-
1
-
-
0022462534
-
Philosophy of new drug discovery
-
Õmura, S. Philosophy of new drug discovery. Microbiol. Rev. 50, 259-279 (1986).
-
(1986)
Microbiol. Rev.
, vol.50
, pp. 259-279
-
-
Õmura, S.1
-
2
-
-
9444263663
-
-
(eds Weber, R. J. & Perkins, D. N.) Chapter 11 (Oxford Univ. Press, New York )
-
Campbell, W. C. in Inventive Minds (eds Weber, R. J. & Perkins, D. N.) Chapter 11, 192-214 (Oxford Univ. Press, New York, 1992).
-
(1992)
Inventive Minds
, pp. 192-214
-
-
Campbell, W.C.1
-
3
-
-
0003504367
-
-
(ed. Campbell, W. C.) (Springer, New York, )
-
Burg, R. W. & Stapley, E. O. in Ivermectin and Abamectin (ed. Campbell, W. C.) 24-32 (Springer, New York, 1989).
-
(1989)
Ivermectin and Abamectin
, pp. 24-32
-
-
Burg, R.W.1
Stapley, E.O.2
-
4
-
-
0036867480
-
Streptomyces avermectinius sp. nov., an avermectin-producing strain
-
Takahashi, Y. et al. Streptomyces avermectinius sp. nov., an avermectin-producing strain. Int. J. Syst. Evol. Microbiol. 52, 2163-2168 (2002).
-
(2002)
Int. J. Syst. Evol. Microbiol.
, vol.52
, pp. 2163-2168
-
-
Takahashi, Y.1
-
5
-
-
0018386220
-
Avermectins, new family of potent anthelmintic agents: Producing organisms and fermentation
-
Burg, R. W. et al. Avermectins, new family of potent anthelmintic agents: producing organisms and fermentation. Antimicrob. Agents Chemother. 15, 361-367 (1979).
-
(1979)
Antimicrob. Agents Chemother.
, vol.15
, pp. 361-367
-
-
Burg, R.W.1
-
6
-
-
0018398943
-
Avermectins, new family of potent anthelmintic, agents: Isolation and chromatographic properties
-
Miller, T. W. Avermectins, new family of potent anthelmintic, agents: isolation and chromatographic properties. Antimicrob. Agents Chemother. 15, 368-371 (1979).
-
(1979)
Antimicrob. Agents Chemother.
, vol.15
, pp. 368-371
-
-
Miller, T.W.1
-
9
-
-
0019135342
-
Ivermectin, a new broad-spectrum antiparasitic agent
-
Chabala, J. C. et al. Ivermectin, a new broad-spectrum antiparasitic agent. J. Med. Chem. 23, 1134-1136 (1980).
-
(1980)
J. Med. Chem.
, vol.23
, pp. 1134-1136
-
-
Chabala, J.C.1
-
10
-
-
0024450271
-
The status of ivermectin in the treatment of human onchocerciasis
-
Taylor, H. R. & Greene, B. M. The status of ivermectin in the treatment of human onchocerciasis. Am. J. Trop. Med. Hyg. 41, 460-466 (1989).
-
(1989)
Am. J. Trop. Med. Hyg.
, vol.41
, pp. 460-466
-
-
Taylor, H.R.1
Greene, B.M.2
-
11
-
-
0035834039
-
Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
-
Ömura, S. et al. Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc. Natl Acad. Sci. USA 98 12215-12220 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 12215-12220
-
-
Ömura, S.1
-
12
-
-
0038561132
-
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
-
Ikeda, H. et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nature Biotechnol. 21, 526-531 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 526-531
-
-
Ikeda, H.1
-
15
-
-
0027319985
-
Haemonchus contortus: Ivermectin-induced paralysis of the pharynx
-
Geary, T. G. et al. Haemonchus contortus: ivermectin-induced paralysis of the pharynx. Exp. Parasitol. 77 88-96 (1993).
-
(1993)
Exp. Parasitol.
, vol.77
, pp. 88-96
-
-
Geary, T.G.1
-
16
-
-
0018461317
-
1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance
-
1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. Proc. Natl Acad. Sci. USA 76, 2062-2066 (1979).
-
(1979)
Proc. Natl. Acad. Sci. USA
, vol.76
, pp. 2062-2066
-
-
Fritz, L.C.1
-
19
-
-
0041990204
-
Tropical Disease Research: Progress 1975-94, highlights 1993-94
-
TDR. Twelfth Programme Report WHO, Geneva )
-
TDR. Twelfth Programme Report, Tropical Disease Research: progress 1975-94, highlights 1993-94. WHO, Geneva, 1995).
