메뉴 건너뛰기




Volumn 2, Issue 12, 2004, Pages 984-989

The life and times of ivermectin - A success story

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ABAMECTIN; ALBENDAZOLE; ANTELMYCIN; ANTHELMINTIC AGENT; ANTHELVENCIN; ANTIBIOTIC G 418; ASPICULOMYCIN; AVERMECTIN A1 A; AVERMECTIN A1 B; AVERMECTIN A2 A; AVERMECTIN A2 B; AVERMECTIN B1 A; AVERMECTIN B1 B; AVERMECTIN B2 A; AVERMECTIN B2 B; AVERMECTIN DERIVATIVE; AXENOMYCIN DERIVATIVE; BENZIMIDAZOLE; DESTOMYCIN DERIVATIVE; DIETHYLCARBAMAZINE; HYGROMYCIN B; IVERMECTIN; LEVAMISOLE; MILBEMYCIN DERIVATIVE; PAROMOMYCIN; S 151; SURAMIN; THIAMYCIN DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 9444230640     PISSN: 17401526     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrmicro1048     Document Type: Article
Times cited : (228)

References (53)
  • 1
    • 0022462534 scopus 로고
    • Philosophy of new drug discovery
    • Õmura, S. Philosophy of new drug discovery. Microbiol. Rev. 50, 259-279 (1986).
    • (1986) Microbiol. Rev. , vol.50 , pp. 259-279
    • Õmura, S.1
  • 2
    • 9444263663 scopus 로고
    • (eds Weber, R. J. & Perkins, D. N.) Chapter 11 (Oxford Univ. Press, New York )
    • Campbell, W. C. in Inventive Minds (eds Weber, R. J. & Perkins, D. N.) Chapter 11, 192-214 (Oxford Univ. Press, New York, 1992).
    • (1992) Inventive Minds , pp. 192-214
    • Campbell, W.C.1
  • 4
    • 0036867480 scopus 로고    scopus 로고
    • Streptomyces avermectinius sp. nov., an avermectin-producing strain
    • Takahashi, Y. et al. Streptomyces avermectinius sp. nov., an avermectin-producing strain. Int. J. Syst. Evol. Microbiol. 52, 2163-2168 (2002).
    • (2002) Int. J. Syst. Evol. Microbiol. , vol.52 , pp. 2163-2168
    • Takahashi, Y.1
  • 5
    • 0018386220 scopus 로고
    • Avermectins, new family of potent anthelmintic agents: Producing organisms and fermentation
    • Burg, R. W. et al. Avermectins, new family of potent anthelmintic agents: producing organisms and fermentation. Antimicrob. Agents Chemother. 15, 361-367 (1979).
    • (1979) Antimicrob. Agents Chemother. , vol.15 , pp. 361-367
    • Burg, R.W.1
  • 6
    • 0018398943 scopus 로고
    • Avermectins, new family of potent anthelmintic, agents: Isolation and chromatographic properties
    • Miller, T. W. Avermectins, new family of potent anthelmintic, agents: isolation and chromatographic properties. Antimicrob. Agents Chemother. 15, 368-371 (1979).
    • (1979) Antimicrob. Agents Chemother. , vol.15 , pp. 368-371
    • Miller, T.W.1
  • 9
    • 0019135342 scopus 로고
    • Ivermectin, a new broad-spectrum antiparasitic agent
    • Chabala, J. C. et al. Ivermectin, a new broad-spectrum antiparasitic agent. J. Med. Chem. 23, 1134-1136 (1980).
    • (1980) J. Med. Chem. , vol.23 , pp. 1134-1136
    • Chabala, J.C.1
  • 10
    • 0024450271 scopus 로고
    • The status of ivermectin in the treatment of human onchocerciasis
    • Taylor, H. R. & Greene, B. M. The status of ivermectin in the treatment of human onchocerciasis. Am. J. Trop. Med. Hyg. 41, 460-466 (1989).
