The calicheamicin gene cluster and its iterative type I enediyne PKS

Science

Volumn 297, Issue 5584, 2002, Pages 1173-1176

  Ahlert, Joachim ^a   Shepard, Erica ^a   Lomovskaya, Natalia ^a   Zazopoulos, Emmanuel ^b   Staffa, Alfredo ^b   Bachmann, Brian O ^b   Huang, Kexue ^b   Fonstein, Leonid ^a   Czisny, Anne ^a   Whitwam, Ross E ^a   Farnet, Chris M ^b   Thorson, Jon S ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; GENES;

GENE CLUSTERS;

BIOSYNTHESIS;

AVILAMYCIN; CALICHEAMICIN; DOXORUBICIN; GEMTUZUMAB OZOGAMICIN; POLYKETIDE SYNTHASE;

BIOCHEMISTRY; GENE;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; GENE CLUSTER; MOLECULAR CLONING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; BLOTTING, SOUTHERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; CONSERVED SEQUENCE; ENEDIYNES; GENES, BACTERIAL; MICROMONOSPORA; MULTIENZYME COMPLEXES; MULTIGENE FAMILY; MUTATION; OPEN READING FRAMES; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, DNA;

PROKARYOTA;

EID: 0037119622     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1072105     Document Type: Article

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26. We gratefully acknowledge Wyeth Research for graciously providing materials and P. R. Hamann for helpful discussion. J.S.T. is a Rita Allen Foundation Scholar and Alfred P. Sloan Fellow. This work was supported in part by grants from the National Institutes of Health (CA84374 and GM58196), the Mizutani Foundation for Glycoscience, and a Cancer Center Support Grant (CA08748). We also thank the Charles A. Dana and Norman and Rosita Winston Foundations for postdoctoral fellowship support (J.A. and R.E.W.).