메뉴 건너뛰기




Volumn 45, Issue 5, 2008, Pages 451-484

Clinical perspectives on hereditary hemochromatosis

Author keywords

Cancer; Cirrhosis; Clinical expression; Genotype; Hemochromatosis; Hepatic iron concentration; Hepcidin; HFE; Iron; Liver; Phenotype; Screening

Indexed keywords

ASCORBIC ACID; CHELATING AGENT; DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; FERROPORTIN; HEPCIDIN; IRON; TRANSFERRIN; TRANSFERRIN RECEPTOR 2;

EID: 49949091638     PISSN: 10408363     EISSN: 1549781X     Source Type: Journal    
DOI: 10.1080/10408360802335716     Document Type: Review
Times cited : (20)

References (218)
  • 1
    • 17544370537 scopus 로고    scopus 로고
    • Duration of hepatic iron exposure increases the risk of significant fibrosis in hereditary hemochromatosis: A new role for magnetic resonance imaging
    • Olynyk JK, St Pierre TG, Britton RS, Brunt EM, Bacon BR. Duration of hepatic iron exposure increases the risk of significant fibrosis in hereditary hemochromatosis: a new role for magnetic resonance imaging. Am J Gastroenterol 2005; 100: 837-841.
    • (2005) Am J Gastroenterol , vol.100 , pp. 837-841
    • Olynyk, J.K.1    St Pierre, T.G.2    Britton, R.S.3    Brunt, E.M.4    Bacon, B.R.5
  • 2
    • 33744942151 scopus 로고    scopus 로고
    • Review article: The modern diagnosis and management of haemochromatosis
    • Adams PC. Review article: the modern diagnosis and management of haemochromatosis. Aliment Pharmacol Ther 2006; 23: 1681-1691.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1681-1691
    • Adams, P.C.1
  • 4
    • 0037164344 scopus 로고    scopus 로고
    • Genetics of haemochromatosis
    • Bomford A. Genetics of haemochromatosis. Lancet 2002; 360: 1673-1681.
    • (2002) Lancet , vol.360 , pp. 1673-1681
    • Bomford, A.1
  • 7
    • 0031002910 scopus 로고    scopus 로고
    • Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract
    • Parkkila S, Waheed A, Britton RS, Feder JN, Tsuchihashi Z, Schatzman RC, Bacon BR, Sly WS. Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract. Proc Natl Acad Sci USA 1997; 94: 2534-2539.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2534-2539
    • Parkkila, S.1    Waheed, A.2    Britton, R.S.3    Feder, J.N.4    Tsuchihashi, Z.5    Schatzman, R.C.6    Bacon, B.R.7    Sly, W.S.8
  • 8
    • 0032427653 scopus 로고    scopus 로고
    • Kupffer cell staining by an HFE-specific monoclonal antibody: Implications for hereditary haemochromatosis
    • Bastin JM, Jones M, O'Callaghan CA, Schimanski L, Mason DY, Townsend ARM. Kupffer cell staining by an HFE-specific monoclonal antibody: implications for hereditary haemochromatosis. Br Haematol 1998; 103: 931-941.
    • (1998) Br Haematol , vol.103 , pp. 931-941
    • Bastin, J.M.1    Jones, M.2    O'Callaghan, C.A.3    Schimanski, L.4    Mason, D.Y.5    Townsend, A.R.M.6
  • 10
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001; 276: 7806-7810.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 11
    • 0033597780 scopus 로고    scopus 로고
    • Molecular cloning of transferrin receptor 2 - A new member of the transferrin receptor-like family
    • Kawabata H, Yang S, Hirama T, Vuong PT, Kawano S, Gombart AF, Koeffler HP. Molecular cloning of transferrin receptor 2 - A new member of the transferrin receptor-like family. J Biol Chem 1999; 274: 20826-20832.
    • (1999) J Biol Chem , vol.274 , pp. 20826-20832
    • Kawabata, H.1    Yang, S.2    Hirama, T.3    Vuong, P.T.4    Kawano, S.5    Gombart, A.F.6    Koeffler, H.P.7
  • 12
    • 0034623930 scopus 로고    scopus 로고
    • Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE
    • West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem 2000; 275: 38135-38138.
    • (2000) J Biol Chem , vol.275 , pp. 38135-38138
    • West, A.P.1    Bennett, M.J.2    Sellers, V.M.3    Andrews, N.C.4    Enns, C.A.5    Bjorkman, P.J.6
  • 13
    • 8644221378 scopus 로고    scopus 로고
    • Transferrin receptor 2 mediates a biphasic pattern of transferrin uptake associated with ligand delivery to multivesicular bodies
    • Robb AD, Ericsson M, Wessling-Resnick M. Transferrin receptor 2 mediates a biphasic pattern of transferrin uptake associated with ligand delivery to multivesicular bodies. Am J Physiol Cell Physiol 2004; 287: C1769-C1775.
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Robb, A.D.1    Ericsson, M.2    Wessling-Resnick, M.3
  • 14
    • 10244225221 scopus 로고    scopus 로고
    • Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin
    • Krijt J, Vokurka M, Chang KT, Necas E. Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. Blood 2004; 104: 4308-4310.
    • (2004) Blood , vol.104 , pp. 4308-4310
    • Krijt, J.1    Vokurka, M.2    Chang, K.T.3    Necas, E.4
  • 16
    • 41949133287 scopus 로고    scopus 로고
    • Iron regulation and erythropoiesis
    • Nemeth E. Iron regulation and erythropoiesis. Curr Opin Hematol 2008; 15: 169-175.
    • (2008) Curr Opin Hematol , vol.15 , pp. 169-175
    • Nemeth, E.1
  • 17
    • 0034733635 scopus 로고    scopus 로고
    • A novel mammalian iron-regulated protein involved in intracellular iron metabolism
    • Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 2000; 275: 19906-19912.
