.6
Mendez, C.7
Salas, J.A.8
-
27
-
-
26244438853
-
Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: Sugar donor substrate flexibility of the StaG glycosyltransferase
-
DOI 10.1111/j.1365-2958.2005.04777.x
-
(Pubitemid 41415028) Salas, A. P., Zhu, L., Sanchez, C., Brana, A. F., Rohr, J., Mendez, C., and Salas, J. A. (2005) Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: Sugar donor substrate flexibility of the StaG glycosyltransferase, Mol. Microbiol. 58, 17-27.
-
(2005)
Molecular Microbiology
, vol.58
, Issue.1
, pp. 17-27
-
-
Salas, A.P.1
Zhu, L.2
Sanchez, C.3
Brana, A.F.4
Rohr, J.5
Mendez, C.6
Salas, J.A.7
-
28
-
-
33745047747
-
Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives
-
DOI 10.1007/s10295-006-0092-5
-
(Pubitemid 43876118) Sanchez, C., Mendez, C., and Salas, J. A. (2006) Engineering biosynthetic pathways to generate antitumorindolocarbazole derivatives, J. Ind. Microbiol. Biotechnol.33, 560-568.
-
(2006)
Journal of Industrial Microbiology and Biotechnology
, vol.33
, Issue.7
, pp. 560-568
-
-
Sanchez, C.1
Mendez, C.2
Salas, J.A.3
-
29
-
-
0038204472
-
Substrate specificity of NovM: Implications for novobiocin biosynthesis and glycorandomization
-
DOI 10.1021/o10341086
-
(Pubitemid 37130653) Albermann, C., Soriano, A., Jiang, J., Vollmer, H., Biggins, J. B., Barton, W. A., Lesniak, J., Nikolov, D. B., and Thorson, J. S. (2003) Substrate specificity of NovM: Implications for novobiocin biosynthesis and glycorandomization, Org. Lett. 5, 933-936.
-
(2003)
Organic Letters
, vol.5
, Issue.6
, pp. 933-936
-
-
Albermann, C.1
Soriano, A.2
Jiang, J.3
Vollmer, H.4
Biggins, J.B.5
Barton, W.A.6
Lesniak, J.7
Nikolov, D.B.8
Thorson, J.S.9
-
30
-
-
34247518972
-
The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification
-
DOI 10.1002/cbic.200600509
-
(Pubitemid 47183656) Zhang, C., Fu, Q., Albermann, C., Li, L., and Thorson, J. S. (2007) The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification, Chembiochem 8, 385-390.
-
(2007)
ChemBioChem
, vol.8
, Issue.4
, pp. 385-390
-
-
Zhang, C.1
Fu, Q.2
Albermann, C.3
Li, L.4
Thorson, J.S.5
-
31
-
-
0347384092
-
Antibiotic optimization via in vitro glycorandomization
-
DOI 10.1038/nbt909
-
(Pubitemid 37522706) Fu, X., Albermann, C., Jiang, J., Liao, J., Zhang, C., and Thorson, J. S. (2003) Antibiotic optimization via in vitro glycorandomization, Nat. Biotechnol. 21, 1467-1469.
-
(2003)
Nature Biotechnology
, vol.21
, Issue.12
, pp. 1467-1469
-
-
Fu, X.1
Albermann, C.2
Jiang, J.3
Liao, J.4
Zhang, C.5
Thorson, J.S.6
-
32
-
-
17844409813
-
Diversifying vancomycin via chemoenzymatic strategies
-
DOI 10.1021/o10501626
-
(Pubitemid 40585919) Fu, X., Albermann, C., Zhang, C., and Thorson, J. S. (2005) Diversifying vancomycin via chemoenzymatic strategies, Org. Lett. 7, 1513-1515.
-
(2005)
Organic Letters
, vol.7
, Issue.8
, pp. 1513-1515
-
-
Fu, X.1
Albermann, C.2
Zhang, C.3
Thorson, J.S.4
-
33
-
-
33748302743
-
Exploiting the reversibility of natural product glycosyltransferase- catalyzed reactions
-
DOI 10.1126/science.1130028
-
(Pubitemid 44330953) Zhang, C., Griffith, B. R., Fu, Q., Albermann, C., Fu, X., Lee, I. K., Li, L., and Thorson, J. S. (2006) Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions, Science 313, 1291-1294.
-
(2006)
Science
, vol.313
, Issue.5791
, pp. 1291-1294
-
-
Zhang, C.1
Griffith, B.R.2
Fu, Q.3
Albermann, C.4
Fu, X.5
Lee, I.-K.6
Li, L.7
Thorson, J.S.8
-
34
-
-
33646804530
-
RebG-and RebM-catalyzed indolocarbazole diversification
-
DOI 10.1002/cbic.200500504
-
(Pubitemid 43764189) Zhang, C., Albermann, C., Fu, X., Peters, N. R., Chisholm, J. D., Zhang, G., Gilbert, E. J., Wang, P. G., Van Vranken, D. L., and Thorson, J. S. (2006) RebG-and RebM-catalyzed indolocarbazole diversification, Chembiochem 7, 795-804.
-
(2006)
Chem. Bio. Chem.
, vol.7
, Issue.5
, pp. 795-804
-
-
Zhang, C.1
Albermann, C.2
Fu, X.3
Peters, N.R.4
Chisholm, J.D.5
Zhang, G.6
Gilbert, E.J.7
Wang, P.G.8
Van Vranken, D.L.9
Thorson, J.S.10
-
35
-
-
33845935524
-
The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility
-
DOI 10.1021/ja065950k
-
(Pubitemid 46032680) Zhang, C., Albermann, C., Fu, X., and Thorson, J. S. (2006) The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility, J. Am. Chem. Soc. 128, 16420-16421.
-
(2006)
Journal of the American Chemical Society
, vol.128
, Issue.51
, pp. 16420-16421
-
-
Zhang, C.1
Albermann, C.2
Fu, X.3
Thorson, J.S.4
-
36
-
-
0030843984
-
A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities [1]
-
(Pubitemid 27438071) Campbell, J. A., Davies, G. J., Bulone, V., and Henrissat, B. (1997) A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities, Biochem. J. 326 (Pt. 3), 929-939.
-
(1997)
Biochemical Journal
, vol.326
, Issue.3
, pp. 929-939
-
-
Campbell, J.A.1
Davies, G.J.2
Bulone, V.3
Henrissat, B.4
-
37
-
-
11944256494
-
Catalytic mechanisms of enzymatic glycosyl transfer
-
Sinnott, M. L. (1990) Catalytic mechanisms of enzymatic glycosyl transfer, Chem. Rev. 90, 1171-1202.
-
(1990)
Chem. Rev
, vol.90
, pp. 1171-1202
-
-
Sinnott, M.L.1
-
38
-
-
49449087287
-
Glycosyltransferase: Structures, functions, and mechanisms
-
Lairson, L. L., Henrissat, B., Davies, G. J., and Withers, S. G. (2008) Glycosyltransferase: Structures, functions, and mechanisms, Annu. Rev. Biochem. 77, 521-555.
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 521-555
-
-
Lairson, L.L.1
Henrissat, B.2
Davies, G.J.3
Withers, S.G.4
-
39
-
-
33750974777
-
Insights into the Synthesis of Lipopolysaccharide and Antibiotics through the Structures of Two Retaining Glycosyltransferases from Family GT4
-
DOI 10.1016/j.chembiol.2006.09.005, PII S1074552106003371
-
(Pubitemid 44750727) Martinez-Fleites, C., Proctor, M., Roberts, S., Bolam, D. N., Gilbert, H. J., and Davies, G. J. (2006) Insights into the synthesis of lipopolysaccharide and antibiotics through the structures of two retaining glycosyltransferases from family GT4, Chem. Biol. 13, 1143-1152.
-
(2006)
Chemistry and Biology
, vol.13
, Issue.11
, pp. 1143-1152
-
-
Martinez-Fleites, C.1
Proctor, M.2
Roberts, S.3
Bolam, D.N.4
Gilbert, H.J.5
Davies, G.J.6
-
40
-
-
0033787822
-
Glycosyltransferase structure and mechanism
-
Unligil, U. M., and Rini, J. M. (2000) Glycosyltransferase structure and mechanism, Curr. Opin. Struct. Biol. 10, 510-517.
-
(2000)
Curr. Opin. Struct. Biol.
, vol.10
, pp. 510-517
-
-
Unligil, U.M.1
Rini, J.M.2
-
41
-
-
0035443118
-
Glycoside hydrolases and glycosyltransferases: Families and functional modules
-
DOI 10.1016/S0959-440X(00)00253-0
-
(Pubitemid 32972023) Bourne, Y., and Henrissat, B. (2001) Glycoside hydrolases and glycosyltransferases: Families and functional modules, Curr. Opin. Struct. Biol. 11, 593-600.
-
(2001)
Current Opinion in Structural Biology
, vol.11
, Issue.5
, pp. 593-600
-
-
Bourne, Y.1
Henrissat, B.2
-
42
-
-
0037466315
-
An evolving hierarchical family classification for glycosyltransferases
-
DOI 10.1016/S0022-2836(03)00307-3
-
(Pubitemid 36407576) Coutinho, P. M., Deleury, E., Davies, G. J., and Henrissat, B. (2003) An evolving hierarchical family classification for glycosyltransferases, J. Mol. Biol. 328, 307-317.
-
(2003)
Journal of Molecular Biology
, vol.328
, Issue.2
, pp. 307-317
-
-
Coutinho, P.M.1
Deleury, E.2
Davies, G.J.3
Henrissat, B.4
-
43
-
-
0035151023
-
Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs
-
DOI 10.1038/84168
-
(Pubitemid 32116071) Persson, K., Ly, H. D., Dieckelmann, M., Wakarchuk, W. W., Withers, S. G., and Strynadka, N. C. (2001) Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs, Nat. Struct. Biol. 8, 166-175.
-
(2001)
Nature Structural Biology
, vol.8
, Issue.2
, pp. 166-175
-
-
Persson, K.1
Ly, H.D.2
Dieckelmann, M.3
Wakarchuk, W.W.4
Withers, S.G.5
Strynadka, N.C.J.6
-
44
-
-
22144432266
-
Structural dissection and high-throughput screening of mannosylglycerate synthase
-
DOI 10.1038/nsmb950
-
(Pubitemid 40980811) Flint, J., Taylor, E., Yang, M., Bolam, D. N., Tailford, L. E., Martinez-Fleites, C., Dodson, E. J., Davis, B. G., Gilbert, H. J., and Davies, G. J. (2005) Structural dissection and highthroughput screening of mannosylglycerate synthase, Nat. Struct. Mol. Biol. 12, 608-614.
-
(2005)
Nature Structural and Molecular Biology
, vol.12
, Issue.7
, pp. 608-614
-
-
Flint, J.1
Taylor, E.2
Yang, M.3
Bolam, D.N.4
Tailford, L.E.5
Martinez-Fleites, C.6
Dodson, E.J.7
Davis, B.G.8
Gilbert, H.J.9
Davies, G.J.10
-
45
-
-
0031749203
-
Sequence-function relationships of prokaryotic and eukaryotic galactosyltransferases
-
(Pubitemid 28305979) Breton, C., Bettler, E., Joziasse, D. H., Geremia, R. A., and Imberty, A. (1998) Sequencefunction relationships of prokaryotic and eukaryotic galactosyltransferases, J. Biochem. 123, 1000-1009.