-
(1995)
-
-
-
20
-
-
2342630488
-
Eliminating onchocerciasis as a public health problem
-
Thylefors, B. Eliminating onchocerciasis as a public health problem. Trop. Med. Int. Health 9, A1-A3 (2004).
-
(2004)
Trop. Med. Int. Health
, vol.9
-
-
Thylefors, B.1
-
21
-
-
0019988320
-
Efficacy and tolerance of ivermectin in human onchocerciasis
-
Aziz, M. A. et al. Efficacy and tolerance of ivermectin in human onchocerciasis. Lancet 2, 171-173 (1982).
-
(1982)
Lancet
, vol.2
, pp. 171-173
-
-
Aziz, M.A.1
-
22
-
-
0020333832
-
Ivermectin in onchocerciasis
-
Aziz, M. A. et al. Ivermectin in onchocerciasis. Lancet 2, 1456-1457 (1982).
-
(1982)
Lancet
, vol.2
, pp. 1456-1457
-
-
Aziz, M.A.1
-
23
-
-
0023239601
-
Controlled tried and dose-finding study of ivermectin for treatment of infectious diseases
-
White, A. T. et al. Controlled tried and dose-finding study of ivermectin for treatment of infectious diseases. J. Infect. Dis. 156, 463-470 (1987).
-
(1987)
J. Infect. Dis.
, vol.156
, pp. 463-470
-
-
White, A.T.1
-
24
-
-
0023476647
-
Single dose therapy with ivermectin for onchocerciasis
-
Greene, B. M. et al. Single dose therapy with ivermectin for onchocerciasis. Trans. Assoc. Am. Physicians 100 131-138 (1987).
-
(1987)
Trans. Assoc. Am. Physicians
, vol.100
, pp. 131-138
-
-
Greene, B.M.1
-
25
-
-
0023715169
-
Effect of single-dose ivermectin therapy on human Onchocerca volvulus infection with onchocercal ocular involvement
-
Newland, H. S. et al. Effect of single-dose ivermectin therapy on human Onchocerca volvulus infection with onchocercal ocular involvement. Br. J. Opthalmol. 72, 561-569 (1988).
-
(1988)
Br. J. Opthalmol.
, vol.72
, pp. 561-569
-
-
Newland, H.S.1
-
26
-
-
0025375493
-
Large-scale ivermectin distribution and its epidemiological consequences
-
Remme, J. H. F. et al. Large-scale ivermectin distribution and its epidemiological consequences. Acta Leiden. 59, 177-191 (1990).
-
(1990)
Acta Leiden.
, vol.59
, pp. 177-191
-
-
Remme, J.H.F.1
-
27
-
-
0025605295
-
Effects of multiple monthly doses of ivermectin on adult Onchocerca volvolus
-
Duke, B. O. L. et al. Effects of multiple monthly doses of ivermectin on adult Onchocerca volvolus. Am. J. Trop. Med. Hyg. 43, 657-664 (1990).
-
(1990)
Am. J. Trop. Med. Hyg.
, vol.43
, pp. 657-664
-
-
Duke, B.O.L.1
-
28
-
-
0020503540
-
Ivermectin: A potent new antiparasitic agent
-
Campbell, W. C. et al. Ivermectin: a potent new antiparasitic agent. Science 221, 823-828 (1983).
-
(1983)
Science
, vol.221
, pp. 823-828
-
-
Campbell, W.C.1
-
29
-
-
0030460794
-
Clinical and parasitological response after up to 6.5 years of ivermectin treatment for onchocerciasis
-
Whitworth, J. A. G. et al. Clinical and parasitological response after up to 6.5 years of ivermectin treatment for onchocerciasis. Trop. Med. Int. Health 1, 786-793 (1992).
-
(1992)
Trop. Med. Int. Health
, vol.1
, pp. 786-793
-
-
Whitworth, J.A.G.1
-
30
-
-
0028073730
-
The impact of five years of annual ivermectin treatment on microfilarial loads in the onchocerciasis focus of Asubende, Ghana
-
Aley, E. S. et al. The impact of five years of annual ivermectin treatment on microfilarial loads in the onchocerciasis focus of Asubende, Ghana. Trans. R. Soc. Top. Mod. Hyg. 88, 581-584 (1994).
-
(1994)
Trans. R. Soc. Top Mod. Hyg.
, vol.88
, pp. 581-584
-
-
Aley, E.S.1
-
31
-
-
9444220725
-
The effect of five years of annual treatment with ivermectin (Mectizan®) on the prevalence and morbidity of onchocerciasis in the village of Gami in the Central African Republic
-
Kennedy, M. H. et al. The effect of five years of annual treatment with ivermectin (Mectizan®) on the prevalence and morbidity of onchocerciasis in the village of Gami in the Central African Republic. Ann. Trop. Med. Parasitol. 49, 804-811 (2002).
