Diversifying vancomycin via chemoenzymatic strategies

Organic Letters

Volumn 7, Issue 8, 2005, Pages 1513-1515

  Fu, Xun ^a   Albermann, Christoph ^b   Zhang, Changsheng ^a   Thorson, Jon S ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF STUTTGART   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPEPTIDE; VANCOMYCIN;

ARTICLE; COMPLEX FORMATION; ENZYME ACTIVITY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

COMBINATORIAL CHEMISTRY TECHNIQUES; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; GENETIC ENGINEERING; GLUCOSYLTRANSFERASES; GLYCOPEPTIDES; METHICILLIN RESISTANCE; MOLECULAR STRUCTURE; SALMONELLA; STAPHYLOCOCCUS AUREUS; VANCOMYCIN;

EID: 17844409813     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0501626     Document Type: Article

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43. Under the conditions described, notable degradation was observed with most β-lactams tested, including derivatives of 6-aminopenicilanic acid and 7-aminocephalosporanic acid (= 5% yield). Under these conditions, decarboxylation en route to 4 was also observed to give 26 as the predominate product (∼45%).
44. -1 in all three strains.
45. -1 (of each compound) in all three strains.