-
(1998)
Journal of Biochemistry
, vol.123
, Issue.6
, pp. 1000-1009
-
-
Breton, C.1
Bettler, E.2
Joziasse, D.H.3
Geremia, R.A.4
Imberty, A.5
-
46
-
-
0032846531
-
Structure/function studies of glycosyltransferases
-
DOI 10.1016/S0959-440X(99)00006-8
-
(Pubitemid 29460581) Breton, C., and Imberty, A. (1999) Structure/function studies of glycosyltransferases, Curr. Opin. Struct. Biol. 9, 563-571.
-
(1999)
Current Opinion in Structural Biology
, vol.9
, Issue.5
, pp. 563-571
-
-
Breton, C.1
Imberty, A.2
-
47
-
-
0029736391
-
Mechanism and specificity of human β-1,3-fucosyltransferase V
-
DOI 10.1021/bi961065a
-
(Pubitemid 26298754) Murray, B. W., Takayama, S., Schultz, J., and Wong, C. H. (1996) Mechanism and specificity of human α-1, 3-fucosyltransferase V, Biochemistry 35, 11183-11195.
-
(1996)
Biochemistry
, vol.35
, Issue.34
, pp. 11183-11195
-
-
Murray, B.W.1
Takayama, S.2
Schultz, J.3
Wong, C.-H.4
-
48
-
-
2442440054
-
Crystal Structure of Vancosaminyltransferase GtfD from the Vancomycin Biosynthetic Pathway: Interactions with Acceptor and Nucleotide Ligands
-
DOI 10.1021/bi036130c
-
(Pubitemid 38620908) Mulichak, A. M., Lu, W., Losey, H. C., Walsh, C. T., and Garavito, R. M. (2004) Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: Interactions with acceptor and nucleotide ligands, Biochemistry 43, 5170-5180.
-
(2004)
Biochemistry
, vol.43
, Issue.18
, pp. 5170-5180
-
-
Mulichak, A.M.1
Lu, W.2
Losey, H.C.3
Walsh, C.T.4
Garavito, R.M.5
-
49
-
-
34248396073
-
The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity
-
DOI 10.1073/pnas.0607897104
-
(Pubitemid 47175681) Bolam, D. N., Roberts, S., Proctor, M. R., Turkenburg, J. P., Dodson, E. J., Martinez-Fleites, C., Yang, M., Davis, B. G., Davies, G. J., and Gilbert, H. J. (2007) The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity, Proc. Natl. Acad. Sci. USA 104, 5336-5341.
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.13
, pp. 5336-5341
-
-
Bolam, D.N.1
Roberts, S.2
Proctor, M.R.3
Turkenburg, J.P.4
Dodson, E.J.5
Martinez-Fleites, C.6
Yang, M.7
Davis, B.G.8
Davies, G.J.9
Gilbert, H.J.10
-
50
-
-
0036913910
-
Remarkable structural similarities between diverse glycosyltransferases
-
DOI 10.1016/S1074-5521(02)00295-8, PII S1074552102002958
-
(Pubitemid 36010684) Hu, Y., and Walker, S. (2002) Remarkable structural similarities between diverse glycosyltransferases, Chem. Biol. 9, 1287-1296.
-
(2002)
Chemistry and Biology
, vol.9
, Issue.12
, pp. 1287-1296
-
-
Hu, Y.1
Walker, S.2
-
51
-
-
0034938546
-
Structure of the udp-glucosyltransferase gtfb that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics
-
Mulichak, A. M., Losey, H. C., Walsh, C. T., and Garavito, R. M. (2001) Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics, Structure 9, 547-557.
-
(2001)
Structure
, vol.9
, pp. 547-557
-
-
Mulichak, A.M.1
Losey, H.C.2
Walsh, C.T.3
Garavito, R.M.4
-
52
-
-
34248400401
-
Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis
-
DOI 10.1073/pnas.0701160104
-
(Pubitemid 47175683) Yuan, Y., Barrett, D., Zhang, Y., Kahne, D., Sliz, P., and Walker, S. (2007) Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis, Proc. Natl. Acad. Sci. USA 104, 5348-5353.
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.13
, pp. 5348-5353
-
-
Yuan, Y.1
Barrett, D.2
Zhang, Y.3
Kahne, D.4
Sliz, P.5
Walker, S.6
-
53
-
-
33947132188
-
Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis
-
Lovering, A. L., de Castro, L. H., Lira, D., and Strynadka, N. C. (2007) Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis, Science 315, 1402-1405.
-
(2007)
Science
, vol.315
, pp. 1402-1405
-
-
Lovering, A.L.1
De Castro, L.H.2
Lira, D.3
Strynadka, N.C.4
-
54
-
-
0041422391
-
Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway
-
DOI 10.1073/pnas.1233577100
-
(Pubitemid 37033913) Mulichak, A. M., Losey, H. C., Lu, W., Wawrzak, Z., Walsh, C. T., and Garavito, R. M. (2003) Structure of the TDP-epi- vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway, Proc. Natl. Acad. Sci. USA 100, 9238-9243.
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.16
, pp. 9238-9243
-
-
Mulichak, A.M.1
Losey, H.C.2
Lu, W.3
Wawrzak, Z.4
Walsh, C.T.5
Garavito, R.M.6
-
55
-
-
33645290775
-
Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification
-
Offen, W, Martinez-Fleites, C., Yang, M., Kiat-Lim, E., Davis, B. G., Tarling, C. A., Ford, C. M., Bowles, D. J., and Davies, G. J. (2006) Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification, EMBO J. 25, 1396-1405.
-
(2006)
Embo J.
, vol.25
, pp. 1396-1405
-
-
Offen, W.1
Martinez-Fleites, C.2
Yang, M.3
Kiat-Lim, E.4
Davis, B.G.5
Tarling, C.A.6
Ford, C.M.7
Bowles, D.J.8
Davies, G.J.9
-
56
-
-
33645281589
-
Crystal structures of a multifunctional triterpene/flavonoid glycosyltransferase from medicago truncatula
-
Shao. H., He, X., Achnine, L., Blount, J. W., Dixon, R. A., and Wang, X. (2005) Crystal structures of a multifunctional triterpene/flavonoid glycosyltransferase from Medicago truncatula. Plant Cell, 17, 3141-3154.
-
(2005)
Plant Cell
, vol.17
, pp. 3141-3154
-
-
Shao, H.1
He, X.2
Achnine, L.3
Blount, J.W.4
Dixon, R.A.5
Wang, X.6
-
57
-
-
3843126366
-
Site-directed mutagenesis and protein 3D-homology modelling suggest a catalytic mechanism for UDP-glucose-dependent betanidin 5-O-glucosyltransferase from Dorotheanthus bellidiformis
-
DOI 10.1111/j.1365-313X.2004.02133.x
-
(Pubitemid 39040138) Hans, J., Brandt, W., and Vogt, T. (2004) Site-directed mutagenesis and protein 30-homology modelling suggest a catalytic mechanism for UDP-glucose-dependent betanidin 5-O-glucosyltransferase from Dorotheanthus bellidiformis, Plant J. 39, 319 333.
-
(2004)
Plant Journal
, vol.39
, Issue.3
, pp. 319-333
-
-
Hans, J.1
Brandt, W.2
Vogt, T.3
-
58
-
-
0035824876
-
Three-dimensional structures of the Mn and Mg dTDP complexes of the family GT-2 glycosyltransferase SpsA: A comparison with related NDP-sugar glycosyltransferases
-
DOI 10.1006/jmbi.2001.5159
-
(Pubitemid 34087836) Tarbouriech, N., Charnock, S. J., and Davies, G. J. (2001) Three-dimensional structures of the Mn and Mg dTDP complexes of the family GT-2 glycosyltransferase SpsA: a comparison with related NDP-sugar glycosyltransferases, J. Mol. Biol. 314, 655-661.
-
(2001)
Journal of Molecular Biology
, vol.314
, Issue.4
, pp. 655-661
-
-
Tarbouriech, N.1
Charnock, S.J.2
Davies, G.J.3
-
59
-
-
0035190313
-
Identification of residues involved in catalytic activity of the inverting glycosyl transferase WbbE from Salmonella enterica serovar borreze
-
DOI 10.1128/JB.183.1.77-85.2001
-
(Pubitemid 32003110) Keenleyside, W. J., Clarke, A. J., and Whitfield, C. (2001) Identification of residues involved in catalytic activity of the inverting glycosyl transferase WbbE from Salmonella enterica serovar borreze, J. Bacteriol. 183, 77-85.
-
(2001)
Journal of Bacteriology
, vol.183
, Issue.1
, pp. 77-85
-
-
Keenleyside, W.J.1
Clarke, A.J.2
Whitfield, C.3
-
60
-
-
4744344735
-
Structure and catalytic cycle of β-1, 4-galactosyltransferase
-
Ramakrishnan, B., Boeggeman, E., Ramasamy, V., and Qasba, P. K. (2004) Structure and catalytic cycle of β-1, 4-galactosyltransferase, Curr. Opin. Struct. Biol. 14, 593-600.
-
(2004)
Curr. Opin. Struct. Biol.
, vol.14
, pp. 593-600
-
-
Ramakrishnan, B.1
Boeggeman, E.2
Ramasamy, V.3
Qasba, P.K.4
-
61
-
-
0033963529
-
Glycosidase mechanisms: Anatomy of a finely tuned catalyst
-
Zechel, D. L., and Withers, S. G. (2000) Glycosidase mechanisms: Anatomy of a finely tuned catalyst, Acc. Chem. Res. 33, 11-18.
-
(2000)
Acc. Chem. Res.
, vol.33
, pp. 11-18
-
-
Zechel, D.L.1
Withers, S.G.2
-
62
-
-
9144219793
-
Mechanistic analogies amongst carbohydrate modifying enzymes
-
Camb.
-
Lairson, L. L., and Withers, S. G. (2004) Mechanistic analogies amongst carbohydrate modifying enzymes, Chem. Commun. (Camb.) 20, 2243-2248.
-
(2004)
Chem. Commun.
, vol.20
, pp. 2243-2248
-
-
Lairson, L.L.1
Withers, S.G.2
-
63
-
-
0035865381
-
Bovine β1,3-galactosyltransferase catalytic domain structure and its relationship with ABO histo-blood group and glycosphingolipid glycosyltransferases
-
DOI 10.1093/emboj/20.4.638
-
(Pubitemid 32167629) Gastinel, L. N., Bignon, C., Misra, A. K., Hindsgaul, O., Shaper, J. H., and Joziasse, D. H. (2001) Bovine α, 3-galactosyltransferase catalytic domain structure and its relationship with ABO histo-blood group and glycosphingolipid glycosyltransferases, EMBO J. 20, 638-649.
-
(2001)
EMBO Journal
, vol.20
, Issue.4
, pp. 638-649
-
-
Gastinel, L.N.1
Bignon, C.2
Misra, A.K.3
Hindsgaul, O.4
Shaper, J.H.5
Joziasse, D.H.6
-
64
-
-
0036909547
-
Insights into trehalose synthesis provided by the structure of the retaining glucosyltransferase OtsA
-
DOI 10.1016/S1074-5521(02)00292-2, PII S1074552102002922
-
(Pubitemid 36010690) Gibson, R. P., Turkenburg, J. P., Charnock, S. J., Lloyd, R., and Davies, G. J. (2002) Insights into trehalose synthesis provided by the structure of the retaining glucosyltransferase OtsA, Chem. Biol. 9, 1337-1346.