-
(2002)
Ann. Trop. Med. Parasitol.
, vol.49
, pp. 804-811
-
-
Kennedy, M.H.1
-
32
-
-
0026681126
-
A community trial of ivermectin for onchocerciasis in Sierra Leone; clinical and parasitological response to four doses given at six-monthly intervals
-
Whitworth, J. A. G. et al. A community trial of ivermectin for onchocerciasis in Sierra Leone; clinical and parasitological response to four doses given at six-monthly intervals. Trans. R. Soc. Trop. Med. Hyg. 86, 277-280 (1996).
-
(1996)
Trans. R. Soc. Trop. Med. Hyg.
, vol.86
, pp. 277-280
-
-
Whitworth, J.A.G.1
-
33
-
-
0026533538
-
Effects of three-month doses of ivermectin on adult Onchocerca volvulus
-
Duke, B. O. L. et al. Effects of three-month doses of ivermectin on adult Onchocerca volvulus. Am. J. Trop. Med. Hyg. 46, 189-194 (1992).
-
(1992)
Am. J. Trop. Med. Hyg.
, vol.46
, pp. 189-194
-
-
Duke, B.O.L.1
-
34
-
-
0022626334
-
Comparison of the treatment of ocular onchocerciaisis with ivermectin and diethylcarbamazine
-
Taylor, H. R. et al. Comparison of the treatment of ocular onchocerciaisis with ivermectin and diethylcarbamazine. Arch. Opthalmol. 104, 863-870 (1986).
-
(1986)
Arch. Opthalmol.
, vol.104
, pp. 863-870
-
-
Taylor, H.R.1
-
35
-
-
0026011670
-
Community-based treatment of onchocerciasis with ivermectin: Safety, efficacy and acceptability of yearly treatment
-
Pacqué, M. et al. Community-based treatment of onchocerciasis with ivermectin: safety, efficacy and acceptability of yearly treatment. J. Infect. Dis. 163, 381-385 (1991).
-
(1991)
J. Infect. Dis.
, vol.163
, pp. 381-385
-
-
Pacqué, M.1
-
36
-
-
0026638702
-
Adverse events following mass ivermectin therapy for onchocerciasis
-
Chijioke, C. P. & Okonkwo, P. Adverse events following mass ivermectin therapy for onchocerciasis. Trans. R. Soc. Top. Med. Hyg. 86, 284-286 (1992).
-
(1992)
Trans. R. Soc. Top Med. Hyg.
, vol.86
, pp. 284-286
-
-
Chijioke, C.P.1
Okonkwo, P.2
-
37
-
-
0024954571
-
Adverse reactions after large-scale treatment of onchocerciasis with ivermectin: Combined results from eight community trials
-
De Sole, G. et al. Adverse reactions after large-scale treatment of onchocerciasis with ivermectin: combined results from eight community trials. Bull. World Health Organ. 67, 707-719 (1989).
-
(1989)
Bull. World Health Organ.
, vol.67
, pp. 707-719
-
-
De Sole, G.1
-
38
-
-
0030981519
-
Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection
-
Gardon, J. et al. Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection. Lancet 350, 18-22 (1997).
-
(1997)
Lancet
, vol.350
, pp. 18-22
-
-
Gardon, J.1
-
39
-
-
0042759615
-
Serious adverse events following treatment with ivermectin for onchocerciais control: A review of reported cases
-
Twum-Danso, N. A. Y. Serious adverse events following treatment with ivermectin for onchocerciais control: a review of reported cases. Filaria J. 2 (Suppl.), S3-S13 (2003).
-
(2003)
Filaria J.
, vol.2
, Issue.SUPPL.
-
-
Twum-Danso, N.A.Y.1
-
40
-
-
0004010584
-
Strategies for ivermectin distribution through primary health care systems
-
WHO WHO/PBL/91. 24. (WHO, Geneva, )
-
WHO. Strategies for ivermectin distribution through primary health care systems. WHO/PBL/91. 24. (WHO, Geneva, 1991).
-
(1991)
-
-
-
41
-
-
9444289828
-
Newsletter of the Mectizan Donation Programme
-
Mectizan Donation Programme. [online]
-
Mectizan Donation Programme. Newsletter of the Mectizan Donation Programme. [online], http://www.mectizan.org/mpn33/mpnhtml336.htm (2004).
-
(2004)
-
-
-
42
-
-
2342652220
-
Economic evaluation of Mectizan distribution
-
Waters, H. R. et al. Economic evaluation of Mectizan distribution. Trop. Med. Int. Health 9, A16-A25 (2004).