    • (2000) J Biol Chem , vol.275 , pp. 19906-19912
    • Abboud, S.1    Haile, D.J.2
  • 20
  • 24
    • 49949086049 scopus 로고
    • Biology of idiopathic hemochromatosis - Without quantitative hormone determination
    • Brissot P, Hitadenercy Y, Pawlotsky Y, Simon M, Bourel M. Biology of idiopathic hemochromatosis - Without quantitative hormone determination. Rev Med 1977; 18: 835.
    • (1977) Rev Med , vol.18 , pp. 835
    • Brissot, P.1    Hitadenercy, Y.2    Pawlotsky, Y.3    Simon, M.4    Bourel, M.5
  • 25
    • 0017698209 scopus 로고
    • Idiopathic hemochromatosis. Demonstration of recessive transmission and early detection by Family HLA typing
    • Simon M, Bourel M, Genetet B, Fauchet R. Idiopathic hemochromatosis. Demonstration of recessive transmission and early detection by Family HLA typing. N Engl J Med 1977; 297: 1017-1021.
    • (1977) N Engl J Med , vol.297 , pp. 1017-1021
    • Simon, M.1    Bourel, M.2    Genetet, B.3    Fauchet, R.4
  • 26
    • 2542560427 scopus 로고    scopus 로고
    • Hereditary hemochromatosis - A new look at an old disease
    • Pietrangelo A. Hereditary hemochromatosis - A new look at an old disease. N Engl J Med 2004; 350: 2383-2397.
    • (2004) N Engl J Med , vol.350 , pp. 2383-2397
    • Pietrangelo, A.1
  • 28
    • 0033066062 scopus 로고    scopus 로고
    • A genotypic study of 217 unrelated probands diagnosed as "genetic hemochromatosis" on "classical" phenotypic criteria
    • Brissot P, Moirand R, Jouanolle AM, Guyader D, Le Gall JY, Deugnier Y, David V. A genotypic study of 217 unrelated probands diagnosed as "genetic hemochromatosis" on "classical" phenotypic criteria. J Hepatol 1999; 30: 588-593.
    • (1999) J Hepatol , vol.30 , pp. 588-593
    • Brissot, P.1    Moirand, R.2    Jouanolle, A.M.3    Guyader, D.4    Le Gall, J.Y.5    Deugnier, Y.6    David, V.7
  • 29
    • 0005600868 scopus 로고    scopus 로고
    • The UK Haemochromatosis Consortium W. M. A simple genetic test identifies 90% of UK patients with haemochromatosis. The UK Haemochromatosis Consortium. Gut 1997; 41: 841-844.
    • The UK Haemochromatosis Consortium W. M. A simple genetic test identifies 90% of UK patients with haemochromatosis. The UK Haemochromatosis Consortium. Gut 1997; 41: 841-844.
  • 33
    • 0033561342 scopus 로고    scopus 로고
    • HFE mutations analysis in 711 hemochromatosis probands: Evidence for S65C implication in mild form of hemochromatosis
    • Mura C, Raguenes O, Ferec C. HFE mutations analysis in 711 hemochromatosis probands: evidence for S65C implication in mild form of hemochromatosis. Blood 1999; 93: 2502-2505.
    • (1999) Blood , vol.93 , pp. 2502-2505
    • Mura, C.1    Raguenes, O.2    Ferec, C.3
  • 34
    • 0032815881 scopus 로고    scopus 로고
    • Spectrum of mutations in the HFE gene implicated in haemochromatosis and porphyria
    • de Villiers JN, Hillermann R, Loubser L, Kotze MJ. Spectrum of mutations in the HFE gene implicated in haemochromatosis and porphyria. Hum Mol Genet 1999; 8: 1517-1522.
    • (1999) Hum Mol Genet , vol.8 , pp. 1517-1522
    • de Villiers, J.N.1    Hillermann, R.2    Loubser, L.3    Kotze, M.J.4
  • 35
    • 0033086244 scopus 로고    scopus 로고
    • Diagnosis of hemochromatosis in family members of probands: A comparison of phenotyping and HFE genotyping
    • Barton JC, Rothenberg BE, Bertoli LF, Acton RT. Diagnosis of hemochromatosis in family members of probands: a comparison of phenotyping and HFE genotyping. Genet Med 1999; 1: 89-93.
    • (1999) Genet Med , vol.1 , pp. 89-93
    • Barton, J.C.1    Rothenberg, B.E.2    Bertoli, L.F.3    Acton, R.T.4
  • 37
    • 28444436913 scopus 로고    scopus 로고
    • Non-HFE hemochromatosis
    • Pietrangelo A. Non-HFE hemochromatosis. Semin Liver Dis 2005; 25: 450-460.
    • (2005) Semin Liver Dis , vol.25 , pp. 450-460
    • Pietrangelo, A.1
  • 47
    • 2942582341 scopus 로고    scopus 로고
    • Early onset hereditary hemochromatosis resulting from a novel TFR2 gene nonsense mutation (R105X) in two siblings of north French descent
    • Le Gac G, Mons F, Jacolot S, Scotet V, Ferec C, Frebourg T. Early onset hereditary hemochromatosis resulting from a novel TFR2 gene nonsense mutation (R105X) in two siblings of north French descent. Br J Haematol 2004; 125: 674-678.
    • (2004) Br J Haematol , vol.125 , pp. 674-678
    • Le Gac, G.1    Mons, F.2    Jacolot, S.3    Scotet, V.4    Ferec, C.5    Frebourg, T.6
  • 56
    • 0037860450 scopus 로고    scopus 로고
    • Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (slc11A3) mutations
    • Hetet G, Devaux I, Soufir N, Grandchamp B, Beaumont C. Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (slc11A3) mutations. Blood 2003; 102: 1904-1910.
    • (2003) Blood , vol.102 , pp. 1904-1910
    • Hetet, G.1    Devaux, I.2    Soufir, N.3    Grandchamp, B.4    Beaumont, C.5
  • 58
    • 30344475534 scopus 로고    scopus 로고
    • Autosomal dominant hereditary hemochromatosis associated with two novel Ferroportin 1 mutations in Spain
    • Bach V, Remacha A, Altes A, Barcelo MJ, Molina MA, Baiget M. Autosomal dominant hereditary hemochromatosis associated with two novel Ferroportin 1 mutations in Spain. Blood Cells Mol Dis 2005; 36: 41-45.