-
(2002)
Chemistry and Biology
, vol.9
, Issue.12
, pp. 1337-1346
-
-
Gibson, R.P.1
Turkenburg, J.P.2
Charnock, S.J.3
Lloyd, R.4
Davies, G.J.5
-
65
-
-
0001403866
-
Solvolysis of d-glucopyranosyl derivatives in mixtures of ethanol and 2, 2, 2-trifluoroethanol
-
Sinnott, M. L., and Jencks, W. P. (1980) Solvolysis of D-glucopyranosyl derivatives in mixtures of ethanol and 2, 2, 2-trifluoroethanol, J. Am. Chem. Soc. 102, 2026-2032.
-
(1980)
J. Am. Chem. Soc.
, vol.102
, pp. 2026-2032
-
-
Sinnott, M.L.1
Jencks, W.P.2
-
66
-
-
1542268957
-
Molecular modeling insights into the catalytic mechanism of the retaining galactosyltransferase LgtC
-
DOI 10.1016/j.carres.2003.11.014, PII S0008621503006128
-
(Pubitemid 38316973) Tvaroska, I. (2004) Molecular modeling insights into the catalytic mechanism of the retaining galactosyltransferase LgtC, Carbohydr. Res. 339, 1007-1014.
-
(2004)
Carbohydrate Research
, vol.339
, Issue.5
, pp. 1007-1014
-
-
Tvaroska, I.1
-
67
-
-
14844353677
-
Genetic approaches to polyketide antibiotics. 1
-
DOI 10.1021/cr0301189
-
(Pubitemid 40351633) McDaniel, R., Welch, M., and Hutchinson, C. R. (2005) Genetic approaches to polyketide antibiotics. 1, Chem. Rev. 105, 543-558.
-
(2005)
Chemical Reviews
, vol.105
, Issue.2
, pp. 543-558
-
-
McDaniel, R.1
Welch, M.2
Hutchinson, C.R.3
-
68
-
-
14844357497
-
Translation and protein synthesis: Macrolides
-
DOI 10.1021/cr030107f
-
(Pubitemid 40351631) Katz, L., and Ashley, G. W (2005) Translation and protein synthesis: Macrolides, Chem. Rev. 105, 499-528.
-
(2005)
Chemical Reviews
, vol.105
, Issue.2
, pp. 499-527
-
-
Katz, L.1
Ashley, G.W.2
-
69
-
-
0030838176
-
Megalomicin disrupts lysosomal functions
-
(Pubitemid 27384786) Bonay, P., Fresno, M., and Alarcon, B. (1997) Megalomicin disrupts lysosomal functions, J. Cell. Sci. 110 (Pt. 16), 1839-1849.
-
(1997)
Journal of Cell Science
, vol.110
, Issue.16
, pp. 1839-1849
-
-
Bonay, P.1
Fresno, M.2
Alarcon, B.3
-
70
-
-
0344074643
-
Antiparasitic effects of the intra-Golgi transport inhibitor megalomicin
-
(Pubitemid 28462912) Bonay, P., Duran-Chica, I., Fresno, M., Alarcon, B., and Alcina, A. (1998) Antiparasitic effects of the intra-Golgi transport inhibitor megalomicin, Antimicmb. Agents Chemother. 42, 2668-2673.
-
(1998)
Antimicrobial Agents and Chemotherapy
, vol.42
, Issue.10
, pp. 2668-2673
-
-
Bonay, P.1
Duran-Chica, I.2
Fresno, M.3
Alarcon, B.4
Alcina, A.5
-
71
-
-
0037407668
-
Structural insight into the role of the ribosomal tunnel in cellular regulation
-
DOI 10.1038/nsb915
-
(Pubitemid 36523271) Berisio, R., Schluenzen, F., Harms, J., Bashan, A., Auerbach, T., Baram, D., and Yonath, A. (2003) Structural insight into the role of the ribosomal tunnel in cellular regulation, Nat. Struct. Biol. 10, 366-370.
-
(2003)
Nature Structural Biology
, vol.10
, Issue.5
, pp. 366-370
-
-
Berisio, R.1
Schluenzen, F.2
Harms, J.3
Bashan, A.4
Auerbach, T.5
Baram, D.6
Yonath, A.7
-
72
-
-
0037334850
-
Structural basis for the antibiotic activity of ketolides and azalides
-
DOI 10.1016/S0969-2126(03)00022-4, PII S0969212603000224
-
(Pubitemid 36287695) Schlunzen, F., Harms, J. M., Franceschi, F., Hansen, H. A., Battels, H., Zarivach, R., and Yonath, A. (2003) Structural basis for the antibiotic activity of ketolides and azalides, Structure 11, 329-338.
-
(2003)
Structure
, vol.11
, Issue.3
, pp. 329-338
-
-
Schlunzen, F.1
Harms, J.M.2
Franceschi, F.3
Hansen, H.A.S.4
Bartels, H.5
Zarivach, R.6
Yonath, A.7
-
73
-
-
0032514668
-
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: Architecture of metabolic diversity
-
DOI 10.1073/pnas.95.21.12111
-
(Pubitemid 28483727) Xue, Y., Zhao, L., Liu, H. W., and Sherman, D. H. (1998) A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: Architecture of metabolic diversity, Proc. Natl. Acad. Sci. USA 95, 12111-12116.
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.21
, pp. 12111-12116
-
-
Xue, Y.1
Zhao, L.2
Liu, H.-W.3
Sherman, D.H.4
-
74
-
-
2542527641
-
Characterization of the glycosyltransferase activity of DesVII: Analysis of and implications for the biosynthesis of macrolide antibiotics
-
DOI 10.1021/ja049967j
-
(Pubitemid 38697337) Borisova, S. A., Zhao, L., Melancon, I. C., Kao, C. L., and Liu, H. W. (2004) Characterization of the glycosyltransferase activity of desVII: Analysis of and implications for the biosynthesis of macrolide antibiotics, J. Am. Chem. Soc. 126, 6534-6535.
-
(2004)
Journal of the American Chemical Society
, vol.126
, Issue.21
, pp. 6534-6535
-
-
Borisova, S.A.1
Zhao, L.2
Melancon III, C.E.3
Kao, C.-L.4
Liu, H.-W.5
-
75
-
-
33746211329
-
Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: Opportunities, limitations, and mechanistic hypotheses
-
DOI 10.1002/anie.200503195
-
(Pubitemid 44099098) Borisova, S. A., Zhang, C., Takahashi, H., Zhang, H., Wong, A. W., Thorson, J. S., and Liu, H. W. (2006) Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: Opportunities, limitations, and mechanistic hypotheses, Angew. Chem. Int. Ed. Engl. 45, 2748-2753.
-
(2006)
Angewandte Chemie - International Edition
, vol.45
, Issue.17
, pp. 2748-2753
-
-
Borisova, S.A.1
Zhang, C.2
Takahashi, H.3
Zhang, H.4
Wong, A.W.5
Thorson, J.S.6
Liu, H.-W.7
-
76
-
-
0034974319
-
Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity
-
DOI 10.1016/S1074-5521(01)00032-1, PII S1074552101000321
-
(Pubitemid 32532971) Tang, L., and McDaniel, R. (2001) Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity, Chem. Biol. 8, 547-555.
-
(2001)
Chemistry and Biology
, vol.8
, Issue.6
, pp. 547-555
-
-
Tang, L.1
McDaniel, R.2
-
77
-
-
0033610483
-
Engineering a methymycin/pikromycin-calicheamicin hybrid: Construction of two new macrolides carrying a designed sugar moiety [6]
-
DOI 10.1021/ja992810k
-
(Pubitemid 29517431) Zhao, L. S., Ahlert, J., Xue, Y. Q., Thorson, J. S., Sherman, D. H., and Liu, H. W. (1999) Engineering a methymycin/pikromycin- calicheamicin hybrid: Construction of two new macrolides carrying a designed sugar moiety, J. Am. Chem. Soc. 121, 9881-9882.
-
(1999)
Journal of the American Chemical Society
, vol.121
, Issue.42
, pp. 9881-9882
-
-
Zhao, L.1
Ahlert, J.2
Xue, Y.3
Thorson, J.S.4
Sherman, D.H.5
Liu, H.-W.6
-
78
-
-
33646547932
-
Linear aglycones are the substrates for glycosyltransferase desvii in methymycin biosynthesis: Analysis and implications
-
Kao, C. L., Borisova, S. A., Kim, H. J., and Liu, H. W. (2006) Linear aglycones are the substrates for glycosyltransferase DesVII in methymycin biosynthesis: Analysis and implications, J. Am. Chem. Soc. 128, 5606-5607.
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 5606-5607
-
-
Kao, C.L.1
Borisova, S.A.2
Kim, H.J.3
Liu, H.W.4
-
79
-
-
0027382486
-
Polyketide synthesis: Prospects for hybrid antibiotics
-
(Pubitemid 23302956) Katz, L., and Donadio, S. (1993) Polyketide synthesis: Prospects for hybrid antibiotics, Annu. Rev. Microbiol. 47, 875-912.
-
(1993)
Annual Review of Microbiology
, vol.47
, pp. 875-912
-
-
Katz, L.1
Donadio, S.2
-
80
-
-
0030720976
-
Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic: Gene cluster in Saccharopolyspora erythraea
-
DOI 10.1007/s004380050566
-
(Pubitemid 27487745) Gaisser, S., Bohm, G. A., Cortes, J., and Leadlay, P. F. (1997) Analysis of seven genes from the eryAl/-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea, Mol. Gen. Genet. 256, 239-251.
-
(1997)
Molecular and General Genetics
, vol.256
, Issue.3
, pp. 239-251
-
-
Gaisser, S.1
Bohm, G.A.2
Cortes, J.3
Leadlay, P.F.4
-
81
-
-
0030831132
-
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharapolyspora erythraea that are involved in L-mycarose and D-desosamine production
-
(Pubitemid 27470173) Summers, R. G., Donadio, S., Staver, M. J., WendtPienkowski, E, Hutchinson, C. R., and Katz, L. (1997) Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production, Microbiology-UK 143, 3251-3262.
-
(1997)
Microbiology
, vol.143
, Issue.10
, pp. 3251-3262
-
-
Summers, R.G.1
Donadio, S.2
Staver, M.J.3
Wendt-Pienkowski, E.4
Hutchinson, C.R.5
Katz, L.6
-
82
-
-
4043053572
-
Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway
-
DOI 10.1021/ja048836f
-
(Pubitemid 39079404) Lee, H. Y, Chung, H. S., Hang, C., Khosla, C., Walsh, C. T., Kahne, D., and Walker, S. (2004) Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway, J. Am. Chem. Soc. 126, 9924-9925.
-
(2004)
Journal of the American Chemical Society
, vol.126
, Issue.32
, pp. 9924-9925
-
-
Lee, H.Y.1
Chung, H.S.2
Hang, C.3
Khosla, C.4
Walsh, C.T.5
Kahne, D.6
Walker, S.7
-
83
-
-
26844543758
-
In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides
-
DOI 10.1021/ja053704n
-
(Pubitemid 41457546) Yuan, Y., Chung, H. S., Leimkuhler, C., Walsh, C. T., Kahne, D., and Walker. S. (2005) In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides, J. Am. Chem. Soc. 127, 14128-14129.