    • (1989) Am. J. Trop. Med. Hyg. , vol.41 , pp. 460-466
    • Taylor, H.R.1    Greene, B.M.2
  • 11
    • 0035834039 scopus 로고    scopus 로고
    • Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
    • Ömura, S. et al. Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc. Natl Acad. Sci. USA 98 12215-12220 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12215-12220
    • Ömura, S.1
  • 12
    • 0038561132 scopus 로고    scopus 로고
    • Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
    • Ikeda, H. et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nature Biotechnol. 21, 526-531 (2003).
    • (2003) Nature Biotechnol. , vol.21 , pp. 526-531
    • Ikeda, H.1
  • 15
    • 0027319985 scopus 로고
    • Haemonchus contortus: Ivermectin-induced paralysis of the pharynx
    • Geary, T. G. et al. Haemonchus contortus: ivermectin-induced paralysis of the pharynx. Exp. Parasitol. 77 88-96 (1993).
    • (1993) Exp. Parasitol. , vol.77 , pp. 88-96
    • Geary, T.G.1
  • 16
    • 0018461317 scopus 로고
    • 1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance
    • 1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. Proc. Natl Acad. Sci. USA 76, 2062-2066 (1979).
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 2062-2066
    • Fritz, L.C.1
  • 19
    • 0041990204 scopus 로고
    • Tropical Disease Research: Progress 1975-94, highlights 1993-94
    • TDR. Twelfth Programme Report WHO, Geneva )
    • TDR. Twelfth Programme Report, Tropical Disease Research: progress 1975-94, highlights 1993-94. WHO, Geneva, 1995).
    • (1995)
  • 20
    • 2342630488 scopus 로고    scopus 로고
    • Eliminating onchocerciasis as a public health problem
    • Thylefors, B. Eliminating onchocerciasis as a public health problem. Trop. Med. Int. Health 9, A1-A3 (2004).
    • (2004) Trop. Med. Int. Health , vol.9
    • Thylefors, B.1
  • 21
    • 0019988320 scopus 로고
    • Efficacy and tolerance of ivermectin in human onchocerciasis
    • Aziz, M. A. et al. Efficacy and tolerance of ivermectin in human onchocerciasis. Lancet 2, 171-173 (1982).
    • (1982) Lancet , vol.2 , pp. 171-173
    • Aziz, M.A.1
  • 22
    • 0020333832 scopus 로고
    • Ivermectin in onchocerciasis
    • Aziz, M. A. et al. Ivermectin in onchocerciasis. Lancet 2, 1456-1457 (1982).
    • (1982) Lancet , vol.2 , pp. 1456-1457
    • Aziz, M.A.1
  • 23
    • 0023239601 scopus 로고
    • Controlled tried and dose-finding study of ivermectin for treatment of infectious diseases
    • White, A. T. et al. Controlled tried and dose-finding study of ivermectin for treatment of infectious diseases. J. Infect. Dis. 156, 463-470 (1987).
    • (1987) J. Infect. Dis. , vol.156 , pp. 463-470
    • White, A.T.1
  • 24
    • 0023476647 scopus 로고
    • Single dose therapy with ivermectin for onchocerciasis
    • Greene, B. M. et al. Single dose therapy with ivermectin for onchocerciasis. Trans. Assoc. Am. Physicians 100 131-138 (1987).
    • (1987) Trans. Assoc. Am. Physicians , vol.100 , pp. 131-138
    • Greene, B.M.1
  • 25
    • 0023715169 scopus 로고
    • Effect of single-dose ivermectin therapy on human Onchocerca volvulus infection with onchocercal ocular involvement
    • Newland, H. S. et al. Effect of single-dose ivermectin therapy on human Onchocerca volvulus infection with onchocercal ocular involvement. Br. J. Opthalmol. 72, 561-569 (1988).
    • (1988) Br. J. Opthalmol. , vol.72 , pp. 561-569
    • Newland, H.S.1
  • 26
    • 0025375493 scopus 로고
    • Large-scale ivermectin distribution and its epidemiological consequences
    • Remme, J. H. F. et al. Large-scale ivermectin distribution and its epidemiological consequences. Acta Leiden. 59, 177-191 (1990).