    • (2005) Blood Cells Mol Dis , vol.36 , pp. 41-45
    • Bach, V.1    Remacha, A.2    Altes, A.3    Barcelo, M.J.4    Molina, M.A.5    Baiget, M.6
  • 60
    • 0037100382 scopus 로고    scopus 로고
    • Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3)
    • Devalia V, Carter K, Walker AP, Perkins SJ, Worwood M, May A, Dooley JS. Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3). Blood 2002; 100: 695-697.
    • (2002) Blood , vol.100 , pp. 695-697
    • Devalia, V.1    Carter, K.2    Walker, A.P.3    Perkins, S.J.4    Worwood, M.5    May, A.6    Dooley, J.S.7
  • 61
    • 13844270538 scopus 로고    scopus 로고
    • Autosomal dominant hereditary hemochromatosis associated with a novel ferroportin mutation and unique clinical features
    • Sham RL, Phatak PD, West C, Lee P, Andrews C, Beutler E. Autosomal dominant hereditary hemochromatosis associated with a novel ferroportin mutation and unique clinical features. Blood Cells Mol Dis 2005; 34: 157-161.
    • (2005) Blood Cells Mol Dis , vol.34 , pp. 157-161
    • Sham, R.L.1    Phatak, P.D.2    West, C.3    Lee, P.4    Andrews, C.5    Beutler, E.6
  • 63
    • 0031001278 scopus 로고    scopus 로고
    • Iron-chelating therapy and the treatment of thalassemia
    • Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of thalassemia. Blood 1997;89: 739-761.
    • (1997) Blood , vol.89 , pp. 739-761
    • Olivieri, N.F.1    Brittenham, G.M.2
  • 65
    • 0033536288 scopus 로고    scopus 로고
    • The beta-thalassemias
    • Olivieri NF. The beta-thalassemias. N Engl J Med 1999; 341: 99-109.
    • (1999) N Engl J Med , vol.341 , pp. 99-109
    • Olivieri, N.F.1
  • 66
    • 33745743014 scopus 로고    scopus 로고
    • Hepcidin and iron-loading anemias
    • Nemeth E, Ganz T. Hepcidin and iron-loading anemias. Haematologica 2006; 91: 727-732.
    • (2006) Haematologica , vol.91 , pp. 727-732
    • Nemeth, E.1    Ganz, T.2
  • 69
    • 34548132409 scopus 로고    scopus 로고
    • Iron chelation, quo vadis?
    • Hanspeter N. Iron chelation, quo vadis? Curr Opin Chem Biol 2007; 11: 419-423.
    • (2007) Curr Opin Chem Biol , vol.11 , pp. 419-423
    • Hanspeter, N.1
  • 70
    • 33644874106 scopus 로고    scopus 로고
    • Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion-dependent thalassaemia
    • CD004450
    • Roberts DJ, Rees D, Howard J, Hyde C, Alderson P, Brunskill S. Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion-dependent thalassaemia. Cochrane Database Syst Rev 2005; 4: CD004450.
    • (2005) Cochrane Database Syst Rev , vol.4
    • Roberts, D.J.1    Rees, D.2    Howard, J.3    Hyde, C.4    Alderson, P.5    Brunskill, S.6
  • 71
    • 33646391919 scopus 로고    scopus 로고
    • Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: New data, new questions
    • Neufeld EJ. Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions. Blood 2006; 107: 3436-3441.
    • (2006) Blood , vol.107 , pp. 3436-3441
    • Neufeld, E.J.1
  • 72
    • 36248992370 scopus 로고    scopus 로고
    • Deferasirox for transfusion-related iron overload: A clinical review
    • Lindsey WT, Olin BR. Deferasirox for transfusion-related iron overload: A clinical review. Clin Ther 2007; 29: 2154-2166.
    • (2007) Clin Ther , vol.29 , pp. 2154-2166
    • Lindsey, W.T.1    Olin, B.R.2
  • 73
    • 36849072425 scopus 로고    scopus 로고
    • Iron loading and its clinical implications
    • Hershko C. Iron loading and its clinical implications. Am J Hematol 2007; 82: 1147-1148.
    • (2007) Am J Hematol , vol.82 , pp. 1147-1148
    • Hershko, C.1
  • 74
    • 35048901389 scopus 로고    scopus 로고
    • Deferasirox - A review of its use in the management of transfusional chronic iron overload
    • Yang LPH, Keam SJ, Keating GM. Deferasirox - A review of its use in the management of transfusional chronic iron overload. Drugs 2007; 67: 2211-2230.
    • (2007) Drugs , vol.67 , pp. 2211-2230
    • Yang, L.P.H.1    Keam, S.J.2    Keating, G.M.3
  • 77
    • 0028868660 scopus 로고
    • Overview and mechanisms of iron regulation
    • Bothwell TH. Overview and mechanisms of iron regulation. Nutr Rev 1995; 53: 237-245.
    • (1995) Nutr Rev , vol.53 , pp. 237-245
    • Bothwell, T.H.1
  • 79
    • 0017167384 scopus 로고
    • Patterns of iron storage in dietary iron overload and idiopathic hemochromatosis
    • Brink B, Disler P, Lynch S, Jacobs P, Charlton R, Bothwell T. Patterns of iron storage in dietary iron overload and idiopathic hemochromatosis. J Lab Clin Med 1976; 88: 725-731.
    • (1976) J Lab Clin Med , vol.88 , pp. 725-731
    • Brink, B.1    Disler, P.2    Lynch, S.3    Jacobs, P.4    Charlton, R.5    Bothwell, T.6
  • 80
    • 0031687548 scopus 로고    scopus 로고
    • Is there a link between African iron overload and the described mutations of the hereditary haemochromatosis gene?