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.41
, pp. 14128-14129
-
-
Yuan, Y.1
Chung, H.S.2
Leimkuhler, C.3
Walsh, C.T.4
Kahne, D.5
Walker, S.6
-
84
-
-
0033404581
-
Interspecies complementation in Saccharopolyspora erythraea: Elucidation of the function of oleP1, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives
-
DOI 10.1046/j.1365-2958.1999.01666.x
-
(Pubitemid 30000320) Doumith, M., Legrand, R., Lang, C., Salas, J. A., and Raynal, M. C. (1999) Interspecies complementation in Saccharopolyspora erythraea: Elucidation of the function of olePl, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives, Mol. Microbiol. 34, 1039-1048.
-
(1999)
Molecular Microbiology
, vol.34
, Issue.5
, pp. 1039-1048
-
-
Doumith, M.1
Legrand, R.2
Lang, C.3
Salas, J.A.4
Raynal, M.-C.5
-
85
-
-
0031799094
-
Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticus
-
DOI 10.1046/j.1365-2958.1998.00880.x
-
(Pubitemid 28293541) Quiros, L. M., Aguirrezabalaga, I., Olano, C., Mendez, C., and Salas, J. A. (1998) Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticus, Mol. Microbiol. 28, 1177-1185.
-
(1998)
Molecular Microbiology
, vol.28
, Issue.6
, pp. 1177-1185
-
-
Quiros, L.M.1
Aguirrezabalaga, I.2
Olano, C.3
Mendez, C.4
Salas, J.A.5
-
86
-
-
0027385134
-
Characterization of a Streptomyces antibioticus gene cluster encoding a glycosyltransferase involved in oleandomycin inactivation
-
DOI 10.1016/0378-1119(93)90189-A
-
(Pubitemid 23353125) Hernandez, C., Olano, C., Mendez, C., and Salas, J. A. (1993) Characterization of a Streptomyces antibioticus gene cluster encoding a glycosyltransferase involved in oleandomycin inactivation, Gene 134, 139-140.
-
(1993)
Gene
, vol.134
, Issue.1
, pp. 139-140
-
-
Hernandez, C.1
Olano, C.2
Mendez, C.3
Salas, J.A.4
-
87
-
-
0029100905
-
Biosynthesis of the macrolide oleandomycin by streptomyces antibioticus. Purification and kinetic characterization of an oleandomycin glucosyltransferase
-
Quiros, L. M., and Salas, J. A. (1995) Biosynthesis of the macrolide oleandomycin by Streptomyces antibioticus. Purification and kinetic characterization of an oleandomycin glucosyltransferase, J. Biol. Chem. 270, 18234-18239.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 18234-18239
-
-
Quiros, L.M.1
Salas, J.A.2
-
88
-
-
0029857797
-
Microbial glycosylation of macrolide antibiotics by Streptomyces hygroscopicus ATCC 31080 and distribution of a macrolide glycosyl transferase in several Streptomyces strains
-
(Pubitemid 26419908) Sasaki, J., Mizoue, K., Morimoto, S., and Omura, S. (1996) Microbial glycosylation of macrolide antibiotics by Streptomyces hygroscopicus ATCC 31080 and distribution of a macrolide glycosyl transferase in several Streptomyces strains, J. Antibiot. (Tokyo) 49, 1110-1118.
-
(1996)
Journal of Antibiotics
, vol.49
, Issue.11
, pp. 1110-1118
-
-
Sasaki, J.1
Mizoue, K.2
Morimoto, S.3
Omura, S.4
-
89
-
-
0034697166
-
Glycosylation of macrolide antibiotics. Purification and kinetic studies of a macrolide glycosyltransferase from streptomyces antibioticus
-
Quiros, L. M., Carbajo, R. J., Brana, A. F., and Salas, J. A. (2000) Glycosylation of macrolide antibiotics. Purification and kinetic studies of a macrolide glycosyltransferase from Streptomyces antibioticus, J. Biol. Chem. 275, 11713-11720.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 11713-11720
-
-
Quiros, L.M.1
Carbajo, R.J.2
Brana, A.F.3
Salas, J.A.4
-
90
-
-
21144450850
-
High-throughput mass-spectrometry monitoring for multisubstrate enzymes: Determining the kinetic parameters and catalytic activities of glycosyltransferases
-
DOI 10.1002/cbic.200400100
-
(Pubitemid 40879748) Yang, M., Brazier, M., Edwards, R., and Davis, B. G. (2005) High-throughput massspectrometry monitoring for multisubstrate enzymes: Determining the kinetic parameters and catalytic activities of glycosyltransferases, Chembiochem 6, 346-357.
-
(2005)
ChemBioChem
, vol.6
, Issue.2
, pp. 346-357
-
-
Yang, M.1
Brazier, M.2
Edwards, R.3
Davis, B.G.4
-
91
-
-
21644437191
-
Probing the breadth of macrolide glycosyltransferases: In vitro remodeling of a polyketide antibiotic creates active bacterial uptake and enhances potency
-
DOI 10.1021/ja051482n
-
(Pubitemid 40934725) Yang, M., Proctor, M. R., Bolam, D. N., Errey, J. C., Field, R. A., Gilbert, H. J., and Davis, B. G. (2005) Probing the breadth of macrolide glycosyltransferases: In vitro remodeling of a polyketide antibiotic creates active bacterial uptake and enhances potency, J. Am. Chem. Soc. 127, 9336-9337.
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.26
, pp. 9336-9337
-
-
Yang, M.1
Proctor, M.R.2
Bolam, D.N.3
Errey, J.C.4
Field, R.A.5
Gilbert, H.J.6
Davis, B.G.7
-
92
-
-
23044507077
-
A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases
-
DOI 10.1021/ja052945s
-
(Pubitemid 41061449) Oberthiir, M., Leimkuhler, C., Kruger, R. G., Lu, W., Walsh, C. T., and Kahne, D. (2005) A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases, J. Am. Chem. Soc. 127, 10747-10752.
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.30
, pp. 10747-10752
-
-
Oberthur, M.1
Leimkuhler, C.2
Kruger, R.G.3
Lu, W.4
Walsh, C.T.5
Kahne, D.6
-
93
-
-
9444230640
-
The life and times of ivermectin - A success story
-
DOI 10.1038/nrmicro1048
-
(Pubitemid 39562537) Omura, S., and Crump, A. (2004) The life and times of ivermectinA success story, Nat. Rev. Microbiol. 2, 984-989.
-
(2004)
Nature Reviews Microbiology
, vol.2
, Issue.12
, pp. 984-989
-
-
Omura, S.1
Crump, A.2
-
94
-
-
0018386220
-
Avermectins, new family of potent anthelmintic agents: Producing organism and fermentation
-
(Pubitemid 9206227) Burg, R. W., Miller, B. M., Baker, E. E., Birnbaum, J., Currie, S. A., Hartman, R., Kong, Y. L., Monaghan, R. L., Olson, G., Putter, I., Tunac, J. B., Wallick, H., Stapley, E. O., Oiwa, R., and Omura, S. 1979 Avermectins, new family of potent anthelmintic agents: Producing organism and fermentation, Antimicrob. Agents Chemother. 15, 361-367.
-
(1979)
Antimicrobial Agents and Chemotherapy
, vol.15
, Issue.3
, pp. 361-367
-
-
Burg, R.W.1
Miller, B.M.2
Baker, E.E.3
-
95
-
-
0033578297
-
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis
-
DOI 10.1073/pnas.96.17.9509
-
(Pubitemid 29398761) Ikeda, H., Nonomiya, T., Usami, M., Ohta, T., and Omura, S. (1999) Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis, Proc. Natl Acad. Sci. USA 96, 9509-9514.
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.17
, pp. 9509-9514
-
-
Ikeda, H.1
Nonomiya, T.2
Usami, M.3
Ohta, T.4
Omura, S.5
-
96
-
-
0025075441
-
Purification and identification of dTDP-oleandrose, the precursor of the oleandrose units of the avermectins
-
(Pubitemid 20334232) Schulman, M. D., Acton, S. L., Valentino, D. L., and Arison, B. H. (1990) Purification and identification of dTDP-oleandrose, the precursor of the oleandrose units of the avermectins, J. Biol. Chem. 265, 16965-16970.
-
(1990)
Journal of Biological Chemistry
, vol.265
, Issue.28
, pp. 16965-16970
-
-
Schulman, M.D.1
Acton, S.L.2
Valentino, D.L.3
Arison, B.H.4
-
97
-
-
0034931736
-
Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans
-
DOI 10.1016/S1074-5521(01)00043-6, PII S1074552101000436
-
(Pubitemid 32632535) Wohlert, S., Lomovskaya, N., Kulowski, K., Fonstein, L., Occi, J. L., Gewain, K. M., MacNeil, D. J., and Hutchinson, C. R. (2001) Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans, Chem. Biol. 8, 681-700.
-
(2001)
Chemistry and Biology
, vol.8
, Issue.7
, pp. 681-700
-
-
Wohlert, S.-E.1
Lomovskaya, N.2
Kulowski, K.3
Fonstein, L.4
Occi, J.L.5
Gewain, K.M.6
MacNeil, D.J.7
Hutchinson C.Richard8
-
98
-
-
22544467806
-
Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A
-
DOI 10.1016/j.chembiol.2005.05.008, PII S1074552105001390
-
(Pubitemid 41009154) Luzhetskyy. A., Fedoryshyn, M., Durr, C., Taguchl, T., Novikov, V., and Bechthold, A. (2005) Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A, Chem. Biol. 12, 725-729.
-
(2005)
Chemistry and Biology
, vol.12
, Issue.7
, pp. 725-729
-
-
Luzhetskyy, A.1
Fedoryshyn, M.2
Durr, C.3
Taguchi, T.4
Novikov, V.5
Bechthold, A.6
-
99
-
-
0023104658
-
The sorangicins, novel and powerful inhibitors of eubacterial RNA polymerase isolated from myxobacteria
-
(Pubitemid 17232943) Irschik, H., Jansen, R., Gerth, K., Hofle, G., and Reichenbach, H. (1987) The sorangicins, novel and powerful inhibitors of eubacterial RNA polymerase isolated from myxobacteria, J. Antibiot. (Tokyo) 40, 7-13.
-
(1987)
Journal of Antibiotics
, vol.40
, Issue.1
, pp. 7-13
-
-
Irschik, H.1
Jansen, R.2
Gerth, K.3
-
100
-
-
15444374664
-
Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
-
DOI 10.1038/sj.emboj.7600499
-
(Pubitemid 40396098) Campbell, E. A., Pavlova, O., Zenkin, N., Leon, F., Irschik, H., Jansen, R., Severinov, K., and Darst, S. A. (2005) Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase, EMBO J. 24, 674-682.
-
(2005)
EMBO Journal
, vol.24
, Issue.4
, pp. 674-682
-
-
Campbell, E.A.1
Pavlova, O.2
Zenkin, N.3
Leon, F.4
Irschik, H.5
Jansen, R.6
Severinov, K.7
Darst, S.A.8
-
101
-
-
0035937403
-
Structural mechanism for rifampicin inhibition of bacterial RNA polymerase
-
DOI 10.1016/S0092-8674(01)00286-0
-
(Pubitemid 32289282) Campbell, E. A., Korzheva, N., Mustaev, A., Murakami, K., Nair, S., Goldfarb, A., and Darst, S. A. (2001) Structural mechanism for rifampicin inhibition of bacterial RNA polymerase, Cell 104, 901-912.