-
(2004)
Trop. Med. Int. Health
, vol.9
-
-
Waters, H.R.1
-
44
-
-
0031757406
-
Willingness to pay for community-based ivermectin distribution: A study of three onchocerciasis endemic communilips in Nigeria
-
Onwujekwe, O. et al. Willingness to pay for community-based ivermectin distribution: a study of three onchocerciasis endemic communilips in Nigeria. Trop. Med. Int. Health 3, 802-808 (1998).
-
(1998)
Trop. Med. Int. Health
, vol.3
, pp. 802-808
-
-
Onwujekwe, O.1
-
45
-
-
0036021067
-
Community-directed treatment with ivermectin in two Nigerian communities: An analysis of first year start-up processes, costs and consequences
-
Onwujekwe, O. et al. Community-directed treatment with ivermectin in two Nigerian communities: an analysis of first year start-up processes, costs and consequences. Health Policy 62, 31-51 (2002).
-
(2002)
Health Policy
, vol.62
, pp. 31-51
-
-
Onwujekwe, O.1
-
46
-
-
0030794174
-
Randomised placebo-controlled comparison of ivermectin and albendazole alone and in combination for Wuchereria bancrofti microfilaraemia in Haitian children
-
Addis, D. G. et al. Randomised placebo-controlled comparison of ivermectin and albendazole alone and in combination for Wuchereria bancrofti microfilaraemia in Haitian children, Lancet 350, 480-484 (1997).
-
(1997)
Lancet
, vol.350
, pp. 480-484
-
-
Addis, D.G.1
-
47
-
-
0027316106
-
Concurrent parastic infections in onchocerciasis and the occurrence of adverse reactions after ivermectin treatment
-
Njoo, FL. et al. Concurrent parastic infections in onchocerciasis and the occurrence of adverse reactions after ivermectin treatment. Am. J. Trop. Med. Hyg. 48, 652-657 (1993).
-
(1993)
Am. J. Trop. Med. Hyg.
, vol.48
, pp. 652-657
-
-
Njoo, F.L.1
-
48
-
-
0034902656
-
Optimising the benefits of anthelmintic treatment in children
-
Stephenson, L. S. Optimising the benefits of anthelmintic treatment in children. Paediatr. Drugs 3, 495-508 (2001).
-
(2001)
Paediatr. Drugs
, vol.3
, pp. 495-508
-
-
Stephenson, L.S.1
-
49
-
-
0025917333
-
A field study of the effects of ivermectin on ectoparasites of man
-
Dunne, C. L. et al. A field study of the effects of ivermectin on ectoparasites of man. Trans. R. Soc. Trop. Med. Hyg. 85, 550-551 (1991).
-
(1991)
Trans. R. Soc. Trop. Med. Hyg.
, vol.85
, pp. 550-551
-
-
Dunne, C.L.1
-
50
-
-
0032531334
-
Selection at a P-glycoprotein gene in ivermectin and moxidectin-selected strains of Haemonchus contortus
-
Blackhall, W. J. et al. Selection at a P-glycoprotein gene in ivermectin and moxidectin-selected strains of Haemonchus contortus. Mol. Biochem. Parasitol. 95, 193-201 (1998).
-
(1998)
Mol. Biochem. Parasitol.
, vol.95
, pp. 193-201
-
-
Blackhall, W.J.1
-
51
-
-
0031865592
-
Use of P-glycoprotein gene probes to investigate anthelmintic resistance in Haemonchus contortus and comparison with Onchocerca volvulus
-
Kwa, M. S. et al. Use of P-glycoprotein gene probes to investigate anthelmintic resistance in Haemonchus contortus and comparison with Onchocerca volvulus. Int. J. Parasitol. 28, 1235-1240 (1998).
-
(1998)
Int. J. Parasitol.
, vol.28
, pp. 1235-1240
-
-
Kwa, M.S.1
-
52
-
-
2342488498
-
Conquering an ancient scourge; river blindness
-
(Jan 8, )
-
Eckholm, E. Conquering an ancient scourge; river blindness. New York Times Magazine, 20-27 (Jan 8, 1989).
-
(1989)
New York Times Magazine
, pp. 20-27
-
-
Eckholm, E.1
-
53
-
-
0004140510
-
-
(ed. Õmura, S.) (Academic Press, San Diego, )
-
Ikeda, H. & Õmura, S. in Macrolide Antibiotics (ed. Õmura, S.) 287-326 (Academic Press, San Diego, 2002).
-
(2002)
Macrolide Antibiotics
, pp. 287-326
-
-
Ikeda, H.1
Õmura, S.2
|