    • McNamara L, MacPhail AP, Gordeuk VR, Hasstedt SJ, Rouault T. Is there a link between African iron overload and the described mutations of the hereditary haemochromatosis gene? Br J Haematol 1998; 102: 1176-1178.
    • (1998) Br J Haematol , vol.102 , pp. 1176-1178
    • McNamara, L.1    MacPhail, A.P.2    Gordeuk, V.R.3    Hasstedt, S.J.4    Rouault, T.5
  • 82
    • 33644873239 scopus 로고    scopus 로고
    • Ferroportin (Q248H) mutations in African families with dietary iron overload
    • McNamara L, Gordeuk VR, MacPhail AP. Ferroportin (Q248H) mutations in African families with dietary iron overload. J Gastroenterol Hepatol 2005; 20: 1855-1858.
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 1855-1858
    • McNamara, L.1    Gordeuk, V.R.2    MacPhail, A.P.3
  • 84
    • 37349099045 scopus 로고    scopus 로고
    • HCV, iron, and oxidative stress: The new choreography of hepcidin
    • Trinder D, Ayonrinde OT, Olynyk JK. HCV, iron, and oxidative stress: the new choreography of hepcidin. Gastroenterology 2008; 134: 348-351.
    • (2008) Gastroenterology , vol.134 , pp. 348-351
    • Trinder, D.1    Ayonrinde, O.T.2    Olynyk, J.K.3
  • 85
    • 28444454447 scopus 로고    scopus 로고
    • Hepatotoxicity of iron overload: Mechanisms of iron-induced hepatic fibrogenesis
    • Ramm GA, Ruddell RG. Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis. Semin Liver Dis 2005; 25: 433-449.
    • (2005) Semin Liver Dis , vol.25 , pp. 433-449
    • Ramm, G.A.1    Ruddell, R.G.2
  • 86
    • 0027131697 scopus 로고
    • Effects of alcohol, carbon-tetrachloride, and choline deficiency on iron-metabolism in the rat
    • Batey RG, Johnston R. Effects of alcohol, carbon-tetrachloride, and choline deficiency on iron-metabolism in the rat. Alcohol Clin Exp Res 1993; 17: 931-934.
    • (1993) Alcohol Clin Exp Res , vol.17 , pp. 931-934
    • Batey, R.G.1    Johnston, R.2
  • 90
    • 34548127283 scopus 로고    scopus 로고
    • Neonatal hemochromatosis: A congenital alloimmune hepatitis
    • Whitington PF. Neonatal hemochromatosis: a congenital alloimmune hepatitis. Semin Liver Dis 2007; 27: 243-250.
    • (2007) Semin Liver Dis , vol.27 , pp. 243-250
    • Whitington, P.F.1
  • 91
    • 0015384214 scopus 로고
    • A family of congenital atransferrinemia
    • Goya N, Miyazaki S, Kodate S, Ushio B. A family of congenital atransferrinemia. Blood 1972; 40: 239-245.
    • (1972) Blood , vol.40 , pp. 239-245
    • Goya, N.1    Miyazaki, S.2    Kodate, S.3    Ushio, B.4
  • 95
    • 0037093206 scopus 로고    scopus 로고
    • Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: Characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization
    • Becker EM, Greer JM, Ponka P, Richardson DR. Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization. Blood 2002; 99: 3813-3822.
    • (2002) Blood , vol.99 , pp. 3813-3822
    • Becker, E.M.1    Greer, J.M.2    Ponka, P.3    Richardson, D.R.4
  • 96
    • 33746830877 scopus 로고    scopus 로고
    • Screening for hereditary hemochromatosis: A systematic review for the US Preventive Services Task Force
    • Whitlock EP, Garlitz BA, Harris EL, Beil TL, Smith PR. Screening for hereditary hemochromatosis: a systematic review for the US Preventive Services Task Force. Ann Intern Med 2006; 145: 209-223.
    • (2006) Ann Intern Med , vol.145 , pp. 209-223
    • Whitlock, E.P.1    Garlitz, B.A.2    Harris, E.L.3    Beil, T.L.4    Smith, P.R.5
  • 97
    • 36348964891 scopus 로고    scopus 로고
    • Clinical expression of hemochromatosis gene (HFE) variants
    • Ayonrinde OT, Olynyk JK. Clinical expression of hemochromatosis gene (HFE) variants. Hepatology 2007; 46: 960-962.
    • (2007) Hepatology , vol.46 , pp. 960-962
    • Ayonrinde, O.T.1    Olynyk, J.K.2
  • 99
    • 25644433561 scopus 로고    scopus 로고
    • Beware of multiple comparisons: A study of symptoms associated with mutations of the HFE hemochromatosis gene
    • Waalen J, Beutler E. Beware of multiple comparisons: a study of symptoms associated with mutations of the HFE hemochromatosis gene. Clin Chim Acta 2005; 361: 128-134.
    • (2005) Clin Chim Acta , vol.361 , pp. 128-134
    • Waalen, J.1    Beutler, E.2
  • 101
    • 0035038147 scopus 로고    scopus 로고
    • Diagnosis and management of hemochromatosis
    • Tavill AS. Diagnosis and management of hemochromatosis. Hepatology 2001; 33: 1321-1328.
    • (2001) Hepatology , vol.33 , pp. 1321-1328
    • Tavill, A.S.1
  • 102
    • 4143140782 scopus 로고    scopus 로고
    • Hereditary hemochromatosis genetic testing of at-risk children: What is the appropriate age?
    • Delatycki MB, Powell LW, Allen KJ. Hereditary hemochromatosis genetic testing of at-risk children: what is the appropriate age? Genet Test 2004; 8: 98-103.
    • (2004) Genet Test , vol.8 , pp. 98-103
    • Delatycki, M.B.1    Powell, L.W.2    Allen, K.J.3
  • 103
    • 0037132786 scopus 로고    scopus 로고
    • Penetrance of 845G - A (C282Y) HFE hereditary haemochromatosis mutation in the USA
    • Beutler E, Felitti VJ, Koziol JA, Ho NJ, Gelbart T. Penetrance of 845G - A (C282Y) HFE hereditary haemochromatosis mutation in the USA. Lancet 2002; 359: 211-218.