-
(2001)
Cell
, vol.104
, Issue.6
, pp. 901-912
-
-
Campbell, E.A.1
Korzheva, N.2
Mustaev, A.3
Murakami, K.4
Nair, S.5
Goldfarb, A.6
Darst, S.A.7
-
102
-
-
34250813293
-
SorF: A glycosyltransferase with promiscuous donor substrate specificity in vitro
-
DOI 10.1002/cbic.200700024
-
(Pubitemid 47183638) Kopp, M., Rupprath, C., Irschik, H., Bechthold, A., Elling, L., and Muller, R. (2007) SorF: A glycosyltransferase with promiscuous donor substrate specificity in vitro, Chembiochem 8, 813-819.
-
(2007)
ChemBioChem
, vol.8
, Issue.7
, pp. 813-819
-
-
Kopp, M.1
Rupprath, C.2
Irschik, H.3
Bechthold, A.4
Elling, L.5
Muller, R.6
-
103
-
-
0344827209
-
Genetic Analysis of a High-Level Vancomycin-Resistant Isolate of Staphylococcus aureus
-
DOI 10.1126/science.1090956
-
(Pubitemid 37475701) Weigel, L. M., Clewell, D. B., Gill, S. R., Clark, N. C., McDougal, L. K., Flannagan, S. E., Kolonay, J. F., Shetty, J., Killgore, G. E., and Tenover, R C. (2003) Genetic analysis of a highlevel vancomycin-resistant isolate of Staphylococcus aureus. Science 302, 1569-1571.
-
(2003)
Science
, vol.302
, Issue.5650
, pp. 1569-1571
-
-
Weigel, L.M.1
Clewell, D.B.2
Gill, S.R.3
Clark, N.C.4
McDougal, L.K.5
Flannagan, S.E.6
Kolonay, J.F.7
Shetty, J.8
Killgore, G.E.9
Tenover, F.C.10
-
104
-
-
0037417230
-
Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene
-
DOI 10.1056/NEJMoa025025
-
(Pubitemid 36384101) Chang, S., Sievert, D. M., Hageman, J. C., Boulton, M. L., Tenover, F. C., Downes, F. P., Shah, S., Rudrik, J. T., Pupp, G. R., Brown, W. J., Cardo, D., and Fridkin, S. K. (2003) Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene, N. Engl. J. Med. 348, 1342-1347.
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.14
, pp. 1342-1347
-
-
Chang, S.1
Sievert, D.M.2
Hageman, J.C.3
Boulton, M.L.4
Tenover, F.C.5
Downes, F.P.6
Shah, S.7
Rudrik, J.T.8
Pupp, G.R.9
Brown, W.J.10
Cardo, D.11
Fridkin, S.K.12
-
105
-
-
0035190999
-
Glycopeptide derivatives
-
(Pubitemid 33072257) Malabarba, A., and Ciabatti, R. (2001) Glycopeptide derivatives, Curr. Med. Chem. 8, 1759-1773.
-
(2001)
Current Medicinal Chemistry
, vol.8
, Issue.14
, pp. 1759-1773
-
-
Malabarba, A.1
Ciabatti, R.2
-
106
-
-
33644521754
-
Glycopeptides: Update on an old successful antibiotic class
-
DOI 10.1016/j.bcp.2005.12.005, PII S0006295205008129, Antibacterials
-
(Pubitemid 43306789) Pace, J. L., and Yang, G. (2006) Glycopeptides: Update on an old successful antibiotic class, Biochem. Pharmacol 71, 968-980.
-
(2006)
Biochemical Pharmacology
, vol.71
, Issue.7
, pp. 968-980
-
-
Pace, J.L.1
Yang, G.2
-
107
-
-
33747605341
-
Glycopeptides and glycodepsipeptides in clinical development: A comparative review of their antibacterial spectrum, pharmacokinetics and clinical efficacy
-
(Pubitemid 44263179) Van Bambeke, F. (2006) Glycopeptides and glycodepsipeptides in clinical development: A comparative review of their antibacterial spectrum, pharmacokinetics and clinical efficacy, Curr. Opin. Invest. Drugs 7, 740-749.
-
(2006)
Current Opinion in Investigational Drugs
, vol.7
, Issue.8
, pp. 740-749
-
-
Van Bambeke, F.1
-
108
-
-
12244297801
-
Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides
-
DOI 10.1016/S1074-5521(02)00270-3, PII S1074552102002703
-
(Pubitemid 36010686) Losey, H. C., Jiang, J., Biggins, J. B., Oberthur, M., Ye, X. Y., Dong, S. D., Kahne, D., Thorson, J. S., and Walsh, C. T. (2002) Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides, Chem. Biol. 9, 1305-1314.
-
(2002)
Chemistry and Biology
, vol.9
, Issue.12
, pp. 1305-1314
-
-
Losey, H.C.1
Jiang, J.2
Biggins, J.B.3
Oberthur, M.4
Ye, X.-Y.5
Dong, S.D.6
Kahne, D.7
Thorson, J.S.8
Walsh, C.T.9
-
109
-
-
0032576124
-
Reconstruction of vancomycin by chemical glycosylation of the pseudoaglycon [20]
-
DOI 10.1021/ja982414m
-
(Pubitemid 28507464) Ge, M., Thompson, C., and Kahne, D. (1998) Reconstruction of vancomycin by chemical glycosylation of the pseudoaglycon, J. Am. Chem. Soc. 120, 11014-11015.
-
(1998)
Journal of the American Chemical Society
, vol.120
, Issue.42
, pp. 11014-11015
-
-
Ge, M.1
Thompson, C.2
Kahne, D.3
-
110
-
-
0033577010
-
Synthesis of vancomycin from the aglycon
-
DOI 10.1021/ja983504u
-
(Pubitemid 29104054) Thompson, C., Ge, M., and Kahne, D. (1999) Synthesis of vancomycin from the aglycon, J. Am. Chem. Soc. 121, 1237-1244.
-
(1999)
Journal of the American Chemical Society
, vol.121
, Issue.6
, pp. 1237-1244
-
-
Thompson, C.1
Ge, M.2
Kahne, D.3
-
111
-
-
1242285111
-
Patents on glycopeptides of the vancomycin family and their derivatives as antimicrobials: January 1999-june 2003
-
Preobrazhenskaya, M. N., and Olsufyeva, E. N. (2004) Patents on glycopeptides of the vancomycin family and their derivatives as antimicrobials: January 1999-June 2003, Expert Opin. Ther. Pat. 14, 141-173.
-
(2004)
Expert Opin. Ther. Pat
, vol.14
, pp. 141-173
-
-
Preobrazhenskaya, M.N.1
Olsufyeva, E.N.2
-
112
-
-
0032033520
-
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic
-
(Pubitemid 28167283) van Wageningen, A. M., Kirkpatrick, P. N., Williams, D. H., Harris, B. R., Kershaw, J. K., Lennard, N. J., Jones, M., Jones, S. J., and Solenberg, P. J. (1998) Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic, Chem. Biol. 5, 155-162.
-
(1998)
Chemistry and Biology
, vol.5
, Issue.3
, pp. 155-162
-
-
Van Wageningen, A.M.A.1
Kirkpatrick, P.N.2
Williams, D.H.3
Harris, B.R.4
Kershaw, J.K.5
Lennard, N.J.6
Jones, M.7
Jones, S.J.M.8
Solenberg, P.J.9
-
113
-
-
0035901490
-
Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: Novel glycopeptides
-
DOI 10.1021/bi010050w
-
(Pubitemid 32374662) Losey, H. C., Peczuh, M. W., Chen, Z., Eggert, U. S., Dong, S. D., Pelczer, I., Kahne, D., and Walsh, C. T. (2001) Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: Novel glycopeptides, Biochemistry 40, 4745-4755.
-
(2001)
Biochemistry
, vol.40
, Issue.15
, pp. 4745-4755
-
-
Losey, H.C.1
Peczuh, M.W.2
Chen, Z.3
Eggert, U.S.4
Dong, S.D.5
Pelczer, I.6
Kahne, D.7
Walsh, C.T.8
-
114
-
-
1842428817
-
Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin
-
DOI 10.1073/pnas.0400277101
-
(Pubitemid 38437422) Lu, W., Oberthur, M., Leimkuhler, C., Tao, J., Kahne, D., and Walsh, C. T. (2004) Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin, Proc. Natl. Acad. Sci. USA 101, 4390-4395.
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.13
, pp. 4390-4395
-
-
Lu, W.1
Oberthur, M.2
Leimkuhler, C.3
Tao, J.4
Kahne, D.5
Walsh, C.T.6
-
115
-
-
0344885564
-
Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin
-
DOI 10.1021/bi0340088
-
(Pubitemid 36418311) Freel Meyers, C. L., Oberthur, M., Anderson, J. W., Kahne, D., and Walsh, C. T. (2003) Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin, Biochemistry 42, 41794189.
-
(2003)
Biochemistry
, vol.42
, Issue.14
, pp. 4179-4189
-
-
Meyers, C.L.F.1
Oberthur, M.2
Anderson, J.W.3
Kahne, D.4
Walsh, C.T.5
-
116
-
-
0027177994
-
Structure-activity relationships of vancomycin-type glycopeptide antibiotics
-
(Pubitemid 23266028) Nagarajan, R. (1993) Structure-activity relationships of vancomycin-type glycopeptide antibiotics, J. Antibiot. (Tokyo) 46, 1181-1195.
-
(1993)
Journal of Antibiotics
, vol.46
, Issue.8
, pp. 1181-1195
-
-
Nagarajan, R.1
-
117
-
-
1142306159
-
Biosynthetic Gene Cluster of the Glycopeptide Antibiotic Teicoplanin: Characterization of Two Glycosyltransferases and the Key Acyltransferase
-
DOI 10.1016/S1074-5521(04)00002-X
-
(Pubitemid 38203995) Li, T. L., Huang, F., Haydock, S. F., Mironenko, T., Leadlay, P. F., and Spencer, J. B. (2004) Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: Characterization of two glycosyltransferases and the key acyltransferase, Chem. Biol. 11, 107-119.
-
(2004)
Chemistry and Biology
, vol.11
, Issue.1
, pp. 107-119
-
-
Li, T.-L.1
Huang, F.2
Haydock, S.F.3
Mironenko, T.4
Leadlay, P.F.5
Spencer, J.B.6
-
118
-
-
33750983625
-
Identification of a deacetylase involved in the maturation of teicoplanin
-
DOI 10.1002/cbic.200600308
-
(Pubitemid 44748648) Truman, A. W., Robinson, L., and Spencer, J. B. (2006) Identification of a deacetylase involved in the maturation of teicoplanin, Chembiochem 7, 1670-1675.
