Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 17, 1999, Pages 9509-9514

  Ikeda, Haruo ^a   Nonomiya, Tomoko ^b   Usami, Masayo ^a   Ohta, Toshio ^b   Omura, Satoshi ^a,b  

^a KITASATO UNIVERSITY   (Japan)

^b KITASATO INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AVERMECTIN; MACROLIDE; MILBEMYCIN; NEMADECTIN; POLYKETIDE;

ARTICLE; CATALYSIS; DNA SEQUENCE; DRUG SYNTHESIS; ENZYME ACTIVITY; GENE CLUSTER; GENETIC TRANSCRIPTION; GLYCOSYLATION; ONCHOCERCIASIS; PRIORITY JOURNAL; STREPTOMYCES; STRONGYLOIDIASIS;

ANTHELMINTICS; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; DNA, BACTERIAL; GENETIC ENGINEERING; IVERMECTIN; MACROLIDES; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MULTIGENE FAMILY; STREPTOMYCES;

EID: 0033578297     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.17.9509     Document Type: Article

References (31)

1. Burg, R. W., Miller, B. M., Baker, E. E., Birnbaum, J., Currie, S. A., Hartman, R., Kong, Y.-L., Monaghan, R. L., Olson, G., Putter, I., et al. (1979) Antimicrob. Agents Chemother. 15, 361-367.
2. Aziz, M. A., Diallo, S., Diop, I. M., Lariviere, M. & Parta, M. (1982) Lancet ii, 171-173.
3. Shikiya, K., Kinjo, N., Uehara, T., Uechi, H., Ohshiro, J., Arakaki, T., Kinjo, F., Saito, A., Iju, M. & Kobari, M. (1992) Intern. Med. 31, 310-312.
4. Ikeda, H., Kotaki, H. & Ōmura, S. (1987) J. Bacteriol. 169, 5615-5621.
5. MacNeil, T., Gewain, K. M. & MacNeil, D. J. (1993) J. Bacteriol. 175, 2552-2563.
6. Ikeda, H. & Ōmura, S. (1993) Actinomycetologica 7, 133-144.
7. Cane, D. E., Liang, T.-C., Kaplan, L. K., Nallin, M. K., Schulman, M. D., Hensens, O. D., Douglas, A. W. & Albers-Schönberg, G. (1983) J. Am. Chem. Soc. 105, 4110-4112.
8. Shoop, W. L., Egerton, J. R., Eary, C. H., Haines, H. W., Michael, B. F., Mrozik, H., Eskola, P., Fisher, M. H., Slayton, L., Ostlind, D. A., et al. (1996) Int. J. Parasitol. 26, 1237-1242.
9. Dutton, C. J., Gibson, S. P., Goudie, A. C., Holdom, K. S., Pacey, M. S., Ruddock, J. C., Bu'Lock, J. D. & Richards, M. K. (1991) J. Antibiot. 44, 357-365.
10. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1999) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
11. Hanahan, D. (1985) in DNA Cloning: A Practical Approach, ed. Glover, D. M. (IRL, Oxford), Vol. 1, pp. 109-132.
12. Pang, C.-H., Shiiyama, M., Ikeda, H., Tanaka, H. & Ōmura, S. (1994) Actinomycetologica 8, 21-25.
13. Ikeda, H., Wang, R.-L., Ohta, T. & Ōmura, S. (1998) Gene 206, 175-180.
14. Strathmann, M., Hamilton, B. A., Mayeda, C. A., Simon, M. I., Meyerowitz, E. M & Palazzolo, J. (1991) Proc. Natl. Acad. Sci. USA 88, 1247-1250.
15. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. (1990) J. Mol. Biol. 215, 403-410.
16. Pearson, W. R. (1990) Methods Enzymol. 183, 63-98.
17. Ishikawa, J. & Hotta, K. (1999) FEMS Microbiol. Lett. 174, 251-253.
18. Thompson, J. D., Higgins, D. G. & Gibson, T. J. (1994) Comput. Appl. Biosci. 10, 19-29.
19. Cortes, J., Haydock, S. F., Robert, G. A., Bevitt, D. J. & Leadlay, P. F. (1990) Nature (London) 348, 176-178.
20. Donadio, S., Staver, M. J., McAlpine, J. B., Swanson, S. J. & Katz, L. (1991) Science 252, 675-679.
21. Xue, Y., Zhao, L., Liu, H.-W. & Sherman, D. (1998) Proc. Natl. Acad. Sci. USA 95, 12111-12116.
22. August, P. R., Tang, L., Yoon, Y. J., Ning, S., Muller, R., Yu, T. W., Taylor, M., Hoffmann, D., Kim, C. G., Zhang, X., et al. (1998) Chem. Biol. 5, 69-79.
23. Molnár, I., Aparicio, J. F., Haydock, S. F., Khaw, L. E., Schwecke, T., König, A., Stauton, J. & Leadlay, P. F. (1996) Gene 169, 1-7.
24. Bevitt, D. J., Cortés, Haydock, S. F. & Leadlay, P. F. (1992) Eur. J. Biochem. 204, 39-49.
25. Ikeda, H., Pang, C.-H., Endo, H., Ohta, T., Tanaka, H. & Ōmura, S. (1995) J. Antibiot. 48, 773-775.
26. Pang, C.-H., Matsuzaki, K., Ikeda, H., Tanaka, H. & Ōmura, S. (1995) J. Antibiot. 48, 59-66.
27. Persson, B., Krook, M. & Jórnvall, H. (1991) Eur. J. Biochem. 200, 537-543.
28. Ikeda, H., Takada, Y., Pang, C.-H., Matsuzaki, K., Tanaka, H. & Ōmura, S. (1995) J. Antibiot. 48, 95-97, 1995.
29. Ikeda, H., Takada, Y., Pang, C-H., Tanaka, H. & Ōmura, S. (1993) J. Bacteriol. 175, 2077-2082.
30. Ruan, X., Stassi, D., Lax, S. A. & Katz, L. (1997) Gene 203, 1-9.
31. Horii, M., Ishizaki, T., Paik, S. Y., Manome, T. & Murooka, Y. (1990) J. Bacteriol. 172, 3644-3653.