    • (2002) Lancet , vol.359 , pp. 211-218
    • Beutler, E.1    Felitti, V.J.2    Koziol, J.A.3    Ho, N.J.4    Gelbart, T.5
  • 105
    • 0036944167 scopus 로고    scopus 로고
    • Hereditary haemochromatosis: Only 1% of adult HFE C282Y homozygotes in South Wales have a clinical diagnosis of iron overload
    • McCune CA, Al-Jader LN, May A, Hayes SL, Jackson HA, Worwood M. Hereditary haemochromatosis: only 1% of adult HFE C282Y homozygotes in South Wales have a clinical diagnosis of iron overload. Hum Genet 2002; 111: 538-543.
    • (2002) Hum Genet , vol.111 , pp. 538-543
    • McCune, C.A.1    Al-Jader, L.N.2    May, A.3    Hayes, S.L.4    Jackson, H.A.5    Worwood, M.6
  • 107
    • 0022656390 scopus 로고
    • Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis
    • Bassett ML, Halliday JW, Powell LW. Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 1986; 6: 24-29.
    • (1986) Hepatology , vol.6 , pp. 24-29
    • Bassett, M.L.1    Halliday, J.W.2    Powell, L.W.3
  • 108
    • 0036163634 scopus 로고    scopus 로고
    • Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis
    • Fletcher LM, Dixon JL, Purdie DM, Powell LW, Crawford DHG. Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis. Gastroenterology 2002; 122: 281-289.
    • (2002) Gastroenterology , vol.122 , pp. 281-289
    • Fletcher, L.M.1    Dixon, J.L.2    Purdie, D.M.3    Powell, L.W.4    Crawford, D.H.G.5
  • 109
    • 0035133172 scopus 로고    scopus 로고
    • Effect of hemochromatosis genotype and lifestyle factors on iron and red cell indices in a community population
    • Rossi E, Bulsara MK, Olynyk JK, Cullen DJ, Summerville L, Powell LW. Effect of hemochromatosis genotype and lifestyle factors on iron and red cell indices in a community population. Clin Chem 2001; 47: 202-208.
    • (2001) Clin Chem , vol.47 , pp. 202-208
    • Rossi, E.1    Bulsara, M.K.2    Olynyk, J.K.3    Cullen, D.J.4    Summerville, L.5    Powell, L.W.6
  • 110
    • 33645121766 scopus 로고    scopus 로고
    • Iron loading and morbidity among relatives of HFE C282Y homozygotes identified either by population genetic testing or presenting as patients
    • McCune CA, Ravine D, Carter K, Jackson HA, Hutton D, Hedderich J, Krawczak M, Worwood M. Iron loading and morbidity among relatives of HFE C282Y homozygotes identified either by population genetic testing or presenting as patients. Gut 2006; 55: 554-562.
    • (2006) Gut , vol.55 , pp. 554-562
    • McCune, C.A.1    Ravine, D.2    Carter, K.3    Jackson, H.A.4    Hutton, D.5    Hedderich, J.6    Krawczak, M.7    Worwood, M.8
  • 113
    • 0029965281 scopus 로고    scopus 로고
    • Serum ferritin in Danes: Studies of iron status from infancy to old age, during blood donation and pregnancy
    • Milman N. Serum ferritin in Danes: studies of iron status from infancy to old age, during blood donation and pregnancy. Int J Hematol 1996; 63: 103-135.
    • (1996) Int J Hematol , vol.63 , pp. 103-135
    • Milman, N.1
  • 118
    • 0035124088 scopus 로고    scopus 로고
    • Is there a threshold of hepatic iron concentration that leads to cirrhosis in C282Y hemochromatosis?
    • Adams PC. Is there a threshold of hepatic iron concentration that leads to cirrhosis in C282Y hemochromatosis? Am J Gastroenterol 2001;96: 567-569.
    • (2001) Am J Gastroenterol , vol.96 , pp. 567-569
    • Adams, P.C.1
  • 119
    • 0025871593 scopus 로고
    • Rheumatic manifestations of haemochromatosis
    • Axford JS. Rheumatic manifestations of haemochromatosis. Baillieres Clin Rheumatol 1991; 5: 351-365.
    • (1991) Baillieres Clin Rheumatol , vol.5 , pp. 351-365
    • Axford, J.S.1
  • 125
    • 0026800818 scopus 로고
    • High stored iron levels are associated with excess risk of myocardial-infarction in eastern Finnish men
    • Salonen JT, Nyyssonen K, Korpela H, Tuomilehto J, Seppanen R, Salonen R. High stored iron levels are associated with excess risk of myocardial-infarction in eastern Finnish men. Circulation 1992; 86: 803-811.
    • (1992) Circulation , vol.86 , pp. 803-811
    • Salonen, J.T.1    Nyyssonen, K.2    Korpela, H.3    Tuomilehto, J.4    Seppanen, R.5    Salonen, R.6
  • 126
    • 0033592398 scopus 로고    scopus 로고
    • Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation - A prospective cohort study in men in eastern Finland
    • Tuomainen TP, Kontula K, Nyyssonen K, Lakka TA, Helio T, Salonen JT. Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation - A prospective cohort study in men in eastern Finland. Circulation 1999; 100: 1274-1279.
    • (1999) Circulation , vol.100 , pp. 1274-1279
    • Tuomainen, T.P.1    Kontula, K.2    Nyyssonen, K.3    Lakka, T.A.4    Helio, T.5    Salonen, J.T.6
  • 127
    • 84942482206 scopus 로고
    • Hemochromatosis, multiorgan hemosiderosis, and coronary-artery disease
    • Miller M, Hutchins GM. Hemochromatosis, multiorgan hemosiderosis, and coronary-artery disease. JAMA 1994;272: 231-233.