-
(2006)
ChemBioChem
, vol.7
, Issue.11
, pp. 1670-1675
-
-
Truman, A.W.1
Robinson, L.2
Spencer, J.B.3
-
119
-
-
3343016696
-
The hedamycin locus implicates a novel aromatic PKS priming mechanism
-
DOI 10.1016/j.chembiol.2004.04.016, PII S1074552104001656
-
(Pubitemid 38991790) Bililign, X, Hyun, C. G., Williams, I. S., Czisny, A. M, and Thorson, J. S. (2004) The hedamycin locus implicates a novel aromatic PKS priming mechanism, Chem. Biol. 11, 959-969.
-
(2004)
Chemistry and Biology
, vol.11
, Issue.7
, pp. 959-969
-
-
Bililign, T.1
Hyun, C.-G.2
Williams, J.S.3
Czisny, A.M.4
Thorson, J.S.5
-
120
-
-
4544291468
-
The glycosyltransferase UrdGT2 catalyzes both C-and O-glycosidic sugar transfers
-
DOI 10.1002/anie.200453758
-
(Pubitemid 39257656) Durr, C., Hoffmeister, D., Wohlert, S. E., Ichinose, K., Weber, M., Von Mulert, U., Thorson, J. S., and Bechthold, A. (2004) The glycosyltransferase UrdGT2 catalyzes both C-and O-glycosidic sugar transfers, Angew. Chem. Int. Ed. Engl. 43, 2962-2965.
-
(2004)
Angewandte Chemie - International Edition
, vol.43
, Issue.22
, pp. 2962-2965
-
-
Durr, C.1
Hoffmeister, D.2
Wohlert, S.-E.3
Ichinose, K.4
Weber, M.5
Von Mulert, U.6
Thorson, J.S.7
Bechthold, A.8
-
121
-
-
34547651180
-
Structure and Action of the C-C Bond-forming Glycosyltransferase UrdGT2 Involved in the Biosynthesis of the Antibiotic Urdamycin
-
DOI 10.1016/j.jmb.2007.06.005, PII S0022283607007875
-
(Pubitemid 47223216) Mittler, M., Bechthold, A., and Schulz, G. E. (2007) Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin, J. Mol. Biol. 372, 67-76.
-
(2007)
Journal of Molecular Biology
, vol.372
, Issue.1
, pp. 67-76
-
-
Mittler, M.1
Bechthold, A.2
Schulz, G.E.3
-
122
-
-
0029868593
-
The interaction of coumarin antibiotics with fragments of the DNA gyrase B protein
-
DOI 10.1021/bi952888n
-
(Pubitemid 26126725) Gormley, N. A., Orphanides, G., Meyer, A., Cullis, P. M., and Maxwell, A. (1996) The interaction of coumarin antibiotics with fragments of DNA gyrase B protein, Biochemistry 35, 5083-5092.
-
(1996)
Biochemistry
, vol.35
, Issue.15
, pp. 5083-5092
-
-
Gormley, N.A.1
Orphanides, G.2
Meyer, A.3
Cullis, P.M.4
Maxwell, A.5
-
123
-
-
0034711270
-
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone
-
DOI 10.1074/jbc.M003701200
-
(Pubitemid 32002137) Marcu, M. G., Chadli, A., Bouhouche, I., Catelli, M., and Neckers, L. M. (2000) The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone, J. Biol. Chem. 275, 37181-37186.
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.47
, pp. 37181-37186
-
-
Marcu, M.G.1
Chadli, A.2
Bouhouche, I.3
Catelli, M.4
Neckers, L.M.5
-
124
-
-
4344674482
-
Targeting multiple signal transduction pathways through inhibition of Hsp90
-
DOI 10.1007/s00109-004-0549-9
-
(Pubitemid 39149859) Zhang, H., and Burrows, F. (2004) Targeting multiple signal transduction pathways through inhibition of Hsp90, J. Mol. Med. 82, 488-499.
-
(2004)
Journal of Molecular Medicine
, vol.82
, Issue.8
, pp. 488-499
-
-
Zhang, H.1
Burrows, F.2
-
125
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D., and Weinberg, R. A. (2000) The hallmarks of cancer, Cell 100, 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
126
-
-
0034048695
-
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891
-
DOI 10.1128/AAC.44.5.1214-1222.2000
-
(Pubitemid 30228297) Steffensky, M., Muhlenweg, A., Wang, Z. X., Li, S. M., and Heide, L. (2000) Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB11891, Antimicrob. Agents Chemother. 44, 1214-1222.
-
(2000)
Antimicrobial Agents and Chemotherapy
, vol.44
, Issue.5
, pp. 1214-1222
-
-
Steffensky, M.1
Muhlenweg, A.2
Wang, Z.-X.3
Li, S.-M.4
Heide, L.5
-
127
-
-
15444377103
-
Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway
-
DOI 10.1021/bi047303g
-
(Pubitemid 40396773) Pacholec, M., Freel Meyers, C. L., Oberthur, M., Kahne, D., and Walsh, C. T. (2005) Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM, P, N from the novobiocin pathway, Biochemistry 44, 4949-4956.
-
(2005)
Biochemistry
, vol.44
, Issue.12
, pp. 4949-4956
-
-
Pacholec, M.1
Meyers, C.L.F.2
Oberthur, M.3
Kahne, D.4
Walsh, C.T.5
-
128
-
-
9744235772
-
Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN
-
DOI 10.1021/bi048457z
-
(Pubitemid 39587479) Freel Meyers, C. L., Oberthur, M., Heide, L., Kahne, D., and Walsh, C. T. (2004) Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN, Biochemistry 43, 15022-15036.
-
(2004)
Biochemistry
, vol.43
, Issue.47
, pp. 15022-15036
-
-
Freel Meyers, C.L.1
Oberthur, M.2
Heide, L.3
Kahne, D.4
Walsh, C.T.5
-
129
-
-
0033673757
-
Understanding and exploiting nature's chemical arsenal: The past, present and future of calicheamicin research
-
Thorson, J. S., Sievers, E. L., Ahlert, J., Shepard, E., Whitwam, R. E., Onwueme, K. C., and Ruppen, M. (2000) Understanding and exploiting nature's chemical arsenal: The past, present and future of calicheamicin research, Curr. Pharm. Des. 6, 1841-1879.
-
(2000)
Curr. Pharm. Des
, vol.6
, pp. 1841-1879
-
-
Thorson, J.S.1
Sievers, E.L.2
Ahlert, J.3
Shepard, E.4
Whitwam, R.E.5
Onwueme, K.C.6
Ruppen, M.7
-
130
-
-
0025127973
-
Characterization of the in vitro cyclization chemistry of calicheamicin and its relation to DNA cleavage
-
Devoss, J. J., Hangeland, J. J., and Townsend, C. A. (1990) Characterization of the in vitro cyclization chemistry of calicheamicin and its relation to DNA cleavage, J. Am. Chem. Soc. 112, 4554-4556.
-
(1990)
J. Am. Chem. Soc.
, vol.112
, pp. 4554-4556
-
-
Devoss, J.J.1
Hangeland, J.J.2
Townsend, C.A.3
-
131
-
-
0036008850
-
I
-
DOI 10.1016/S1074-5521(02)00103-5, PII S1074552102001035
-
(Pubitemid 34196662) Watanabe, C. M., Supekova, L., and Schultz, P. G. (2002) Transcriptional effects of the potent enediyne anti-cancer agent Calicheamicin γ, Chem. Biol. 9, 245-251.
-
(2002)
Chemistry and Biology
, vol.9
, Issue.2
, pp. 245-251
-
-
Watanabe, C.M.H.1
Supekova, L.2
Schultz, P.G.3
-
132
-
-
0034753903
-
Mylotarg: Antibody-targeted chemotherapy comes of age
-
DOI 10.1097/00001622-200111000-00016
-
(Pubitemid 33027906) Sievers, E. L., and Linenberger, M. (2001) Mylotarg: Antibody-targeted chemotherapy comes of age, Curr. Opin. Oncol. 13, 522-527.
-
(2001)
Current Opinion in Oncology
, vol.13
, Issue.6
, pp. 522-527
-
-
Sievers, E.L.1
Linenberger, M.2
-
133
-
-
0037119622
-
The calicheamicin gene cluster and its iterative type I enediyne PKS
-
DOI 10.1126/science.1072105
-
(Pubitemid 36193351) Ahlert, J., Shepard, E., Lomovskaya, N., Zazopoulos, E., Staffa, A., Bachmann, B. O., Huang, K., Fonstein, L., Czisny, A., Whitwam, R. E., Farnet, C. M., and Thorson, J. S. (2002) The calicheamicin gene cluster and its iterative type I enediyne PKS, Science 297, 1173-1176.
-
(2002)
Science
, vol.297
, Issue.5584
, pp. 1173-1176
-
-
Ahlert, J.1
Shepard, E.2
Lomovskaya, N.3
Zazopoulos, E.4
Staffa, A.5
Bachmann, B.O.6
Huang, K.7
Fonstein, L.8
Czisny, A.9
Whitwam, R.E.10
Farnet, C.M.11
Thorson, J.S.12
-
134
-
-
0032516343
-
Absolute stereochemistry of vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic
-
DOI 10.1016/S0040-4039(98)00454-7, PII S0040403998004547
-
(Pubitemid 28197983) Shindo, K., Kamishohara, M., Odagawa, A., Matsuoka, M., and Kawai, H. (1993) Vicenistatin, a novel 20-membered macrocyclic łactam antitumor antibiotic. J. Antibiot. (Tokyo) 46, 1076-1081.
-
(1998)
Tetrahedron Letters
, vol.39
, Issue.20
, pp. 3181-3184
-
-
Arai, H.1
Matsushima, Y.2
Eguchi, T.3
Shindo, K.4
Kakinuma, K.5
-
135
-
-
1142281949
-
Cloning, Sequencing, and Functional Analysis of the Biosynthetic Gene Cluster of Macrolactam Antibiotic Vicenistatin in Streptomyces halstedii
-
DOI 10.1016/S1074-5521(03)00282-5
-
(Pubitemid 38203992) Ogasawara, Y., Katayama, K., Minami, A., Otsuka, M., Eguchi, T., and Kakinuma, K. (2004) Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii, Chem. Biol. 11, 79-86.
-
(2004)
Chemistry and Biology
, vol.11
, Issue.1
, pp. 79-86
-
-
Ogasawara, Y.1
Katayama, K.2
Minami, A.3
Otsuka, M.4
Eguchi, T.5
Kakinuma, K.6
-
136
-
-
23744505970
-
Aglycon switch approach toward unnatural glycosides from natural glycoside with glycosyltransferase VinC
-
DOI 10.1016/j.tetlet.2005.07.083, PII S0040403905015832
-
(Pubitemid 41140158) Minami, A., Kakinuma, K., and Eguchi, T. (2005) Aglycon switch approach toward unnatural glycosides from natural glycoside with glycosyltransferase VinC, Tetrahedr. Lett. 46, 6187-6190.
-
(2005)
Tetrahedron Letters
, vol.46
, Issue.37
, pp. 6187-6190
-
-
Minami, A.1
Kakinuma, K.2
Eguchi, T.3
-
137
-
-
18244392948
-
Enzymatic approach to unnatural glycosides with diverse aglycon scaffolds using glycosyltransferase VinC
-
DOI 10.1021/ja042848j
-
(Pubitemid 40627722) Minami, A., Uchida, R., Eguchi, T, and Kakinuma, K. (2005) Enzymatic approach to unnatural glycosides with diverse aglycon scaffolds using glycosyltransferase VinC, J. Am. Chem. Soc. 127, 6148-6149.