    • (1990) Acta Leiden. , vol.59 , pp. 177-191
    • Remme, J.H.F.1
  • 27
    • 0025605295 scopus 로고
    • Effects of multiple monthly doses of ivermectin on adult Onchocerca volvolus
    • Duke, B. O. L. et al. Effects of multiple monthly doses of ivermectin on adult Onchocerca volvolus. Am. J. Trop. Med. Hyg. 43, 657-664 (1990).
    • (1990) Am. J. Trop. Med. Hyg. , vol.43 , pp. 657-664
    • Duke, B.O.L.1
  • 28
    • 0020503540 scopus 로고
    • Ivermectin: A potent new antiparasitic agent
    • Campbell, W. C. et al. Ivermectin: a potent new antiparasitic agent. Science 221, 823-828 (1983).
    • (1983) Science , vol.221 , pp. 823-828
    • Campbell, W.C.1
  • 29
    • 0030460794 scopus 로고
    • Clinical and parasitological response after up to 6.5 years of ivermectin treatment for onchocerciasis
    • Whitworth, J. A. G. et al. Clinical and parasitological response after up to 6.5 years of ivermectin treatment for onchocerciasis. Trop. Med. Int. Health 1, 786-793 (1992).
    • (1992) Trop. Med. Int. Health , vol.1 , pp. 786-793
    • Whitworth, J.A.G.1
  • 30
    • 0028073730 scopus 로고
    • The impact of five years of annual ivermectin treatment on microfilarial loads in the onchocerciasis focus of Asubende, Ghana
    • Aley, E. S. et al. The impact of five years of annual ivermectin treatment on microfilarial loads in the onchocerciasis focus of Asubende, Ghana. Trans. R. Soc. Top. Mod. Hyg. 88, 581-584 (1994).
    • (1994) Trans. R. Soc. Top Mod. Hyg. , vol.88 , pp. 581-584
    • Aley, E.S.1
  • 31
    • 9444220725 scopus 로고    scopus 로고
    • The effect of five years of annual treatment with ivermectin (Mectizan®) on the prevalence and morbidity of onchocerciasis in the village of Gami in the Central African Republic
    • Kennedy, M. H. et al. The effect of five years of annual treatment with ivermectin (Mectizan®) on the prevalence and morbidity of onchocerciasis in the village of Gami in the Central African Republic. Ann. Trop. Med. Parasitol. 49, 804-811 (2002).
    • (2002) Ann. Trop. Med. Parasitol. , vol.49 , pp. 804-811
    • Kennedy, M.H.1
  • 32
    • 0026681126 scopus 로고    scopus 로고
    • A community trial of ivermectin for onchocerciasis in Sierra Leone; clinical and parasitological response to four doses given at six-monthly intervals
    • Whitworth, J. A. G. et al. A community trial of ivermectin for onchocerciasis in Sierra Leone; clinical and parasitological response to four doses given at six-monthly intervals. Trans. R. Soc. Trop. Med. Hyg. 86, 277-280 (1996).
    • (1996) Trans. R. Soc. Trop. Med. Hyg. , vol.86 , pp. 277-280
    • Whitworth, J.A.G.1
  • 33
    • 0026533538 scopus 로고
    • Effects of three-month doses of ivermectin on adult Onchocerca volvulus
    • Duke, B. O. L. et al. Effects of three-month doses of ivermectin on adult Onchocerca volvulus. Am. J. Trop. Med. Hyg. 46, 189-194 (1992).
    • (1992) Am. J. Trop. Med. Hyg. , vol.46 , pp. 189-194
    • Duke, B.O.L.1
  • 34
    • 0022626334 scopus 로고
    • Comparison of the treatment of ocular onchocerciaisis with ivermectin and diethylcarbamazine
    • Taylor, H. R. et al. Comparison of the treatment of ocular onchocerciaisis with ivermectin and diethylcarbamazine. Arch. Opthalmol. 104, 863-870 (1986).