    • (1994) JAMA , vol.272 , pp. 231-233
    • Miller, M.1    Hutchins, G.M.2
  • 130
    • 14744271419 scopus 로고    scopus 로고
    • Inflammation, genetics, and ischemic heart disease: Focus on the major histocompatibility complex (MHC) genes
    • Porto I, Leone AM, Crea F, Andreotti F. Inflammation, genetics, and ischemic heart disease: focus on the major histocompatibility complex (MHC) genes. Cytokine 2005; 29: 187-196.
    • (2005) Cytokine , vol.29 , pp. 187-196
    • Porto, I.1    Leone, A.M.2    Crea, F.3    Andreotti, F.4
  • 133
    • 0031030733 scopus 로고    scopus 로고
    • The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic hemochromatosis
    • Adams PC, Deugnier Y, Moirand R, Brissot P. The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic hemochromatosis. Hepatology 1997; 25: 162-166.
    • (1997) Hepatology , vol.25 , pp. 162-166
    • Adams, P.C.1    Deugnier, Y.2    Moirand, R.3    Brissot, P.4
  • 134
    • 0032401683 scopus 로고    scopus 로고
    • Hemochromatosis- associated mortality in the United States from 1979 to 1992: An analysis of multiple-cause mortality data
    • Yang Q, McDonnell SM, Khoury MJ, Cono J, Parrish RG. Hemochromatosis- associated mortality in the United States from 1979 to 1992: an analysis of multiple-cause mortality data. Ann Intern Med 1998; 129: 946-953.
    • (1998) Ann Intern Med , vol.129 , pp. 946-953
    • Yang, Q.1    McDonnell, S.M.2    Khoury, M.J.3    Cono, J.4    Parrish, R.G.5
  • 135
    • 23844470848 scopus 로고    scopus 로고
    • Early diagnosis of hemochromatosis-related cardiomyopathy with magnetic resonance imaging
    • Ptaszek LM, Price ET, Hu MY, Yang PC. Early diagnosis of hemochromatosis-related cardiomyopathy with magnetic resonance imaging. J Cardiovasc Magn Reson 2005; 7: 689-692.
    • (2005) J Cardiovasc Magn Reson , vol.7 , pp. 689-692
    • Ptaszek, L.M.1    Price, E.T.2    Hu, M.Y.3    Yang, P.C.4
  • 137
    • 36749100955 scopus 로고    scopus 로고
    • Cardiac magnetic resonance in myocardial disease
    • Sechtem U, Mahrholdt H, Vogelsberg H. Cardiac magnetic resonance in myocardial disease. Heart 2007; 93: 1520-1527.
    • (2007) Heart , vol.93 , pp. 1520-1527
    • Sechtem, U.1    Mahrholdt, H.2    Vogelsberg, H.3
  • 138
    • 3142726133 scopus 로고    scopus 로고
    • Review article. Targeted screening for hereditary haemochromatosis in high-risk groups
    • DuBois S, Kowdley KV. Review article. Targeted screening for hereditary haemochromatosis in high-risk groups. Aliment Pharmacol Ther 2004; 20: 1-14.
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 1-14
    • DuBois, S.1    Kowdley, K.V.2
  • 141
    • 0037242550 scopus 로고    scopus 로고
    • The liver, liver disease and diabetes mellitus
    • Albright ES, Bell DSH. The liver, liver disease and diabetes mellitus. Endocrinologist 2003; 13: 58-66.
    • (2003) Endocrinologist , vol.13 , pp. 58-66
    • Albright, E.S.1    Bell, D.S.H.2
  • 144
    • 33744919003 scopus 로고    scopus 로고
    • High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis
    • McClain DA, Abraham D, Rogers J, Brady R, Gault P, Ajioka R, Kushner JP. High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis. Diabetologia 2006; 49: 1661-1669.
    • (2006) Diabetologia , vol.49 , pp. 1661-1669
    • McClain, D.A.1    Abraham, D.2    Rogers, J.3    Brady, R.4    Gault, P.5    Ajioka, R.6    Kushner, J.P.7
  • 145
  • 148
    • 36349010904 scopus 로고    scopus 로고
    • Hemochromatosis genotypes and risk of 31 disease endpoints: Meta-analyses including 66,000 cases and 226,000 controls
    • Ellervik C, Birgens H, Tybjaerg-Hansen A, Nordestgaard BG. Hemochromatosis genotypes and risk of 31 disease endpoints: meta-analyses including 66,000 cases and 226,000 controls. Hepatology 2007; 46: 1071-1080.
    • (2007) Hepatology , vol.46 , pp. 1071-1080
    • Ellervik, C.1    Birgens, H.2    Tybjaerg-Hansen, A.3    Nordestgaard, B.G.4
  • 149
    • 0037701646 scopus 로고    scopus 로고
    • Typical type 2 diabetes mellitus and HFE gene mutations: A population-based case-control study
    • Halsall DJ, McFarlane I, Luan J, Cox TM, Wareham NJ. Typical type 2 diabetes mellitus and HFE gene mutations: a population-based case-control study. Hum Mol Genet 2003; 12: 1361-1365.
    • (2003) Hum Mol Genet , vol.12 , pp. 1361-1365
    • Halsall, D.J.1    McFarlane, I.2    Luan, J.3    Cox, T.M.4    Wareham, N.J.5
  • 150
    • 0033789809 scopus 로고    scopus 로고
    • Is diabetes mellitus a sufficient condition to suspect hemochromatosis?
    • Dubois-Laforgue D, Larger E, Timsit J. Is diabetes mellitus a sufficient condition to suspect hemochromatosis? Diabetes Metab 2000; 26: 318-321.
    • (2000) Diabetes Metab , vol.26 , pp. 318-321
    • Dubois-Laforgue, D.1    Larger, E.2    Timsit, J.3
  • 152
    • 0034184778 scopus 로고    scopus 로고
    • The neurochemical basis of cognitive deficits induced by brain iron deficiency: Involvement of dopamine-opiate system
    • Youdim MB, Yehuda S. The neurochemical basis of cognitive deficits induced by brain iron deficiency: involvement of dopamine-opiate system. Cell Mol Biol (Noisy-le-grand) 2000; 46: 491-500.
