Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans

Chemistry and Biology

Volumn 8, Issue 7, 2001, Pages 681-700

  Wohlert, Sven Eric ^a   Lomovskaya, Natalia ^a   Kulowski, Kerry ^a   Fonstein, Leonid ^a   Occi, James L ^b   Gewain, Keith M ^b   MacNeil, Douglas J ^b   Hutchinson, C Richard ^a,c  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c KOSAN BIOSCIENCES INC   (United States)

Author keywords

Avermectin; avr Gene; Biotransformation; Combinatorial biosynthesis; Deoxysugar biosynthesis; Epimerase; Glycosyltransferase; Methyltransferase; Mycarose; Oleandrose

Indexed keywords

ANTHELMINTIC AGENT; AVERMECTIN; DEOXYSUGAR; DRUG DERIVATIVE; HEXOSE; ISOMERASE; IVERMECTIN; OLEANDROSE;

ARTICLE; BIOSYNTHESIS; CHEMISTRY; COMBINATORIAL CHEMISTRY; GENE EXPRESSION; GENETICS; METABOLISM; MULTIGENE FAMILY; PLASMID; PROTEIN ENGINEERING; STEREOISOMERISM; STREPTOMYCES;

ANTHELMINTICS; COMBINATORIAL CHEMISTRY TECHNIQUES; DEOXY SUGARS; GENE EXPRESSION; HEXOSES; IVERMECTIN; MULTIGENE FAMILY; PLASMIDS; PROTEIN ENGINEERING; RACEMASES AND EPIMERASES; STEREOISOMERISM; STREPTOMYCES;

EID: 0034931736     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00043-6     Document Type: Article

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