    • (1986) Arch. Opthalmol. , vol.104 , pp. 863-870
    • Taylor, H.R.1
  • 35
    • 0026011670 scopus 로고
    • Community-based treatment of onchocerciasis with ivermectin: Safety, efficacy and acceptability of yearly treatment
    • Pacqué, M. et al. Community-based treatment of onchocerciasis with ivermectin: safety, efficacy and acceptability of yearly treatment. J. Infect. Dis. 163, 381-385 (1991).
    • (1991) J. Infect. Dis. , vol.163 , pp. 381-385
    • Pacqué, M.1
  • 36
    • 0026638702 scopus 로고
    • Adverse events following mass ivermectin therapy for onchocerciasis
    • Chijioke, C. P. & Okonkwo, P. Adverse events following mass ivermectin therapy for onchocerciasis. Trans. R. Soc. Top. Med. Hyg. 86, 284-286 (1992).
    • (1992) Trans. R. Soc. Top Med. Hyg. , vol.86 , pp. 284-286
    • Chijioke, C.P.1    Okonkwo, P.2
  • 37
    • 0024954571 scopus 로고
    • Adverse reactions after large-scale treatment of onchocerciasis with ivermectin: Combined results from eight community trials
    • De Sole, G. et al. Adverse reactions after large-scale treatment of onchocerciasis with ivermectin: combined results from eight community trials. Bull. World Health Organ. 67, 707-719 (1989).
    • (1989) Bull. World Health Organ. , vol.67 , pp. 707-719
    • De Sole, G.1
  • 38
    • 0030981519 scopus 로고    scopus 로고
    • Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection
    • Gardon, J. et al. Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection. Lancet 350, 18-22 (1997).
    • (1997) Lancet , vol.350 , pp. 18-22
    • Gardon, J.1
  • 39
    • 0042759615 scopus 로고    scopus 로고
    • Serious adverse events following treatment with ivermectin for onchocerciais control: A review of reported cases
    • Twum-Danso, N. A. Y. Serious adverse events following treatment with ivermectin for onchocerciais control: a review of reported cases. Filaria J. 2 (Suppl.), S3-S13 (2003).
    • (2003) Filaria J. , vol.2 , Issue.SUPPL.
    • Twum-Danso, N.A.Y.1
  • 40
    • 0004010584 scopus 로고
    • Strategies for ivermectin distribution through primary health care systems
    • WHO WHO/PBL/91. 24. (WHO, Geneva, )
    • WHO. Strategies for ivermectin distribution through primary health care systems. WHO/PBL/91. 24. (WHO, Geneva, 1991).
    • (1991)
  • 41
    • 9444289828 scopus 로고    scopus 로고
    • Newsletter of the Mectizan Donation Programme
    • Mectizan Donation Programme. [online]
    • Mectizan Donation Programme. Newsletter of the Mectizan Donation Programme. [online], http://www.mectizan.org/mpn33/mpnhtml336.htm (2004).
    • (2004)
  • 42
    • 2342652220 scopus 로고    scopus 로고
    • Economic evaluation of Mectizan distribution
    • Waters, H. R. et al. Economic evaluation of Mectizan distribution. Trop. Med. Int. Health 9, A16-A25 (2004).
    • (2004) Trop. Med. Int. Health , vol.9
    • Waters, H.R.1
  • 44
    • 0031757406 scopus 로고    scopus 로고
    • Willingness to pay for community-based ivermectin distribution: A study of three onchocerciasis endemic communilips in Nigeria
    • Onwujekwe, O. et al. Willingness to pay for community-based ivermectin distribution: a study of three onchocerciasis endemic communilips in Nigeria. Trop. Med. Int. Health 3, 802-808 (1998).
    • (1998) Trop. Med. Int. Health , vol.3 , pp. 802-808
    • Onwujekwe, O.1
  • 45
    • 0036021067 scopus 로고    scopus 로고
    • Community-directed treatment with ivermectin in two Nigerian communities: An analysis of first year start-up processes, costs and consequences
    • Onwujekwe, O. et al. Community-directed treatment with ivermectin in two Nigerian communities: an analysis of first year start-up processes, costs and consequences. Health Policy 62, 31-51 (2002).