    • (2000) Cell Mol Biol (Noisy-le-grand) , vol.46 , pp. 491-500
    • Youdim, M.B.1    Yehuda, S.2
  • 153
    • 0345714885 scopus 로고    scopus 로고
    • Iron misregulation in the brain: A primary cause of neurodegenerative disorders
    • Ke Y, Qian ZM. Iron misregulation in the brain: a primary cause of neurodegenerative disorders. Lancet Neurol 2003; 2: 246-253.
    • (2003) Lancet Neurol , vol.2 , pp. 246-253
    • Ke, Y.1    Qian, Z.M.2
  • 155
    • 2142828035 scopus 로고    scopus 로고
    • Alterations in the interaction between Fe regulatory proteins and their Fe responsive element in normal and Alzheimer's diseased brains
    • Pinero DJ, Hu J, Connor JR. Alterations in the interaction between Fe regulatory proteins and their Fe responsive element in normal and Alzheimer's diseased brains. Cell Mol Biol (Noisy-le-grand) 2000; 46: 761-776.
    • (2000) Cell Mol Biol (Noisy-le-grand) , vol.46 , pp. 761-776
    • Pinero, D.J.1    Hu, J.2    Connor, J.R.3
  • 157
    • 0035964047 scopus 로고    scopus 로고
    • New genes reveal major role for iron in neurodegeneration
    • Senior K. New genes reveal major role for iron in neurodegeneration. Lancet 2001; 358: 302.
    • (2001) Lancet , vol.358 , pp. 302
    • Senior, K.1
  • 160
    • 1842504248 scopus 로고    scopus 로고
    • Xu X, Pin S, Gathinji M, Fuchs R, Harris ZL. Aceruloplasminemia. An inherited neurodegenerative disease with impairment of iron homeostasis. Ann NY Acad Sci 2004; 1012: 299-305.
    • Xu X, Pin S, Gathinji M, Fuchs R, Harris ZL. Aceruloplasminemia. An inherited neurodegenerative disease with impairment of iron homeostasis. Ann NY Acad Sci 2004; 1012: 299-305.
  • 162
    • 28944450552 scopus 로고    scopus 로고
    • Late-onset Friedreich ataxia: Phenotypic analysis, magnetic resonance imaging findings, and review of the literature
    • Bhidayasiri R, Perlman SL, Pulst SM, Geschwind DH. Late-onset Friedreich ataxia: phenotypic analysis, magnetic resonance imaging findings, and review of the literature. Arch Neurol 2005; 62: 1865-1869.
    • (2005) Arch Neurol , vol.62 , pp. 1865-1869
    • Bhidayasiri, R.1    Perlman, S.L.2    Pulst, S.M.3    Geschwind, D.H.4
  • 164
    • 0033961913 scopus 로고    scopus 로고
    • Transferrin and receptor function in brain barrier systems
    • Moos T, Morgan EH. Transferrin and receptor function in brain barrier systems. Cell Mol Neurobiol 2000; 20: 77-95.
    • (2000) Cell Mol Neurobiol , vol.20 , pp. 77-95
    • Moos, T.1    Morgan, E.H.2
  • 165
    • 0036970417 scopus 로고    scopus 로고
    • A morphological study of the developmentally regulated transport of iron into the brain
    • Moos T, Morgan EH. A morphological study of the developmentally regulated transport of iron into the brain. Dev Neurosci 2002; 24: 99-105.
    • (2002) Dev Neurosci , vol.24 , pp. 99-105
    • Moos, T.1    Morgan, E.H.2
  • 166
    • 1042301280 scopus 로고    scopus 로고
    • Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain
    • Deane R, Zheng W, Zlokovic BV. Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J Neurochem 2004; 88: 813-820.
    • (2004) J Neurochem , vol.88 , pp. 813-820
    • Deane, R.1    Zheng, W.2    Zlokovic, B.V.3
  • 167
    • 0032427653 scopus 로고    scopus 로고
    • Kupffer cell staining by an HFE-specific monoclonal antibody: Implications for hereditary haemochromatosis
    • Bastin JM, Jones M, O'Callaghan CA, Schimanski L, Mason DY, Townsend AR. Kupffer cell staining by an HFE-specific monoclonal antibody: implications for hereditary haemochromatosis. Br J Haematol 1998; 103: 931-941.
    • (1998) Br J Haematol , vol.103 , pp. 931-941
    • Bastin, J.M.1    Jones, M.2    O'Callaghan, C.A.3    Schimanski, L.4    Mason, D.Y.5    Townsend, A.R.6
  • 168
    • 0030885482 scopus 로고    scopus 로고
    • Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
    • Smith MA, Harris PL, Sayre LM, Perry G. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc Natl Acad Sci USA 1997; 94: 9866-9868.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9866-9868
    • Smith, M.A.1    Harris, P.L.2    Sayre, L.M.3    Perry, G.4
  • 179
  • 181
    • 0036559746 scopus 로고    scopus 로고
    • Hereditary haemochromatosis in two cousins with cluster headache
    • Stovner LJ, Hagen K, Waage A, Bjerve KS. Hereditary haemochromatosis in two cousins with cluster headache. Cephalgia 2002; 22: 317-319.
    • (2002) Cephalgia , vol.22 , pp. 317-319
    • Stovner, L.J.1    Hagen, K.2    Waage, A.3    Bjerve, K.S.4
  • 184
    • 0037110658 scopus 로고    scopus 로고
    • Morbidity risk in HFE associated hereditary hemochromatosis C282Y heterozygotes
    • Fuchs J, Podda M, Packer L, Kaufmann R. Morbidity risk in HFE associated hereditary hemochromatosis C282Y heterozygotes. Toxicology 2002; 180: 169-181.