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.17
, pp. 6148-6149
-
-
Minami, A.1
Uchida, R.2
Eguchi, T.3
Kakinuma, K.4
-
138
-
-
34247496765
-
Substrate flexibility of vicenisaminyltransferase VinC involved in the biosynthesis of vicenistatin
-
DOI 10.1021/ja0685250
-
(Pubitemid 46651388) Minami, A., and Eguchi, T. (2007) Substrate flexibility of vicenisaminyltransferase VinC involved in the biosynthesis of vicenistatin, J. Am. Chem. Soc. 129, 5102-5107.
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.16
, pp. 5102-5107
-
-
Minami, A.1
Eguchi, T.2
-
139
-
-
0001716655
-
Biosynthetic studies of daunorubicin and tetracenomycin c
-
Hutchinson, C. R. (1997) Biosynthetic studies of daunorubicin and tetracenomycin C, Chem. Rev. 97, 2525-2536.
-
(1997)
Chem. Rev.
, vol.97
, pp. 2525-2536
-
-
Hutchinson, C.R.1
-
140
-
-
0025313642
-
Cloning and expression of daunorubicin biosynthesis genes from streptomyces peucetius and s. Peucetius subsp. Caesius
-
Otten, S. L., Stutzman-Engwall, K. J., and Hutchinson, C. R. (1990) Cloning and expression of daunorubicin biosynthesis genes from Streptomyces peucetius and S. peucetius subsp. caesius, J. Bacteriol. 172, 3427-3434.
-
(1990)
J. Bacteriol.
, vol.172
, pp. 3427-3434
-
-
Otten, S.L.1
Stutzman-Engwall, K.J.2
Hutchinson, C.R.3
-
141
-
-
0036215766
-
Fluorinated anthracyclines: Synthesis and biological activity
-
(Pubitemid 34296198) Giannini, G. (2002) Fluorinated anthracyclines: Synthesis and biological activity, Curr. Med. Chem. 9, 687-712.
-
(2002)
Current Medicinal Chemistry
, vol.9
, Issue.6
, pp. 687-712
-
-
Giannini, G.1
-
142
-
-
0042346439
-
Catalytic topoisomerase II inhibitors in cancer therapy
-
DOI 10.1016/S0163-7258(03)00058-5
-
(Pubitemid 36897748) Larsen, A. K., Escargueil, A. E., and Skladanowski, A. (2003) Catalytic topoisomerase II inhibitors in cancer therapy, Pharmacol Ther. 99, 167-181.
-
(2003)
Pharmacology and Therapeutics
, vol.99
, Issue.2
, pp. 167-181
-
-
Larsen, A.K.1
Escargueil, A.E.2
Skladanowski, A.3
-
143
-
-
17744365161
-
Anthracycline metabolism and toxicity in human myocardium: Comparisons between doxorubicin, epirubicin, and a novel disaccharide analogue with a reduced level of formation and [4Fe-4S] reactivity of its secondary alcohol metabolite
-
DOI 10.1021/tx000143z
-
(Pubitemid 32104013) Minotti, G., Licata, S., Saponiero, A., Menna, P., Calafiore, A. M., Di Giammarco, G., Liberi, G., Animati, F., Cipollone, A., Manzini, S., and Maggi, C. A. (2000) Anthracycline metabolism and toxicity in human myocardium: Comparisons between doxorubicin, epirubicin, and a novel disaccharide analogue with a reduced level of formation and [4Fe-4S] reactivity of its secondary alcohol metabolite, Chem Res. Toxicol. 13, 1336-1341.
-
(2000)
Chemical Research in Toxicology
, vol.13
, Issue.12
, pp. 1336-1341
-
-
Minotti, G.1
Licata, S.2
Saponiero, A.3
Menna, P.4
Calafiore, A.M.5
Di Giamniarco, G.6
Liberi, G.7
Animati, F.8
Cipollone, A.9
Manzini, S.10
Maggi, C.A.11
-
144
-
-
13444287995
-
Role of the amino sugar in the DNA binding of disaccharide anthracyclines: Crystal structure of the complex MAR70/d(CGATCG)
-
DOI 10.1016/j.bmc.2004.12.007
-
(Pubitemid 40215255) Temperini, C., Cirilli, M., Aschi, M., and Ughetto, G. (2005) Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d (CGATCG), Bioorg. Med Chem. 13, 1673-1679.
-
(2005)
Bioorganic and Medicinal Chemistry
, vol.13
, Issue.5
, pp. 1673-1679
-
-
Temperini, C.1
Cirilli, M.2
Aschi, M.3
Ughetto, G.4
-
145
-
-
9544232513
-
Biochemical and pharmacological activity of novel 8-fluoroanthracyclines:
-
(Pubitemid 26303592) Animati, F., Arcamone, F., Bigioni, M, Capranico, G., Caserini, C., De Cesare, M., Lombardi, P., Pratesi, G., Salvatore, C., Supino, R., and Zunino, F. (1996) Biochemical and pharmacological activity of novel 8-fluoroanthracyclines: Influence of stereochemistry and conformation, Mol. Pharmacol. 50, 603-609.
-
(1996)
Molecular Pharmacology
, vol.50
, Issue.3
, pp. 603-609
-
-
Animati, F.1
Arcamone, F.2
Bigioni, M.3
Capranico, G.4
Caserini, C.5
De Cesare, M.6
Lombardi, P.7
Pratesi, G.8
Salvatore, C.9
Supino, R.10
Zunino, F.11
-
146
-
-
0141448860
-
N-methylation of anthracyclines modulates their cytotoxicity and pharmacokinetic in wild type and multidrug resistant cells
-
DOI 10.1016/S0753-3322(03)00037-4
-
(Pubitemid 37123102) Gate, L., Couvreur, P., Nguyen-Ba, G., and Tapiero, H. (2003) N-methylation of anthracyclines modulates their cytotoxicity and pharmacokinetic in wild type and multidrug resistant cells, Biomed. Pharmacother. 57, 301-308.
-
(2003)
Biomedicine and Pharmacotherapy
, vol.57
, Issue.7
, pp. 301-308
-
-
Gate, L.1
Couvreur, P.2
Nguyen-Ba, G.3
Tapiero, H.4
-
147
-
-
0034119194
-
Doxorubicin metabolism and toxicity in human myocardium: Role of cytoplasmic deglycosidation and carbonyl reduction
-
DOI 10.1021/tx000013q
-
(Pubitemid 30327162) Licata, S., Saponiero, A., Mordente, A., and Minotti, G. (2000) Doxorubicin metabolism and toxicity in human myocardium: Role of cytoplasmic deglycosidation and carbonyl reduction, Chem. Res. Toxicol. 13, 414-420.
-
(2000)
Chemical Research in Toxicology
, vol.13
, Issue.5
, pp. 414-420
-
-
Licata, S.1
Saponiero, A.2
Mordente, A.3
Minotti, G.4
-
148
-
-
1642617697
-
Cardiotoxicity of cytotoxic drugs
-
Schimmel, K. J., Richel, D. J., van den Brink, R. B., and Guchelaar, H. J. (2004) Cardiotoxicity of cytotoxic drugs, Cancer Treat. Rev. 30, 181-191.
-
(2004)
Cancer Treat. Rev.
, vol.30
, pp. 181-191
-
-
Schimmel, K.J.1
Richel, D.J.2
Van Den, B.R.B.3
Guchelaar, H.J.4
-
149
-
-
0035807832
-
The anticancer drug-DNA complex: Femtosecond primary dynamics for anthracycline antibiotics function
-
DOI 10.1073/pnas.241509698
-
(Pubitemid 33121371) Qu, X., Wan, C., Becker, H. C., Zhong, D., and Zewail, A. H. (2001) The anticancer drug-DNA complex: Femtosecond primary dynamics for anthracycline antibiotics function, Proc. Natl. Acad Sci. USA 98, 14212-14217.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.25
, pp. 14212-14217
-
-
Qu, X.1
Wan, C.2
Becker, H.-C.3
Zhong, D.4
Zewail, A.H.5
-
150
-
-
0035834005
-
Femtosecond dynamics of a drug-protein complex: Daunomycin with apo riboflavin-binding protein
-
DOI 10.1073/pnas.211440298
-
(Pubitemid 32959794) Zhong, D., Pal, S. K., Wan, C., and Zewail, A. H. (2001) Femtosecond dynamics of a drug-protein complex: Daunomycin with Apo riboflavin-binding protein, Proc. Natl. Acad. Sci. USA 98, 11873-11878.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.21
, pp. 11873-11878
-
-
Zhong, D.1
Pal, S.K.2
Wan, C.3
Zewail, A.H.4
-
151
-
-
0037178274
-
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster
-
DOI 10.1016/S0378-1119(02)00699-6, PII S0378111902006996
-
(Pubitemid 34876467) Raty, K., Kantola, J., Hautala, A., Hakala, J., Ylihonko, K., and Mantsala, P. (2002) Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster, Gene 293, 115-122.
-
(2002)
Gene
, vol.293
, Issue.1-2
, pp. 115-122
-
-
Raty, K.1
Kantola, J.2
Hautala, A.3
Hakala, J.4
Ylihonko, K.5
Mantsala, P.6
-
152
-
-
4444222040
-
AknK Is an L-2-Deoxyfucosyltransferase in the Biosynthesis of the Anthracycline Aclacinomycin A
-
DOI 10.1021/bi035945i
-
(Pubitemid 38500584) Lu, W, Leimkuhler, C., Oberthur, M., Kahne, D., and Walsh, C. T. (2004) AknK is an l-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A, Biochemistry 43, 4548-4558.
-
(2004)
Biochemistry
, vol.43
, Issue.15
, pp. 4548-4558
-
-
Lu, W.1
Leimkuhler, C.2
Oberthur, M.3
Kahne, D.4
Walsh, C.T.5
-
153
-
-
19544377358
-
AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A
-
DOI 10.1016/j.chembiol.2005.02.016, PII S1074552105000931
-
(Pubitemid 40727927) Lu, W., Leimkuhler, C., Gatto, G. J., Jr., Kruger, R. G., Oberthur, M., Kahne, D., and Walsh, C. T. (2005) AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A, Chem. Biol. 12, 527-534.
-
(2005)
Chemistry and Biology
, vol.12
, Issue.5
, pp. 527-534
-
-
Lu, W.1
Leimkuhler, C.2
Gatto Jr., G.J.3
Kruger, R.G.4
Oberthur, M.5
Kahne, D.6
Walsh, C.T.7
-
154
-
-
34548214188
-
Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A
-
DOI 10.1021/ja072909o
-
(Pubitemid 47330273) Leimkuhler, C., Fridman, M., Lupoli, T., Walker, S., Walsh, C. T., and Kahne, D. (2007) Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A, J. Am. Chem. Soc. 129, 10546-10550.
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.34
, pp. 10546-10550
-
-
Leimkuhler, C.1
Fridman, M.2
Lupoli, T.3
Walker, S.4
Walsh, C.T.5
Kahne, D.6
-
155
-
-
33747093695
-
Cloning, purification and characterization of a functional anthracycline glycosyltransferase
-
DOI 10.1016/j.jbiotec.2006.03.035, PII S0168165606003117
-
(Pubitemid 44223837) Sianidis, G., Wohlert, S. E., Pozidis, C., Karamanou, S., Luzhetskyy, A., Vente, A., and Economou, A. (2006) Cloning, purification and characterization of a functional anthracycline glycosyltransferase, J. Biotechnol. 125, 425-433.