    • (2002) Health Policy , vol.62 , pp. 31-51
    • Onwujekwe, O.1
  • 46
    • 0030794174 scopus 로고    scopus 로고
    • Randomised placebo-controlled comparison of ivermectin and albendazole alone and in combination for Wuchereria bancrofti microfilaraemia in Haitian children
    • Addis, D. G. et al. Randomised placebo-controlled comparison of ivermectin and albendazole alone and in combination for Wuchereria bancrofti microfilaraemia in Haitian children, Lancet 350, 480-484 (1997).
    • (1997) Lancet , vol.350 , pp. 480-484
    • Addis, D.G.1
  • 47
    • 0027316106 scopus 로고
    • Concurrent parastic infections in onchocerciasis and the occurrence of adverse reactions after ivermectin treatment
    • Njoo, FL. et al. Concurrent parastic infections in onchocerciasis and the occurrence of adverse reactions after ivermectin treatment. Am. J. Trop. Med. Hyg. 48, 652-657 (1993).
    • (1993) Am. J. Trop. Med. Hyg. , vol.48 , pp. 652-657
    • Njoo, F.L.1
  • 48
    • 0034902656 scopus 로고    scopus 로고
    • Optimising the benefits of anthelmintic treatment in children
    • Stephenson, L. S. Optimising the benefits of anthelmintic treatment in children. Paediatr. Drugs 3, 495-508 (2001).
    • (2001) Paediatr. Drugs , vol.3 , pp. 495-508
    • Stephenson, L.S.1
  • 49
    • 0025917333 scopus 로고
    • A field study of the effects of ivermectin on ectoparasites of man
    • Dunne, C. L. et al. A field study of the effects of ivermectin on ectoparasites of man. Trans. R. Soc. Trop. Med. Hyg. 85, 550-551 (1991).
    • (1991) Trans. R. Soc. Trop. Med. Hyg. , vol.85 , pp. 550-551
    • Dunne, C.L.1
  • 50
    • 0032531334 scopus 로고    scopus 로고
    • Selection at a P-glycoprotein gene in ivermectin and moxidectin-selected strains of Haemonchus contortus
    • Blackhall, W. J. et al. Selection at a P-glycoprotein gene in ivermectin and moxidectin-selected strains of Haemonchus contortus. Mol. Biochem. Parasitol. 95, 193-201 (1998).
    • (1998) Mol. Biochem. Parasitol. , vol.95 , pp. 193-201
    • Blackhall, W.J.1
  • 51
    • 0031865592 scopus 로고    scopus 로고
    • Use of P-glycoprotein gene probes to investigate anthelmintic resistance in Haemonchus contortus and comparison with Onchocerca volvulus
    • Kwa, M. S. et al. Use of P-glycoprotein gene probes to investigate anthelmintic resistance in Haemonchus contortus and comparison with Onchocerca volvulus. Int. J. Parasitol. 28, 1235-1240 (1998).
    • (1998) Int. J. Parasitol. , vol.28 , pp. 1235-1240
    • Kwa, M.S.1
  • 52
    • 2342488498 scopus 로고
    • Conquering an ancient scourge; river blindness
    • (Jan 8, )
    • Eckholm, E. Conquering an ancient scourge; river blindness. New York Times Magazine, 20-27 (Jan 8, 1989).
    • (1989) New York Times Magazine , pp. 20-27
    • Eckholm, E.1
  • 53
    • 0004140510 scopus 로고    scopus 로고
    • (ed. Õmura, S.) (Academic Press, San Diego, )
    • Ikeda, H. & Õmura, S. in Macrolide Antibiotics (ed. Õmura, S.) 287-326 (Academic Press, San Diego, 2002).
    • (2002) Macrolide Antibiotics , pp. 287-326
    • Ikeda, H.1    Õmura, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.