    • (2002) Toxicology , vol.180 , pp. 169-181
    • Fuchs, J.1    Podda, M.2    Packer, L.3    Kaufmann, R.4
  • 189
    • 16444363495 scopus 로고    scopus 로고
    • HFE gene mutations in leukemia: HuGE review susceptibility to childhood
    • Dorak MT, Burnett AK, Worwood M. HFE gene mutations in leukemia: HuGE review susceptibility to childhood. Genet Med 2005; 7: 159-168.
    • (2005) Genet Med , vol.7 , pp. 159-168
    • Dorak, M.T.1    Burnett, A.K.2    Worwood, M.3
  • 196
    • 0035116099 scopus 로고    scopus 로고
    • Hemochromatosis: Diagnosis and management
    • Bacon BR. Hemochromatosis: diagnosis and management. Gastroenterology 2001; 120: 718-725.
    • (2001) Gastroenterology , vol.120 , pp. 718-725
    • Bacon, B.R.1
  • 197
    • 43549101420 scopus 로고    scopus 로고
    • Screening for hemochromatosis by measuring ferritin levels: A more effective approach
    • Waalen J, Felitti VJ, Gelbart T, Beutler E. Screening for hemochromatosis by measuring ferritin levels: a more effective approach. Blood 2008; 111: 3373-3376.
    • (2008) Blood , vol.111 , pp. 3373-3376
    • Waalen, J.1    Felitti, V.J.2    Gelbart, T.3    Beutler, E.4
  • 198
    • 1442282237 scopus 로고    scopus 로고
    • Evolution of untreated hereditary hemochromatosis in the Busselton population: A 17-year study
    • Olynyk JK, Hagan SE, Cullen DJ, Beilby J, Wihttall DE. Evolution of untreated hereditary hemochromatosis in the Busselton population: a 17-year study. Mayo Clin Proc 2004; 79: 309-313.
    • (2004) Mayo Clin Proc , vol.79 , pp. 309-313
    • Olynyk, J.K.1    Hagan, S.E.2    Cullen, D.J.3    Beilby, J.4    Wihttall, D.E.5
  • 200
    • 0018766064 scopus 로고
    • Nuclear resonant scattering ofgammarays - A new technique for in vivo measurement of body iron stores
    • Vartsky D, Ellis KJ, Hull DM, Cohn SH. Nuclear resonant scattering ofgammarays - A new technique for in vivo measurement of body iron stores. Phys Med Biol 1979; 24: 689-701.
    • (1979) Phys Med Biol , vol.24 , pp. 689-701
    • Vartsky, D.1    Ellis, K.J.2    Hull, D.M.3    Cohn, S.H.4
  • 202
    • 0037217987 scopus 로고    scopus 로고
    • Noninvasive measurement of iron: Report of an NIDDK workshop
    • Brittenham GM, Badman DG. Noninvasive measurement of iron: report of an NIDDK workshop. Blood 2003; 101: 15-19.
    • (2003) Blood , vol.101 , pp. 15-19
    • Brittenham, G.M.1    Badman, D.G.2
  • 208
    • 0014297319 scopus 로고
    • Liver biopsy in diagnosis of hemochromatosis
    • Kent G, Popper H. Liver biopsy in diagnosis of hemochromatosis. Am J Med 1968; 44: 837-841.
    • (1968) Am J Med , vol.44 , pp. 837-841
    • Kent, G.1    Popper, H.2
  • 209
    • 0042855876 scopus 로고    scopus 로고
    • Ethical, legal, and social implications of genomic medicine
    • Clayton EW. Ethical, legal, and social implications of genomic medicine. N Engl J Med 2003; 349: 562-569.
    • (2003) N Engl J Med , vol.349 , pp. 562-569
    • Clayton, E.W.1
  • 210
    • 36448992223 scopus 로고    scopus 로고
    • Genetic discrimination in health insurance: Current legal protections and industry practices
    • Pollitz K, Peshkin BN, Bangit E, Lucia K. Genetic discrimination in health insurance: current legal protections and industry practices. Inquiry 2007; 44: 350-368.
    • (2007) Inquiry , vol.44 , pp. 350-368
    • Pollitz, K.1    Peshkin, B.N.2    Bangit, E.3    Lucia, K.4
  • 213
    • 0037140203 scopus 로고    scopus 로고
    • Insurance agreement to facilitate genetic testing
    • Delatycki M, Allen K, Williamson R. Insurance agreement to facilitate genetic testing. Lancet 2002; 359: 1433.
    • (2002) Lancet , vol.359 , pp. 1433
    • Delatycki, M.1    Allen, K.2    Williamson, R.3
  • 215
    • 0034869504 scopus 로고    scopus 로고
    • Psychosocial impact of C282Y mutation testing for hemochromatosis
    • Power TE, Adams PC. Psychosocial impact of C282Y mutation testing for hemochromatosis. Genet Test 2001;5: 107-110.
    • (2001) Genet Test , vol.5 , pp. 107-110
    • Power, T.E.1    Adams, P.C.2
  • 216
    • 0031743057 scopus 로고    scopus 로고
    • Clinical trial on the effect of regular tea drinking on iron accumulation in genetic haemochromatosis
    • Kaltwasser JP, Werner E, Schalk K, Hansen C, Gottschalk R, Seidl C. Clinical trial on the effect of regular tea drinking on iron accumulation in genetic haemochromatosis. Gut 1998; 43: 699-704.
    • (1998) Gut , vol.43 , pp. 699-704
    • Kaltwasser, J.P.1    Werner, E.2    Schalk, K.3    Hansen, C.4    Gottschalk, R.5    Seidl, C.6
  • 217
    • 34547508591 scopus 로고    scopus 로고
    • Survival of liver transplant recipients with hemochromatosis in the United States
    • Yu L, Ioannou GN. Survival of liver transplant recipients with hemochromatosis in the United States. Gastroenterology 2007; 133: 489-495.
    • (2007) Gastroenterology , vol.133 , pp. 489-495
    • Yu, L.1    Ioannou, G.N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.