-
(2006)
Journal of Biotechnology
, vol.125
, Issue.3
, pp. 425-433
-
-
Sianidis, G.1
Wohlert, S.-E.2
Pozidis, C.3
Karamanou, S.4
Luzhetskyy, A.5
Vente, A.6
Economou, A.7
-
156
-
-
0033977621
-
Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717
-
(Pubitemid 30066316) Faust, B., Hoffmeister, D., Weitnauer, G., Westrich, L., Haag, S., Schneider, P., Decker, H., Kunzel, E., Rohr, J., and Bechthold, A. (2000) Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717, Microbiology 146Pt.1, 147-154.
-
(2000)
Microbiology
, vol.146
, Issue.1
, pp. 147-154
-
-
Faust, B.1
Hoffmeister, D.2
Weitnauer, G.3
Westrich, L.4
Haag, S.5
Schneider, P.6
Decker, H.7
Kunzel, E.8
Rohr, J.9
Bechthold, A.10
-
157
-
-
17444449236
-
Function of glycosyltransferase genes involved in urdamycin A biosynthesis
-
DOI 10.1016/S1074-5521(00)00079-X
-
(Pubitemid 30086839) Trefzer, A., Hoffmeister, D., Kunzel, E., Stockert, S., Weitnauer, G., Westrich, L., Rix, U., Fuchser, J., Bindseil, K. U., Rohr, J., and Bechthold, A. (2000) Function of glycosyltransferase genes involved in urdamycin A biosynthesis, Chem. Biol. 7, 133-142.
-
(2000)
Chemistry and Biology
, vol.7
, Issue.2
, pp. 133-142
-
-
Trefzer, A.1
Hoffmeister, D.2
Kunzel, E.3
Stockert, S.4
Weitnauer, G.5
Westrich, L.6
Rix, U.7
Fuchser, J.8
Bindseil, K.U.9
Rohr, J.10
Bechthold, A.11
-
158
-
-
0034976452
-
Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity
-
DOI 10.1016/S1074-5521(01)00039-4, PII S1074552101000394
-
(Pubitemid 32532972) Hoffmeister, D., Ichinose, K., and Bechthold, A. (2001) Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity, Chem. Biol. 8, 557-567.
-
(2001)
Chemistry and Biology
, vol.8
, Issue.6
, pp. 557-567
-
-
Hoffmeister, D.1
Ichinose, K.2
Bechthold, A.3
-
159
-
-
0036009337
-
Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity
-
DOI 10.1016/S1074-5521(02)00114-X, PII S107455210200114X
-
(Pubitemid 34253411) Hoffmeister, D., Wilkinson, B., Foster, G., Sidebottom, P. J., Ichinose, K., and Bechthold, A. (2002) Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity, Chem. Biol. 9, 287-295.
-
(2002)
Chemistry and Biology
, vol.9
, Issue.3
, pp. 287-295
-
-
Hoffmeister, D.1
Wilkinson, B.2
Foster, G.3
Sidebottom, P.J.4
Ichinose, K.5
Bechthold, A.6
-
160
-
-
4143092938
-
Alteration of sugar donor specificities of plant glycosyltransferases by a single point mutation
-
DOI 10.1016/j.abb.2004.06.021, PII S0003986104003698
-
(Pubitemid 39099251) Kubo, A., Arai, Y., Nagashima, S., and Yoshikawa, T. (2004) Alteration of sugar donor specificities of plant glycosyltransferases by a single point mutation, Arch. Biochem. Biophys. 429, 198-203.
-
(2004)
Archives of Biochemistry and Biophysics
, vol.429
, Issue.2
, pp. 198-203
-
-
Kubo, A.1
Arai, Y.2
Nagashima, S.3
Yoshikawa, T.4
-
161
-
-
33846815083
-
Characterization and engineering of glycosyltransferases responsible for steroid saponin biosynthesis in Solanaceous plants
-
DOI 10.1016/j.phytochem.2006.11.020, PII S003194220600728X
-
(Pubitemid 46201830) Kohara, A., Nakajima, C., Yoshida, S., and Muranaka, T. (2007) Characterization and engineering of glycosyltransferases responsible for steroid saponin biosynthesis in Solanaceous plants, Phytochemistry 68, 478-486.
-
(2007)
Phytochemistry
, vol.68
, Issue.4
, pp. 478-486
-
-
Kohara, A.1
Nakajima, C.2
Yoshida, S.3
Muranaka, T.4
-
162
-
-
33748579951
-
Engineering of glycosidases and glycosyltransferases
-
Hancock, S. M., Vaughan, M. D., and Withers, S. G. (2006) Engineering of glycosidases and glycosyltransferases, Curr. Opin. Chem. Biol. 10, 509-519.
-
(2006)
Curr. Opin. Chem. Biol.
, vol.10
, pp. 509-519
-
-
Hancock, S.M.1
Vaughan, M.D.2
Withers, S.G.3
-
163
-
-
33645467890
-
Mutant glycosyltransferases assist in the development of a targeted drug delivery system and contrast agents for MRI
-
Qasba, P. K., Ramakrishnan, B., and Boeggeman, E. (2006) Mutant glycosyltransferases assist in the development of a targeted drug delivery system and contrast agents for MRI, AAPS L. 8, E190-E195.
-
(2006)
AAPS. L.
, vol.8
-
-
Qasba, P.K.1
Ramakrishnan, B.2
Boeggeman, E.3
-
164
-
-
14644434401
-
Mutation of arginine 228 to lysine enhances the glucosyltransferase activity of bovine -1,4-galactosyltransferase I
-
DOI 10.1021/bi0479454
-
(Pubitemid 40321993) Ramakrishnan, B., Boeggeman, E., and Qasba, P. K. (2005) Mutation of arginine 228 to lysine enhances the glucosyltransferase activity of bovine β-1, 4-galactosyltransferase I, Biochemistry 44, 3202-3210.
-
(2005)
Biochemistry
, vol.44
, Issue.9
, pp. 3202-3210
-
-
Ramakrishnan, B.1
Boeggeman, E.2
Qasba, P.K.3
-
165
-
-
0037036376
-
Structure-based design of 1,4-galactosyltransferase I (4Gal-T1) with equally efficient N-acetylgalactosaminyltransferase activity: Point mutation broadens 4Gal-T1 donor specificity
-
DOI 10.1074/jbc.M111183200
-
(Pubitemid 34967390) Ramakrishnan, B., and Qasba, P. K. (2002) Structure-based design of β, 4-galactosyltransferase I (4Gal-Tl) with equally efficient N-acetylgalactosaminy ltransferase activity: Point mutation broadens β4Gal-T1 donor specificity, J. Biol. Chem. 277, 20833-20839.
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.23
, pp. 20833-20839
-
-
Ramakrishnan, B.1
Qasba, P.K.2
-
166
-
-
0347064326
-
A Chemoenzymatic Approach toward the Rapid and Sensitive Detection of O-GlcNAc Posttranslational Modifications
-
DOI 10.1021/ja038545r
-
(Pubitemid 38020622) Khidekel, N., Arndt, S., Lamarre-Vincent, N., Lippert, A., Poulin-Kerstien, K. G., Ramakrishnan, B., Qasba, P. K., and Hsieh-Wilson, L. C. (2003) A chemoenzymatic approach toward the rapid and sensitive detection of O-GlcNAc posttranslational modifications, J. Am. Chem. Soc. 125, 16162-16163.
-
(2003)
Journal of the American Chemical Society
, vol.125
, Issue.52
, pp. 16162-16163
-
-
Khidekel, N.1
Arndt, S.2
Lamarre-Vincent, N.3
Lippert, A.4
Poulin-Kerstien, K.G.5
Ramakrishnan, B.6
Qasba, P.K.7
Hsieh-Wilson, L.C.8
-
167
-
-
33845928213
-
Mutational analysis of the Medicago glycosyltransferase UGT71G1 reveals residues that control regioselectivity for (Iso)flavonoid glycosylation
-
DOI 10.1074/jbc.M605767200
-
(Pubitemid 46036651) He, X. Z., Wang, X., and Dixon, R. A. (2006) Mutational analysis of the Medicago glycosyltransferase UGT71G1 reveals residues that control regioselectivity for (iso) flavonoid glycosylation, J. Biol. Chem 281, 34441-34447.
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.45
, pp. 34441-34447
-
-
He, X.-Z.1
Wang, X.2
Dixon, R.A.3
-
168
-
-
33746439461
-
High-throughput screening methodology for the directed evolution of glycosyltransferases
-
DOI 10.1038/nmeth899, PII NMETH899
-
(Pubitemid 44123427) Aharoni, A., Thieme, K., Chiu, C. P., Buchini, S., Lairson, L. L., Chen, H., Strynadka, N. C., Wakarchuk, W. W., and Withers, S. G. (2006) High-throughput screening methodology for the directed evolution of glycosyltransferases, Nat. Methods 3, 609-614.
-
(2006)
Nature Methods
, vol.3
, Issue.8
, pp. 609-614
-
-
Aharoni, A.1
Thieme, K.2
Chiu, C.P.C.3
Buchini, S.4
Lairson, L.L.5
Chen, H.6
Strynadka, N.C.J.7
Wakarchuk, W.W.8
Withers, S.G.9
-
169
-
-
34548685673
-
Directed evolution of a natural product glycosyltransferase
-
Williams, G. J., Zhang, C., and Thorson, J. S. (2007) Directed evolution of a natural product glycosyltransferase, Nat. Chem. Biol. 3, 657-662.
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 657-662
-
-
Williams, G.J.1
Zhang, C.2
Thorson, J.S.3
-
170
-
-
0033810470
-
A highly sensitive fluorescent microplate method for the determination of udp-glucuronosyl transferase activity in tissues and placental cell lines
-
Collier, A. C., Tingle, M. D., Keelan, J. A., Paxton, J. W., and Mitchell, M. D. (2000) A highly sensitive fluorescent microplate method for the determination of UDP-glucuronosyl transferase activity in tissues and placental cell lines, Drug Metab. Dispos. 28, 1184-1186.
-
(2000)
Drug Metab. Dispos.
, vol.28
, pp. 1184-1186
-
-
Collier, A.C.1
Tingle, M.D.2
Keelan, J.A.3
Paxton, J.W.4
Mitchell, M.D.5
-
171
-
-
0034999624
-
Directed evolution of new glycosynthases from Agrobacterium -glucosidase: A general screen to detect enzymes for oligosaccharide synthesis
-
DOI 10.1016/S1074-5521(01)00022-9, PII S1074552101000229
-
(Pubitemid 32455898) Mayer, C., Jakeman, D. L., Mah, M., Karjala, G., Gal, L., Warren, R. A., and Withers, S. G. (2001) Directed evolution of new glycosynthases from Agrobacterium betaglucosidase: A general screen to detect enzymes for oligosaccharide synthesis, Chem. Biol. 8, 437-443.
-
(2001)
Chemistry and Biology
, vol.8
, Issue.5
, pp. 437-443
-
-
Mayer, C.1
Jakeman, D.L.2
Mah, M.3
Karjala, G.4
Gal, L.5
Warren, R.A.J.6
Withers, S.G.7
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