AknK Is an L-2-Deoxyfucosyltransferase in the Biosynthesis of the Anthracycline Aclacinomycin A

Biochemistry

Volumn 43, Issue 15, 2004, Pages 4548-4558

  Lu, Wei ^a   Leimkuhler, Catherine ^b   Oberthür, Markus ^b   Kahne, Daniel ^b   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; DRUG PRODUCTS; POLYSACCHARIDES; PURIFICATION; SUGARS; TUMORS;

ANTITUMOR DRUGS; DISACCHARIDES;

ENZYMES;

ACLARUBICIN; ANTHRACYCLINE DERIVATIVE; DAUNORUBICIN; DEOXYSUGAR; DISACCHARIDE; DOXORUBICIN; ENZYME INHIBITOR; FUCOSYLTRANSFERASE; GLYCOSYLTRANSFERASE; IDARUBICIN; LEVO 2 DEOXYFUCOSYL LEVO RHODOSAMINYLAKLAVINONE; LEVO 2 DEOXYFUCOSYLTRANSFERASE; LEVO DEOXYFUCOSYL LEVO DEOXYFUCOSYL LEVO RHODOSAMINYLAKLAVINONE; PROTEIN AKNK; RHODOSAMINYLAKLAVINONE; THYMIDINE DIPHOSPHATE; THYMIDINE DIPHOSPHATE LEVO 2 DEOXYFUCOSE; THYMIDINE DIPHOSPHATE LEVO DAUNOSAMINE; TRISACCHARIDE; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; CATALYSIS; CATALYST; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME PURIFICATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS;

ACLARUBICIN; CATALYSIS; CLONING, MOLECULAR; FUCOSE; FUCOSYLTRANSFERASES; GLYCOSYLATION; HEXOSAMINES; NAPHTHACENES; STREPTOMYCES; SUBSTRATE SPECIFICITY; THYMINE NUCLEOTIDES; TRISACCHARIDES;

ACTINOBACTERIA (CLASS); UNCULTURED ACTINOMYCETE;

EID: 4444222040     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035945i     Document Type: Article

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