Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin

Biochemistry

Volumn 42, Issue 14, 2003, Pages 4179-4189

  Meyers, Caren L Freel ^a   Oberthür, Markus ^b   Anderson, John W ^b   Kahne, Daniel ^b   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOSYNTHESIS; DNA; ENZYMES;

ANTIBIOTIC ACTIVITY;

BIOCHEMISTRY;

ANTIBIOTIC AGENT; CARBOHYDRATE; CLOROBIOCIN; COUMAMYCIN A1; COUMARIN DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); GLYCOSYLTRANSFERASE; HISTIDINE; HYBRID PROTEIN; NATURAL PRODUCT; NOVIOSYLAMINOCOUMARIN PRENYLBENZOATE; NOVOBIOCIC ACID NOVIOSYLTRANSFERASE; NOVOBIOCIN; RHAMNOSE; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ANTIMICROBIAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYST; DEGRADATION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME SUBSTRATE; ESCHERICHIA COLI; GLYCOSYLATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOMYCES;

ANTI-BACTERIAL AGENTS; BASE SEQUENCE; DNA PRIMERS; ENZYME INHIBITORS; ESCHERICHIA COLI; NOVOBIOCIN; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; STREPTOMYCES; SUBSTRATE SPECIFICITY; TRANSFERASES;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; STREPTOMYCES; STREPTOMYCES CAERULEUS; UNCULTURED ACTINOMYCETE;

EID: 0344885564     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0340088     Document Type: Article

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